Relating to the technical field of moxibustion in Chinese medicinal physiotherapy, the invention discloses a moxa stick with a Chinese medicinal prescription and a preparation method thereof. The moxa stick is composed of artemisia argyi, Tainding, herba siegesbeckiae, girardinia cuspidata, trachelospermum jasminoide, rosin, clove, costus root, frankincense, radix angelicae pubescentis, angelica dahurica, radix saposhnikoviae, herba schizonepetae, herba selaginellae, sapindus, sophora japonical, Baicaodan and barley koji. According to the invention, by adding various important ingredients into artemisia argyi, the moxa stick has wider curative effect, and because of the use of a food grade adhesive, the moxa stick does not deteriorate easily, at the same time by combining several groups of moxa sticks into a large diameter moxa stick, thus prolonging the burning time of the moxa stick, and ensuring the burning stability and continuity of the moxa stick. The preparation method of the moxa stick is simple, and can change the Chinese medicinal components in the moxa stick according to the treated disease category.