87 results about "Ph regulation" patented technology

The invention discloses a preparation method of an aluminum hydroxide adjuvant capable of regulating and controlling pH in stages, and aims to solve the problems of non-uniform particle size, unstable adsorption and large inter-batch difference in the traditional process. According to the method, phosphate radical modified hydroxyapatite nanocrystal seeds are taken as an induction template, and three-stage accurate pH regulation and control are carried out: a pre-crystal seed stage activates crystal seed active sites, a main crystallization stage guides directional growth of aluminum hydroxide, and an aluminum phosphate coating layer is formed in a stabilization stage. Compared with a traditional process, the finished product yield is improved, energy consumption is reduced, and the method is suitable for vaccine industrial production.

The invention discloses a green preparation method for realizing a high-performance chitosan film through pH regulation and control of a citric acid buffering agent, and belongs to the field of food packaging and high polymer materials. According to the method, a water phase separation method is adopted, a citric acid buffering agent serves as a water phase environment, and a chitosan solution is induced to be subjected to phase separation and gelation by regulating and controlling the pH value (preferably 5.0-5.5) of the citric acid buffering agent. The preparation method comprises the following specific steps: dissolving chitosan powder in an alkali urea solvent (KOH: urea: water = 7: 12: 81), inducing gelation through a citric acid buffer agent, carrying out solvent replacement through an ethanol solution, and drying and curing. According to the method, a chemical cross-linking agent does not need to be used, and the core is that a buffer system is used for regulating and controlling the phase separation process to promote aggregation among chitosan molecular chains, so that a compact physical structure network is constructed. The prepared chitosan film has excellent mechanical strength, water resistance, gas barrier property, biocompatibility and degradability, and is suitable for the fields of food, medicine packaging and the like.

The invention provides a directional recovery method of pickling wastewater. According to the treatment method disclosed by the invention, a decomplexing agent is used for promoting a complex of fluorine, iron, chromium and nickel to be dissociated into free fluorine, then nanofiltration is adopted for realizing separation of the free fluorine, the iron, the chromium and the nickel, and a fluorine removal agent is added into the separated fluorine-rich solution for realizing fluorine recovery, so that the problem that the complex fluorine is difficult to recover is solved; meanwhile, according to the treatment method, a reducing agent is added into a separated solution rich in iron, chromium and nickel to promote ferric ions to be reduced into ferrous ions, then ion exchange resin is used for preferentially adsorbing chromium and nickel, the ion exchange resin containing chromium and nickel is subjected to desorption treatment, and then graded recovery of chromium and nickel is achieved through gradient pH regulation and control. And finally, pH regulation and control are carried out on the effluent obtained after ion exchange resin adsorption, iron recovery can be achieved, and therefore the problem that separation is difficult due to the fact that the pH of iron and chromium precipitates is close is solved.

The invention discloses an Apopsin3 mutant and a method for regulating an environment in a plant cell to be acidic, and belongs to the technical field of pH regulation in the plant cell. The regulation and control method comprises the following steps: mutating 83rd and 120th amino acids of the light-operated hydrogen ion pump protein Apopsin3, converting into hydrogen ion channels, expressing the hydrogen ion channels on a cell membrane in a targeting manner, and stimulating with green light of 40-500 [mu] W / mm < 2 > and 520-560 nm so as to regulate the pH in the cell to be acidic. By adopting the cell specific promoter and performing site-specific mutagenesis modification on the specific hydrogen ion pump, accurate pH regulation and control on specific cells or organelles can be realized. An Apopsin3 (FARH) gene is fused with a cell membrane targeting sequence, and under the stimulation of specific light, only the pH of cytoplasm is obviously changed, and the pH of other cell regions is not influenced.

The invention provides a method for synergistically removing impurities through pH regulation and complexing of ionic rare earth ore leachate, the ionic rare earth ore leachate is stirred and mixed uniformly, a plant polyphenol sulfonic acid derivative complexing agent is added, the complexing agent is prepared through sulfonation, neutralization, concentration and drying by taking gallic acid as a raw material, and the complexing agent can automatically regulate the pH value of the solution and stabilize the pH value at 5.1-5.3; under the condition, phenolic hydroxyl groups, carboxyl groups and sulfonic functional groups in complexing agent molecules preferentially form stable precipitates with impurity ions such as Al < 3 + > and Fe < 3 + > in the leachate, and the complexing effect with rare earth ions (RE < 3 + >) is weak; and after the reaction is completed, carrying out solid-liquid separation to obtain the purified leachate and impurity-containing precipitation slag. The method solves the problem of ammonia nitrogen pollution caused by use of ammonium bicarbonate, ammonia water and other ammonium salts in the traditional process, is a novel method with high impurity removal rate, simple process flow and environmental friendliness, and is suitable for industrial application.

The application discloses a bifidobacterium splitting activity detection method based on pH regulation and application thereof, and belongs to the technical field of microbial fermentation. The detection method comprises high-density fermentation of bifidobacterium with fluorescent labeling under pH regulation and splitting cycle detection through flow cytometry, and the pH regulation range is 4.30-6.30. The bifidobacterium splitting activity detection method based on pH regulation and application thereof can quickly and accurately quantitatively and qualitatively detect the real-time fermentation state of bifidobacterium. The bifidobacterium splitting activity detection method based on pH regulation can be used for quantitative evaluation of cell splitting in a complex fermentation system, and realizes bifidobacterium fermentation optimization and precise fermentation control.

The invention relates to the technical field of biological detection, and discloses a tyrosinase activity detection method based on in-situ fluorescence generation and application, and the method comprises the following steps: mixing L-tyrosine with 3-hydroxyphenylboronic acid; adding a biological enzyme sample solution, incubating at a constant temperature, and accumulating L-dopa by enzyme catalysis; then adding an alkaline adjusting solution to construct an alkaline environment, inducing the 3-hydroxyphenylboronic acid and L-dopa to generate a specific boric acid esterification reaction, and generating a fluorescent borate compound in situ; and finally, adding a constant-volume stop solution to maintain an alkaline environment and complement the volume, and detecting the fluorescence intensity. According to the method, a step-by-step pH regulation strategy is adopted, the enzyme activity is guaranteed under the neutral condition, then color development is promoted under the alkaline condition, and the problem that dynamic conditions of the two are incompatible is solved. The method has the advantages of low background interference, high sensitivity, good reproducibility and the like by utilizing specific recognition of a phenylboronic acid group on a catechol structure, and can be applied to food browning analysis, whitening drug screening and disease diagnosis.

The invention discloses a production method for improving the ring opening rate of monascus milovastatin, and belongs to the technical field of monascus rice production. According to the method, a monascus purpureus high-yield strain is selected and inoculated into a solid indica rice matrix containing a specific additive for fermentation after spore activation, and the matrix comprises 1, 5-p-coumaroylquinic acid, sodium acetate, sodium citrate, a thermally modified soybean protein isolate polysaccharide sulfate compound and other components. Wherein sodium acetate and sodium citrate can serve as short-chain fatty acid precursors, the activity of closed-loop lactonase is inhibited through pH regulation, and generation of lactone type products is reduced; 1, 5-p-coumaroylquinic acid activates the expression of a polyketide synthase gene cluster, so that the synthesis flux of the Monacolin K with an open-loop structure is improved; nicotinamide ribose enhances the electron transfer efficiency of glycolysis and TCA circulation, provides sufficient ATP for polyketone synthesis, and promotes synthesis of Monacolin K. The compound further strengthens the synthesis flux of secondary metabolites by changing the form of hyphae and continuously releasing a nitrogen / carbon source, and promotes intracellular products to be transferred to extracellular.

The invention provides an RGI pectin dissolution promoting preparation method based on pH regulation and control. The technical prejudice that the extracting solution is adjusted to be neutral before alcohol precipitation in the original common means is overcome, the pH value of the extracting solution before alcohol precipitation is adjusted to be 1-3 so as to influence the structural form of the RGI pectin, the anti-aggregation ability of the whole system is enhanced, the purpose of promoting dissolution of the hot-dried RG-I pectin is achieved, and the method has good industrial application prospects.

The application provides a grey water PH regulating device, relates to the technical field of PH regulation, and comprises an adjusting tank and a filtering device, a water inlet pipe is fixedly connected to one side of the adjusting tank, a water outlet is fixedly connected to the lower end of the one side of the adjusting tank, a filtering device is arranged on the inner wall of the adjusting tank and corresponds to the position of the water inlet pipe, the filtering device comprises a filtering pipe, the two ends of the filtering pipe are slidably connected with the inner wall of the adjusting tank, mounting plates are fixedly connected to the two ends of the filtering pipe, sliding blocks are fixedly connected to the two sides of the mounting plates, sliding grooves are formed in the inner wall of the adjusting tank and correspond to the positions of the sliding blocks, and the surfaces of the sliding blocks are slidably connected with the inner walls of the sliding grooves. The filtering device, the stirring device and the gas exchange device are designed, so that the problem that the traditional filtering device is inconvenient to disassemble and clean, is easy to cause the mesh holes to be blocked by sundries, affects the water inflow, and has low PH regulation precision is solved.

The invention provides pH regulation systems of buffer-loaded hydrogels that can regulate pH of solutions for long periods of time. These pH-regulating hydrogels may be used in a variety of pH-dependent systems, including water treatment, agricultural soil, and biological applications. Demonstrated is an application in increasing the efficacy of weak base chemotherapeutics used for cancer treatments.

The invention discloses a coal chemical industry wastewater treatment device, and relates to the technical field of industrial wastewater treatment equipment, the coal chemical industry wastewater treatment device comprises a box body and a pH adjusting assembly, a first partition plate is arranged in the box body, and the first partition plate divides the interior of the box body into a first reaction zone and a second reaction zone. The pH adjusting assembly comprises a lifting box, a pH detection part and an acid-base injection pipe, the lifting box is provided with a liquid storage tank, the lifting box is slidably connected with the first partition plate and can take liquid from the first reaction area through the liquid storage tank during sliding, and the pH detection part can detect the pH value of liquid in the lifting box when the lifting box gets close; the acid-alkali injection pipe is arranged on the box body and can inject acid liquor or alkali liquor into the lifting box according to the pH value detected by the pH detection part. The pH detection piece of the coal chemical industry wastewater treatment device can accurately detect the pH value of liquid in the liquid storage tank of the lifting box in real time, so that acid liquor or alkali liquor is accurately injected into the lifting box through the acid-alkali injection pipe according to an actual detection result to carry out pH regulation, and pH regulation and control are accurate and high in efficiency.

The utility model discloses a dosing system capable of accurately regulating and controlling the dosage of acid and alkali, which comprises an acid and alkali storage tank, a high-position dosing tank, a delivery pipe and a first liquid pumping piece, the acid and alkali storage tank is communicated with the high-position dosing tank through the delivery pipe, and the first liquid pumping piece is connected with the delivery pipe, the bottom of the high-level dosing tank is communicated with at least one first dosing pipe used for a first-level pH regulation and control dosing point and at least one second dosing pipe used for a second-level pH regulation and control dosing point, the first dosing pipe is connected with a first manual valve and a pneumatic valve, the pneumatic valve is located at the tail end of the first dosing pipe, the second dosing pipe is connected with a second manual valve and a regulating valve, and the regulating valve is located at the tail end of the second dosing pipe. And the regulating valve is positioned at the tail end of the second dosing pipe. The technical scheme provided by the utility model has the beneficial effects that the problems that in the prior art, the pH value deviation is relatively large and adverse effects are easily caused to subsequent processes such as reaction flocculation, chemical precipitation and the like due to the fact that an acid-base agent is slightly added excessively or not added in time are solved.

The invention provides pH regulation systems of buffer-loaded hydrogels that can regulate pH of solutions for long periods of time. These pH-regulating hydrogels may be used in a variety of pH-dependent systems, including water treatment, agricultural soil, and biological applications. Demonstrated is an application in increasing the efficacy of weak base chemotherapeutics used for cancer treatments.

The utility model discloses a filtering device for low-concentration copper-containing wastewater. Comprising a grating tank used for collecting low-concentration copper-containing wastewater, a first pH adjusting tank communicated with the grating tank, a coagulation and flocculation tank communicated with the first pH adjusting tank, a first sedimentation tank communicated with the coagulation and flocculation tank, a second pH adjusting tank communicated with the first sedimentation tank, and a third pH adjusting tank communicated with the second sedimentation tank, a ceramic membrane filtration module used for filtering suspended solids is arranged between the first pH regulation tank and the coagulation flocculation tank, the first pH regulation tank is used for regulating the pH value of the low-concentration copper-containing wastewater to be weak acidic, and the second pH regulation tank is used for regulating the pH value of the low-concentration copper-containing wastewater to be weak acidic; according to the filtering device for the low-concentration copper-containing wastewater, disclosed by the utility model, the waste liquid containing medium-concentration and low-concentration copper ions is enriched and recycled, so that the pollutant emission can be reduced.

This invention discloses *Paenibacillus alvei* CHWJ-P3 for dissolving phosphorus and potassium in acidic soils and its applications. *Paenibacillus alvei* CHWJ-P3 is classified as *Paenibacillus alvei* CHWJ-P3 and was deposited at the China Center for Type Culture Collection (CCTCC) on December 8, 2025, with accession number CCTCC NO: M 20252813. The *Paenibacillus alvei* CHWJ-P3 of this invention exhibits a significant ability to dissolve phosphorus and potassium in the environment, along with high acid resistance and efficient pH regulation. It can be used for the release of insoluble phosphorus and potassium in soil, i.e., the bioremediation of phosphorus and potassium dissolution in acidic soils; and for the bioremediation of acidic soil pH regulation. It features high remediation efficiency, stable remediation effects, and no secondary pollution, demonstrating promising application prospects.

The utility model relates to the technical field of pure water pH regulation, and discloses a stable high-purity water pH regulation dosing device which comprises a pure water tank, a medicine box is fixedly arranged above the pure water tank, an opening is formed in the top of the pure water tank, a dosing pipe is fixedly arranged on the inner wall of the opening, the dosing pipe is communicated with the medicine box, a medicine storage chamber is arranged in the medicine box, and the medicine storage chamber is communicated with the pure water tank. A medicine discharging opening is formed in the bottom of the medicine storage chamber, the medicine adding pipe is located under the medicine discharging opening, a movable cavity is formed in the medicine box, and a sealing base is arranged on the inner wall of the movable cavity in a sliding mode. The regulating agent can be quantitatively added into the pure water tank, the situation that the pH value of high-purity water fluctuates greatly due to excessive agent adding amount is avoided, if the agent adding amount is insufficient, the flow guide opening continues to be moved to the position under the agent discharging opening for agent adding till the high-purity water reaches the proper pH value, and therefore the agent adding amount can be controlled according to the pH value of the high-purity water, and the effect of controlling the pH value of the high-purity water is achieved. The condition of excessive or insufficient dosing is effectively avoided, and the stability and precision of pH regulation are improved.

The invention discloses a wastewater treatment process optimization control system based on diversified analysis. The system comprises a wastewater segmented treatment module, a multi-source data acquisition module, a multi-target analysis decision module and a terminal regulation and control module. The method comprises the following steps: monitoring a plurality of processes such as pH regulation, Fenton reaction, neutralization reaction and flocculation precipitation reaction in series, obtaining an initial dosing rate of a medicament according to feed-forward water inlet data before reaction of each process, analyzing a process treatment effect based on feedback monitoring data in the reaction process, judging whether wastewater treatment of each process reaches the standard or not, and if so, judging whether the wastewater treatment reaches the standard or not. If the wastewater does not reach the standard, obtaining an agent adding correction value based on deviation analysis of feedback monitoring data, and based on a composite control mechanism of feedforward setting reference and feedback real-time fine adjustment, not only can cope with complex and changeable water inlet conditions in different wastewater treatment processes, but also can perform dynamic feedback optimization based on water quality fluctuation and reaction conditions; the intelligent dynamic dosing of the medicament is realized.

The invention discloses a treatment method of aluminum profile production sewage, which treats the aluminum profile production sewage step by step through reasonable process design and processes of pH regulation, grating separation, flocculent precipitation, adsorption, secondary flocculation and activated carbon fine treatment, and the final effluent quality can meet the aluminum profile production reuse standard. And cyclic utilization of water resources is realized. Wherein after chitosan, polyacrylamide and potassium sulfate are compounded, metal ions can be effectively captured through chelation, efficient flocculation bridging, coagulation accelerating and mutual synergistic effects, formation of a flocculating constituent with certain strength is accelerated, a better flocculation effect is achieved, and the cost is low; kaolin and porous silicon carbide are used as adsorption carriers, hexadecyl trimethyl ammonium bromide is introduced, adsorption is modified and enhanced, sodium polyacrylate and silica sol promote component dispersion and bonding, and the adsorbent with the mechanical property meeting the use requirement is prepared and has the excellent adsorption effect.

The invention belongs to the field of disinfection materials, and provides a skin disinfectant and a preparation method thereof.The skin disinfectant adopts the design that sodium hyaluronate and polyhexamethylene biguanide hydrochloride are subjected to ion complexation to form nanoparticles, and the nanoparticles are stably dispersed in an alcohol-based system; by accurately controlling the particle size of the nanoparticles, the component proportion and the pH regulation, the synergism of low-viscosity spraying and high-molecular film-forming moisturizing in a high-ethanol environment, the balance of stable dispersion of the nanoparticles in a mixed solvent and the contact property of an active ingredient interface, and the consideration of small particle size distribution and high active ingredient carrying capacity are realized; the problem that an existing alcohol-based disinfection system is difficult to meet the requirements for use convenience and disinfection persistence at the same time is solved, and the alcohol-based disinfection system has excellent antibacterial performance, skin moisture retention and long-term stability and has wide application value in the fields of medical treatment and public health, public epidemic prevention and daily disinfection.

The invention discloses a collagen peptide enzymolysis process pH value self-adaptive regulation and control method and a collagen peptide enzymolysis process pH value self-adaptive regulation and control system, particularly relates to the technical field of industrial process automatic control, and is used for solving the problem of control instability caused by sensor interface adsorption and mixing lag of an existing pH control system in a solid-liquid multiphase complex reaction system. The method comprises the following steps: acquiring a pH measurement value sequence and an acid-base reagent addition amount in real time, performing baseline drift evaluation to identify a pseudo signal component, performing signal decomposition on a pH dynamic response sequence to determine mixed dead zone time when the pseudo signal component exceeds a set threshold value, delimiting a pH stable observation window based on the mixed dead zone time, extracting a process gain through spectral analysis, and determining the pH stable observation window according to the process gain. Finally, dynamic control parameters are generated, pH regulation and control with delay judgment logic are executed, meanwhile, pseudo signal components are deducted in pH value collection, cooperative compensation of measurement distortion and execution lag is achieved, and the control quality and stability under a complex reaction system are remarkably improved.

The invention relates to a lidocaine hydrochloride injection and a preparation method thereof, and relates to the technical field of biological medicine manufacturing, and the preparation method of the lidocaine hydrochloride injection comprises the steps of liquid preparation, filtration, potting and sterilization. The solution preparation comprises the following steps: adding a pH regulator into the water for injection accounting for 75-80% vol of the prescription dosage, regulating the pH to 8.3-8.8, adding lidocaine hydrochloride accounting for the prescription dosage, stirring to obtain a first solution, and the like. Compared with the prior art, lidocaine hydrochloride is fed in a suitable alkalescent environment, so that the dissolving speed and the dissolving uniformity of raw material medicines are improved, meanwhile, the strategy also reduces the amplitude of follow-up pH regulation, the impact on a solution system is greatly reduced, and the preparation method is suitable for industrial production. And the whole liquid preparation process can be more slowly completed at room temperature, so that the quality stability of the lidocaine hydrochloride injection is improved.

The invention provides a crystallization process of recombinant insulin glargine and a product, and relates to the technical field of biological medicines. The crystallization process comprises the following steps: mixing and dissolving recombinant insulin glargine, organic acid, an organic solvent, salt and water, and adding zinc substances to obtain a crystallization solution; adjusting the pH value, stirring at low temperature, standing, and separating the recombinant insulin glargine crystal; in the crystallization solution, when the concentration of insulin is 5g / L, the concentration of the organic solvent is 10-30%, and the pH is 8.0-9.3; when the concentration of insulin is more than 5 and less than or equal to 10g / L, the concentration of the organic solvent is 15-30%, and the pH is 8.8-9.5. Under the condition of no phenolic substances, the successful crystallization of the high-concentration recombinant insulin glargine is realized by adopting the specific concentration of the recombinant insulin glargine and the concentration of the organic solvent and combining the conditions of pH regulation and the like; the crystal form of the recombinant insulin glargine is similar to that of the insulin glargine with phenol, and the obtained crystallized recombinant insulin glargine is applied to preparation of drugs for treating diabetes.

The invention provides a device for regulating and controlling the pH value of mineralized water and a water dispenser, the device is arranged at the tail end of a purified water supply pipeline, the device comprises a conversion valve, a mineralization unit, a water mixing tank, a pH value detection unit, a liquid level sensor and a water outlet valve, the conversion valve is connected with the purified water supply pipeline, and the water outlet valve is connected with the mineralization unit. Communicating the purified water supply pipe with a first pipeline or a second pipeline; the mineralization unit is arranged on the first pipeline; the first pipeline and the second pipeline are respectively connected to the water mixing tank; the pH value detection unit is arranged at the bottom of the water mixing tank; the liquid level sensor is arranged above the liquid level in the water mixing tank; and the water outlet valve is arranged at the bottom of the water mixing tank so as to outwards convey direct drinking mineralized water in a set pH value range. According to the technical scheme, real-time dynamic pH regulation and control can be achieved at low cost without chemical addition, and water quality health and pipe network safety are both considered while the mineralization effect is improved.

The present invention discloses a glucose oxidase-metal-curcumin self-assembled nanoparticle and its preparation and application, belonging to the field of nanomaterial preparation and biomedical application. 2+ , curcumin as self-assembly units, and the coordinated hydrophobic force is used to drive the three to self-assemble at the nanoscale to obtain self-assembled particles, thereby achieving a high loading of GOx (54%). 2+ The competitive inhibitory effect on GOx enzyme activity can achieve precise pH regulation of enzyme activity, allowing starvation therapy to selectively "turn on" and "turn off". By modifying the target molecule RGD on the surface of the self-assembled particles, the differentiated inhibitory effect of the self-assembled particles on normal cells and cancer cells is further enhanced, so that the obtained self-assembled nanoparticles can achieve high inhibition (75%) of tumor cells at a very low GOx dose (1.43μg / ml) relying only on a single starvation therapy.

This invention discloses a pH-responsive dye platform, its preparation method, and its applications. The invention achieves precise pH regulation by introducing a heteroaryl amine at position 9 of a traditional rhodamine dye and replacing different heteroatoms at position 10. Based on this strategy, a pH-responsive dye platform spanning the entire physiological pH range (the platform consists of a series of pH-responsive dyes suitable for different pH ranges) is constructed. Furthermore, the pH-responsive dyes in this platform possess excellent photophysical properties, sensitive pH response capabilities, and cover a response range from pH 0.5 to 7.0, meeting the monitoring needs of different pH microenvironments in vivo.

The present invention relates to the measurement of ionic strength using closed loop electrochemical pH regulation. A method for monitoring changes in ionic strength in a sample solution by means of a closed loop device is provided, which provides for continuous electrochemical pH regulation cycles between predetermined pH values. In particular, changes in ionic strength can be induced by chemical reactions and can eventually change the electrical control parameters of the closed loop device. By measuring these electrical control parameters, the extent and progress of the respective chemical reactions can be monitored.

This invention belongs to the field of oil-in-water emulsion preparation technology, and relates to a pH-controlled gelatin-lecithin composite system stabilized oil-in-water emulsion and its preparation method. In the preparation process, lecithin, gelatin, and water are mixed to obtain solution A. The pH value of solution A is adjusted to 3-6. Finally, the pH-adjusted solution A is used as the aqueous phase, and then the oil phase is added to the aqueous phase. Emulsification is performed at a shear rate of 15000-18000 rpm to obtain the pH-controlled gelatin-lecithin composite system stabilized oil-in-water emulsion. The oil phase consists of cyclic monoterpenes. The particle size of the pH-controlled gelatin-lecithin composite system stabilized oil-in-water emulsion is 1-15 μm. The method of this invention is simple and easy to operate; the obtained pH-controlled gelatin-lecithin composite system stabilized oil-in-water emulsion exhibits good dispersibility and stability.

The invention relates to the technical field of dairy product processing, and particularly discloses fulvic acid health-care yoghourt and a preparation method thereof, the fulvic acid health-care yoghourt comprises the following components: 80-90 wt% of a milk protein matrix, 0.5-3.0 wt% of fulvic acid, 0.05-0.1 wt% of a calcium enhancer, 3-5 wt% of a fermentation strain, and the balance of water; wherein the fulvic acid comprises a high molecular weight component greater than 10 kDa, a medium molecular weight component of 3-10 kDa and a low molecular weight component less than 3 kDa, and the low molecular weight component accounts for 20-30% of the total fulvic acid; according to the method, fulvic acid with different molecular weights is added in a graded mode, a dynamic pH regulation and control fermentation technology is combined, degradation of fulvic acid in an acid environment is effectively avoided, the activity retention rate of fulvic acid is increased, whey protein and fulvic acid form a covalent compound by regulating and controlling the heat treatment condition of the whey protein, the bioavailability of fulvic acid is increased, and the activity retention rate of fulvic acid is increased. By constructing a fulvic acid-calcium-casein ternary chelating structure, the bioavailability of calcium is improved, meanwhile, the stability of a yoghourt system is enhanced, and precipitation and layering are prevented.

The invention provides an artemisinin-chitosan multifunctional microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing artemisinin and Span80 with degraded chitosan and Tween 80 to obtain an emulsion; adjusting the pH value to 9-11, and carrying out a single condensation reaction; after dilution, rapidly cooling with an ice-water bath, and adding glutaraldehyde for low-temperature cross-linking curing; and after the reaction is finished, carrying out suction filtration at room temperature, washing and drying to obtain the microcapsule. Based on the synergistic effect of chitosan and artemisinin, a low-temperature composite crosslinking technology is developed, and efficient encapsulation and controllable release of artemisinin in the microcapsule are achieved; the problem that artemisinin is prone to thermal degradation is solved by optimizing the core-wall ratio, pH regulation and control and low-temperature cross-linking curing, and meanwhile, the long-acting slow release performance of the microcapsule in a complex oral environment is remarkably improved by utilizing a dual stabilization mechanism of chitosan single condensation reaction and glutaraldehyde cross-linking. The product has higher active matter loading capacity and release efficiency, and has long-acting application in the scenes of oral cavity bacteria (spots) resistance (inhibition), gingival problem alleviation, hemostasis and the like.