729 results about "Phenethyl alcohol" patented technology

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

The invention relates to the field of biotechnology and discloses an agilawood production method. The method comprises the steps of first drilling a hole in a trunk of aquilaria malaccensis or aquilaria sinensis, enabling an agilawood inducer formed by plant hormones, inorganic salt and phenethyl alcohol to be added dropwise into the tree in a transfusion mode, then sealing the hole, adding the agilawood inducer dropwise at an interval of 1-2 months, performing treatment for 3-24 months in total, then cutting brown oily matter and yellowish-brown discolored xylem in the trunk, and obtaining agilawood after drying in the sun. The plant hormones are one or more than two of methyl jasmonate, ethephon and 6-BA; and the inorganic salt is one or both of sodium chloride and magnesium chloride. Components of the agilawood inducer are adjusted on the basis of an existing agilawood inducer, a trunk defense system is excited, related enzymes for synthesizing agilawood chemical components are generated and act on phenethyl alcohol, the trunk generates related chemical components in the agilawood, and finally the agilawood is formed by accumulation. According to the method, not only are contents of agilawood oil and sesquiterpenes in the agilawood oil improved, but also contents of alcohol-soluble extracts are improved.

The present invention belongs to the field of chemical technology, and is new type of amorphous catalyst for acetophenone hydrogenating process to prepare phenethyl alcohol and its preparation process. The catalyst consists of Ni, B, metal additive M and carrier material L, where, Ni exists mainly in Ni-B or Ni-M-B amorphous alloy form and the metal additive M is one of Sn, Cr, Mo, W, Fe, Co and La. The catalyst is prepared through reducing metal ion and subsequent impurity elimination. The catalyst is used for acetophenone hydrogenating process to prepare phenethyl alcohol, and has simple preparation process, relatively low cost and much higher acetophenone hydrogenating activity and selectivity compared with traditional industrial Rancy Ni catalyst.

The invention discloses a Huangguanyin black tea processing technology. The Huangguanyin black tea processing technology utilizes Huangguanyin which is a Tieguanyin-Huangjingui hybrid as a raw material. The Huangguanyin black tea has effects of generating body fluid and clearing heat, inducing dieresis, diminishing inflammation and killing bacteria, removing toxins, and nourishing stomach. The Huangguanyin black tea processing technology improves the existing processing technology, reduces volatilization of aromatic alcohol, geraniol, benzyl alcohol, alpha-phenethyl alcohol, cis-3-vinyl ester and methyl salicylate, and reduces harmful substances such as trans-2-hexenal. Through the Huangguanyin black tea processing technology, the Huangguanyin black tea has a good fragrance, a mellow taste and a golden color.

The invention relates to a monochamus alternatus imago attractant which belongs to the technical field of pest control. The monochamus alternatus imago attractant contains the following components according to volume percent: 60-80 percent of turpentine oil, 16-24 percent of ethanol, 2-10 percent of phenethyl alcohol and 2-6 percent of terpilenol. The monochamus alternatus imago attractant contains the following ingredients according to volume percent: 24.64-32.86 percent of Alpha-pinene, 22.91-30.55 percent of Beta-pinene, 6.51-8.68 percent of 3-carene, 2.97-3.96 percent of Beta-phellandrene, 0.74-0.99 percent of terpinolene, 0.62-0.83 percent of laurene, 1.60-2.13 percent of others, 16-24 percent of ethanol, 2-10 percent of phenethyl alcohol and 2-6 percent of terpilenol. The monochamus alternatus imago attractant has remarkable attracting effect to both monochamus alternatus female worms and male worms, and stronger attracting effect to the male worms; and also has certain attracting effect to other coleopteran forestry pests. The invention has the advantages of high efficiency, environmental protection, simple and convenient preparation, low cost and good durability, can be used for prediction and control in monochamus alternatus forest with the control effect up to 53.59-67.30 percent and can effectively control the population density in the monochamus alternatus forest and restrains the spread and the extension of pine wood nematode disease.

The invention relates to total glycosides of Rhodiola rosea, medical application and a preparation method thereof. In the invention, the total glycoside extract prepared from the Rhodiola rosea contains flavone glycosides, phenethyl alcohol glycosides, cinnamyl alcohol glycosides and total terpenoid glycosides, and is mainly characterized by containing Rhodiola rosea flavone (1).

The invention provides a preparing method of crizotinib. The preparing comprises the following steps of: 1) preparing (S)-construction phenethyl alcohol by taking acetophenone the structural formula of which is shown in a formula (1) as a raw material; 2) preparing a nitrocompound; 3) preparing an aromatic amine compound; 4) preparing a bromo-compound; 5) preparing an N-Boc compound; and 6) preparing the crizotinib. Compared with the prior art, the preparing method of the crizotinib has the advantages that 1, the conventional biological enzymatic method and chemical resolution method are replaced by an organic micromolecule catalysis method, thus the whole line is short in reaction cycle, high in yield, simple in operation, wide in raw material source and low in price; and 2) the preparing method of the crizotinib is high in total yield, the obtained product has high optical purity, the required reaction condition and reaction process are easy to control, and a new choice is provided for preparation and production of the medicament crizotinib.

The invention belongs to the technical field of medicament synthesis, and in particular relates to a chemical synthetic method of hydroxytyrosol. The chemical synthetic method comprises the steps of (1) protecting two phenolic hydroxyl groups of catechol by using dichloromethane, and enabling catechol to react with dichloromethane to prepare 1,2-methylenedioxybenzene; (2) enabling 1,2-methylenedioxybenzene to react with various monoesters of oxalyl chloride to prepare 3,4-methylenedioxy phenylglyoxylic acid ester; (3) preparing 3,4-methylenedioxy phenylacetic acid by using 3,4-methylenedioxy phenylglyoxylic acid ester through a Wollff-kishner-Huang Minglong reduction reaction; and (4) reducing the 3,4-methylenedioxy phenylacetic acid by using lithium aluminum hydride, lithium borohydride or sodium borohydride to prepare 3,4-methylenedioxy phenethyl alcohol, and then removing methylene protection of the 3,4-methylenedioxy phenethyl alcohol by using boron tribromide or palladium on activated carbon to prepare hydroxytyrosol. A reactive reagent used in the synthetic method disclosed by the invention is easy to obtain and low in price, the reaction condition is mild, and the final yield of the whole reaction is 23%.

The invention discloses a tobacco extract, an extracting method and application and belongs to the field of tobacco additives. The tobacco extract is extracted with the method including the following steps that firstly, propylene glycol is added into tobacco raw materials, and then baking is carried out after standing; secondly, smashing is carried out, and a solvent is added into powder materials for extraction; thirdly, extract liquid passes through an ultrafiltrtion membrane, penetrating liquid is obtained and subjected to reduced pressure distillation, and concentrate is obtained; fourthly, the concentrate is subjected to secondary separation with a molecule distillation method, light components are collected, and the tobacco extract is obtained. The extract contains rich megastigmatrienone, Damascone, neophytadiene, phenylcarbinol, phenethyl alcohol, farnesylacetone and pyrone and furanone aroma components, and the tobacco extract is thick in baking aroma and tobacco aroma, good in penetration, small in irritation and miscellaneous gas, high in satisfaction, capable of improving the smoking quality of cigarettes and providing a certain amount of nicotine to meet the physiological needs of consumers when used.

The invention discloses an essence particle additive as well as a preparation method and an application thereof. The particle additive consists of a particle carrier, cigarette essence and a polymeric membrane, wherein the particle carrier is used for loading the cigarette essence, and the polymeric membrane is used for coating the particle carrier loaded with the cigarette essence; the particle carrier is composed of calcium carbonate particles, a molecular sieve, tea dust, microcrystalline cellulose or cellulose microspheres; the cigarette essence is isoamyl alcohol, phenethyl alcohol, menthol, linalool, terpinol or limonene; and the polymeric membrane is prepared from sodium alginate tech grade, carboxymethyl cellulose, hydroxyethyl cellulose or pullulan. According to the physical form of the cigarette essence, the essence particle additive can be prepared by a liquid-state method and a solid-state method. When being applied to the flavoring of a cigarette filter and the production of a cigarette, the essence particle additive has the beneficial effects that when the cigarette is not sucked, the volatilization and diffusion of the essence are restrained, and when the cigarette is sucked, the essence can be uniformly released without the dependence on external forces.

The invention discloses a preparation method of fermentation type plant flower rice wine, belonging to the technical field of food production. The preparation method comprises the following steps of: steaming sticky rice and adding saccharifying enzyme for saccharification; crushing sweet osmanthus, rose or jasmine and performing ultrasonic extraction and concentration; adding the concentrated solution into the saccharified sticky rice, and adding distiller yeast for fermentation, wherein the fermentation temperature is 28-32 DEG C, and the fermentation time is 24-48 hours; juicing the obtained product, collecting the juice and feeding the juice into a superfilter; filtering and collecting the juice, and brewing the juice in a storage tank at room temperature below 30 DEG C for 3-6 months; blending until the alcoholic strength is greater than or equal to 8.0 (vol), the total acid (based on lactic acid) is greater than or equal to 2.20g/L, the total sugar (based on glucose) is greater than or equal to 40.0g/L, the amino acid nitrogen is greater than or equal to 0.10g/L, and the beta-phenethyl alcohol is greater than or equal to 20.0mg/L; and filling. The preparation method disclosed by the invention has the beneficial effects that: the flavor components and physiological activators of the plant flower are richer than those in the product of the prior art.

The invention relates to a preparation method of essence for an electronic cigarette with strawberry flavor. The preparation method comprises the following steps: a first step of preparing materials according to a certain mass percent; a second step of stirring and mixing prepared ethyl butyrate, styralyl acetate, benzyl alcohol, phenethyl alcohol, ethyl benzoate, strawberry acid, alpha-ionone, beta-ionone, beta-dihydrogen damascenone, waxberry aldehyde and gamma-octyl lactone in sealed space; a third step of adding the prepared ethyl maltol, vanillin, methyl cinnamate and raspberry ketone in the uniformly stirred and mixed liquor in sequence, and stirring until dissolving completely; and a fourth step of placing the completely dissolved liquor under the room temperature for ageing for 30 hours-60 hours. According to the preparation method disclosed by the invention, the whole process is simple and controllable, the prepared electronic cigarette has special thick fresh strawberry flavor which is strong and mellow, and lasting, so that breath of a user is fresh.

The present invention relates to a Pichia kudriavzevii strain for preparing beta-phenethyl alcohol through biological transformation of L-phenylalanine, a culture method and applications thereof, wherein the Pichia kudriavzevii strain is named Pichia kudriavzevii Y1511, is preserved in the China General Microbiological Culture Collection Center on May 31, 2016, and has the preservation number of CGMCC 12567. According to the present invention, the 26S rDNA D1/D2 sequence of the strain and the 26S rDNA D1/D2 sequences of other Pichia kudriavzevii strains have the similarity of 99%; the strain of the present invention has advantages of good sugar tolerance, good ethanol tolerance, good phenethyl alcohol tolerance, wide growth pH valve range and wide temperature range; the screened Pichia kudriavzevii Y1511 of the present invention has the high beta-phenethyl alcohol yield, wherein the detection results show that the beta-phenethyl alcohol yield can achieve 1.0-11.0 g/L, such that the strain can be easily applied in the industrial production of beta-phenethyl alcohol; and the strain of the present invention has advantages of mild reaction conditions, environmentally friendly and natural product, low cost, environmental friendliness and the like.

A genetically engineered bacterium producing 2-phenylethanol and an applying method thereof are disclosed. The recombinant bacterium is constructed by coexpressing aromatic amino acid aminotransferase and exogenous phenylpyruvate decarboxylase (Aro10) (or indole-3-pyruvic acid decarboxylase), phenylethanol dehydrogenase or phenylacetaldehyde reductase in escherichia coli to obtain the recombinant bacterium producing the 2-phenylethanol. Glutamate dehydrogenase is coexpressed on this basis to achieve self-balancing cofactor circulation, thus increasing the yield of the 2-phenylethanol. The conversion ratio of the 2-phenylethanol prepared through the recombinant bacterium is high. The bacterium and the method have important application value in production of the 2-phenylethanol in the future.

The invention discloses a preparation method of natural spice 2-phenethyl alcohol, which is implemented by selecting Candida drusei, Saccharomyces cerevisiae, Kluyveromyces marxianus, inoculating cultivated seed liquid or active dried yeast powder into fermentation culture medium, taking L-PHE produced by fermentation method or enzyme method as substrate, performing liquid aerobic fermentation in a fermentation shake flask or a fermentation tank, adding solid phase absorption medium, L-PHE and glucose in the process of fermentation, obtaining the solid phase absorption medium in a filtration or centrifugation manner, then adopting an elution solvent to carry out elution on the absorption medium, further distilling the eluent to obtain the natural 2-phenethyl alcohol with purity of 97.5-99.5%. The invention combines the fermentation and absorption separation of 2-phenethyl alcohol, has low production cost and excellent aroma quality of the product.

The invention relates to a technology for extracting active ingredients from Herba Cistanches, and belongs to the technology field of traditional Chinese medicine component extraction. The extraction technology comprises the following steps: broomrape is dried and crushed, and is extracted by adopting ethanol ranging from 90 to 95 percent; extracting solution is concentrated, crystallized and dried to obtain broomrape D-mannite; residue is extracted by using ethanol solution the concentration of which ranges from 60 to 80 percent; the extracting solution passes through macroporous resin; eluent is concentrated and dried to obtain broomrape phenethyl alcohol glycosides; the obtained extracting residue is continuously added with distilled water for heat extraction; after being decompressed and concentrated, supernatant fluid is added with the ethanol of 95 percent for deposition, wherein, the volume of the ethanol is three times of the volume of the supernatant fluid; precipitate is dried to obtain broomrape polyoses. Compared with the traditional method, the technology obtains three broomrape biology bioactive components that are broomrape mannite, the broomrape phenethyl alcohol glycosides and the broomrape polyoses at the same time, and the disadvantage that single-component is emphasized excessively in the traditional extracting method is made up. The ethanol which is used can be recovered during the decompressing and concentrating process to achieve the recycling purpose, thereby effectively lowering the production cost.

The present invention relates to rose oil and its production process. The present invention uses rose of separated and screened Rosa Damascena Mill variety as material, and the rose oil contains cephrol 18-39 wt%, nerol 5-14 wt%, geraniol 14-29 wt%, paraffin 16-20 wt%, and phenylethanol <3.0 wt%. The present invention has high paraffin content and low phenylethanol content and scent lasting time as long as 48 hr, and features the sum of total geraniol and nerol content higher than cephrol content and thus special quality and scent. The present invention provides rose oil producing process with high production capacity, short processing time and rose oil yield as high as 0.035-0.050 %.

The chemical process of synthesizing rhodiola glycoside includes the following steps: the Lewis acid catalyzed glycosidation between pentacetyl-beta-D-glucose and p-hydroxy phenethyl alcohol inside organic solvent to produce tetracetyl rhodiola glycoside; and the subsequent deacetylation of tetracetyl rhodiola glycoside inside the methanol solution of NaOCH3 to obtain rhodiola glycoside. Compared with traditional synthesis process, the present invention has the advantages of wide material source, less reaction steps and low preparation cost. The process of the present invention is suitable for industrial production.

The invention provides a synthesis method of mirabegron and belongs to the technical field of medicine synthesis. The synthesis method solves the problems that the synthesis method of the mirabegron is low in product yield and is not suitable for large-scale industrialized production in the prior art. The synthesis method comprises the following steps: 1) amino protection: reacting 2-aminothiazole-5-acetic acid with an amino protective agent to obtain a mirabegron intermediate product A; 2) condensation reaction: performing condensation reaction on the mirabegron intermediate product A and 4-amino phenethyl alcohol to obtain a mirabegron intermediate product B; 3) oxidation reaction: performing oxidation reaction on the mirabegron intermediate product B and an oxidant to obtain a mirabegron intermediate product C; and 4) reductive amination and protecting group removal: reacting the mirabegron intermediate product C with (R)-2-amino-1-phenethyl alcohol and removing the protecting group from the mirabegron intermediate product C to obtain the mirabegron. The synthesis method of the mirabegron is low in cost, high in product yield and suitable for large-scale industrialized production.

An improved antifungal composition for topical application to the skin and nails comprises: (1) an allylamine antifungal compound; (2) an aliphatic alcohol substituted with an aromatic substituent in which the allylamine antifungal compound is soluble to a degree that a therapeutically effective concentration of the allylamine antifungal compound can be applied topically in solution; (3) a lower aliphatic alcohol in which the aromatic alcohol is soluble; and (d) water or a water-compatible solvent mixture. The allylamine antifungal compound can be terbinafine or naftifine. The aliphatic alcohol substituted with an aromatic substituent can be benzyl alcohol or phenethyl alcohol. The lower aliphatic alcohol can be ethyl alcohol or isopropyl alcohol. In an alternative, the composition can further comprise an additional antifungal compound. Another aspect of the invention is a method for treatment of a fungal infection of skin or nails comprising administering the antifungal composition of the present invention topically to the skin or nails in an amount therapeutically effective to treat the fungal infection.

The invention discloses a method of preparing microfibrillated cellulose from bamboo parenchyma cells, which comprises following steps: (1) separation of the bamboo parenchyma cells: performing chemical separation or drying and crushing process to raw materials, sieving the treated raw materials through a 20-mesh sieve screen to obtain the parenchyma cells; (2) chemical pre-treatment: adding the parenchyma cells to a phenethyl alcohol solution for extraction, adding a 1-3% sodium chlorite solution for treating the parenchyma cells for one hour, and adding the parenchyma cells in an alkaline solution for treating the parenchyma cells for two hours, treating the parenchyma cells in a diluted hydrochloric acid solution for two hours, and finally washing the parenchyma cells with deionized water to neutralization; and (3) dispersing the treated parenchyma cells in deionized water to form a 1% suspension liquid, and performing high-frequency ultrasonic treatment or high-pressure homogenizing treatment. According to the method, the bamboo parenchyma cells are separated through the sieving process in early stage to prepare the microfibrillated cellulose. The raw materials are wide in sources and are low in cost. The method is simple and easy to carry out, is high in production efficiency, can reach 90% in yield and can basically achieve all-conversion of the raw materials.

The invention discloses a broad-spectrum antibacterial cosmetic antiseptic comprising the components of, by mass: 8-12% of caprylhydroxamic acid, 38-45% of phenethyl alcohol, and 46-54% of methylpropanediol. The antiseptic provided by the invention has the advantages that: (1) the antiseptic has broad-spectrum antibacterial activity, and can effectively inhibit Gram-negative and positive bacteria, yeasts and molds; (2) the antiseptic does not contain traditional antiseptic and bactericide, and is a cosmetic-use complex system completely satisfying a concept of no antiseptic addition; and the antiseptic has low irritation and high safety; and (3) the antiseptic has good compatibility with most of cosmetic raw materials; and the antibacterial capability of the antiseptic is not affected by surfactant, proteins and Chinese herbal medicine additives in cosmetics.

The invention relates to a monochamus alternatus imago attractant and a trap thereof, which belong to the technical field of pest control. The volume percents of the components of the attractant are 60 to 80 percent of oil of turpentine, 16 to 24 percent of alcohol, 2 to 10 percent of phenethyl alcohol and 2 to 6 percent of terpineol. The volume percents of each component of the attractant are 24.64 to 32.86 percent of alpha-pinene, 22.91 to 30.55 percent of beta-pinene, 6.51 to 8.68 percent of 3-carene, 2.97 to 3.96 percent of beta-phellandrene, 0.74 to 0.99 percent of terpinolene, 0.62 to 0.83 percent of laurene, others for 1.60 to 2.13 percent, 16 to 24 percent of alcohol, 2 to 10 percent of phenethyl alcohol and 2 to 6 percent of terpineol. The trap consists of a cylindrical body (3), a funnel-shaped imago picking device (6) arranged at the lower part of the body (3), and an imago collecting bottle (7) connected with the lower end of the funnel-shaped imago picking device (6). The attractant has the advantages of convenient preparation, simple usage and long lasting period, and is a nuisanceless plant protection product; and the trap has the advantages of simple structure, low cost, long service life and good attracting effect, and can be wildly applied to the monochamus alternatus imago control in the field.

The invention relates to chiral magnetic nano-particles and preparation and application thereof. The preparation comprises the following steps of: (1) preparing Fe3O4 magnetic nano-particles; (2) preparing Fe3O4/SiO2 composite magnetic nano-particles; (3) preparing cellulose-2,3-di(3,5-dimethyl phenyl carbamate); and (4) performing surface chiral modification on the Fe3O4/SiO2 composite magnetic nano-particles by using the cellulose-2,3-di(3,5-dimethyl phenyl carbamate). The chiral magnetic nano-particles are used for separating a racemic compound DL-1-phenethyl alcohol, and an optical rotation value test for obtaining components through singly spinning a guide sample and separation proves that laevo-rotation and dextro-rotation are separated very well. The chiral magnetic nano-particles have the advantages of short separation time, simple and convenient operation, and good separation effect of chiral compounds; besides, the chiral magnetic nano-particles can be thoroughly separated from base solution under an external magnetic field, and not only cannot cause pollution to a target separation object but also can be completely recycled, thereby fulfilling two aims of ecumenical efficiency and environmental protection.

An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.

The invention discloses a preparation method of mango-flavored essence for electronic cigarettes. The preparation method comprises the following preparation steps: step 1, preparing raw materials according to certain mass percent; step 2, stirring and mixing prepared cis-3-hexen-1-ol, cis-3-hexenyl acetate, ethyl acetate, ethyl butyrate, allyl hexanoate, butyric acid, glyceryl triacetate, propylene glycol, phenethyl alcohol, ethyl thioacetate, para-mentha-8-thiolone and delta-decalactone/ethanol in a sealed space; step 3, sequentially adding prepared ethyl maltol, maltol, cedar leaf oil, sweet orange oil terpeneless, linalool and mango ketone into the stirred mixed solution; stirring until all the raw materials are completely dissolved; step 4, putting a mixed solution at room temperature and ageing for 30h to 60h. According to the preparation method of mango-flavored essence for the electronic cigarettes, disclosed by the invention, the mango-flavored essence has a special rich and fresh mango flavor and the flavor is rich, mellow and lasting; the mango-flavored essence has no nicotine, has the mango flavor which is favored by the majority of female consumers and has the effect of refreshing breath of a user.