This invention discloses a
rifaximin nanoemulsion, its preparation method, and its application, belonging to the field of
veterinary drug technology. The technical solution includes a
rifaximin nanoemulsion comprising
rifaximin, a compound
essential oil, a surfactant, a co-surfactant, and water; the compound
essential oil includes
oregano oil,
cinnamon oil, and
tea tree oil. This invention prepares a rifaximin nanoemulsion using a compound of oregano, cinnamon, and
tea tree oils as the
oil phase, exhibiting both high antibacterial efficiency and high safety. The three essential oils have a synergistic
antibacterial effect, complementing rifaximin through multi-
target action, broadening the antibacterial spectrum, and showing significant inhibitory effects against various
bacteria and fungi. It can enhance uterine
smooth muscle contraction function by stimulating the synthesis and
secretion of prostaglandins and
oxytocin, providing potential support for uterine involution and endometrial repair. After administration, it can effectively reduce the number of inflammatory cells such as leukocytes and neutrophils in experimental dairy cows, significantly reduce purulent
vaginal discharge, and restore the softness and elasticity of the
uterus upon rectal examination.