Soft capsule oral care agent and preparation method thereof

An oral care agent and soft capsule technology, applied in the field of daily chemicals, can solve the problems of inconvenient portability, inability to fully clean the oral cavity, and poor permeability, etc., and achieve the effects of easy portability and use, fresh and pleasant smell, and strong bactericidal effect

Inactive Publication Date: 2012-12-19
广州安德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above-mentioned methods, toothbrushing can only remove surface dirt, chewing products cannot fully clean the oral cavity due to their low permeability, and gargling products are inconvenient to carry because of their liquid nature (for example, liquid substances above 100ml are forbidden on airplanes) , physical flushing and mechanical scrubbing are generally limited to use in hospital operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Accurately weigh 30g of thymol, 30g of eucalyptol, 20g of wintergreen oil, and 20g of menthol, add them to 175g of soybean oil, and mechanically stir at 25°C for 30min to form a uniform oil phase for later use. Weigh 150g of polyoxyethylene castor oil (RH-40), 74g of polyethylene glycol 400 (PEG-400), and 1g of vitamin E. Mix the above-mentioned substances, ultrasonicate at a constant temperature of 40°C (power 500 W, frequency 50 kHz) for 30 minutes, mechanically stir for 10 minutes to make it fully mixed, 4000 r min －1 Centrifuge for 5 minutes under the same conditions, discard the precipitate, and obtain the emulsified medicinal solution. Take 0.1g of this emulsified drug solution, add it to 200mL at 37 ℃, the concentration is 0.1mol·L －1 HCl solution, using a magnetic stirrer at 50 r min －1 The speed is gentle stirring, and the self-emulsification time, color, and clarity are used as indicators. If the self-emulsification time can form a clear and transparent solu...

Embodiment 2

[0032] Accurately weigh 30g of thymol, 30g of eucalyptol, 20g of wintergreen oil, and 20g of menthol, add them to 175g of purified peanut oil, and mechanically stir at 25°C for 30min to form a uniform oil phase for later use. Weigh 150g polyoxyethylene hydrogenated castor oil, 74g polyethylene glycol 400 (PEG-400), 1g vitamin E. Mix the above-mentioned substances, ultrasonicate at a constant temperature of 40°C (power 500 W, frequency 50 kHz) for 30 minutes, mechanically stir for 10 minutes to make it fully mixed, 4000 r min －1 Centrifuge for 5 minutes under the same conditions, discard the precipitate, and obtain the emulsified medicinal solution. Take 0.1g of this emulsified drug solution, add it to 200mL at 37 ℃, the concentration is 0.1mol·L －1 HCl solution, using a magnetic stirrer at 50 r min －1The speed is gentle stirring, and the self-emulsification time, color, and clarity are used as indicators. If the self-emulsification time can form a clear and transparent solut...

Embodiment 3

[0035] Accurately weigh 30g of thymol, 30g of eucalyptol, 20g of wintergreen oil, and 20g of menthol, add them to 175g of sesame oil, and mechanically stir at 25°C for 30min to form a uniform oil phase for later use. Weigh 150g Tween 80, 74g polyethylene glycol 400 (PEG-400), 1g vitamin E. Mix the above-mentioned substances, ultrasonicate at a constant temperature of 40°C (power 500 W, frequency 50 kHz) for 30 minutes, mechanically stir for 10 minutes to make it fully mixed, 4000 r min －1 Centrifuge for 5 minutes under the same conditions, discard the precipitate, and obtain the emulsified medicinal solution. Take 0.1g of this emulsified drug solution, add it to 200mL at 37 ℃, the concentration is 0.1mol·L －1 HCl solution, using a magnetic stirrer at 50 r min －1 The speed is gentle stirring, and the self-emulsification time, color, and clarity are used as indicators. If the self-emulsification time can form a clear and transparent solution with opalescence within 2 minutes, ...

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PUM

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Abstract

The invention relates to a soft capsule oral care agent and a preparation method thereof. The soft capsule oral care agent comprises one or several of the following natural product extracts with anti-inflammation and bactericidal activity: thymol, menthol crystal, tea polyphenol, clove oil, wintergreen oil, eucalyptus oil, blumea oil, cinnamon oil, tea tree essential oil, lavender oil, lemon oil, litsea cubeba oil, citronella oil, patchouli oil, perilla oil, zanthoxylum oil, geranium essential oil, juniper berry essential oil, evening primrose essential oil, grape seed oil, origanum oil, rose essential oil, aloe powder, rutin, hydroxyrutin, dihydroquercetin, curcumin, bisdethoxy curcumin, aloesin, barbaloin, ferulic acid, citric acid, tea purine, bitter betaine and the like, wherein the natural product extracts account for 5-75 weight percent of the soft capsule oral care agent. Moreover, the invention discloses a preparation method for the soft capsule oral care agent. The soft capsule oral care agent has the characteristics of broad antibacterial spectrum, efficient and quick effect, high safety and no toxin. The advantages of oral care products, such as chewing gum, mouth wash and the like, are integrated, and the defects of a traditional oral care agent are discarded by the soft capsule oral care agent. The soft capsule oral care agent is good in effect, convenient in carrying and simple in application.

Description

technical field [0001] The invention belongs to the field of daily chemicals and relates to a soft capsule oral care agent and a preparation method thereof. Background technique [0002] The mouth is the beginning of the digestive tract and has many important functions. Oral care is an important part of basic care. First of all, healthy teeth can make people look good and feel better in daily life such as eating and talking. Secondly, good oral care for critically ill patients can avoid some complications, and the condition can be observed according to the health of the oral cavity. Third, disease in the oral cavity is a harbinger of disease in other parts of the body. For example, dry oral mucosa is the first signal of water and salt metabolism disorders; patients with anemia may have persistent oral ulcers and pharyngitis; patients with leukemia may have bleeding gums. Fourth, the environment in the oral cavity is moist and rich in nutrients, which is convenient for ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/11A61Q11/00A61P1/02
Inventor 蒋庆于艳君
Owner 广州安德生物科技有限公司
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