1382results about "Oral care" patented technology

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention discloses a tooth repair composition containing mesoporous hydroxyapatite, a tooth repair product and a preparation method and application of the tooth repair composition and the tooth repair product. The tooth repair composition comprises nano-hydroxyapatite, fluoride and a chelating agent, the logarithm value logK of the stability constant K of the chelating agent to calcium ions is 1 < = logK < = 5, and K is measured in an aqueous solution with the temperature of 25 DEG C, the pH value of 7.0 and the ionic strength of 0.1 M; the nano-hydroxyapatite is prepared from nano-scale mesoporous hydroxyapatite, and the nano-hydroxyapatite contains nano-scale mesoporous hydroxyapatite. By adding the specific chelating agent, dynamic balance is formed in the tooth repairing composition, slow release protection can be formed on free calcium ions, the double inactivation effect possibly occurring when hydroxyapatite and fluoride exist at the same time is effectively avoided, the synergistic repairing effect of hydroxyapatite and fluoride is fully exerted, and the tooth repairing effect is improved. The use of fluorides can be greatly reduced, and safety and reliability are achieved.

The invention discloses an oral care composition containing ampelopsis japonica polysaccharide and application of the oral care composition in inhibiting gingival bleeding. The oral care composition comprises ampelopsis japonica polysaccharide and an orally acceptable carrier, wherein the pH (Potential of Hydrogen) range of the oral care composition is 5.9 to 7.7. The invention also discloses an application of the ampelopsis japonica polysaccharide in the oral care composition for inhibiting gingival bleeding. The invention discloses application of silicon dioxide with a high oil absorption value in an oral care composition for improving the gingival bleeding inhibiting effect of ampelopsis japonica polysaccharide. The combination of the high-oil-absorption-value silicon dioxide and the low-oil-absorption-value silicon dioxide is applied to the oral care composition for improving the gingival bleeding inhibiting effect of the ampelopsis japonica polysaccharide; the invention further discloses application of sorbitol in the oral care composition for improving the effect of inhibiting gingival bleeding by the ampelopsis japonica polysaccharide. The oral care composition has a hemostatic effect and can effectively solve the problem of gingival bleeding.

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention discloses a surface-modified bioactive glass oral cavity desensitization paste and a preparation method thereof, and relates to the technical field of oral cavity desensitization pastes. The surface-modified bioactive glass oral desensitization paste is prepared from the following raw materials in parts by weight: 5 to 15 parts of bioactive glass, 3 to 6 parts of modifier, 3 to 5 parts of silicon dioxide, 20 to 30 parts of humectant, 0.5 to 1 part of sweetening agent, 0.5 to 1.5 parts of foaming agent, 0.5 to 2 parts of thickening agent and 60 to 120 parts of deionized water. The surface modified bioactive glass oral cavity desensitization paste prepared by the invention has excellent antibacterial performance and dentinal tubule sealing effect.

The invention discloses a gel composition for improving compatibility and gelling speed of a tooth whitening product. The gel composition comprises whitening gel and a catalyst, respectively filling the whitening glue and the catalyst into a double-barrel injector; when the tooth whitening gel is used, the push rod is pushed, the whitening gel and the catalyst in the double-tube barrel are squeezed out at the same time and mixed at the mixing head to form the tooth whitening gel capable of being smeared on the tooth surface of a patient, and the pH value of the tooth whitening gel is 7.5-10.0. The catalyst comprises potassium salt or strontium salt, sodium fluoride, glycerol, cross-linked polyacrylamide gels, strong alkaline substances, essence and water; the whitening gel comprises a hydrogen peroxide solution, a cross-linked polyacrylamide gel, glycerin, essence and water. The cross-linked polyacrylamide gel is adopted, the gel is resistant to strong-alkalinity and high-pH environment and various inorganic salt ions such as fluoride, sylvite or strontium salt, the prepared gel is stable in form and good in compatibility, the gel preparation process is simple, the gel is rapidly swelled when encountering water and does not huddle, and long-time standing is not needed.

The invention relates to the use of chitosan hydrochloride as a tooth enamel remineralizing agent and dental or oral care products comprising chitosan hydrochloride for medical and aesthetic use.

The invention relates to a composition with functions of protecting gingiva and repairing enamel and a preparation method of the composition, and belongs to the technical field of oral care. The composition contains a functional additive, a plant compound fermentation extract and the like, the functional additive is a mixture of corn starch, calcium phosphosilicate, hydroxyapatite, ubiquinone, sodium guaiazulene sulfonate, menthol and vitamin E, and the plant compound fermentation extract is obtained by fermenting and purifying honeysuckle flowers, radix polygonati officinalis and dandelions according to a specific proportion. Through the synergistic effect of the fermentation extract and the functional components, the problems that an existing toothpaste body is hardened, the storage stability is poor, the gingival protecting effect is short, and the enamel repairing persistence is insufficient are solved, the gingival protecting effect can be enhanced, the enamel repairing effect can be improved, the stability of the toothpaste body can be optimized, the antibacterial property and the oral mucosa relieving effect are achieved, and the oral cavity repairing effect is achieved. And the preparation process is scientific and reasonable, and is suitable for daily oral care.

There is herein described a dissolvable oral strip or film. In particular, the present invention relates to a dissolvable or substantially dissolvable oral strip or film comprising at least one whitening agent and at least one oral hygiene agent. There is also described a process for the manufacture of a dissolvable or substantially dissolvable oral strip or film. There is further described a method of using a dissolvable oral strip or film comprising at least one whitening agent to whiten teeth and at least one oral hygiene agent that is effective against oral health conditions.

An aqueous oleanolic acid solution, including from about 0.10 to 2.5 weight % oleanolic acid, from about 60 to 90 weight % solvent, and from about 20 to 40 weight % solubility agent, wherein the solvent includes water, the solubility agent includes sodium lauryl sulfate (SLS), and the aqueous oleanolic acid solution is substantially free of ethanol and dimethyl sulfoxide (DMSO).

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values and / or high opacity without the use of a solid opacifier. Jammed oil-in-water emulsion toothpaste compositions with a hydrophobic phase with a particular droplet size of from about 0.4 microns to about 1000 microns, which can lead to toothpaste compositions with unexpectedly high yield stress values and / or high opacity without the use of a solid opacifier.

A method for producing calcium phosphate crystals according to the present invention comprises a step (S11) for preparing a weakly basic phosphoric acid solution containing a complex comprising a rare earth element ion and a coordination compound having a ligand coordinated to the rare earth element ion and a step (S12) for adding a calcium-containing compound to the weakly basic phosphoric acid solution and hydrolyzing. Some of the plurality of calcium ions contained in the structure of the calcium phosphate crystals are substituted by the rare earth element ion.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.

A flowpack for oral delivery of active ingredients comprises a population of particles and one or more active ingredients, the population of particles including at least two types of sugar alcohol particles, wherein at least one of said two types of sugar alcohol particles comprises granulated sugar alcohol particles.

The invention relates to the technical field of oral care and anhydrous toothpaste, in particular to bioactive glass-containing anhydrous toothpaste based on rheological property regulation and control and a preparation method and application thereof.The anhydrous toothpaste adopts glycerin and polyethylene glycol as a humectant compound system to construct an anhydrous system, and the situation that active ingredients of bioactive glass lose efficacy when meeting water is avoided; and the chemical activity and the structural stability can be kept during long-term storage. A thickening agent compound system composed of carbomer, quaternary ammonium salt-22 and hydroxypropyl gelatin is cooperatively adopted, so that a rigid-soft, compact and firm spatial network structure can be formed, an abrasive and bioactive glass particles can be stably suspended for a long time, the high activity of bioactive glass is kept, and the bioactivity of the bioactive glass is improved. And in the aspect of rheological properties, the composite material shows excellent thixotropy, relatively high structure recovery rate and appropriate yield stress, and has a remarkable remineralization repair effect and an excellent sensory effect. And the preparation process is simple, low in cost and suitable for large-scale industrial production.

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

The invention relates to the technical field of toothpaste preparation, and particularly discloses bamboo leaf flavonoid toothpaste as well as a preparation method and application thereof. The bamboo leaf flavonoid toothpaste is prepared from the following raw materials in parts by weight: 26 to 30 parts of a wetting agent, 1.6 to 1.8 parts of a binding agent, 0.2 to 0.4 part of a sweetening agent, 20 to 24 parts of a friction agent, 1.2 to 1.6 parts of a surfactant, 0.3 to 0.5 part of a pH (Potential of Hydrogen) regulator, 2.4 to 2.8 parts of active microcapsules, 0.4 to 0.6 part of essence and 14 to 18 parts of de-ionized water. A core material of the active microcapsule is a nano-dispersion, a wall material of the active microcapsule is prepared from Arabic gum and chitosan through a complex coacervation method, the nano-dispersion is prepared from xanthan gum, a bamboo leaf flavone extract, xylitol, calcium chloride and modified pectin through a reaction, and the modified pectin is prepared by mixing degreased pectin and chlorogenic acid according to a specific proportion. Through the synergistic effect of the substances, the dispersibility and antibacterial and anti-inflammatory performance of the bamboo leaf flavonoid toothpaste are improved.

The invention belongs to the technical field of synthesis and antibiosis of nano-enzyme catalysis systems, and discloses an enzyme catalysis system with a function of targeted inhibition of growth of streptococcus mutans as well as preparation and application of the enzyme catalysis system. The enzyme catalysis system with the targeted inhibition function on the growth of the streptococcus mutans is formed by loading AuNPs and PCN-22 (Fe) on a CMD molecular chain through in-situ growth, and the mass ratio of the AuNPs to the PCN-22 (Fe) to the CMD is (0.22%-0.33%) to (12.34%-21.79%) to (77.88%-87.44%). The cascade catalytic effect of the nano-enzyme is adjusted by regulating and controlling the carboxymethyl substitution degree of CMD, so that glucose in a decayed tooth pathological environment is efficiently catalyzed in one step to generate ROS, and damage to probiotics is reduced while the inhibition efficiency of pathogenic bacteria is improved.

Disclosed are oral care compositions comprising: a tooth ligand mixture comprising a monocarboxylic acid, a dicarboxylic acid, and / or a tetracarboxylic acid; and a stannous ion source and a fluoride ion source, such as stannous fluoride. The oral care compositions show the ability to prevent and / or treat dental erosion and / or dental caries.

To provide a method for simply and efficiently evaluating the inducibility of a foreign matter response reaction in the skin of a test sample without using an animal, and to provide a substance having the inhibitory properties of the foreign matter response reaction in the skin and a method for searching the same.SOLUTION: The method includes a step of bringing keratinocytes transformed with a vector having an enhancer sequence containing a foreign body-responsive sequence and a sequence encoding a reporter protein downstream of the enhancer sequence into contact with a solution containing a test sample, a step of measuring the expression level of the reporter protein in the keratinocytes, and a step of evaluating the inducibility of a foreign body response reaction of the test sample in the skin based on the expression level of the reporter protein. The problem is solved by providing an agent for suppressing foreign matter response reaction in the skin containing fregula 1 found by the search method.SELECTED DRAWING: Figure 3

This invention relates to a pharmaceutical composition for the repair of oral gingivitis and its preparation method, belonging to the field of biomedical technology. The pharmaceutical composition includes *Lactobacillus salivarius* fermentation extract, *Viola yedoensis* extract, cicada nymph extract peptide, guava polyphenol, and resveratrol. The *Lactobacillus salivarius* fermentation extract is obtained by aerobic and anaerobic fermentation of *Lactobacillus salivarius*, and purified by XAD7HP macroporous adsorption resin column. The *Viola yedoensis* extract is obtained by enzymatic hydrolysis of the whole *Viola yedoensis* herb by pectinase and cellulase, followed by enzymatic hydrolysis by a complex protease, and purified by a complex adsorption column. The cicada nymph extract peptide is obtained by stepwise enzymatic hydrolysis of cicada nymphs by papain and trypsin, yielding a 5kDa enzymatic hydrolysate, and purified by Q agarose gel FF adsorption column. The components are used in a specific ratio to achieve precise antibacterial activity, exhibiting highly effective anti-inflammatory and antioxidant properties, and are safe and reliable.

The invention provides nanoscale hydroxyapatite as well as a preparation method and application thereof, and relates to the technical field of hydroxyapatite. The preparation method provided by the invention comprises the following steps: completely reacting calcium hydroxide slurry with a phosphoric acid solution under mechanical mixing, and standing and curing to obtain hydroxyapatite slurry; mixing the hydroxyapatite slurry with a binder, and calcining at 800-1200 DEG C to obtain a precursor; and grinding the precursor in a water phase to obtain a nano suspension, and carrying out spray drying to obtain the nano-scale hydroxyapatite. According to the preparation method disclosed by the invention, a stable multi-stage pore structure can be constructed through high-temperature calcination, and the regularity and the stability of the size of the hydroxyapatite can be improved through spray drying treatment, so that the nano-scale hydroxyapatite has high biological activity and stability, and the defect that pure hydroxyapatite slurry is not resistant to scouring is effectively overcome.

A dental polishing cup includes a body that defines a cup cavity for holding a dental treatment material, with the cup having an opening at its distal end. A portion of the body includes an enhanced-flexibility band (EFB) situated circumferentially at a certain distance from the distal end, the EFB providing a lesser stiffness of the body than other portions of the body that are situated lengthwise immediately distally and immediately proximately of the EFB.

To provide a compound that can be readily synthesized, exhibits antibacterial activity against Porphyromonas gingivalis being a pathogenic bacterium of periodontitis, with greater specificity, and exhibits increased stability against esterase as well as reduced cytotoxicity.SOLUTION: The present invention provides a compound represented by a general formula (1) [where R1 is a halogen atom or a nitro group, and R2 is an alkoxy group or an acylamino group] or a salt thereof or a solvate thereof.SELECTED DRAWING: None

The invention provides a novel antibacterial and anti-inflammatory functional additive, a preparation method and application, and belongs to the technical field of biological materials, the additive is organic-inorganic hybrid nanoparticles, and is formed by self-assembly of metal ions, natural polyphenol compounds and quaternary ammonium salt compounds. According to the antibacterial / anti-inflammatory functional additive disclosed by the embodiment of the invention, the antibacterial / anti-inflammatory functional additive has the effects of high biocompatibility, rapid active sterilization, long-acting passive bacteriostasis and inflammation immunity regulation and control.

The invention relates to the technical field of oral biological materials, in particular to a self-adaptive anti-caries coating as well as a preparation method and application thereof. The coating is prepared from random and block polymers, and is specifically prepared by polymerizing acid radical-containing functional monomers, phenylboronic acid and derivatives thereof. Construction of the coating depends on specific coordination of a functional group and Ca < 2 + > in enamel, and stable anchoring on the tooth surface is achieved. The core action mechanism is to introduce phenylboronic acid groups to endow the coating with pH sensitive characteristics: in a cariogenic acid environment, biofilm formation is synergistically inhibited through a plurality of mechanisms such as physical barrier, electrostatic repulsion and inhibition of mucoprotein-mediated adhesion. According to the application, the Ca < 2 + > anchoring monomer, phenylboronic acid and the derivative thereof are copolymerized, design is carried out aiming at two key links of protein adsorption and bacterial adhesion, multi-mechanism synergy and environment dynamic response are integrated, and an integrated anti-caries effect from early intervention to long-term protection is realized.