49 results about "Demineralization" patented technology

Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.

A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of all physiologically active components of native bone. The invention hinges on the newly discovered ability of bone particles of defined sizes to exert osteoinduction by a pathway superior to and distinct from demineralized bone matrix and similar preparations.

The invention discloses a manufacturing method of a biological tooth root bracket material. The method comprises the following steps of: flushing teeth with phosphate buffered saline (PBS) in a sterile state for three times; removing dental crown parts by grinding with a carborundum disc, and keeping tooth root parts; pulling pulp tissues out of the tooth roots and repeatedly flushing the inside of root canals with physiological saline; gradually expanding the inside of teeth with a dental expander and repeatedly flushing the inside of the root canals with 5 to 17 percent of ethylene diamine tetraacetic acid (EDTA) solution; grinding outer side tissues of the tooth roots by grinding with a dental turbine and constructing a biological tooth root profile as required so as to obtain a bracket with a specific shape; preserving the teeth in the PBS and treating in an ultrasonic oscillator for 3 to 8 times; performing stepped demineralization on a dentine with EDTA with different concentrations in a magnetic stirrer with the rotating speed of between 100 and 500 revolutions per minute so as to obtain a dentine substrate; and preserving the dentine substrate in double-antibody-containing PBS. The biological tooth root bracket material has a tooth root profile, the thickness of 1mm to 3mm, the length of 1cm to 2.5cm and certain tooth inducing capability, comprises a large number of proteins and factors related to the manufacturing of teeth, can release the proteins and factors continuously, can better solve the problem of induction micro-environment, and contributes to application to tooth socket intra-alveolar orthotopic transplantation.

An acidic solution is applied to the tooth surface in the oral cavity and has the ingredients thymol, eucalyptol and menthol. It kills bacteria in the mouth and makes the environment acidic. The acidity in the oral cavity causes demineralization to occur, releasing calcium and phosphate through open pores in the tooth surface. The acidic solution is removed from the oral cavity after a predetermined amount of time. The non-acidic mouthwash is applied to the tooth surface subsequent to the removal of the acidic solution. It has sodium fluoride and works to neutralize acidic conditions in the oral cavity allowing remineralization to occur. Calcium and phosphate ions fill the open pores in the tooth surface, hardening the enamel. After a predetermined amount of time the user removes the non-acidic solution.

The invention provides an oral care composition obtainable by: (i) preparing an oil-in-water emulsion by dispersing an oil phase into an aqueous continuous phase, the aqueous continuous phase comprising an oil-in-water emulsifier which is selected from one or more hydrophobins, so that emulsified particles of oil phase are formed which are emulsified with the one or more hydrophobins; and (ii) combining the emulsion so obtained with an oral care base formulation which is suitable for treating the surfaces of the oral cavity. Compositions of the invention demonstrate enhanced deposition of oil phase components onto oral cavity surfaces such as tooth enamel and tooth dentine, and in particular onto damaged surfaces such as scratched and demineralised enamel.

The invention discloses an acid etching mineralizer for increasing adhesion of dentin, and belongs to the technical field of dental restoration agents. A certain proportion of a soluble fluoride saltis added into an acid etching agent phosphoric acid. 0.5-5 g of the fluoride salt is correspondingly added into every 100 ml of 5-50% phosphoric acid. Fluoride is used as a part of a treating agent and acts on the dentin bonding surface together with phosphoric acid, and after conventional water washing is performed, fluoride is generated and deposited on the surface of dentin and blocks dentinaltubules while acid etching demineralization is performed, so that exposure of collagen fibers on the surface of the acid etched dentin is reduced, the influence of liquid in dentin tubules on adhesionis reduced, the sensitivity of teeth to external stimulation is reduced, mineralization of the dentin is promoted, and the adhesion and the anti-aging performance are improved.

The invention provides a plastic filling material used for surgical treatment of a bone defect and a preparation method thereof. The method comprises the steps of using an allogenous cortical bone forpreparing bone grains in particle size of 0.1-1 mm; adopting a chloroform/methyl alcohol (1 to 1) solution for room-temperature soak degreasing; in purified water at 60+/-1 DEG C, soaking the bone grains subjected to degreasing for 10 h to conduct virus inactivation; in hydrochloric acid or acetic acid, using an ultrasonic method for conducting demineralization treatment, wherein the residual calcium amount of the bone grains subjected to demineralization treatment is lower than 8%; using purified water for ultrasonic cleaning, and replacing the water hourly until a cleaning liquid pH is 5.8-7.5; conducting freeze drying treatment, using two layers of bacteria-isolating plastic bags for packaging, and making the bone grains subjected to irradiation sterilization for use; and in a sterileenvironment, preparing a hyaluronic acid solution in a concentration of 2.5%-2.9%, and adding 450 mg of the bone grains into each milliliter of hyaluronic acid solution for mixing. By means of the provided material and method, without changing bone induction activity of the demineralized bone, the plastic mixture of the demineralized bone matrix and hyaluronic acid can be prepared, and can be directly used in clinic.

The invention provides an allogeneic demineralized bone material used for nose job filling and a preparation method thereof. The method comprises the steps of using a human cortical bone as a raw material, and taking the cortical bone of a middle segment of a tibia or a femur to prepare a cortical bone lamella with thickness of 2-10 mm, width of 15-50 mm and length of 20-80 mm; drilling the cortical bone on a drilling machine evenly, wherein holes are through holes or non-through holes; adopting a chloroform/methyl alcohol (1 to 1) solution for conducting room-temperature soak degreasing on the cortical bone with the holes; soaking the cortical bone with the holes in purified water at 60+/-1 DEG C for 10 h to conduct virus inactivation; conducting demineralization treatment in hydrochloricacid or acetic acid by means of an ultrasonic method, conducting ultrasonic cleaning on the demineralized cortical bone by means of purified water, and replacing the purified water hourly until a cleaning liquid pH is 5.8-7.5; conducting freeze-drying treatment on the demineralized cortical bone; and adopting at least two layers of bacteria-isolating plastic bags for packaging the freeze-dried cortical bone, and conducting irradiation sterilization. The method is simple in preparation process, the structure is stable, the biocompatibility is good, shaping is easy, complications of translocation and the like are not liable to happen, and finally, the allogeneic demineralized bone material used for nose job filling can be replaced by self-tissue.

Disclosed herein are compositions and methods for their use in treating dental disorders, whitening teeth, restoring and retaining the tooth structure and restoring the mineral content of the tooth-mineral loss due to demineralization, wherein the compositions include a first formulation that includes a polypeptide effective to treat a dental disorder and/or whiten teeth, and one or more further formulations including at least one calcium ion source and/or at least one phosphate ion source, wherein the first formulation is configured to release the polypeptide more rapidly than Ca2+ is released from the at least one calcium ion source and PO4 3- is released from the at least one phosphate ion source.

The present invention relates to an oral care dye composition for detection of demineralization lesions comprising: a first phase (or first composition) comprising from about 0.1% to about 10% by weight of the composition of a blue dye and mixtures thereof; a second phase (or second composition) comprising from about 0.1% to about 10% by weight of the composition of a red dye or a yellow dye or mixtures thereof; a safe and effective amount of a solvent wherein the dye is soluble in the solvent; and optionally a safe and effective amount of a flavor; wherein the composition is effective for detection of demineralized lesions. The present invention further relates to method of visually highlighting demineralization lesions, in tooth surfaces, or a method of detecting the mineralization health of teeth, wherein the above dye composition is applied to the oral cavity or to the teeth, of a human or animal subject, in need thereof. In one embodiment a first dye composition and a second dye composition are applied, sequentially, to a human or animal subject's oral cavity or teeth, in need thereof, wherein after the dye compositions are applied, the teeth are visually observed to assess demineralized lesions stained by the dyes.

The invention discloses application of carboxymethyl chitosan in preparing a dentin collagenous fiber demineralization material, and meanwhile provides the dentin collagenous fiber demineralization material prepared from the carboxymethyl chitosan and deionized water. The mass percent concentration of the carboxymethyl chitosan is 0.1%-1%. The demineralization material can be used for dentin demineralization treatment before direct or indirect restoration in the dental department, mineral substances outside dentin collagenous fibers can be selectively removed, the physical and mechanical performance of demineralized collagen is reserved to the maximum degree, bacterial infection is effectively resisted, degradation damage to a bonding interface is reduced, and the clinical service life ofbonding restoration is prolonged. The demineralization material is especially suitable for the dry bonding restoration technology with lower susceptibility to the technology.

Teeth can be hardened and made more resistant to acid damage if treated with compositions that allow for the remineralization and demineralization of minerals found in teeth. Exchanging ions in hydroxyapatite for fluoride or other metal ions can result in teeth that are more resistant to chemical and physical insults.

Disclosed is a visual imaging device based on PS-OCT for early demineralization and caries of dental hard tissues, comprising a laser light source for emitting a laser light, a coupler for receiving and dividing the laser light emitted by the laser light source into a reference laser light and a detection laser light; wherein the reference laser light backtracking to the coupler and the detection laser light backtracking to the coupler are coupled and then passed through a transmission grating and a convex lens to input as an optical signal into a linear CCD detector for converting the optical signal into an electrical signal which is then input to a computer control system and collected by a built-in capture card; and the computer is configured to perform a three-dimensional reconstruction of an image and perform two-dimensional cross-section image analysis; and the computer control system is connected to the scanning galvanometer to control a vibration of the scanning galvanometer. The device of the present application can be used for performing PS-OCT imaging detection of the dental hard tissue surface in the oral cavity of a subject. The computer control system automatically performs two-dimensional cross-section imaging and three-dimensional reconstruction imaging of the image, thereby completing a three-dimensional quantitative evaluation. The present application provides a new method for clinically detecting early demineralization of dental hard tissue with high resolution.

The invention discloses caries-preventing toothpaste and a preparation method thereof. The caries-preventing toothpaste comprises the following components: 0.05-0.1% of lanthanum chloride, 1-8% of chitosan, 0.2-0.3% of xylitol, 2.0-2.5% of sodium lauroyl sarcosinate, 24-27% of glycerol, 0.8-1.2% of edible essence, 0.6-0.8% of sodium carboxymethyl cellulose, 0.5-0.8% of sodium pyrophosphate, 40-45% of calcium hydrophosphate, 3-5% of aluminum hydroxide, 1-2% of sodium benzoate and the balance of deionized water, wherein the total amount is 100.0%. Lanthanum chloride has the effects of preventing demineralization of teeth, enabling the teeth to be firm and preventing decayed teeth; chitosan has the effects of resisting inflammation, promoting tissue repair and stopping bleeding; xylitol is a sweetening agent; the sodium lauroyl sarcosinate is a foaming agent; the glycerol has the effects of lubricating and moisturizing; the edible essence has the effect of shielding bad breath; the sodium carboxymethyl cellulose has the effect of a thickening agent or a stabilizing agent; sodium pyrophosphate, calcium hydrophosphate and aluminum hydroxide all have the effect of a friction agent, the cleaning effect of the toothpaste can be improved, and sodium benzoate has the anti-corrosion effect.

The invention provides a delivery system based on nano-hydroxyapatite, the delivery system comprises nano-hydroxyapatite, the surface of the nano-hydroxyapatite is coated with a chitosan derivative to obtain a first nano-system, and the surface of the first nano-system is loaded with a photosensitizer; wherein the chitosan derivative is a water-soluble chitosan derivative. The invention also provides a preparation method and application of the delivery system based on nano-hydroxyapatite, a pharmaceutical composition, a spray and hydrogel. The delivery system provided by the invention can prevent further deterioration of decayed teeth, prevent demineralization of the teeth, maintain the microenvironment on the surfaces of the teeth, and realize a remineralization effect on damaged enamel.

The invention discloses a dentale material with extracorporeal collagen demineralization. The dentale material is based on the size exclusion effect of collagenous fibers, a macromolecular chelating agent is combined with calcium outside the dentin collagenous fibers, mineral crystals outside the collagenous fibers are removed, and the external demineralization dentale material with a unique nano structure and high mechanical strength is obtained. The extrafibrous demineralized dental bone material shows a unique nano-structure formed by endomineralized collagen fibers, has excellent mechanical strength and biocompatibility, can effectively promote adhesion and proliferation of cells, support cell growth, promote osteogenic differentiation of stem cells, and has a good application prospect. And pores left after the mineral substances outside the fibers are removed are beneficial to tissue vascularization and nutrient substance transportation. Therefore, the collagen in-vitro demineralized dental bone material can be used as a tissue engineering scaffold material to be applied to bone tissue regeneration, and has a good biomedical application prospect.