22 results about "Demineralization" patented technology

An osteogenic composition comprises growth-factor augmented cortical bone and cancellous bone having viable endogenous osteogenic cells that remain adherent to the cancellous bone. The growth-factor augmented cortical bone comprises demineralized cortical bone amplified with growth factors derived from a demineralized bone, and the cancellous bone not having been subjected to a loosening agent. The osteogenic composition is cryopreserved or lyopreserved. A method for preparing an enhanced graft composition with improved osteoinductive properties includes processing demineralized cortical bone; solubilizing growth factors from demineralized bone; and mixing the demineralized cortical bone with the solubilized growth factors.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

A method for detecting demineralization of a tooth substance, including the steps of irradiating (S101) a structured light pattern onto the tooth substance; detecting (S102) a light intensity of the light pattern remitted from the volume of the tooth substance; and determining (S103) demineralization of the tooth substance based on the detected light intensity.

The application belongs to the technical field of nanomaterials, and particularly relates to a graphene oxide composite nanocoating, application thereof and modified dental metal material. The obtained graphene oxide composite nanocoating overcomes the problem of easy agglomeration of GO alone, has the advantages of long-term antibacterial property, strong corrosion resistance, low toxicity, good remineralization effect on dental enamel, reduced occurrence of dental demineralization and dental caries, effectively reduced friction between dental metal materials, especially between metal materials for orthodontic treatment, is conducive to the sliding between arch wires and bracket grooves in the orthodontic process, and further conducive to improving the efficiency of aligning and flattening the dental arch in orthodontic treatment and shortening the treatment course. In addition, the application has the characteristics of simple operation, low cost and strong controllability, and provides a simple and universal strategy for preparing dental metal materials with long-term antibacterial property, corrosion resistance, low toxicity, good remineralization effect and low friction.

A fully dissolvable anticaries remineralization toothpaste for children and a preparation method thereof. The toothpaste has a three-layer composite structure: a dissolvable backing protective layer, an anticaries remineralization active layer, and a pH responsive layer. All components are food grade or pharmaceutical excipient grade, and completely dissolve within 10-30 minutes in the oral environment, without the need to remove after use. The active layer contains a "fluoride-nano hydroxyapatite-xylitol" ternary synergistic system, which can inhibit demineralization, promote remineralization, and inhibit cariogenic bacteria. The active layer also contains pH-responsive food colorants, which visually indicate the end of use through color changes. Formulas are designed for children aged 3-6 and 6-12, respectively, and the toothpaste can be cut along the preset line to fit different arch sizes. The invention solves the problems of poor use compliance, high risk of swallowing, and short residence time of active ingredients in existing children's anticaries products, and achieves safe, effective, and fun oral care for children.

An apparatus for mixing bone material with a liquid is provided. The apparatus includes a chamber having a proximal end and a distal end and bone material disposed within the chamber, the bone material comprising DBM particles of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with the liquid from the distal end of the chamber when the plunger is in an extended position.

Aqueous-based compositions for remineralizing dentinal tissues in vivo are disclosed to arrest demineralization and early-stage caries, treat dentin / tooth sensitivity, fix white spot lesions, and strengthen dentinal hard tissues (enamel, dentin, cementum), among others. Methods utilizing the remineralizing composition are also disclosed.

An enhanced osteoinductive composition is prepared by subjecting particulate bone to a demineralization process that is optimized based on the particle size. In broad particle size ranges, ground bone is separated by particle size and each size range is subjected to independent demineralization conditions that maintain high levels of endogenous growth factors found in bone. Following demineralization, the size ranges are recombined to create an enhanced osteoinductive composition. In narrow particle size ranges, bone is milled to achieve a predetermined size, and the demineralization process is adjusted to this size range. Size-optimized demineralization is also used to create enhanced demineralized bone matrix particles in the size range of <125 μm. Enhanced osteoinductive compositions using size-optimized demineralization bone matrix and protein isolation and / or bone gelatin creation techniques are disclosed. Tissue repair compositions using the enhanced osteoinductive particles are also disclosed.

A multi-layer collagen-based membrane that includes a bioresorbable mesh embedded between a first decellularized natural collagen-based membrane and a second decellularized natural collagen-based membrane. The bioresorbable mesh can be formed of a synthetic polymer or demineralized laminar bone. Also provided are two methods for manufacturing a multi-layer collagen-based membrane with or without an embedded bioresorbable mesh.

This invention relates to the field of dental restoration technology, providing a glucose solution-stabilized calcium phosphate ion cluster, its preparation method, and its application. The invention utilizes a glucose solution to stabilize calcium phosphate ion clusters. In a high-concentration glucose aqueous solution, calcium ions and phosphate groups aggregate to form ion clusters. Upon contact with saliva, the glucose dissolves, releasing the calcium phosphate ion clusters, which then attach to the enamel prism structure of the tooth, triggering a mineralization reaction. This promotes the deposition and growth of calcium phosphate crystals along a specific orientation, restoring the original morphology of the tooth and improving the strength and hardness of the enamel. Furthermore, the glucose solution used in this invention stabilizes the calcium phosphate ion clusters, resulting in clusters with a size <2 nm, allowing them to penetrate nanoscale demineralization pores and easily penetrate enamel micropores. This results in high mineralization efficiency, high enamel restoration strength, and the mineralization process does not require high temperature, high pressure, or ultraviolet irradiation, exhibiting good biosafety and high clinical translation feasibility, thus possessing broad application prospects in the field of dental restoration.

This invention discloses a multifunctional tooth desensitizing agent and its preparation method, belonging to the field of medical devices. The main components of the multifunctional tooth desensitizing agent prepared by this invention include: gallnut water extract, ethyl acetate, *Sanguisorba officinalis* extract, *Sophora flavescens* extract, hydroxymethyl chitosan, thymol, sodium carboxymethyl cellulose, and mannitol. Currently, oral health issues are receiving increasing attention. This invention aims to address the current imbalance in the oral microecology, where plaque accumulation easily leads to demineralization of tooth hard tissues, subsequently causing caries and tooth sensitivity. Furthermore, existing products have limited effects and cannot simultaneously achieve remineralization, desensitization, caries prevention, and plaque prevention. The multifunctional tooth desensitizing agent prepared by this invention is neutral and non-irritating, and can inhibit oral plaque growth and accumulation while simultaneously providing desensitization, remineralization, and caries prevention effects.

To provide a method for determining areas of a tooth substance subject to demineralization that may occur in a dental caries case.SOLUTION: Provided is a method for detecting demineralization of a tooth substance, including the steps of: irradiating (S101) a structured light pattern onto the tooth substance; detecting (S102) a light intensity of the light pattern remitted from the volume of the tooth substance; and determining (S103) demineralization of the tooth substance based on the detected light intensity.SELECTED DRAWING: Figure 4

The present invention relates to an amorphous calcium phosphate / bioactive glass composite material (ACP / BG) that combines the short-term ion-releasing ability of ACP with the long-term ion-releasing ability of BG, thereby (i) efficiently remineralizing damaged enamel and (ii) inducing the formation of a new HA layer on the surface of enamel and dentin. The ACP / BG composite material is obtained by embedding BG particles in a matrix of ACP nanoparticles to maximize homogenization between these two components and produce a composite material with high uniformity from the macroscale to the nanoscale. This is achieved by a method including precipitating ACP onto BG particles. The BG particles can be nanoparticles, microparticles, or macroparticles. The particles can also be porous or mesoporous. The present invention also relates to the use of the composite material of the present invention for preventing demineralization and promoting remineralization of teeth. In other words, the composite material disclosed herein is 2+ ions and PO4 3- By releasing ions, it has the ability to restore the structure and maintain the mechanical properties of dental hard tissues, and it can be used as a remineralization agent, mimicking the spontaneous remineralization process induced by saliva. The composite material can also be used for bone regeneration.

The invention belongs to the technical field of collagen peptide, and particularly discloses a preparation method of yak bone collagen peptide for improving bone mineral density, which comprises the following steps: crushing fresh yak bone into bone grains of 3-5mm, degreasing the bone grains, adding a phosphate buffer solution, and adding compound bacteria for demineralization treatment; adding the demineralized product into a compound enzyme, and carrying out enzymolysis to obtain a clear enzymolysis filtrate; and concentrating the enzymolysis filtrate by adopting vacuum concentration equipment until the volume of the concentrated solution is reduced to 20% of the original volume, uniformly mixing the concentrated solution with the mixed oil phase, shearing and homogenizing for 2 minutes to obtain a primary mixed solution, adding the emulsified liquid into the primary mixed solution, and performing high-pressure homogenization to obtain the yak bone collagen peptide. According to the preparation method of the yak bone collagen peptide for improving the bone mineral density, the collagen peptide prepared by the method is remarkable in effect and high in bioavailability, and the problems of collagen peptide in the prior art are solved.

The invention discloses a processing method of pawpaw decoction pieces. The processing method comprises the following steps: (1) preparing a calcined oyster decoction; (2) taking pawpaw, washing, drying in the sun, slicing, and treating pawpaw slices with calcined oyster shell decoction; and (3) drying to obtain the calcined oyster processed pawpaw decoction pieces, the calcined oyster processed pawpaw decoction pieces can significantly reduce demineralization of tooth enamel, the acidity of the processed calcined oyster is reduced, the effect of protecting tooth surfaces can be achieved, the VC loss of a steamed group is obvious, and the VC of a calcined oyster processed group is well retained. The steaming process leads to more obvious reduction of flavonoids and oxidation resistance, and the calcined oyster shell prepared by the preparation method has better active ingredient retention.

Aqueous-based compositions for remineralizing dentinal tissues in vivo are disclosed to arrest demineralization and early-stage caries, treat dentin / tooth sensitivity, fix white spot lesions, and strengthen dentinal hard tissues (enamel, dentin, cementum), among others. Methods utilizing the remineralizing composition are also disclosed.

The invention relates to the technical field of oral care, and provides a water-containing bioactive glass composition which comprises the following raw material components: bioactive glass, exoskeleton molecules, a synergistic active substance and a water-phase toothpaste matrix, wherein the exoskeleton molecule comprises an anchoring end, a skeleton section and a triggering end. A three-dimensional grid is formed through self-assembly of exoskeleton molecules, BG is stably dispersed in a water-containing toothpaste system, BG particles are mechanically isolated out of a water phase in the storage period, hydrolysis is remarkably inhibited, the BG particles are uniformly dispersed, and the storage stability is greatly improved; during tooth brushing, disintegration is triggered through saliva and mechanical shearing, BG is rapidly released, and the problems of poor storage stability, poor taste, poor BG activity, low repair efficiency, non-uniform mineralization and the like are solved. The BG release rate gt within 5 minutes in the oral environment is gt; and the 7d enamel microhardness recovery rate is improved by 79% or above, the demineralization area is reduced by 70% or above, the dental tubule plugging rate is larger than 90%, and a remineralization layer is uniform and compact.

The invention belongs to the technical field of efficacy evaluation of oral care products, and discloses a test method for in-vitro evaluation of anti-acid calcium locking effects of oral care products, which comprises the following specific steps: step 1, preparing an acidic solution, weighing a proper amount of phytic acid solution, adding into deionized water, adjusting the pH value to 4.5, fixing the volume to 1000mL, and shaking uniformly for later use; 2, sample configuration (pretreatment); the method comprises the following steps: by taking in-vitro bovine tooth enamel as a model, pretreating by using a sample, performing primary demineralization for 1 hour by using a phytic acid solution with the pH value of 4.5, measuring the calcium ion concentration of demineralization liquid, calculating the calcium locking multiple / proportion, and performing statistical test to judge whether the toothpaste has the acid-resisting and calcium-locking effects or not. According to the method, the experimental period is greatly shortened, only about 4 h is needed from sampling to quantitative result obtaining, and the time is shortened compared with that of a traditional pH circulation model; the cost is low, and expensive animal experiments or complex buffer systems are not needed; the method is good in reproducibility, adopts one-time phytic acid demineralization, is fixed in condition and high in stability, and reduces batch difference.

Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.

An osteogenic composition comprises growth-factor augmented cortical bone and cancellous bone having viable endogenous osteogenic cells that remain adherent to the cancellous bone. The growth-factor augmented cortical bone comprises demineralized cortical bone amplified with growth factors derived from a demineralized bone, and the cancellous bone not having been subjected to a loosening agent. The osteogenic composition is cryopreserved or lyopreserved. A method for preparing an enhanced graft composition with improved osteoinductive properties includes processing demineralized cortical bone; solubilizing growth factors from demineralized bone; and mixing the demineralized cortical bone with the solubilized growth factors.

Use of a radically polymerizable composition to reduce demineralization of teeth, during the remineralization of teeth, in reducing the drop in oral pH in patients after acid exposure, for the treatment or prevention of caries, of initial carious lesions and / or for caries protection in selected areas of the teeth. (1) 25 - 80 wt% solvent, (2) 10 - 20 wt% of at least one radically polymerizable monomer with buffer groups, (3) 0 - 20 wt% of at least one monofunctional radically polymerizable monomer, (4) 0 - 10 wt% of at least one crosslinking radically polymerizable monomer and (5) Contains 0.1 - 1 wt% of at least one radical polymerization initiator, based on the total mass of the composition.

The present invention relates to oral care compositions. There is a need to provide an oral care composition that remineralizes and at the same time prevents or at least reduces demineralization. The inventors of the present invention have observed that the combination of 1: 1 phyllosilicate clay, 2: 1 phyllosilicate clay and xanthan gum has a synergistic effect and they together remineralize teeth, preferably reduce their demineralization.