50 results about "Demineralization" patented technology

Peptides that bind with high affinity to oral cavity surfaces, such as tooth enamel, have been discovered. The peptides exhibit antibacterial and mineralizing abilities, and are useful in many aspects of oral care. The peptides include the amino acid sequence AKRHHGYKRKFH-SpSp. The peptides can be included in oral care compositions such as toothpastes and mouthwashes. The oral care compositions can be used in methods to treat or prevent diseases or conditions induced by acidophilic oral bacteria. Exemplary methods include reducing or preventing tooth decay or demineralization, biofilm or dental plaque formation, and / or bacterial adhesion to a tooth surface; and promoting mineralization of teeth surfaces.

An osteogenic composition comprises growth-factor augmented cortical bone and cancellous bone having viable endogenous osteogenic cells that remain adherent to the cancellous bone. The growth-factor augmented cortical bone comprises demineralized cortical bone amplified with growth factors derived from a demineralized bone, and the cancellous bone not having been subjected to a loosening agent. The osteogenic composition is cryopreserved or lyopreserved. A method for preparing an enhanced graft composition with improved osteoinductive properties includes processing demineralized cortical bone; solubilizing growth factors from demineralized bone; and mixing the demineralized cortical bone with the solubilized growth factors.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

A method for detecting demineralization of a tooth substance, including the steps of irradiating (S101) a structured light pattern onto the tooth substance; detecting (S102) a light intensity of the light pattern remitted from the volume of the tooth substance; and determining (S103) demineralization of the tooth substance based on the detected light intensity.

The application belongs to the technical field of nanomaterials, and particularly relates to a graphene oxide composite nanocoating, application thereof and modified dental metal material. The obtained graphene oxide composite nanocoating overcomes the problem of easy agglomeration of GO alone, has the advantages of long-term antibacterial property, strong corrosion resistance, low toxicity, good remineralization effect on dental enamel, reduced occurrence of dental demineralization and dental caries, effectively reduced friction between dental metal materials, especially between metal materials for orthodontic treatment, is conducive to the sliding between arch wires and bracket grooves in the orthodontic process, and further conducive to improving the efficiency of aligning and flattening the dental arch in orthodontic treatment and shortening the treatment course. In addition, the application has the characteristics of simple operation, low cost and strong controllability, and provides a simple and universal strategy for preparing dental metal materials with long-term antibacterial property, corrosion resistance, low toxicity, good remineralization effect and low friction.

A fully dissolvable anticaries remineralization toothpaste for children and a preparation method thereof. The toothpaste has a three-layer composite structure: a dissolvable backing protective layer, an anticaries remineralization active layer, and a pH responsive layer. All components are food grade or pharmaceutical excipient grade, and completely dissolve within 10-30 minutes in the oral environment, without the need to remove after use. The active layer contains a "fluoride-nano hydroxyapatite-xylitol" ternary synergistic system, which can inhibit demineralization, promote remineralization, and inhibit cariogenic bacteria. The active layer also contains pH-responsive food colorants, which visually indicate the end of use through color changes. Formulas are designed for children aged 3-6 and 6-12, respectively, and the toothpaste can be cut along the preset line to fit different arch sizes. The invention solves the problems of poor use compliance, high risk of swallowing, and short residence time of active ingredients in existing children's anticaries products, and achieves safe, effective, and fun oral care for children.

The present invention relates to an oral care composition for treating or preventing aggressive tooth demineralization, plaque and dental caries. The oral care composition includes zinc lactate dihydrate, a source of stannous ions, at least one phosphate, and a buffer system.

An enhanced osteoinductive composition is prepared by subjecting particulate bone to a demineralization process that is optimized based on the particle size. In broad particle size ranges, ground bone is separated by particle size and each size range is subjected to independent demineralization conditions that maintain high levels of endogenous growth factors found in bone. Following demineralization, the size ranges are recombined to create an enhanced osteoinductive composition. In narrow particle size ranges, bone is milled to achieve a predetermined size, and the demineralization process is adjusted to this size range. Size-optimized demineralization is also used to create enhanced demineralized bone matrix particles in the size range of <125 μm. Enhanced osteoinductive compositions using size-optimized demineralization bone matrix and protein isolation and / or bone gelatin creation techniques are disclosed. Tissue repair compositions using the enhanced osteoinductive particles are also disclosed.

The presently disclosed subject matter relates to compositions and methods for preventing and / or treating of an oral disease and / or a biofilm-associated disease. In particular, the presently disclosed subject matter provides a composition for preventing and / or treating of an oral disease comprising (a) one or more iron oxide nanoparticles and (b) stannous fluoride (SnF2) that provide synergistic properties, including enhanced solubility, stability, co-delivery and catalytic activity, while creating a protective antibacterial and anti-demineralization layer on the target surface for disease prevention.

An apparatus for mixing bone material with a liquid is provided. The apparatus includes a chamber having a proximal end and a distal end and bone material disposed within the chamber, the bone material comprising DBM particles of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with the liquid from the distal end of the chamber when the plunger is in an extended position.

The invention discloses a composition for repairing tooth enamel and a preparation method of the composition. The composition comprises 10-15% by mass of bioactive glass; the bioactive glass comprises the following components by mole percent: 8%-15% of P2O5; 50%-60% of SiO2; and 30-40% of CaO. The composition disclosed by the invention can be used for repairing mineral loss caused by demineralization and restoring the structural integrity of enamel hydroxyapatite. According to the bioactive glass, the mineral deposition efficiency and enamel structure reconstruction are improved through a biomimetic mineralization mechanism, dual repair of functions and forms of enamel is achieved, the bioactive glass has remarkable advantages in enamel repair and chalk spot reversal, and an experimental basis is provided for developing efficient enamel repair agents (such as toothpaste and gel).

A process for the production of bone gelatin includes demineralization of bone using a demineralization solution of acid, wherein the bone is washed for a demineralized time in the demineralization solution to remove soft tissue. The demineralized bone is then pulverized to produce particles of the demineralized bone in a homogenized bone tissue. Lipids are then removed from the homogenized bone tissue using a lipid removal series of washing steps which may include washing the homogenized bone tissue in a series of solutions, including a lipid removal solution and an ethanol solution. Gelatin is then removed from the lipid removed bone tissue in a gelatin extraction process, wherein lipid removed bone tissue is placed in a pepsin solution followed by an extraction solution. The gelatin from the gelatin extracted bone tissue may then be separated and the bone gelatin may then be lyophilized.

Aqueous-based compositions for remineralizing dentinal tissues in vivo are disclosed to arrest demineralization and early-stage caries, treat dentin / tooth sensitivity, fix white spot lesions, and strengthen dentinal hard tissues (enamel, dentin, cementum), among others. Methods utilizing the remineralizing composition are also disclosed.

The present invention relates an oral care composition. There is need for oral care composition that provides remineralization and at the same time, prevents or at least reduces demineralization. The present inventors have observed that a combination of a 1:1 layered silicate clay, a 2:1 layered silicate clay and xanthan gum is synergistic and together they remineralize the teeth and preferably reduce their demineralization.

An enhanced osteoinductive composition is prepared by subjecting particulate bone to a demineralization process that is optimized based on the particle size. In broad particle size ranges, ground bone is separated by particle size and each size range is subjected to independent demineralization conditions that maintain high levels of endogenous growth factors found in bone. Following demineralization, the size ranges are recombined to create an enhanced osteoinductive composition. In narrow particle size ranges, bone is milled to achieve a predetermined size, and the demineralization process is adjusted to this size range. Size-optimized demineralization is also used to create enhanced demineralized bone matrix particles in the size range of <125 μm. Enhanced osteoinductive compositions using size-optimized demineralization bone matrix and protein isolation and / or bone gelatin creation techniques are disclosed. Tissue repair compositions using the enhanced osteoinductive particles are also disclosed.

A process for the production of bone gelatin includes demineralization of bone using a demineralization solution of acid, wherein the bone is washed for a demineralized time in the demineralization solution to remove soft tissue. The demineralized bone is then pulverized to produce particles of the demineralized bone in a homogenized bone tissue. Lipids are then removed from the homogenized bone tissue using a lipid removal series of washing steps which may include washing the homogenized bone tissue in a series of solutions, including a lipid removal solution and an ethanol solution. Gelatin is then removed from the lipid removed bone tissue in a gelatin extraction process, wherein lipid removed bone tissue is placed in a pepsin solution followed by an extraction solution. The gelatin from the gelatin extracted bone tissue may then be separated and the bone gelatin may then be lyophilized.

A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

A bone gel composition comprising cortical bone is provided. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is placed in jars and kept at room temperature or frozen for later use. The cortical bone has the cut pieces having a width, a length and a thickness in the range of 1 to 4 mm. The cortical bone pieces are ground to a particle size up to 125 microns.

A multi-layer collagen-based membrane that includes a bioresorbable mesh embedded between a first decellularized natural collagen-based membrane and a second decellularized natural collagen-based membrane. The bioresorbable mesh can be formed of a synthetic polymer or demineralized laminar bone. Also provided are two methods for manufacturing a multi-layer collagen-based membrane with or without an embedded bioresorbable mesh.

To provide a method for manufacturing a demineralized hard tissue that can reduce labor required for replacing a demineralization solution, and alternatively, to provide a method for manufacturing a demineralized hard tissue that can stabilize the quality of demineralized hard tissues obtained when a plurality of demineralized hard tissues are manufactured.SOLUTION: One embodiment of the present invention includes a method for manufacturing at least two demineralized hard tissues, the method including: an immersion step of immersing at least two hard tissues in a demineralization solution within a single liquid-impermeable container, the at least two hard tissues being immersed in a state in which each of the hard tissues is identifiable.SELECTED DRAWING: Figure 3

This invention relates to the field of dental restoration technology, providing a glucose solution-stabilized calcium phosphate ion cluster, its preparation method, and its application. The invention utilizes a glucose solution to stabilize calcium phosphate ion clusters. In a high-concentration glucose aqueous solution, calcium ions and phosphate groups aggregate to form ion clusters. Upon contact with saliva, the glucose dissolves, releasing the calcium phosphate ion clusters, which then attach to the enamel prism structure of the tooth, triggering a mineralization reaction. This promotes the deposition and growth of calcium phosphate crystals along a specific orientation, restoring the original morphology of the tooth and improving the strength and hardness of the enamel. Furthermore, the glucose solution used in this invention stabilizes the calcium phosphate ion clusters, resulting in clusters with a size <2 nm, allowing them to penetrate nanoscale demineralization pores and easily penetrate enamel micropores. This results in high mineralization efficiency, high enamel restoration strength, and the mineralization process does not require high temperature, high pressure, or ultraviolet irradiation, exhibiting good biosafety and high clinical translation feasibility, thus possessing broad application prospects in the field of dental restoration.

An enhanced osteoinductive composition is prepared by subjecting particulate bone to a demineralization process that is optimized based on the particle size. In broad particle size ranges, ground bone is separated by particle size and each size range is subjected to independent demineralization conditions that maintain high levels of endogenous growth factors found in bone. Following demineralization, the size ranges are recombined to create an enhanced osteoinductive composition. In narrow particle size ranges, bone is milled to achieve a predetermined size, and the demineralization process is adjusted to this size range. Size-optimized demineralization is also used to create enhanced demineralized bone matrix particles in the size range of <125 µm. Enhanced osteoinductive compositions using size-optimized demineralization bone matrix and protein isolation and / or bone gelatin creation techniques are disclosed. Tissue repair compositions using the enhanced osteoinductive particles are also disclosed.

Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.

This invention discloses a multifunctional tooth desensitizing agent and its preparation method, belonging to the field of medical devices. The main components of the multifunctional tooth desensitizing agent prepared by this invention include: gallnut water extract, ethyl acetate, *Sanguisorba officinalis* extract, *Sophora flavescens* extract, hydroxymethyl chitosan, thymol, sodium carboxymethyl cellulose, and mannitol. Currently, oral health issues are receiving increasing attention. This invention aims to address the current imbalance in the oral microecology, where plaque accumulation easily leads to demineralization of tooth hard tissues, subsequently causing caries and tooth sensitivity. Furthermore, existing products have limited effects and cannot simultaneously achieve remineralization, desensitization, caries prevention, and plaque prevention. The multifunctional tooth desensitizing agent prepared by this invention is neutral and non-irritating, and can inhibit oral plaque growth and accumulation while simultaneously providing desensitization, remineralization, and caries prevention effects.

The utility model relates to the technical field of orthodontic education, and particularly discloses an orthodontic fixed correction risk propaganda and education model, which is characterized in that on the basis of an existing tooth and fixed correction appliance model, various risk types such as damage of a fixed correction appliance and oral discomfort, tooth offset, dental surface demineralization and the like caused by the damage of the fixed correction appliance are added; in addition, buttons and prompting lamps which are in one-to-one correspondence with indicated teeth are further arranged, a patient can know tooth symptoms or damaged parts of the fixed appliance through light indication by pressing the buttons beside the teeth, and related knowledge can be more easily understood by playing propaganda and education audios in cooperation with explanation of medical staff. According to the scheme, various risk types of orthodontic fixing correction are clearly and specifically displayed, a propaganda and education mode of autonomous interactive learning of a patient is realized, the time and energy of medical personnel are saved, and the understanding difficulty of the patient is reduced.

To provide a method for determining areas of a tooth substance subject to demineralization that may occur in a dental caries case.SOLUTION: Provided is a method for detecting demineralization of a tooth substance, including the steps of: irradiating (S101) a structured light pattern onto the tooth substance; detecting (S102) a light intensity of the light pattern remitted from the volume of the tooth substance; and determining (S103) demineralization of the tooth substance based on the detected light intensity.SELECTED DRAWING: Figure 4

The invention relates to preparation of silk fibroin oligopeptide based on a high-pressure micro-jet technology and application of the silk fibroin oligopeptide in toothpaste. According to the invention, the advantage of excellent biocompatibility of silk fibroin is fully utilized, the silk fibroin is subjected to oxidative degradation, high-pressure microjet and other process treatments, and the homogenization pressure in the high-pressure microjet treatment process is strictly controlled, so that the particle size of the silk fibroin oligopeptide can be greatly reduced, and the solubility of the silk fibroin oligopeptide can be improved. The toothpaste prepared from the mineralization material can effectively reduce the degree of caries, increase the molar ratio of calcium to phosphorus on the enamel surface, improve the repair effect on enamel after demineralization, and meanwhile contribute to inhibiting the progress of demineralization of enamel caries patients and promoting remineralization. In addition, the silkworm cocoons which are naturally sourced are used as main preparation raw materials, no fluorine-containing chemical component is added, the cost is low, the safety is good, various toxic and side effects caused by traditional fluorides in the dental caries treatment process can be effectively avoided, and great market prospects and social significance are achieved.

The invention provides a tooth superficial layer caries identification method and system based on a convolutional neural network, which processes an intraoral photo image acquired by an image acquisition device through a deep learning network, comprehensively analyzes a white light image and a fluorescence image, quantifies a tooth surface demineralization level through multi-modal analysis, and realizes accurate identification of tooth superficial layer caries. Moreover, a shallow-deep two-layer network structure is adopted, the region where the teeth are located is identified by utilizing the shallow network, and the teeth have obvious edge features, so that the influence on the identification accuracy is still small even if the intraoral picture is compressed to be 640 * 640. The deep network is used for identifying the area where the tooth glaze white spots are located, the identification accuracy can be guaranteed only when the tooth glaze white spots need to be close to the original image resolution, the tooth glaze white spots lack clear edge features, a larger receptive field can be obtained only through the deeper network, and it is guaranteed that the network better uses image global information for identification.

The invention provides an intelligent decayed tooth detection method and system. The method comprises the following steps: acquiring intensity data of excitation fluorescence of each part of a tooth lesion area of a target patient in a tooth dehydration process of the target patient in real time through a fluorescence sensor; converting all the intensity data into time sequence data of fluorescence loss amount of each part of the lesion area of the target patient, and determining a hydraulic connection coefficient of enamel micro-channels of each part of the tooth lesion area of the target patient based on relevance of each time sequence data; according to all the hydraulic communication coefficients and the flow velocity of the compressed gas, demineralization conditions of all positions of the tooth lesion area of the target patient are inverted, and the mineral loss amount of all positions of the tooth lesion area of the target patient is obtained; and according to all mineral loss amounts, identifying the activity of caries at each part of the tooth lesion area of the target patient, and according to the activity of all caries, calibrating the smooth surface caries of the target patient. By adopting the scheme provided by the invention, the influence of different permeability of micro-channels in enamel on the activity judgment of the early stage of caries of the smooth surface can be eliminated.