57 results about "Demineralization" patented technology

A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.

Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.

Ceramic materials operable to repair a defect in bone of a human or animal subject comprising a porous ceramic scaffold having a bioresorbable coating, and a carrier comprising denatured demineralized bone. The ceramic may contain a material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium phosphates, calcium carbonates, calcium sulfates, and combinations thereof. The compositions may also contain a bone material selected from the group consisting of: bone powder, bone chips, bone shavings, and combinations thereof. The bioresorbable coating may be, for example, demineralized bone matrix, gelatin, collagen, hyaluronic acid, chitosan, polyglycolic acid, polylactic acid, polypropylenefumarate, polyethylene glycol, or mixtures thereof.

A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of all physiologically active components of native bone. The invention hinges on the newly discovered ability of bone particles of defined sizes to exert osteoinduction by a pathway superior to and distinct from demineralized bone matrix and similar preparations.

Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.

Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.

A human oral care composition, includes safe and effective amounts of the fluoride ion and stabilized chlorine dioxide, that may take the form of a paste, gel, rinse, spray, powder, varnish or similar that reduces demineralization and promotes remineralization of teeth. The method includes the topical application of the composition to the human oral cavity (including but not limited to the teeth, gingiva, and tongue), preferably at least once daily, to enhance the anti-caries effect of fluoride by released chlorine dioxido compromising any biofilm present.

A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of all physiologically active components of native bone. The invention hinges on the newly discovered ability of bone particles of defined sizes to exert osteoinduction by a pathway superior to and distinct from demineralized bone matrix and similar preparations.

A composite material comprising: (i) hyaluronic acid and / or hyaluronic acid derivatives, (ii) demineralised bone and / or biocompatible partially or totally demineralised bone tissue matrix and / or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.

The present disclosure is for a device for filling the gap (kerf) left in the repair of a craniotomy and the methods for using and manufacturing such a device. The kerf device may be a preparation of demineralized or partially demineralized bone or bone substitute formed into a malleable strip that can be pressed or molded into the opening in between the skull and bone flap in order to allow bone healing without a gap or indentation.

The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid continuous acid demineralization process. The process includes subjecting bone to a continuous exchange of demineralizing acid solution where the demineralizing acid solution is recirculated from the substantially closed container through an ion exchange media to remove calcium and phosphate thereby producing a regenerated acid, and returning the regenerated acid to the substantially closed container to produce osteoinductive demineralized bone. The process allows bone to be rapidly demineralized to a precise and specific desired residual calcium level, without sacrificing osteoinductivity.

A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

The invention discloses a manufacturing method of a biological tooth root bracket material. The method comprises the following steps of: flushing teeth with phosphate buffered saline (PBS) in a sterile state for three times; removing dental crown parts by grinding with a carborundum disc, and keeping tooth root parts; pulling pulp tissues out of the tooth roots and repeatedly flushing the inside of root canals with physiological saline; gradually expanding the inside of teeth with a dental expander and repeatedly flushing the inside of the root canals with 5 to 17 percent of ethylene diamine tetraacetic acid (EDTA) solution; grinding outer side tissues of the tooth roots by grinding with a dental turbine and constructing a biological tooth root profile as required so as to obtain a bracket with a specific shape; preserving the teeth in the PBS and treating in an ultrasonic oscillator for 3 to 8 times; performing stepped demineralization on a dentine with EDTA with different concentrations in a magnetic stirrer with the rotating speed of between 100 and 500 revolutions per minute so as to obtain a dentine substrate; and preserving the dentine substrate in double-antibody-containing PBS. The biological tooth root bracket material has a tooth root profile, the thickness of 1mm to 3mm, the length of 1cm to 2.5cm and certain tooth inducing capability, comprises a large number of proteins and factors related to the manufacturing of teeth, can release the proteins and factors continuously, can better solve the problem of induction micro-environment, and contributes to application to tooth socket intra-alveolar orthotopic transplantation.

A system for the optical measurement of pH includes a light emitter to emit an excitation light, and a detector coupled to receive florescence light produced by a compound in a mouth of a patient in response to the excitation light. A controller is coupled to the detector, and the controller includes logic that when executed by the controller, causes the system to perform operations. The operations may include emitting the excitation light from the light emitter; measuring an intensity of the florescence light emitted from a surface of individual teeth in a plurality of teeth in the mouth; and determining, based on the intensity of the florescence light, one or more locations on the individual teeth likely to develop demineralization.

The invention relates to a dentin collagen fiber demineralization material and a preparation method and an application thereof. In particular, the invention relates to a conjugate of water-soluble chitosan and an amino carboxylic acid metal chelating agent, and a use thereof for dental demineralization, preferably for dentin demineralization. The invention also discloses the dentin collagen fiberdemineralization material and the preparation method and the application thereof. The material is prepared from 0.5-1 part by mass of water-soluble chitosan, 10-30 parts by mass of EDTA and 0.8-1.5 parts by mass of a crosslinking agent. The invention also relates to a dental demineralization composition including the conjugate and the material. The conjugate, material and composition can be used for dentin demineralization treatment before dental adhesive repair. When being used as a dentin collagen demineralization agent, the conjugate, material and composition have excellent selective extrafibrous demineralization performance, good biocompatibility, effective bacteriostasis, inhibition of endogenous matrix proteinase activity and extremely low cytotoxicity.

An acidic solution is applied to the tooth surface in the oral cavity and has the ingredients thymol, eucalyptol and menthol. It kills bacteria in the mouth and makes the environment acidic. The acidity in the oral cavity causes demineralization to occur, releasing calcium and phosphate through open pores in the tooth surface. The acidic solution is removed from the oral cavity after a predetermined amount of time. The non-acidic mouthwash is applied to the tooth surface subsequent to the removal of the acidic solution. It has sodium fluoride and works to neutralize acidic conditions in the oral cavity allowing remineralization to occur. Calcium and phosphate ions fill the open pores in the tooth surface, hardening the enamel. After a predetermined amount of time the user removes the non-acidic solution.

The invention provides an oral care composition obtainable by: (i) preparing an oil-in-water emulsion by dispersing an oil phase into an aqueous continuous phase, the aqueous continuous phase comprising an oil-in-water emulsifier which is selected from one or more hydrophobins, so that emulsified particles of oil phase are formed which are emulsified with the one or more hydrophobins; and (ii) combining the emulsion so obtained with an oral care base formulation which is suitable for treating the surfaces of the oral cavity. Compositions of the invention demonstrate enhanced deposition of oil phase components onto oral cavity surfaces such as tooth enamel and tooth dentine, and in particular onto damaged surfaces such as scratched and demineralised enamel.

The invention discloses an acid etching mineralizer for increasing adhesion of dentin, and belongs to the technical field of dental restoration agents. A certain proportion of a soluble fluoride saltis added into an acid etching agent phosphoric acid. 0.5-5 g of the fluoride salt is correspondingly added into every 100 ml of 5-50% phosphoric acid. Fluoride is used as a part of a treating agent and acts on the dentin bonding surface together with phosphoric acid, and after conventional water washing is performed, fluoride is generated and deposited on the surface of dentin and blocks dentinaltubules while acid etching demineralization is performed, so that exposure of collagen fibers on the surface of the acid etched dentin is reduced, the influence of liquid in dentin tubules on adhesionis reduced, the sensitivity of teeth to external stimulation is reduced, mineralization of the dentin is promoted, and the adhesion and the anti-aging performance are improved.

The invention discloses an experimental method for simulating an oral environment, a material for the environment, and application of the material. The experimental method comprises: preparing a lactic acid solution and treating a demineralization dentin sample. NACP resin comprises 100 parts of resin containing nano amorphous calcium phosphate, 0.2 part of camphorquinone, and 0.8 part of p-N,N-dimethylamino isoamyl benzoate. The cooperation with a PAMAM solution has the effects of buffering the pH value of the lactic acid solution, releasing calcium phosphate particles and promoting remineralization of the demineralization dentin sample. An extreme oral environment where saliva does not exist totally is simulated, thereby facilitating prevention and treatment of dental caries of a patient suffering from decrease of saliva quantity. The experimental method can be clinically applied to prevention and treatment of the dental caries of the patient suffering from the decrease of the saliva quantity, and is simple in operation and high in feasibility.

The invention provides a plastic filling material used for surgical treatment of a bone defect and a preparation method thereof. The method comprises the steps of using an allogenous cortical bone forpreparing bone grains in particle size of 0.1-1 mm; adopting a chloroform / methyl alcohol (1 to 1) solution for room-temperature soak degreasing; in purified water at 60+ / -1 DEG C, soaking the bone grains subjected to degreasing for 10 h to conduct virus inactivation; in hydrochloric acid or acetic acid, using an ultrasonic method for conducting demineralization treatment, wherein the residual calcium amount of the bone grains subjected to demineralization treatment is lower than 8%; using purified water for ultrasonic cleaning, and replacing the water hourly until a cleaning liquid pH is 5.8-7.5; conducting freeze drying treatment, using two layers of bacteria-isolating plastic bags for packaging, and making the bone grains subjected to irradiation sterilization for use; and in a sterileenvironment, preparing a hyaluronic acid solution in a concentration of 2.5%-2.9%, and adding 450 mg of the bone grains into each milliliter of hyaluronic acid solution for mixing. By means of the provided material and method, without changing bone induction activity of the demineralized bone, the plastic mixture of the demineralized bone matrix and hyaluronic acid can be prepared, and can be directly used in clinic.

The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and / or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.

A new composition has been developed that incorporates S1P into a conventional demineralized bone matrix material. Once the device is implanted into the spine, the S1P will elute out of the device, thereby setting up a concentration gradient in the vicinity of the device. This gradient will cause stem cells to preferentially migrate to the device.

The invention provides an allogeneic demineralized bone material used for nose job filling and a preparation method thereof. The method comprises the steps of using a human cortical bone as a raw material, and taking the cortical bone of a middle segment of a tibia or a femur to prepare a cortical bone lamella with thickness of 2-10 mm, width of 15-50 mm and length of 20-80 mm; drilling the cortical bone on a drilling machine evenly, wherein holes are through holes or non-through holes; adopting a chloroform / methyl alcohol (1 to 1) solution for conducting room-temperature soak degreasing on the cortical bone with the holes; soaking the cortical bone with the holes in purified water at 60+ / -1 DEG C for 10 h to conduct virus inactivation; conducting demineralization treatment in hydrochloricacid or acetic acid by means of an ultrasonic method, conducting ultrasonic cleaning on the demineralized cortical bone by means of purified water, and replacing the purified water hourly until a cleaning liquid pH is 5.8-7.5; conducting freeze-drying treatment on the demineralized cortical bone; and adopting at least two layers of bacteria-isolating plastic bags for packaging the freeze-dried cortical bone, and conducting irradiation sterilization. The method is simple in preparation process, the structure is stable, the biocompatibility is good, shaping is easy, complications of translocation and the like are not liable to happen, and finally, the allogeneic demineralized bone material used for nose job filling can be replaced by self-tissue.

Disclosed herein are compositions and methods for their use in treating dental disorders, whitening teeth, restoring and retaining the tooth structure and restoring the mineral content of the tooth-mineral loss due to demineralization, wherein the compositions include a first formulation that includes a polypeptide effective to treat a dental disorder and / or whiten teeth, and one or more further formulations including at least one calcium ion source and / or at least one phosphate ion source, wherein the first formulation is configured to release the polypeptide more rapidly than Ca2+ is released from the at least one calcium ion source and PO4 3- is released from the at least one phosphate ion source.

Bone repair compositions comprising bone particles and periosteum tissue. The bone particles may be demineralized, and may comprise powder or fibers from cortical bone or from cancellous bone. The periosteal tissue can be micronized periosteal tissue, and may comprise periosteal powder, particulates, pieces, or combinations thereof. The bone repair composition can further comprise bone chips, mineralized cancellous bone, or additional materials. The present technology also provides methods of repairing a bone defect, comprising administering a bone repair composition to the site of the bone defect.

The present invention relates to an oral care dye composition for detection of demineralization lesions comprising: a first phase (or first composition) comprising from about 0.1% to about 10% by weight of the composition of a blue dye and mixtures thereof; a second phase (or second composition) comprising from about 0.1% to about 10% by weight of the composition of a red dye or a yellow dye or mixtures thereof; a safe and effective amount of a solvent wherein the dye is soluble in the solvent; and optionally a safe and effective amount of a flavor; wherein the composition is effective for detection of demineralized lesions. The present invention further relates to method of visually highlighting demineralization lesions, in tooth surfaces, or a method of detecting the mineralization health of teeth, wherein the above dye composition is applied to the oral cavity or to the teeth, of a human or animal subject, in need thereof. In one embodiment a first dye composition and a second dye composition are applied, sequentially, to a human or animal subject's oral cavity or teeth, in need thereof, wherein after the dye compositions are applied, the teeth are visually observed to assess demineralized lesions stained by the dyes.

The invention discloses application of carboxymethyl chitosan in preparing a dentin collagenous fiber demineralization material, and meanwhile provides the dentin collagenous fiber demineralization material prepared from the carboxymethyl chitosan and deionized water. The mass percent concentration of the carboxymethyl chitosan is 0.1%-1%. The demineralization material can be used for dentin demineralization treatment before direct or indirect restoration in the dental department, mineral substances outside dentin collagenous fibers can be selectively removed, the physical and mechanical performance of demineralized collagen is reserved to the maximum degree, bacterial infection is effectively resisted, degradation damage to a bonding interface is reduced, and the clinical service life ofbonding restoration is prolonged. The demineralization material is especially suitable for the dry bonding restoration technology with lower susceptibility to the technology.

Teeth can be hardened and made more resistant to acid damage if treated with compositions that allow for the remineralization and demineralization of minerals found in teeth. Exchanging ions in hydroxyapatite for fluoride or other metal ions can result in teeth that are more resistant to chemical and physical insults.

The present invention provides an experimental device and a research method capable of simulating the change of beverage concentration in the oral cavity. Due to the inconvenient use of the experimental device in the adjustment process, the present invention can accurately control the saliva entering the container through the flow rate control device, and then realize the control of the beverage concentration in the container during the experimental observation period, so that the concentration of the solution in the container is consistent with the real The changes in the oral cavity are consistent, making the experimental simulation situation closer to reality, and the experimental results are more credible and convincing.