72 results about "Cariogenic bacteria" patented technology

The invention discloses an anti-caries polypeptide capable of preventing bacteria and promoting remineralization, a polypeptide derivative or a polypeptide pharmaceutical salt thereof. The anti-caries polypeptide contains an amino acid sequence a and an amino acid sequence b; the amino acid sequence a is Xn, wherein X is used for representing S, T, Y, K, R, N, or Q, n is used for representing the amino acid repeat times, and is an integer selected from 5 to 8; the amino acid sequence b is of a alpha double helix structure, is positively charged, and contains 8 to 12 amino acids, and the hydrophilic amino acids and hydrophobic amino acid in the amino acid sequence b appear alternately. The functional anti-caries polypeptide capable of preventing cariogenic bacteria and promoting remineralization is capable of inhibiting growth of streptococcus mutans, inhibiting formation of biological membrane of streptococcus mutans, reducing the metabolism capability of formed biological membrane of streptococcus mutans, killing viable bacteria in the formed biological membrane of streptococcus mutans, promoting remineralization of demineralization tooth enamel, and reducing caries depth and mineral loss of demineralization tooth enamel, and possesses excellent stability, and no obvious cytotoxicity.

Disclosed is a live bacterium preparation or food containing a lactic acid bacterium comprising a lactic acid bacterium, Lactobacillus salivarius, as an active ingredient. There is provided a live bacterium preparation and food containing a lactic acid bacterium that can prevent onset, recurrence and exacerbation of periodontal disease and/or dental caries caused by periodontopathic bacteria and cariogenic bacteria and can prevent generation of halitosis and maintain pH of saliva at a physiologically normal level by normalizing intraoral microflora.

Antibodies, as well as binding fragments and mimetics thereof, that specifically bind to Actinomyces or Lactobacillus cariogenic bacteria are provided. The subject binding agents, e.g., antibodies, fragments and mimetics thereof, etc., are characterized in that they are highly sensitive and specific for their target bacteria. Also provided are methods and devices for screening samples for the presence of cariogenic bacteria. In addition therapeutic treatment protocols and compositions are provided.

The invention provides biological toothpaste for resisting helicobacter pylori, and relates to the field of medical application. The biological toothpaste comprises the following substances in parts by weight: 25 parts of sorbitol, 1.5 parts of sodium carboxymethyl cellulose, 2.5 parts of sodium dodecyl sulfate, 13 parts of polyethylene glycol, 4 parts of calcium hydrogen phosphate, 20 parts of silicon dioxide, 0.3 part of xylitol, 1 part of broccoli essence, 0.5 part of eugenol, 0.5 part of tea tree essential oil, 0.3 part of lactoferrin, 1 part of probiotics and the balance of deionized water. In the biological toothpaste provided by the invention, the broccoli essence, lactoferrin and eugenol play a role in killing helicobacter pylori and cariogenic bacteria, the tea tree essential oilcan remove dental plaques and freshen breath, the xylitol can prevent dental caries, and the probiotics can balance oral floras. The raw materials are organically combined to prepare the toothpaste, which can play a role in eliminating oral helicobacter pylori, preventing dental caries and balancing oral floras, thereby realizing the purpose of the invention. The biological toothpaste provided bythe invention is simple to manufacture, is used as a daily necessity, is convenient and quick to use, economical and applicable, and good for long-term use, prevents and treats helicobacter pylori andcariogenic bacteria in an oral cavity, and keeps the oral cavity healthy.

The invention discloses xylitol and radix puerariae jelly. The xylitol and radix puerariae jelly is prepared from the following raw materials in percentage by weight: 5-15 percent of radix puerariae powder, 8-20 percent of xylitol, 0.4-1.0 percent of carrageenan, 0.2-0.5 percent of sodium citrate, 0.1-0.5 percent of citric acid and the balance of water. According to the effects of radix puerariae and the xylitol, the xylitol and radix puerariae jelly has the functions of reducing cariogenic bacteria in the mouth and preventing decayed teeth of children through the xylitol, and has the beautifying and fitness effects of the radix puerariae powder. The xylitol and radix puerariae jelly, added with the sodium citrate, is sour, sweet, delicious, and free from an extraneous odor, so that the flavor and taste of the xylitol radix puerariae jelly are improved. The xylitol and radix puerariae jelly facilitates mouth health and decayed tooth prevention, is capable of strengthening tendons and bones, prolonging the life and enhancing the organic immunity, can be eaten by patients such as diabetic patients, obese patients and hypertensive patients, can be used for prediction, and can be appreciated by a great number of consumers.

The invention discloses a method capable of inhibiting a streptococcus mutans and candida albicans double-bacteria biofilm and belongs to the technical field of microorganisms. At different stages offorming the double-bacteria biofilm, lactobacillus plantarum CCFM8724 can inhibit the double-bacteria biofilm in vitro, exopolysaccharide amount and pathogenic bacteria number in the biofilm can be reduced remarkably when the double-bacteria biofilm is allowed to act at different times, 1.6mg/mL of lysozyme can be tolerated, film forming performance is poor at different sucrose concentrations andlower than below 0.80, and it shows that lactobacillus plantarum cannot replace cariogenic bacteria to form a cariogenic biofilm. The method has efficacy of reducing oral cariogenic bacterial plaque and preventing and treating decayed teeth and is expected to open a new functional market for preventing and treating decayed teeth through probiotics.

The invention relates to a daily chemical and particularly relates to pet toothpaste and a preparation method thereof. The pet toothpaste contains the following components in parts by weight: 80-600 parts of a friction agent, 50-300 parts of a humectant, 0-10 parts of a flavoring agent, 10-50 parts of a foaming agent, 5-30 parts of a thickening agent, 4-20 parts of a functional reinforcing component and 1-6 parts of a stabilizer, wherein the functional reinforcing component is a mixture of a traditional Chinese medicine active component and a ferment. The toothpaste can be specially applied to pets, particularly dogs, cats and the like and is capable of effectively preventing dental calculus of the pets, relieving dental arthritis and preventing decayed teeth, and toxic and side effects are not caused after the toothpaste is swallowed; by virtue of the cooperation of the components, the microcirculation of oral cavities of the pets can be improved, the dental ulcer can be prevented, main cariogenic bacteria can be effectively inhibited and killed, the formation process of dental plaques can be inhibited, and multiple oral diseases of the pets can be prevented and treated. A preservative and the like are not added, so that the pet toothpaste is harmless to the bodies of the pets; and by utilizing the formula, the toothpaste is long in guarantee period and good in stability. The pet toothpaste is easy to implement, safe in formula and suitable for daily use of the pets.

The invention provides an oral toothpaste with anti-helicobacter pylori and anti-caries and stomach-enhancing functions. The toothpaste contains bismuth glycyrrhizinate at a concentration of 0.001% to 10% by weight. Bismuth Glycyrrhizinate combines the anti-inflammatory, analgesic, anti-ulcer, anti-oxidation effects of glycyrrhizic acid and the gastric mucosal protection function of bismuth. The bismuth glycyrrhizinate toothpaste of the present invention is a kind of daily oral hygiene article, practical and convenient, multi-effect of one product, can effectively kill HP and cariogenic bacteria, simultaneously bismuth glycyrrhizinate is dental plaque inhibitory and cleaning agent, thereby helps to inhibit and remove dental plaque, reduce the chance of bacterial adhesion and aggregation, and treat both symptoms and root causes; making it into toothpaste for external use can effectively, conveniently and durably kill Helicobacter pylori in the oral cavity, thereby effectively preventing gastrointestinal The purpose of treating tract infection and preventing the recurrence of gastritis, gastric and duodenal ulcers.

The invention relates to clinical stomatology, in particular to a cariogenic bacteria quantitative detection method which includes the steps of A and B, sampling and preparing a treatment fluid; C, counting strains; D, extracting 1mL of treatment fluid, centrifugally treating the treatment fluid by 12000 r/m for one minute, discarding supernatant, extracting DNA of four types of cariogenic bacteria in the sampled fluid by means of a DNA kit; E, feeding the DNA of four types of cariogenic bacteria into corresponding single-tube PCR (Polymerase Chain Reaction) systems to perform PCR amplification and then recording corresponding amplification curves, comparing the obtained amplification curves with a standard curve to calculate template quantity of the sample; and F, calculating proportion values of the four types of strains and then calculating quantity of different strains within 1cm*1cm. Since proportion of the four types of cariogenic bacteria in dental plaque is detected and according to comparison between the proportion to actual situation of dental caries of people under test, current caries risk assessment model is improved further and becomes more scientific and accurate.

The present invention relates to child edible calcium, ferrum and zinc chewable tablets. The chewable tablets consist of isomaltulose, whey protein powder, milk mineral salts, zinc enriched yeast, ferric pyrophosphate, and magnesium stearate. The provided child edible calcium, ferrum and zinc chewable tablets can complement a variety of minerals and trace elements at the same time, effectively inhibit the bacterium number of cariogenic bacteria in the oral cavity in the presence of cariogenic sugar, and have relative strong antibacterial effects.

The invention discloses antibacterial peptide for killing oral cariogenic bacteria and inhibiting formation of dental plaque and application thereof, and relates to the field of microorganism application. The antibacterial peptide is provided based on the situation that a traditional antibacterial agent cannot continuously resist bacteria and is lack of ability of combining with teeth. The antibacterial peptide is formed by an amino acid sequence which is as shown in SEQ ID NO: 1 and a group having a function of combining with the surfaces of the teeth through polymerizing. The antibacterial peptide disclosed by the invention has the beneficial effects that the antibacterial peptide has the capability of combining with the surfaces of the teeth and can be applied to treatment and prevention of a dental caries disease.

The present invention relates to an anti-cariogenic bacteria saccharide composition, which comprises, by weight, 5-95% of isomaltulose and 5-95% of isomaltooligosaccharide. The saccharide composition provides a significant anti-cariogenic bacteria effect in the presence of cariogenic sugars, is an ideal component for food ingredients and additives, has a dental caries prevention/anti-dental caries function, and can be applicable for various foods and products.

The invention belongs to a chewing gum, and relates to a chewing gum capable of resisting oral helicobacter pylori (HP), and a preparation method of the chewing gum, aiming at overcoming the defects that in the prior art, the HP is treated by a large dose of antibiotic, so that a great deal of beneficial bacteria can be killed, and the drug resistance of the HP can be improved. The chewing gum comprises the following components in parts by weight: 1-2 parts of wild buckwheat glycoside, 0.005-0.015 part of total matrines, 0.1-0.6 part of forsythiaside, 0.1-0.5 part of glycyrrhizin, 0.5-1.5 parts of tea polyphenol, 3-6 parts of milk protein, 0.01-0.02 part of phytic acid lanthanum bismuth, 0.01-0.004 part of enzymic preparation, 20-22 parts of gum base, 34-34.88 parts of sorbitol, 12 parts of 75% hydrogenated starch hydrolysate, 16-18 parts of xylitol, 2.5-3.5 parts of glycerinum and 2.5-3.5 parts of menthol. The chewing gum has the advantages of being capable of effectively killing the oral HP and cariogenic bacteria and preventing dental caries, and being convenient to take.

The invention belongs to the biopharmaceutical field and relates to a method for constructing and preparing human streptococcus mutans gene engineering vaccine for tooth decay. In the method, the genes at a glucan binding domain at the end of glucosyltransferase C and at an N end immunodominance domain of glucan-binding protein B which are major protective antigens of streptococcus mutans of human primary cariogenic bacteria and the mucous membrane immunologic adjuvant heat-labile toxin B subunit are used for constructing fusion engineering bacteria by a gene recombination method, and fusion protein molecular vaccine with high purity is obtained by high density fermentation and a series of purifying procedures. The technology for preparing the vaccine is simple and easy for amplifying and has good repeatability; the obtained protein has high purity; primary animal experiments prove that the fusion protein can stimulate body to produce efficient immunity response; and the fusion protein is approved as good candidate antigens of gene engineering vaccine for tooth decay and has good application prospect.

The invention belongs to the technical field of articles of daily use, and particularly relates to caries-prevention toothpaste and a preparing method thereof. The caries-prevention toothpaste comprises, by weight, 0.1-0.3 part of functional powder body, 22-28 parts of calcium carbonate, 23-28 parts of sorbitol, 1-2 parts of cocamidopropyl betaine, 0.4-1.2 parts of sodium carboxymethylcellulose, 0.03-0.05 part of saccharin sodium salt, 0.03-0.06 part of methyl 4-hydroxybenzoate, 0.2-0.5 part of sodium alginate, and 24-30 parts of deionized water. The caries-prevention toothpaste does not contain fluorine, and conducts daily maintenance of teeth, at the same time, the caries-prevention toothpaste has a good anti-microbial and anti-inflammation effect, can more effectively reduce oral cavity germs, alleviate the oral cavity problem generated by the germs, the germs are prevented from invading the human body from the oval cavity, an oval cavity environment in which cariogenic bacteria do not easily propagate is created for the human body, and the formation of decayed teeth can be effectively inhibited.

The invention discloses caries-prevention toothpaste and a preparation method thereof. The caries-prevention toothpaste is prepared from the following ingredients in parts by weight: 2-8 parts of ginseng, 5-12 parts of lotus seed, 3-15 parts of tea polyphenol, 5-15 parts of sorbitol, 1-8 parts of mannitol, 2-8 parts of flower of operculate cleistocalyx, 1-6 parts of Chinese pholidota herb, 5-12 parts of licorice, 3-18 parts of walnut powder, 5-25 parts of poria cocos, 1-6 parts of glycerin, 3-12 parts of silica, 5-15 parts of sweet tea, 1-6 parts of mint and 2-12 parts of cortex moutan. The method for preparing the caries-prevention toothpaste comprises the following steps: weighing all medicines in parts by weight, mixing all medicines, fermenting, extracting fermenting liquid, adding residual ingredients and uniformly mixing. The caries-prevention toothpaste disclosed by the invention can clean dental plaque, increase an anti-corrosion function of dental enamel, prevent caries, restrain or eliminate cariogenic bacteria, promote remineralization of damaged acid-etched surfaces of teeth and promote oral hygiene.

The invention belongs to the technical field of pharmaceutical biology, and relates to an Fmoc chemosynthesis peptide, in particular to an anti-oral cariogenic bacteria polypeptide Pm1 and a preparation method. The preparation method comprises the following steps that: by finding the active center of a natural polypeptide pleurocidin, certain antibacterial and bactericidal capacities on common oral cariogenic bacteria are realized; on the basis of determining the active center, amino acid deletion and replacement are carried out on the active center of the natural polypeptide pleurocidin to form a novel antibacterial peptide with bactericidal capacity; the sequence of the novel antibacterial peptide Pm1 is GWGRFFKKWWRVGKRVGK; the common oral cariogenic bacteria are streptococcus mutans according to the preparation method; the common oral cariogenic bacteria are streptococcus sobrinus according to the preparation method; and the common oral cariogenic bacteria are streptococcus sanguis according to the preparation method. The anti-oral cariogenic bacteria polypeptide Pm1 overcomes the defects that the natural antibacterial peptide is too long, and the synthesis cost is relatively higher.

The invention discloses bacteriostatic stain-removing traditional Chinese medicine toothpaste which comprises, by weight, 15-25 parts of stain-removing traditional Chinese medicine, 10-20 parts of bacteriostatic traditional Chinese medicine, 7-11 parts of abrasive, 2-4 parts of xylitol, 5-7 parts of moisturizer, 0.5-0.9 part of foamer, 1-3 parts of tea polyphenol, 1-2 parts of thickener and 8-12 parts of deionized water. The traditional Chinese medicine toothpaste can effectively inhibit and remove dental plaque, effectively kill cariogenic bacteria, prevent dental decay, protect oral mucosa, refresh breath and relieve symptoms like gum swelling and aching. Raw materials for preparation are safe, nontoxic and easy to get, and the traditional Chinese medicine toothpaste is low in production cost, simple and clear in process, high in practical value and good in application prospect.

The invention relates to mouth-holding smokeless tobacco products, in particular to a mouth-holding smokeless tobacco product packing bag. The packing bag has certain antibacterial effect and can prevent dental caries. The materials of the packing bag is soaked or sprayed by natural extract solution for inhibiting streptococcus mutants or lactobacillus or soaked or sprayed by salivation promoting solution, and the concentration of the two solutions are 20-50WT%. The materials attached to the packing bag can inhibit or kill the cariogenic bacteria in oral cavities and improve oral hygiene. In addition, the processed packing bag has certain antibacterial effect, and the smokeless tobacco products are less prone to deterioration during storage.

The invention discloses toothpaste capable of repairing enamel, and relates to the technical field of toothpaste. The toothpaste is composed of the following raw materials in parts by weight of 3-8 parts of probiotics ADP-1, 3-8 parts of lactoferrin, 1-3 parts of biological lysozyme, 1-3 parts of a Nepalese odoratus extract, 1-3 parts of sorbitol, 2-5 parts of hydrated silica, 2-5 parts of plant polypeptide, 1-3 parts of propolis, 3-5 parts of menthol, 3-5 parts of a honeysuckle extract, 1-2 parts of glycerin, 5-8 parts of a bletilla striata extract, 5-8 parts of a dendrobium officinale extract, 5-8 parts of sodium lauryl sulfate, 1-3 parts of essence and 10-20 parts of purified water. The toothpaste capable of repairing the enamel has very strong bacteriostatic and antibacterial effects, can inhibit various bacteria such as escherichia coli and the like, prevents acid generated by metabolic sugar of cariogenic bacteria, avoids the caries of the enamel, and achieves the effect of repairing the enamel.

The invention relates to the technical field of daily chemicals, and more specifically, the invention relates to a bacteriostatic toothpaste containing bamboo shavings triterpenes, and a preparation method thereof. A natural, healthy, green and safe botanical drug ''bamboo shavings triterpenes'' is used as a raw material, and a friction agent, a phosphate, a solubilizer and the like in the systemare synergized to prepare the natural bacteriostatic toothpaste. The prepared bacteriostatic toothpaste can effectively inhibit the growth of common oral pathogenic bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Candida albicans, Helicobacter pylori, Staphylococcus aureus, and Escherichia coli, can remove some odor-causing bacteria and oral residual odor-causing substrates, and inhibits the increase of cariogenic bacteria, periodontal pathogens, and oral lichen planus pathogens. In the bacteriostatic toothpaste containing bamboo shavings triterpenes of the invention, the friction agent hydrated silica with a special type and tetrasodium pyrophosphate are added, and thereby a biofilm on the tooth surface is removed by mechanical friction and dissociation. The synergy of hydrated silica and tetrasodium pyrophosphate solves the barrier of the prior art.