The invention discloses a compound tetrastigma hemsleyanum pharyngitis lozenge and a preparation method thereof. The lozenge is prepared from a tetrastigma hemsleyanum extract powder prepared from the tetrastigma hemsleyanum with botrychium officinale and roots of imperata cylindrica, mannitol powder and aspartame as raw materials, with ethanol as a wetting agent and with addition of menthol and magnesium stearate. The oral lozenge is prepared through following steps: preparation of the extract powder, mixing of a filling agent, preparation of a soft material, granulation, a drying process, a granule reshaping process, a lozenge pressing process and a sterilizing and packaging process. The lozenge has a broad-spectrum antibacterial effect and a strong anti-respiratory syncytial virus and anti-influenza virus effect. In addition, the lozenge also has a certain inhibiting effect on staphylococcus aureus, pneumococcus, hemolytic streptococcus, shigella dysenteriae and the like. The lozenge can act on a disease location for a long period when being applied locally and a curative effect can be achieved maximumly. In addition, defects in orally-taking of traditional Chinese medicines and western medicines are overcome. The lozenge is sweet in taste, is refreshing in flavor, is good in mouthfeel and disintegration, is convenient to use, is easy to take and is suitable for people in various age.