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Nicotine salts and methods of making and using same

A technology of nicotine salt and nicotine, which is applied in the fields of tobacco, application, and treatment of tobacco, etc.

Inactive Publication Date: 2020-05-29
NUDE NICOTINE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These compounds pose a risk of exposure to users for diseases such as cancer, emphysema and / or cardiovascular disease

Method used

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  • Nicotine salts and methods of making and using same
  • Nicotine salts and methods of making and using same
  • Nicotine salts and methods of making and using same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] 2) In certain embodiments herein, different nicotine-organic acid salts have different properties. While free base nicotine has a different and characteristic "flavor" and "throat feel" or "throat hit", nicotine salts provide additional and in some embodiments all have pleasant positive effects. Different user experience. Specific formulations have the potential to favorably alter the user's vaping experience compared to free base nicotine, whether by smoothing, such as reducing the "throat hit" or throat sensation, or by increasing the amount of throat "tingle". features, and in some respects, depends on user preferences. These methods can be modified, changed and / or manipulated in certain embodiments, for example by using specific organic acids to bind to certain centers of nicotine in an orderly fashion (i.e., one or both rings of nicotine Electronegative center of nitrogen). This combination can be controlled by the chemist or manufacturer by embodiments of the i...

Embodiment approach

[0099](1) The type of nicotine salt complex selected can have an impact on the overall effect of depositing nicotine onto the mucous membrane of the alveoli in the lung. Preferably, the nicotine salt complex between pH 6-7 is delivered to the lungs with the target environment closest to the alveolar mucosa. Once not bound to nicotine, the alkali-buffering action of organic acids is critical to counteract the alkali onslaught to cells lining the airways. This action would further enhance nicotine diffusion without shock to exposed mucosal cells, resulting in more efficient diffusion of nicotine into surrounding capillaries. Nicotine salt complexes between pH 5-6 will optionally be partially deposited in the alveolar pulmonary mucosa and possibly also along the pharynx of the upper airway. For this application, it is preferred to choose a nicotine salt complex with a higher acidic character.

[0100] (2) The perception to the user can also be controlled by the pH of the overal...

Embodiment I

[0149] Example I: Identification of preferred ketoacid-nicotine salt complexes

[0150] It was determined experimentally which of these embodiments are preferred over others for the ketoacid-nicotine salt complexes described herein. Complexes are listed in descending order according to the following criteria:

[0151] (a) Bridging and higher order bonds: Preferably, one carboxylic acid function is located on one end of the molecule while at least one keto function is located on the other. The bridged ketoacid nicotine salt complex requires a 2-3 carbon spacing between the keto functional group and the carboxylic acid functional group for bridging to occur.

[0152] (b) Steric hindrance: Excessive molecular size is not desirable for preferred embodiments of the invention.

[0153] (c) Number of carbons relative to functional groups: lesser amount of carbon on the molecule and lesser amount of excess functional groups (other than the required keto and -carboxylate functional...

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PUM

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Abstract

The present invention provides for compositions including nicotine salts, solutions thereof, methods of manufacture and methods of use. Certain embodiments provide for the delivery of the compositionsincluding by: transdermal, oral, nasal and inhalation modes. Certain embodiments provide nicotine salts and solutions thereof, suitable for or packaged in or with devices including: oral lozenges, chewing gum, transdermal patches, intranasal sprays and intranasal inhalers, e-liquids and e-cigarette or vaping devices.

Description

technical field [0001] The field generally relates to compositions comprising nicotine salts and methods of making and using the same. Specifically, the compounds disclosed herein comprise a nicotine molecule complexed with an acid to form a nicotine salt. Background technique [0002] The experience from the use of combusted tobacco products, such as cigarettes, is preferred by some tobacco users as they describe the perception of a "throat hit" sensation in their airways. This experience is associated with the smoker's pleasure. This "throat hit" experience does not occur in e-cigarettes using purified free base nicotine. [0003] Tobacco cigarettes expose users to harmful or potentially harmful components (HPHCs), also known as Hoffman Analytes. These compounds pose a risk of exposure to the user for conditions such as cancer, emphysema and / or cardiovascular disease. [0004] Electronic cigarettes (e-cigarettes) that heat a solution of diluted nicotine-containing solu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/167
CPCA24B13/00A24B15/167A61K47/542A61K9/08A61P25/34A61M15/00A61M5/178A61K9/0056A61K9/0058A61K31/455
Inventor J·鲁本斯坦
Owner NUDE NICOTINE INC
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