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The application provides osmanthus fragrans plant extract mosquito repellent spray with long-acting mosquito repellent and itching, swelling relieving effects and a preparation method thereof, and relates to the technical field of mosquito repellent products. The raw materials of the mosquito repellent spray are as follows: osmanthus fragrans flower extract 7-9 parts, melaleuca alternifolia leaf extract 8-11 parts, chrysanthemum artemisia extract 1-2 parts, radix morindae officinalis extract 12-16 parts, platycodon grandiflorum root powder 16-19 parts, plant essential oil 20-24 parts, glycerol 18-23 parts, sucrose stearate 6-9 parts, p-hydroxyacetophenone 0.2-0.5 parts, stabilizer 3-5 parts and peppermint water 110-120 parts. The mosquito repellent spray can interfere with the activities of mosquitoes to achieve a good mosquito repellent effect, and can form a uniform and stable protective film on the skin surface to prolong the mosquito repellent effect, and can also play a good soothing and skin converging role, reduce local inflammatory reactions, promote skin barrier repair, and effectively relieve itching, swelling and other discomforts caused by mosquito bites.