361 results about "Butyrate" patented technology

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention provides a bio-based 1, 4-butanediol composition as well as a preparation method and application thereof, and the bio-based 1, 4-butanediol composition comprises bio-based 1, 4-butanediol, 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether. The total mass content of 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether in the bio-based 1, 4-butanediol composition is 51 to 220 ppm. The bio-based 1, 4-butanediol composition has low hygroscopicity, and can maintain low water content after long-term storage; meanwhile, when the bio-based 1, 4-butanediol composition is used for polyester synthesis, the esterification time can be shortened, the reaction efficiency can be improved, side reactions can be reduced, and a polyester product with better damp-heat resistance stability can be obtained.

Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and / or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

This invention belongs to the field of coating technology, specifically relating to a moisture-proof and stain-resistant acrylic resin coating and its preparation process. The moisture-proof and stain-resistant acrylic resin coating comprises 100 parts by weight of a main agent and 20-25 parts by weight of a curing agent. The main agent comprises the following raw materials in weight percentages: dispersant 1.5-3%, butyl acetate 10-15%, xylene 5-10%, filler 10-20%, titanium dioxide 10-20%, carbon black 1-5%, cellulose acetate butyrate 1-2%, anti-settling agent 1-1.5%, leveling agent 0.5-1%, defoamer 0.1-0.5%, with the balance being acrylic resin. The moisture-proof and stain-resistant acrylic resin coating of this invention exhibits excellent comprehensive performance, high filling and sealing properties, strong adhesion to alloys, and good stain resistance, water resistance, and gloss retention.

The application discloses a continuous synthesis method of an amicarbazone intermediate 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone. The method comprises two continuous processes of hydrazinolysis and phosgenation: continuously feeding a mixture of isobutyric acid and a solvent, a mixture of hydrazine hydrate and a catalyst into a hydrazinolysis continuous reactor respectively, carrying out a warming reflux dehydration reaction, and obtaining an isobutyryl hydrazine solution shown in formula I; continuously feeding the isobutyryl hydrazine solution and phosgene into a phosgenation continuous reactor, carrying out a phosgenation reaction, and after distillation and desolventizing treatment of a reaction solution, obtaining 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone shown in formula II. The application has the advantages of simple reaction flow, high product yield, and significant production efficiency improvement, and is suitable for industrial large-scale production.

The application relates to a method for continuously preparing imidacloprid intermediate 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester, and the specific steps are as follows: raw material morpholinyl propylene and methyl acrylate are respectively introduced into a preheater, then the preheated raw materials are pumped into a micro-channel reactor for reaction, after the reaction is completed, the materials are discharged from the micro-channel reactor outlet into a reaction kettle, reaction is carried out, then the cyclization liquid obtained in the reaction kettle is subjected to light removal in a light removal tower, 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester after light removal is collected from the tower kettle of the light removal tower, the 3-methyl-2-(4-morpholinyl)cyclobutyl acid methyl ester is introduced into a pentyl ester synthesis process, and the recovered methyl acrylate collected from the top of the light removal tower is reused in the reaction kettle to participate in the ripening reaction. The application has the advantages of high product purity, low raw material unit consumption, good safety, low labor cost and the like.

The application discloses a non-oxidative weak-acid polyacrylamide degrading agent and a preparation and use method thereof, and the degrading agent comprises the following components: a reducing agent, a regulator, a mutual solvent and water; the reducing agent is one of 3-O-ethyl ascorbic acid ether and L-ascorbic acid-2,6-dibutyrate; the regulator is ammonium chloride; and the mutual solvent is one of ethylene glycol monobutyl ether and isopropyl alcohol. The problems that the existing degrading agent needs to be isolated by a plug for redox reaction with subsequent injected mud acid or secondary precipitation is caused by metal ions such as Na + , K + , Fe 2+ and the like in the degrading agent and subsequent injected mud acid are effectively solved.

This invention relates to a strain of Bacillus cereus and its applications, specifically Bacillus cereus (… Bacillus cereus Bacillus cereus (W1) was deposited at the China Center for Type Culture Collection on July 21, 2022, with accession number CCTCC NO: M 20221147. Bacillus cereus W1 can grow and ferment high-yield butyric acid under non-strict anaerobic conditions, and has the advantages of strong oxygen tolerance and high butyric acid yield.

Compositions and methods for providing a person with an exogenous and therapeutically effective supply of short chain fatty acids, chlorogenic acid, and, optionally, ketones are disclosed. The compositions include one or more short chain fatty acids (such as butyric acid, butyrate salts, propionic acid, propionate salts, acetic acid, or acetate salts); chlorogenic acid; and, optionally, one or more beta-hydroxybutyrate salts. The compositions and methods are useful for inducing ketosis and / or beta-oxidative activity in a subject. In addition, compositions that include concentrated forms of, and methods of using, chlorogenic acid (alone or in combination with short chain fatty acids and ketones) to induce ketogenesis in a subject are disclosed.

The application discloses a feed additive for improving intestinal health of animals and preventing and treating intestinal diseases and application thereof, and relates to the technical field of green and healthy breeding. The application firstly confirms that indole-3-butyric acid (IBA) has no toxic effect on cells and can relieve oxidative stress damage and inflammation damage of the cells in an effective concentration. Meanwhile, the application also fills the application blank of IBA as one of indole derivatives in livestock production, and provides experimental basis and theoretical basis for the fact that IBA is expected to be a new green additive for replacing antibiotics and zinc oxide. More importantly, the application also finds that IBA has positive effects in aspects of resisting diarrhea, repairing intestinal barrier damage, relieving intestinal inflammation and preventing and treating intestinal related diseases.

The application provides a preparation method of an indobufen key intermediate. The method uses 2-(4-nitrophenyl) butyric acid and phthalic anhydride as raw materials, and obtains the target compound (I) through a one-pot method. The method has the advantages of simple operation, mild conditions, high reaction yield, reduced cost through mother liquor recycling and reuse, significantly reduced "three wastes" and environmental protection, and is suitable for large-scale industrial production.

The invention discloses a hand brushing and spraying dual-purpose odorless anti-yellowing transparent polyurethane primer suitable for various base materials and a preparation method thereof. The primer mainly comprises a component A, a component B and a component C, the component A is mainly prepared from odorless coconut oil alkyd resin, zinc stearate, a defoaming agent, a flatting agent, an anti-settling agent, functional resin and an organic solvent; the component B is mainly prepared from an HDI (hexamethylene diisocyanate) tripolymer, a TDI (toluene diisocynate) tripolymer, a dehydrating solvent and a dehydrating agent; the component C is mainly prepared from dimethyl carbonate, n-butyl acetate and propylene glycol methyl ether acetate; the anti-settling agent is a mixed solution of polyamide wax slurry 6900-20X and n-butyl acetate, and the mass concentration of the polyamide wax slurry 6900-20X in the mixed solution is 40%; the functional resin is a mixed solution of cellulose acetate butyrate CAB-381-0.5 and n-butyl acetate, and the mass concentration of the cellulose acetate butyrate CAB-381-0.5 in the mixed solution is 20%. The odorless yellowing-resistant transparent polyurethane primer has the advantages of no blistering, no prickly heat, suitability for various base materials, dual purposes of hand brushing and spraying, and the like.

The invention provides a process for efficiently recovering butyric acid from polyalcohol device concentrated wastewater, and relates to the technical field of industrial wastewater resource utilization, the process comprises the following steps: S1, wastewater pretreatment: filtering polyalcohol device concentrated wastewater containing sodium butyrate and sodium hydroxide to obtain pretreated wastewater; s2, acidification and neutralization: adding sulfuric acid into the pretreated wastewater to carry out acidification reaction, controlling the pH value at the end point of the reaction to be 1.5-2.5, neutralizing sodium hydroxide, and converting sodium butyrate into butyric acid; by accurately controlling acidification pH and reaction conditions, efficient and complete conversion from sodium butyrate to butyric acid is ensured, a two-stage counter-current extraction process is adopted, the mass transfer efficiency of butyric acid from a complex water phase to an organic phase is remarkably improved, the total extraction rate can reach 92% or above, the final butyric acid recovery rate is larger than or equal to 85%, the product purity is larger than or equal to 99.0%, and industrial-grade use requirements are met.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

This invention provides a strain derived from Clostridium difficile (Clostridium difficile) Clostridioides difficile This invention relates to mutants of glutamate dehydrogenase and their preparation, including single-site, two-site, or multi-site mutants. The invention effectively solves the problems of inactivity or low activity of glutamate dehydrogenase in the biocatalytic transformation of 2-carbonyl-4-(hydroxymethylphosphono)butyric acid as a substrate, and provides a continuous chemical method for the synthesis of 2-carbonyl-4-(hydroxymethylphosphono)butyric acid using a microchannel reactor throughout the entire process.

One bacterial strain, designated HC1M1C21T, was isolated from human faeces and analyzed using phylogenetic, morphologic and biochemical approaches. Phylogenetic analyses based on 16S rRNA sequences and a set of 92 bacterial core genes indicated that this strain belongs to the Lachnospiraceae family and clusters near Pilosibacter fragilis (96.9% 16S rRNA sequence identity). HC1M1C21T has a DNA G+C content of 48.7 mol%. This strain is anaerobic, Gram- stain-positive, non-motile and non-spore-forming. HC1M1C21T cells appear as single rods or chained rods with tapered ends. Optimal growth was observed at 37°C, at pH between 5.5 and 6.5 and at salinity below 10 g / L. HC1M1C21T is a potent butyrate producer. The invention pertains to a new bacterial strain that produces butyrate and several independent factors with anti-inflammatory properties.

The invention relates to a process for preparing polyol esters, in particular polyglycerol esters, of 3-hydroxybutyric acid blocked or with terminal acyl groups, to the products that can be obtained in this way and to their functionalized (e.g., esterified) derivatives, as well as to various uses and applications of these products.

This invention provides a chlorambucil NO donor prodrug having the structure shown in Formula (I) or a pharmaceutically acceptable salt thereof: Formula (I). It involves reacting chlorambucil with a dihaloalkane to obtain a halochlorambucil intermediate; reacting the halochlorambucil intermediate with silver nitrate to obtain the chlorambucil NO donor prodrug. This invention applies the chlorambucil NO donor prodrug to the preparation of drugs for treating tumors, such as melanoma, lymphoma, leukemia, or breast cancer. This nanosystem exhibits good NO release levels under light irradiation. Cellular experiments have demonstrated its good antitumor effect, providing a new strategy for multimodal combined antitumor therapy.

The application discloses a modified organosilicon defoaming agent and a preparation method thereof, and relates to the technical field of defoaming. The modified organosilicon defoaming agent and the preparation method thereof comprise the following components by mass ratio: 89.57 g of liquid mercaptan silicone oil, 20.30 g of triethylamine, 89.57 g of dimethyl sulfoxide, 3.45 g of a methyl-terminated allyl polyoxyethylene ether, 13.80 g of a methyl-terminated allyl polyoxypropylene ether, 0.34 g of azobisdimethyl isobutyronitrile, 32.25 g of butyl acetate, 19.29 g of 2-bromoisobutyrate methyl ester, a magnesium sulfate and sodium chloride aqueous solution, a coupling agent and a thickening agent. The modified organosilicon defoaming agent has good defoaming performance and bubble inhibiting performance, has strong compatibility with different emulsions, and has defoaming performance and bubble inhibiting performance equivalent to polyether defoaming agents in a water-based resin system.

The present disclosure is directed to compositions comprising between 50% and 95% weight per weight (w / w) of acetic acid, between 0.1% and 5% (w / w) of butyric acid or a derivative thereof, and between 0.1% and 5% (w / w) of Quercetin or a derivative thereof. Further, methods of use such as for the treatment and prevention of a medical condition associated with cancer, inflammatory diseases or disorders, metabolic disorders, obesity, diabetes, high blood pressure, vascular diseases, viral infection, and any combination thereof, in a subject in need thereof are also provided.

The application provides a synthesis method of 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid, comprising the following steps: a) mixing acryloyl chloride, a first solvent, a polymerization inhibitor, a catalyst and sodium cyanide, performing a substitution reaction, and obtaining an acryloyl cyanide intermediate after reduced pressure distillation; b) mixing the acryloyl cyanide intermediate obtained in the step a) with hydrochloric acid and a polymerization inhibitor, performing a hydrolysis reaction, and obtaining 2-carbonyl-3-butenoic acid crude product after purification treatment; c) mixing the 2-carbonyl-3-butenoic acid crude product obtained in the step b) with a second solvent and methyl phosphinite, performing an addition reaction, recovering the solvent after water separation and extraction, and obtaining a ketonic acid ester solution; and d) adding hydrochloric acid to the ketonic acid ester solution obtained in the step c) to adjust the pH to be less than or equal to 3, performing a hydrolysis reaction, and obtaining 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid after purification. The synthesis method selects inexpensive acryloyl chloride as a raw material, has mild reaction conditions, is simple to operate, has low production cost, is easy to realize industrialization, and has high yield.

The invention relates to a method for synthesizing (R)-3-methylheptanoic acid. According to the method, the application range of steroid sapogenin degradation waste is further expanded. According to the method disclosed by the invention, the (R)-3-methyl-heptanoic acid can be conveniently obtained by taking the (R)-4-methyl-gamma-butyric acid lactone obtained by degrading steroid sapogenin as a raw material. According to the method provided by the invention, the use of highly toxic and controlled reagents is avoided, high-risk reactions such as hydrogenation in the prior art are avoided, and the method is mild in reaction condition and low in synthesis cost. Meanwhile, the utilization rate of steroid sapogenin resources is increased, and waste generated in the utilization process of the steroid sapogenin resources is reduced.

This invention relates to compositions containing acetic acid, butyric acid, and quercetin, and to the use thereof. This disclosure relates to a composition comprising, by weight, 50% to 95% (w / w) acetic acid, 0.1% to 5% (w / w) butyric acid or its derivatives, and 0.1% to 5% (w / w) quercetin or its derivatives. Furthermore, methods for use in the treatment and prevention of medical conditions associated with cancer, inflammatory diseases or disorders, metabolic disorders, obesity, diabetes, hypertension, vascular diseases, viral infections, and any combination thereof, and for use in subjects in need thereof.

The invention discloses an application of 2-amino-3-indolyl butyric acid as a plant phytotoxicity alleviator. According to the application of the 2-amino-3-indolyl butyric acid in the preparation of the plant phytotoxicity alleviator, the concentration of the 2-amino-3-indolyl butyric acid in the preparation is 10-1000 nM. The 2-amino-3-indolyl butyric acid is found to be capable of effectively relieving plant phytotoxicity through seed soaking treatment, and the yield of plants is increased. Under the concentration of 1000nM, the damage of the fluridine.pentus.fenitrothion and the fenitrothion .ethylicin to the rice seeds is relieved in a seed soaking manner, so that the purpose of strengthening the seedlings is achieved; when the concentration is 100 nM, the pesticide damage of isoproturon to wheat seeds can be relieved, and the germination rate, bud length and root length of the wheat seeds are remarkably increased. The 2-amino-3-indolyl butyric acid is a natural product, is low in dosage and environment-friendly, and can effectively relieve plant phytotoxicity, so that the 2-amino-3-indolyl butyric acid is a green and efficient biological source plant phytotoxicity alleviator.

The invention relates to the technical field of paper printing processing, in particular to a coating liquid for improving the adhesive force of printing ink as well as a preparation method and application of the coating liquid. The water-based adhesive is prepared from the following raw materials in parts by weight: 25-30% of acrylic resin, 45-50% of a polyurethane-vinyl acetate-acrylate copolymer emulsion, 4-8% of a cellulose acetate butyrate resin emulsion, 2-5% of a composite surfactant and the balance of water, wherein the composite surfactant is prepared from C6-12 short-chain fatty alcohol, polyvinyl alcohol and sulfonate; according to the coating liquid, the interface bonding force between ink and paper can be improved, and the problems of poor adhesive force, ink falling and the like are solved. The drying rate of the drying agent can adapt to a high-speed flexographic printing or gravure process with the production line speed higher than 150 m / min, and set-off and adhesion faults caused by insufficient drying are effectively avoided. And under the storage or transportation condition that the relative humidity is larger than 75%, the after-tack phenomenon is prevented, and the strict requirement for special paper printing treatment is comprehensively met.

The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises a medicine granulated substance containing 4-((L-valyl) oxy) butyric acid and an excipient granulated substance. When the pharmaceutical composition is combined and mixed with water, the excipient particles rapidly dissolve to form a viscous solution in which the pharmaceutical granules are suspended. The pharmaceutical granulate provides a palatable oral pharmaceutical composition.

A process for preparing 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, in which 1 mole of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 moles of chloromethylenedimethyliminium chloride or more than 2.2 to 5 moles of chloromethylenedimethyliminium chloride to prepare a by-product in the form of 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid, which can be used in the pharmaceutical field.

The present application relates to a kind of anti-metallic effect paint and its preparation method and application, the raw material of the metallic effect paint includes the following mass parts of components: polyester resin 15~30 parts, amino resin 5~15 parts, directional arrangement aid 3~8 parts, cellulose acetate butyrate 15~30 parts, metal pigment 5~10 parts, anti-sedimentation agent 1~3 parts, leveling agent 0.1~1 part, light aging aid 0.2~2 parts and solvent 20~40 parts;The directional arrangement aid uses microgel.Compared with prior art, the present application has excellent storage stability, prevents metal pigment from blooming, and has good paint film brightness and weather resistance.

The present application relates to a kind of 2,2,4,4-tetramethyl-1,3-cyclobutanedione preparation method.The present application first mixes isobutyric anhydride, small molecule alcohol and organic acid and carries out high-temperature cracking, so that isobutyric anhydride in it is cracked to generate isobutyric acid and dimethyl ethylene ketone, and the isobutyric acid generated simultaneously is esterified with small molecule alcohol under the action of organic acid to generate isobutyrate;The product after cracking is separated, and dimethyl ethylene ketone is absorbed using the isobutyrate obtained by separation, and dimerization is obtained 2,2,4,4-tetramethyl-1,3-cyclobutanedione.The present application can obtain higher yield under the same operating load, reduce the generation of carbon deposition and the corrosion to equipment in the reaction process, long running cycle, and low equipment investment.