1379 results about "Butyrate" patented technology

Disclosed herein are “ketone body-HMB” or “KB-HMB” compositions including a combination of: (1) hydroxymethyl butyrate; (2) a ketone body component such as beta-hydroxybutyrate (BHB) and / or acetoacetate; and (3) optionally a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such compositions for producing desired physiological effects, such as fat loss, in a mammal. The compositions beneficially enhance fat loss through ketosis while also reducing or eliminating muscle wasting and / or promoting muscle formation.

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention relates to the technical field of dispersing agents, and particularly discloses a high-concentration water-based graphene dispersing agent. The high-concentration water-based graphene dispersing agent is prepared from the following raw materials in parts by weight: 25 to 30 parts of a modified nonionic surfactant, 8 to 12 parts of sodium lignin sulfonate, 0.4 to 0.8 part of a de-foaming agent and 90 to 100 parts of de-ionized water, the modified nonionic surfactant is prepared by the following steps: carrying out dehydration esterification reaction on 1-pyrene butyric acid and N-hydroxysuccinimide, carrying out nucleophilic substitution reaction on the obtained product and polyethylene glycol monododecyl ether to obtain modified 1-pyrene butyric acid, and finally polymerizing the modified 1-pyrene butyric acid and n-butyl acrylate. The method is easy to operate, graphene does not need to be subjected to oxidation reduction, the integrity of a graphene sheet layer can be completely kept, and the performance of the graphene can be fully exerted; the prepared graphene dispersing agent realizes efficient dispersing effect, excellent stability and environment-friendly safety characteristics, and provides solid technical support for wide application of graphene in multiple fields.

The invention belongs to the technical field of acyclic compounds, and particularly relates to a preparation method of tert-butyl peroxyisobutyrate. Stirring and cooling a solvent, a tert-butyl hydroperoxide aqueous solution and deionized water to obtain a mixed solution A; adding liquid caustic soda and a solid base catalyst into the mixed solution A under a stirring condition, and continuously stirring for reaction to obtain a mixed solution B; under the stirring condition, isobutyryl chloride and a water-soluble distributing agent are added into the mixed solution B, stirring reaction continues to be conducted, and a mixed solution C is obtained; standing and layering the mixed solution C, separating to obtain a tert-butyl peroxyisobutyrate crude product, and refining the tert-butyl peroxyisobutyrate crude product to obtain the tert-butyl peroxyisobutyrate. According to the method, the raw material utilization rate is increased, the reaction speed is increased, the reaction time is shortened, and the product yield is high.

The invention relates to the technical field of adhesives, and discloses weather-resistant high-viscosity single-component composite glue, a preparation method and application in a multi-layer structure car cover. The weather-resistant high-viscosity single-component composite glue is prepared from the following components in parts by weight: 10 to 15 parts of high-performance polyurethane prepolymer, 10 to 15 parts of high-acid-value acrylic resin, 1 to 5 parts of cellulose acetate butyrate, 1 to 5 parts of SBS (Styrene Butadiene Styrene) rubber, 1.5 to 4.5 parts of multifunctional nano filler, 1 to 3 parts of potential curing agent and 57 to 75 parts of solvent. The weather-resistant high-viscosity single-component composite glue disclosed by the invention has the advantages of high viscosity and excellent weather resistance and self-repairing performance, and is used for connecting TPU (Thermoplastic Polyurethane) base material layers in a multi-layer structure car cover.

The invention relates to a preparation method of a flame-retardant, high-refraction and melt-drop-resistant water-based polyurethane coating, which comprises the following steps: adding dihydric alcohol, isocyanate and dibutyltin dilaurate into a 500mL flask, heating to 70-85 DEG C, and stirring to react for 1-2 hours to obtain a polyurethane prepolymer; adding a charring agent into the polyurethane prepolymer, and continuously reacting for 1-2 hours; cooling to 60 DEG C, and then adding 2, 2-dimethylolbutyric acid and amino carbon nanotubes to react for 0.5-1 hour; adding a high-refraction material, reacting at 65-70 DEG C for 1-2 hours, cooling to 40 DEG C, adding triethylamine, and reacting for 0.5-1 hour; the preparation method comprises the following steps: adding deionized water, adding an ammonium polyphosphate solution at a rotating speed of 2000r / min, and carrying out high-speed shearing emulsification for 0.5-1h to obtain the flame-retardant, high-refraction and melt-drop-resistant polyurethane coating which has the advantages of high flame retardance, high refractive index and no melt drop.

The invention belongs to the technical field of microorganisms, and particularly relates to clostridium butyricum and application thereof, and the preservation number of the clostridium butyricum is CGMCC (China General Microbiological Culture Collection Center) No.27853. According to the present invention, with the application of the bacterial strain, the species diversity of the host intestinal flora can be significantly reduced, the Firmicite / Bacteroidetes ratio can be significantly increased, the abundance of harmful bacteria such as Escherichia coli and Salmonella bacteria can be reduced, and the abundance of beneficial bacteria can be improved; in addition, the yield of butyric acid of the clostridium butyricum is larger than or equal to 1.5 g / L, and the activity of amylase in fermentation liquor of the clostridium butyricum is 16.04 + / -0.46 U / mL. When the feed additive is used in feed, intestinal functions of organisms can be effectively improved.

The invention discloses clostridium and application thereof in fermentation production of alcohol, and belongs to the technical field of industrial microorganisms. The clostridium is a carbon monoxide eating clostridium strain GG6, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.34975, and the preservation time is June 23, 2025. The clostridium is a carbon monoxide eating clostridium strain GG6 which is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.34975, and the preservation number is CGMCC No.34975. The carbon monoxide eating clostridium GG6 is obtained by enriching tail gas flue sediments of a coal chemical plant through an abundant culture medium, evolving a screening culture medium and sorting single bacteria, the bacterial strain is fermented by taking synthesis gas (CO / H2 / CO2) as raw material gas to generate acetic acid, ethanol, butyric acid and butanol, the thallus biomass OD600 is more than or equal to 6, the concentration of produced ethanol is more than or equal to 10g / L, the concentration of produced butanol is more than or equal to 2.5 g / L, and the concentration of produced butanol is more than or equal to 2.5 g / L; and commercialized implementation of butanol production through gas fermentation is facilitated.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention provides a bio-based 1, 4-butanediol composition as well as a preparation method and application thereof, and the bio-based 1, 4-butanediol composition comprises bio-based 1, 4-butanediol, 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether. The total mass content of 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether in the bio-based 1, 4-butanediol composition is 51 to 220 ppm. The bio-based 1, 4-butanediol composition has low hygroscopicity, and can maintain low water content after long-term storage; meanwhile, when the bio-based 1, 4-butanediol composition is used for polyester synthesis, the esterification time can be shortened, the reaction efficiency can be improved, side reactions can be reduced, and a polyester product with better damp-heat resistance stability can be obtained.

The invention discloses a beta-amino acid dehydrogenase mutant and application of the beta-amino acid dehydrogenase mutant in preparation of (S)-3-aminobutyric acid. The beta-amino acid dehydrogenase mutant disclosed by the invention can be used for selectively reducing and aminating 3-oxobutyric acid to obtain (S)-3-aminobutyric acid, the substrate concentration can reach 20g / L, the conversion rate is greater than or equal to 99%, the ee value is greater than or equal to 99%, and the method is simple to operate and high in reaction efficiency and can be used for industrial production.

Pharmaceutical compositions including a pharmaceutical granulation comprising 4-((L-valyl)oxy) butanoic acid and an excipient granulation are disclosed. When the pharmaceutical compositions are combined and mixed with water the excipient granules rapidly dissolve to form a viscous solution with a pharmaceutical granulation suspended in the viscous solution. The pharmaceutical granulations provide palatable oral pharmaceutical compositions.

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and / or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

A beverage can include D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and / or D hydroxybutyric acid of at least 0.5 percent by volume. The percentage of D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and D hydroxybutyric acid can be between 5 and 19 percent, or can be higher than 19 percent. The beverage can be improved by the incorporation of flavor from hops and / or from other ingredients.

The invention belongs to the field of microorganisms, and particularly relates to application of lactobacillus paracasei L9 in preparation of a preparation for improving pulmonary fibrosis of an aged mouse. According to the lactobacillus paracasei L9 disclosed by the invention, the synthesis of I-type collagen is reduced by regulating and controlling gene expression, so that pulmonary fibrosis is relieved; meanwhile, the L9 improves the content of propionic acid and butyric acid in intestinal tracts and serum by regulating the abundance of SCFA-producing microbial flora in the intestinal tracts, so that pulmonary fibrosis is inhibited, and the L9 is a potential ideal preparation for improving or treating aging-related pulmonary fibrosis.

The invention discloses a recombinant halomonas for producing polyhydroxyalkanoate as well as a construction method and application of the recombinant halomonas. The recombinant halomonas comprises an exogenous gene, the exogenous gene comprises a combination of an aldD gene, a dhaT gene and an orfz gene, and the recombinant halomonas weakens the expression of an endogenous prpc gene. According to the invention, a P34HB synthesis route is successfully constructed through a synthesis route of exogenous introduction from 1, 4-butanediol (BDO) to 4-hydroxybutyryl coenzyme A, the proportion of each monomer in the copolymer can be effectively regulated and controlled, especially after exogenous addition of short-chain fatty acids (such as formic acid, acetic acid, propionic acid, butyric acid and the like), the synthesis of copolymers such as PHB, PHBV, P34HB, P34HB3HV and the like can be further improved, and the synthesis efficiency of the copolymer is improved. And the proportion of different monomers is adjusted, so that the diversity and yield of the copolymer are enhanced.

The invention relates to the technical field of wastewater treatment, and discloses a preparation process of a flocculant applied to wastewater treatment.The preparation process comprises the steps that divinyl-containing diphenylethylene triazolyl amide butyric acid, acrylamide and starch are subjected to a cross-linking polymerization reaction, and an acrylamide-starch-based flocculant with a cross-linked network structure is obtained; the cross-linked network structure improves the specific surface area of the flocculant, increases adsorption sites, and improves the adsorption performance of metal ions such as cadmium. The acrylamide-starch-based flocculant contains functional groups such as triazole, carboxyl and Schiff base, nitrogen atoms in the triazole and the Schiff base contain lone pair electrons and can be coordinated and chelated with cadmium ions, and the carboxyl also has a very strong adsorption effect, so that the adsorption capacity and the adsorption rate of the flocculant to the cadmium ions are remarkably improved.

The invention belongs to the technical field of chemical synthesis of medicines, and particularly relates to a preparation method of a CETP inhibitor Obicterapib. The invention provides three preparation schemes. According to the scheme I, 2-phenyl pentenoate and (R)-N-(1-phenethyl)-4-(trifluoromethyl) aniline are subjected to a reaction, and a target compound Obicterapib is prepared through hydrolysis, cyclization, acylation, asymmetric chiral amine and other multi-step reactions; according to the second scheme, 4-halogenated benzotrifluoride reacts with (R)-3-amino valeronitrile, then nitrile hydrolysis is carried out, the product reacts with ethyl chloroformate, bis (trifluoromethyl) benzyl bromide, bis (pinacolato) diboron and ethyl 4-bromobutyrate, and finally hydrolysis is carried out to prepare the target compound Obictapib. According to the third scheme, (R)-3-(4-trifluoromethyl-phenyl amino)-valeric acid is substituted by amino to obtain a compound (R)-3-[4-(trifluoromethyl) phenyl amino]-valeric acid amide, then the compound (R)-3-[4-(trifluoromethyl) phenyl amino]-valeric acid amide reacts with ethyl chloroformate, bis (trifluoromethyl) benzyl bromide, bis (pinacolato) diboron, ethyl 4-bromobutyrate and 5-bromine-2-chloropyrimidine, and finally hydrolysis is conducted to prepare the target compound Obictapib.

This invention belongs to the field of coating technology, specifically relating to a moisture-proof and stain-resistant acrylic resin coating and its preparation process. The moisture-proof and stain-resistant acrylic resin coating comprises 100 parts by weight of a main agent and 20-25 parts by weight of a curing agent. The main agent comprises the following raw materials in weight percentages: dispersant 1.5-3%, butyl acetate 10-15%, xylene 5-10%, filler 10-20%, titanium dioxide 10-20%, carbon black 1-5%, cellulose acetate butyrate 1-2%, anti-settling agent 1-1.5%, leveling agent 0.5-1%, defoamer 0.1-0.5%, with the balance being acrylic resin. The moisture-proof and stain-resistant acrylic resin coating of this invention exhibits excellent comprehensive performance, high filling and sealing properties, strong adhesion to alloys, and good stain resistance, water resistance, and gloss retention.

The invention discloses a preparation method of cellulose acetate butyrate, which comprises the following steps: firstly preparing cellulose acetate butyrate ester, then hydrolyzing the cellulose acetate butyrate ester, and neutralizing a reaction solution obtained by hydrolyzing the cellulose acetate butyrate ester by using chitosan. The chitosan neutralizer disclosed by the invention has good solubility in a cellulose acetate butyrate reaction system, can quickly and thoroughly neutralize sulfuric acid to generate chitosan sulfate precipitate with a porous structure, remarkably reduces the sulfate content in a product, and meanwhile, plays a role in filtering unreacted small impurity particles in the system; and a low-turbidity cellulose acetate butyrate product can be produced.

The invention relates to the technical field of anti-yellowing, in particular to anti-yellowing lining cloth with a hot melt coating and a preparation method of the anti-yellowing lining cloth. Composite carbon dots, an anti-yellowing agent and a composite chitosan solution are adopted to prepare finishing liquid for finishing the lining cloth; the preparation method comprises the following steps: selecting furfural and urea as a carbon source and a nitrogen source, performing one-step hydrothermal synthesis to obtain a nitrogen-doped furfural-based carbon dot, and grafting an amino-terminated polyimidazolium salt antibacterial compound to obtain a composite carbon dot; wherein the amino-terminated polyimidazolium salt antibacterial compound is an amino-terminated halogen-free polyimidazolium salt antibacterial compound which is prepared by taking ethylenediamine, butyric acid, glyoxal and formaldehyde as raw materials based on amine-aldehyde polycondensation and has good biocompatibility; the preparation method comprises the following steps: by taking polybutylene adipate, toluene diisocynate and isophorone diisocyanate as main monomers, polypropylene oxide triol as a crosslinking monomer, 2, 2-dimethylolpropionic acid and 4, 4 '-diaminodiphenyl disulfide as chain extenders and composite carbon dots as an end-capping reagent, adding water and emulsifying to obtain the waterborne polyurethane hot melt adhesive.

The invention relates to the technical field of microorganisms, in particular to application of butyric acid producing enterobacter as a probiotic for resisting eimeria tenella. In the invention, an antibiotic cocktail-induced eimeria tenella infection model is utilized to explore the effect of butyric acid-producing enterobacter DSM 26588 on eimeria tenella development. The enterobacter butyricum DSM 26588 inhibits the growth of gametes by inhibiting the expression of the eimeria tenella gamete EtGFAT gene; according to the present invention, the intestinal tract lesion caused by Eimeria tenella infection can be improved, the intestinal tract pathological injury can be alleviated so as to reduce the Eimeria tenella oocyst discharge amount, the ACI value is 162, and the good anti-coccidiosis effect can be provided.

The invention relates to the technical field of industrial microorganisms, and particularly discloses a yeast strain and application thereof. The invention provides clavipora lusitaniae YJHT233, which is obtained through space mutation breeding, can tolerate 9% of alcohol, can tolerate an acid environment with the lowest pH value of 2.5, can tolerate a 12% high NaCl system, a 55% high glucose system and a 44 DEG C high temperature environment, and has excellent ester production capacity. The strain is used for brewing rice-flavor liquor or yellow wine, the total content of ester substances in the obtained product is greatly increased, the content of main volatile ester substances such as ethyl acetate, ethyl butyrate, isoamyl acetate, ethyl caprylate and ethyl lactate is remarkably increased, the whole flavor is coordinated and pleasant, and the fruit fragrance is rich and rich in layers.

Disclosed here is the method of treating general inflammation, metabolic health / insulin resistance / glycemic-glucose uptake & management (affecting skeletal muscle, liver, adipose, skin, gut, fibro-connective / joint, kidney, brain / CNS and other tissues), systemic inflammation, Immuno-modulation & Metabolic Syndrome / Nonalcoholic fatty liver disease (NAFLD), and provide Immuno-modulation, Insulin Sensitizing and Immuno-Metabolic benefits with at least one short fatty acid, such as butyrate or butyric acid in form of tributyrin, used in conjunction with one cannabinoid, such as cannabidiol or CBD, and with at least one terpene, such as beta-caryophyllene or BCP.

Provided herein are methods and compositions for treating a neurodegenerative disease (e.g., AD or PSP). The methods can include administering to the subject a bile acid or a pharmaceutically acceptable salt thereof and a phenylbutyrate compound.

The invention discloses a bacterial synbiotic beneficial to growth promotion of pasture in saline-alkali soil and application of the bacterial synbiotic. The bacterial synbiotic is a combination of bacterial strains NAU-RHO, NAU-MIC2 and NAU-FLA4 with 4-guanidinobutyric acid. The bacterial strains NAU-MIC2, NAU-FLA4, NAU-RHO are respectively classified and named as microbacterium laeviniform, Flavobacterium anhuiense and Rhodococcus oxyrhenium, and the research result shows that the bacterial synbiotics can be used for improving the salt tolerance and growth promoting effects of the bacteria on the medicago sativa and promoting the high yield of the medicago sativa in the saline-alkali soil.

The invention discloses an aging-resistant sealant for cable joints and a preparation method thereof, and belongs to the technical field of sealants, the aging-resistant sealant for cable joints comprises the following raw materials by mass: 35-50 parts of hydroxyl silicone oil, 45-60 parts of a filler, 3-5 parts of fumed silica, and 2-5 parts of a fluorine-containing hydroxyl-terminated hyperbranched polymer; 3-6 parts of hydrogen-containing silicone oil, 1-5 parts of a silane coupling agent, 1-3 parts of a ketoxime cross-linking agent, 0.05-0.1 part of an organic tin catalyst, 0.1-0.2 part of a lubricant and 1-3 parts of carbon black; the fluorine-containing hydroxyl-terminated hyperbranched polymer is prepared by taking trimethylolpropane, dimethylolbutyric acid and 2, 2-difluoro-3-hydroxy-succinic acid as monomers. The sealant disclosed by the invention has excellent comprehensive performance and aging resistance, and still has excellent performance under the conditions of high temperature, high humidity and high salt mist.

The invention relates to the field of pharmaceutical preparations, in particular to water-free swallowing granules and a preparation method thereof. The water-free swallowing granules provided by the invention comprise drug-containing taste-masking granules and a taste-modifying material, and the drug-containing taste-masking granules are prepared from drug-containing pellets and the taste-masking material; the raw material of the drug-containing pellet comprises an adhesive, and the adhesive is selected from one or more of povidone, hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose or starch slurry; the weight ratio of the drug-containing pellet to the taste masking material is (2-10): 1; the taste masking material comprises a coating component and an anti-sticking agent, wherein the coating component is selected from one or more of ethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, hydroxypropyl methyl cellulose phthalate and carboxymethyl ethyl cellulose; the anti-sticking agent is selected from one or two of lauryl sodium sulfate and talcum powder, and the obtained water-free swallowing granules are easy to swallow and good in stability.