35 results about "Piperonal" patented technology

The invention relates to a preparing method of a phosphodiesterase 5 inhibitor tadalafil. D-methyl tryptophanate hydrochloride is adopted as an initial raw material, and is subjected to cyclization with heliotropin, N-acylation, aminolysis-cyclization, and other reactions to obtain a tadalafil crude product. The tadalafil crude product is recrystallized to obtain a tadalafil finished product. The method has characteristics of mild reaction conditions, short reaction time, high yield, good product stability and convenience for industrial production.

The invention relates to a method of preparing piperonal in a one kettle way, which is a technical improvement of using 1,2-(methylenedioxy) benzene as a raw material to synthesize the piperonal. By the measures of selecting a proper solvent, adding an additive, diluting a reaction solution, and the like, the intermediate 3,4-(methylenedioxy) mandelic acid can be directly oxidized without being separated and purified to synthesize the piperonal in the 'one kettle' way. The invention has the characteristics of simple operation, high yield and the like, and both the purity and the quality of the product meet the requirements.

The invention relates to the technical field of industrial wastewater treatment, and specifically discloses a treatment method for piperonal production wastewater. The method for treating the piperonal production wastewater includes: adding 1,2-methylenedioxybenzene to the piperonal production wastewater, mixing uniformly, performing distillation, collecting fractions, and separating liquids to obtain recovered materials; cooling the remaining mother liquor from the distillation , After adjusting the pH to weak acidity, adding transition metal oxides, performing high-pressure pulse treatment, filtering, and treating the treated water through the sewage treatment system and discharging. The method for treating wastewater from piperonal production provided by the invention has the advantages of simple process operation and low energy consumption, and solves the problem that the reaction raw materials and reaction products in the wastewater cannot be recovered by the traditional treatment process, and the treated wastewater can reach the level of "Chemical Synthesis Pharmaceutical Industry" "Water Pollutant Discharge Standard" discharge standard, will not cause secondary pollution, realize the comprehensive treatment and resource utilization of wastewater, has high economic and environmental benefits, and has high promotion value.

The invention provides a preparation method of piperonal, comprising: reacting piperonyl cycline, a catalyst and urotropine in an alcohol solvent at 50-120° C. for 1-10 hours to obtain piperonal. The overall process only needs one-step reaction, the process is simplified, the yield is high, the discharge of three wastes is relatively low, the waste water is easy to treat, and it is easy to realize industrial production.

The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.

The preparation method for cyan-free silver plating lustre-coating agent comprises: adding 0.1-1mol / L heliotropin into saturated 0.1-2mol / L NaHSO3 solution for ultrasonic oscillating; dissolving 0.1-2mol / L triethanolamine and 0.1-1mol / L butynediol into the solution, adding solvent to dilute to 1L. This invention overcomes the defects in prior art withnot sulfur-containing compound, and has well dispersion.

The invention relates to an asymmetric synthesis method of (+)-tanshinol, which comprises the following steps: carrying out Knoevenagel condensation on the raw material heliotropin, hydrolyzing for ring opening to obtain beta-(3,4-3,4-methylenedioxyphenyl)pyruvic acid, carrying out key asymmetric reduction reaction to obtain R-beta-(3,4-dibenzyloxyphenyl)-alpha-hydracrylic acid, and finally, deprotecting to obtain the (+)-tanshinol. The method has the advantages of accessible raw material and high optical purity of the product, is simple to operate, and can implement large-scale preparation.

The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.