14 results about "Glyoxylic acid" patented technology

This invention discloses a crystallization method for glyoxylic acid monohydrate, comprising the following steps: Step 1: Adding seed crystals to a drum granulator, the seed crystal mass being 9 times the mass of an 80% glyoxylic acid solution; Step 2: Adding the 80% glyoxylic acid solution to the drum granulator through spray guns located at the feed end of the drum granulator. The maximum flow rate of each spray gun is 2 t / h, and each spray gun is equipped with two solid conical atomizing nozzles with a solid cone angle of 55-60°. The number of spray guns is selected according to the production scale. This invention, by adding seed crystals at a mass of 9 times the mass of an 80% glyoxylic acid solution, allows the atomized 80% glyoxylic acid solution to mix with the seed crystals within the drum granulator, achieving rapid agglomeration and hardening of the mixture within a short time. After crystallization, the mixture is cooled. The product is graded according to particle size, with intermediate grades directly packaged. The implementation scheme is highly operable and economical to operate; it can be operated continuously and is suitable for large-scale industrial continuous production.

The technical scheme of the present application discloses a continuous preparation process of industrial glyoxylic acid, and belongs to the technical field of fine organic chemical industry and glyoxylic acid synthesis. The main innovation of the present application is to introduce microfluidic technology and microporous membrane separation technology into the synthesis process, and to use a composite catalyst to catalyze the air oxidation of glyoxal to synthesize glyoxylic acid. Compared with the prior art, the present application has the following obvious beneficial effects: (1) the process is safe, continuous, fast, high in production efficiency and small in space occupation; (2) no waste water, waste gas and waste solid are produced, and the recycled water can be recycled, which is very beneficial to environmental protection and water resource saving; (3) the composite noble metal catalyst is low in consumption, and the conversion rate of glyoxal is greatly improved; and (4) the present application has the characteristics that high-content glyoxylic acid can be obtained without distillation and concentration, which is very beneficial to reducing the production cost.

This invention discloses a method for preparing sulindac. The method involves first performing an Arbuzov reaction and a Wittig-Horner reaction sequentially to obtain 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene. 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene undergoes a condensation dehydration reaction with glyoxylic acid, followed by double bond rearrangement under acidic conditions to obtain (Z)-5-fluoro-2-methyl-1-(p-methylthiobenzyl)-1H-indene-3-acetic acid. Finally, it undergoes a single oxidation reaction with an oxidant to obtain sulindac. The raw materials and excipients used in this invention are readily available, and the entire reaction route is short, the reaction conditions are mild, the operation is safe and simple, the yield is high, the purity is high, the production cost is low, and the emissions of waste are minimal, conforming to green industrial production standards. The total yield of the obtained sulindac product is over 75%, which is conducive to industrial production.

An aqueous composition is provided comprising water and a cationic polymeric resin having at least one reactive aldehyde group and formed by the reaction of glyoxal with a polymer. The polymer comprises at least one acrylamide repeat unit and at least one cationic repeat unit, wherein the number of equivalents of reactive aldehyde divided by the number of equivalents of residual glyoxal is greater than about 1.2 based on the total weight of the polymer, wherein the polymer has greater than about 50 mole percent acrylamide repeat units and from about 2 to about 30 mole percent cationic repeat units prior to reaction, wherein greater than about 5 mole percent of the acrylamide repeat units are converted to reactive aldehyde groups in the cationic polymeric resin; and wherein the composition exhibits a viscosity increase of less than about 200 percent.

Coating compositions comprising a phenolic resin and a film-forming resin having functional groups that are reactive with the functionality of the phenolic resin are disclosed herein. The phenolic resin comprises a phenol group containing compound and a glyoxylic acid containing compound. Such phenolic resins may be used as formaldehyde-free crosslinkers in coating compositions and such coating compositions may be used on substrates comprising a non-porous material, such as metal, glass, and / or plastic. Also disclosed are methods of coating a substrate and coated substrates, including food and / or beverage containers.

This invention relates to mutant microorganisms for producing 1,3-propanediol and a method for producing 1,3-propanediol using the same. Specifically, the invention involves recombining the genes of microorganisms to enhance the TCA cycle and glycoxylate pathway in strains that strengthen the PP pathway (pentose phosphate pathway) and ED pathway (Entner-Doudoroff pathway), thereby enabling the production of 1,3-propanediol. Therefore, high concentrations of 1,3-propanediol can be produced using the mutant microorganisms according to the invention.

The application provides a preparation method of a sodium iron phosphate pyrophosphate positive electrode material, a positive electrode material and an electrochemical device. The preparation method comprises the following steps: mixing a sodium source, an iron source, a phosphorus source and a first carbon source, performing one-time grinding and drying, and then performing one-time sintering to obtain a sodium iron phosphate pyrophosphate precursor; dispersing the sodium iron phosphate pyrophosphate precursor, the first carbon source and an organic acid in a solvent, performing two-time grinding, and then drying to obtain a powder, wherein the organic acid comprises at least one of glyoxylic acid, phthalic acid, maleic acid, malic acid, oxalic acid, citric acid, acetic acid, squaric acid and tartaric acid; and performing two-time sintering on the powder to obtain the sodium iron phosphate pyrophosphate positive electrode material. The sodium iron phosphate pyrophosphate positive electrode material prepared by the preparation method has the advantages of low surface residual alkali content, good air stability and excellent electrochemical performance.

The application discloses a preparation method of a monoamine oxidase B inhibitor, and comprises the following steps: 6-fluoroindole and 1-(dimethylamino)-2-nitroethylene are subjected to trifluoroacetic acid catalysis to generate 6-fluoro-3-[(E)-2-nitrovinyl]-1H-indole, and then subjected to sodium borohydride and iron powder / hydrochloric acid reduction to generate 6-fluoro-tryptamine; under an acidic condition, Pictet-Spengler reaction is carried out between 6-fluoro-tryptamine and ethyl glyoxylate to generate ethyl 7-fluoro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate and 7-fluoro-4,9-dihydro-3H-pyrido[3,4-b]indole-1-carboxylate, and then subjected to oxidative dehydrogenation aromatization reaction to generate ethyl 7-fluoro-9H-pyrido[3,4-b]indole-1-carboxylate; under the catalysis of aluminum trichloride, amine ester exchange reaction is carried out between ethyl 7-fluoro-9H-pyrido[3,4-b]indole-1-carboxylate and 3-fluorobenzylamine to generate a target compound. The method has high overall yield.

This application discloses an intramolecular hydrogen bond-enhanced anthraquinone derivative, its synthesis method, and its application, relating to the field of electrochemical energy storage. The acetic acid-modified anthraquinone RH-DA or AE-DA is 2,2'-(3-carboxyl-1,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid and 2,2'-(1,8-dihydroxy-3-(hydroxymethyl)-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid. Rhein or aloe-emodin is dissolved in NaOH, glyoxylic acid solution and sodium dithionite are added, and after stirring, sodium dithionite is added again. After stirring and cooling to room temperature, hydrogen peroxide solution and HCl solution are added, causing precipitation. After washing with HCl, the precipitate is dried in a vacuum drying oven to obtain a black-green solid RH-DA or a yellow-green solid AE-DA. Its application in alkaline aqueous organic flow batteries is also disclosed.

The invention relates to a process for in-situ glyoxylation of polyacrylamide in paper mills, board mills and the like, wherein a discontinuous batch glyoxylation reaction of an aqueous reaction mixture is performed in a reactor vessel equipped with a drive stirrer to form an aqueous polymer composition comprising glyoxylated polyacrylamide. The process comprises forming or obtaining an aqueous reaction mixture having a starting viscosity and comprising a polyacrylamide base polymer having a weight average molecular weight of 30000 - 300000 g / mol and glyoxal. The concentration of the polyacrylamide base polymer in the reaction mixture is 1.5% - 8% higher than the critical concentration of the polyacrylamide base polymer. A base feed is added to the reaction mixture while measuring the viscosity of the reaction mixture and / or a process variable related to the viscosity of the reaction mixture and allowing the in-situ glyoxylation reaction of the polyacrylamide base polymer in the reaction mixture to proceed. When a predetermined final viscosity value is reached, the base feed is terminated and an acid is added to the reaction mixture. The aqueous polymer composition comprising glyoxylated polyacrylamide is removed from the reaction vessel.

The application provides a heat-resistant and moisture-resistant water-based adhesive applied to a polarizing sheet, a preparation method and application, and belongs to the technical field of polarizing sheets. The water adhesive is prepared by reacting acetyl acetyl-modified polyvinyl alcohol with a diacylhydrazine type and a glyoxylate type crosslinking agent under the regulation of various metal ions, is attached between a phase difference compensation film and a polarizing sheet base film (element), has excellent water vapor barrier effect and heat resistance, and can also improve the anti-blue light effect.

The application discloses a chemical nickel plating pretreatment activator and a preparation method thereof, and relates to the field of chemical nickel plating. The chemical nickel plating pretreatment activator comprises the following raw materials in mass concentrations: nickel salt 20-30 g / L, rare earth salt 15-23 mg / L, glyoxylate derivative 12-20 g / L, complexing agent 8-13 g / L, stabilizer 80-120 mg / L, accelerator 0.8-2 g / L, 10-15 g / L of a sodium citrate-citric acid buffer pair with a mass ratio of (3-5):1, and 0.05-0.1 g / L of a surfactant; and the pH value of the pretreatment activator is 4.5-5.5. The prepared palladium-free activator has high stability, low cost, low plating leakage and plating overflow probabilities, high environmental protection, and high bonding force with a plating layer.

The present invention relates to a method for producing L-methionine comprising the fermentation under aerobic conditions of a genetically modified microorganism which produces more L-methionine than the microorganism before the genetical modification in a medium comprising a primary alcohol upon increasing the activity of the glyoxylate shunt.

The application discloses a recombinant ammonium acetate-producing bacterium and a method for preparing ammonium acetate, and belongs to the technical field of bioengineering.The application aims to provide a method for producing ammonium acetate.The application provides a recombinant ammonium acetate-producing bacterium, which is obtained by knocking out the genes poxB of pyruvate oxidase, pflB of pyruvate formate-lyase and the key subunit aceE of pyruvate dehydrogenase of Escherichia coli as a starting bacterium, and overexpressing the genes Agx1 / BhcA of glyoxylate aminotransferase, Dhaa / BhcC of hydroxyaspartate aldolase, BhcB of beta-hydroxyaspartate dehydratase and BhcD of iminosuccinate reductase.The application combines the carbon sequestration path with the fermentation process optimization, realizes direct and efficient synthesis from glucose to ammonium acetate, significantly simplifies the process flow, and improves the carbon atom utilization efficiency and product yield.