304 results about "Phenylacetic acid" patented technology

A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

The invention belongs to the technical field of separation of products for synthesizing antibiotics by an enzymic method, and particularly relates to a method for separating and recycling an amoxicillin product synthesized by a one-step method based on catalysis of kluyveromyces citricacidophilus beta subunit G385 mutant penicillin acylase. An immobilized penicillin acylase mutant is used for catalyzing penicillin potassium to synthesize amoxicillin in one step, a set of method for separating amoxicillin and phenylacetic acid is developed for an obtained reaction mixture, and the technical scheme mainly comprises the following steps: firstly, separating the immobilized penicillin acylase mutant from a reaction solution through filtration; then, amoxicillin is separated out through crystallization; and then crystallizing, separating and recovering phenylacetic acid through toluene extraction, back extraction and the like. According to the separation method, the amoxicillin can be rapidly and efficiently separated, the yield of the amoxicillin is relatively high, and the average crystallization rate reaches 93.22%; meanwhile, the separation and recovery effects of phenylacetic acid are good; and the extraction agent toluene can be recycled.

The invention discloses a 4-hydroxyphenylacetic acid-3-hydroxylase mutant with improved activity and application thereof, the 4-hydroxyphenylacetic acid-3-hydroxylase mutant is obtained by mutating wild type 4HPA3H enzyme from Escherichia coli, the amino acid sequence of the wild type 4HPA3H enzyme is as shown in SEQ ID No.1, and the amino acid sequence is specifically mutated into any one of the following: (1) M205F; and (2) T398S. According to the present invention, the whole-cell catalysis activity of the 4-hydroxyphenylacetic acid-3-hydroxylase mutant, the M205F mutant and the T398S mutant on the p-hydroxyphenyllactic acid is improved by 1.70 times and 1.24 times compared with the WT;

The invention discloses a high-strength moisture-proof gypsum board and a preparation method thereof, and relates to the technical field of gypsum board preparation. The high-strength moisture-proof gypsum board is prepared by dipping the surface paper in the composite dipping liquid and then pouring the surface paper and the gypsum core with the waterproof agent, the composite dipping liquid comprises the methoxy vinyl ether copolymer and the epoxy polyoxymethylene dimethyl ether, and the methoxy vinyl ether copolymer is 2, 3, 5-trimethyl-1, 3-pentanediol monoisobutyrate. According to the present invention, epoxy polyoxymethylene dimethyl ether is prepared by reacting 2, 4-dimethoxymethoxyphenylacetic acid with 2-hydroxyethyl vinyl ether, and the epoxy polyoxymethylene dimethyl ether is prepared by terminating polyoxymethylene dimethyl ether with allyl and then reacting with phthalimide hexperoxy acid, such that the waterproofness and the mechanical property of the gypsum board are improved; the waterproof agent is prepared by reacting hydrogen-containing silicone oil and fluorine-containing hyperbranched amide polyurea urethane, so that the moisture resistance and bonding strength of the gypsum board surface paper are enhanced, and additional mechanical support is provided for the gypsum board.

The invention belongs to the technical field of medicines, and discloses a near-infrared cyanine probe for detecting penicillin G acylase as well as a preparation method and application of the near-infrared cyanine probe. According to the research, a near-infrared fluorescent probe Cy-NEO-PA responding to penicillin G acylase (PGA) is developed, so that the influence of environmental factors on the formation of an acinetobacter baumannii biological membrane is observed. Research results show that glucose inhibits the generation of PGA to enhance the formation of a biological membrane, while phenylacetic acid (PAA) stimulates the generation of PGA and inhibits the formation of the biological membrane. The observation results highlight the excellent capability of Cy-NEO-PA in accurately measuring PGA kinetics, and reveal the key effect of PGA in biological membrane development. In addition, the Cy-NEO-PA has good biocompatibility, strong active oxygen generation, efficient photo-thermal conversion and bacterial targeting ability, so that the Cy-NEO-PA becomes a promising drug for resisting bacterial infection and promoting wound healing through photo-thermal / photodynamic therapy.

The invention discloses a 4-hydroxyphenylacetic acid 3-hydroxylase mutant and application thereof, recombinant expression plasmids and corresponding genetically engineered bacteria M214V, R290N and E294I are constructed by using genes for coding the mutants (EcHpaBM214V, EcHpaBR290N and EcHpaBE294I) and nucleotide sequences for coding EcHpaC genes respectively, and after the genetically engineered bacteria disclosed by the invention are subjected to shake flask fermentation in a 30mL M9Y culture medium containing 50mu g / mL chloramphenicol for 24 hours, the yield of the mutants is increased, and the yield of the mutants is increased. The yield of the tanshinol is 748.04 mg / L, 895.55 mg / L and 793.36 mg / L. The method breaks through the limitation that the substrate generated by the 4-hydroxyphenylacetic acid 3-hydroxylase through catalysis is poor in specificity and low in catalysis efficiency, and the yield of the tanshinol is high. The method has the advantages of being high in catalytic efficiency, simple in process and environmentally friendly.

The invention discloses a 2, 4, 5-trifluorophenylacetic acid hydrolysis wastewater reuse device and process, and relates to the technical field of wastewater reuse, the 2, 4, 5-trifluorophenylacetic acid hydrolysis wastewater reuse device comprises a sewage treatment tank, the top of the sewage treatment tank is fixedly provided with a water inlet pipe, the bottom of the sewage treatment tank is fixedly provided with a water outlet pipe, and the inner wall of the sewage treatment tank is slidably provided with a filter plate; a feeding box is fixedly mounted at the top of the sewage treatment tank, and a discharging pipe is arranged at the bottom of the feeding box; the wastewater treatment device is arranged in the sewage treatment tank, the wastewater treatment device comprises a motor, a reciprocating screw rod, stirring blades, a moving frame, an L-shaped rod, a supporting plate, an elastic telescopic rod, an arc-shaped plate, a guide plate, a short rod, a rotating plate and a limiting plate, the motor rotates to drive the reciprocating screw rod to rotate, the reciprocating screw rod rotates to drive the stirring blades to rotate, and the stirring blades can rotate to drive the moving frame to move; the waste residue is prevented from adhering to the inner wall of the sewage treatment tank to reduce the reaction efficiency and affect the wastewater treatment and recovery efficiency.

The invention discloses a synthesis method of 2, 4, 5-trifluorophenylacetic acid, which comprises the following steps: by taking cheap and easily available o-chloronitrobenzene as a raw material, reacting with sodium nitrate in a sulfuric acid and trifluoroacetic acid system, separating generated 2, 4-dinitrochlorobenzene through melt crystallization, and continuing to synthesize 2, 4-dinitrochlorobenzene in methyl chloroacetate to obtain 2, 4, 5-trifluorophenylacetic acid. The method comprises the following steps: carrying out indirect aromatic nucleophilic substitution reaction on 2, 4-dinitrophenylacetic acid under the condition of sodium hydride to generate 5-chloro-2, 4-dinitrophenylacetic acid methyl ester, separating, carrying out fluorination reaction on the 5-chloro-2, 4-dinitrophenylacetic acid methyl ester and potassium fluoride under the action of a phase transfer catalyst, carrying out rectification separation to obtain 2, 4, 5-trifluorophenylacetic acid, and carrying out hydrolytic acidification on the 2, 4, 5-trifluorophenylacetic acid in a sodium hydroxide aqueous solution to obtain 2, 4, 5-trifluorophenylacetic acid. And the process route is safer, more environment-friendly, more efficient and lower in cost.

The invention discloses a refenasin triphenyl acetate and an inhalation powder inhalation thereof. The refenasin triphenyl acetate can be prepared into inhalation powder inhalation, has the effects of good preparation stability, high deposition proportion in an effective part in a body, good curative effect and low side effect, and provides a new drug choice for treatment of COPD patients.

The invention belongs to the technical field of silicon solar cells, and particularly relates to a copper electrode material and a method for preparing a copper electrode of a silicon solar cell by using the copper electrode material, the copper electrode material comprises the following components: a copper wire, a tin-bismuth alloy and modified rosin, and the preparation method of the modified rosin comprises the following steps: firstly, taking polyethylene glycol and aniline phenylacetic acid as raw materials; carrying out esterification reaction to obtain aniline modified polyethylene glycol; then, rosin and acrylic acid are used as raw materials, and acrylic acid modified rosin is obtained through a D-A addition reaction; and finally, by taking aniline modified polyethylene glycol and acrylic acid modified rosin as raw materials, carrying out esterification reaction. The invention also provides a method for preparing a silicon solar cell copper electrode by using the copper electrode material. The surface of a copper wire is sequentially coated with a modified rosin layer, a tin-bismuth alloy layer and a modified rosin layer. The copper electrode provided by the invention has relatively low bulk resistance and relatively good oxidation stability, and also has excellent adhesive force and relatively low interface contact resistance when the copper electrode is fused and welded on the surface of a substrate.

To provide a method for producing vinyl catechol compounds that enables the production of the vinyl catechol compounds without heavy metals.SOLUTION: A method for producing a vinyl catechol compound disclosed herein includes the step for reacting a vinylphenol compound represented by formula (I) with at least one selected from the group consisting of a first microbial cell containing 4-hydroxyphenylacetic acid-3-monooxygenase, a processed product of the first microbial cell, a second microbial cell containing phenol-2-monooxygenase, and a processed product of the second microbial cell. In formula (I), R represents hydrogen or a methyl group, and the position of the hydroxyl group is in the meta or para position relative to the -C(R)=CH2 group.SELECTED DRAWING: None

The present invention relates to the technical field of heated cigarettes, and in particular to a spicy-flavored tobacco flavor for heated cigarettes and heated cigarettes. The tobacco flavor includes, by mass, 0.1-1.5 parts of main aroma components, including Chinese cinnamon bark oil, cinnamic acid, cinnamaldehyde, piperonal, benzyl cinnamate and isoamyl cinnamate; 5.0-14.0 parts of modified components, including plum extract, ethyl acetate, furfural, methylcyclopentenolone, benzaldehyde, phenylacetic acid, vanillin and ethyl vanillin; fixative: 2.0-5.0 parts, the fixative components include Peruvian extract and triacetin; solvent 75.0-93.0 parts. The tobacco flavor can overcome the problems of large taste irritation and obvious spiciness of existing spicy-flavored raw material flavors, and effectively improve and enrich the quality of the suction aroma while giving the heated cigarette a spicy style, and improve the consistency and persistence of aroma release.

The invention provides a diagnostic marker for metabolic syndrome and preclinical stage thereof, and the diagnostic marker or a plasma small molecule metabolism biomarker consists of the following substances: pyrimidine, (S)-beta-aminoisobutyric acid, 3-hydroxybutyric acid, L-serine, guanidine acetic acid, 3-hydroxyisovaleric acid, L-homoserine, L-cysteine, piperidine acid, hypotaurine and creatinine. The beverage is prepared from phenylacetic acid, erythritol, picolinic acid, taurine, pyroglutamic acid, lemonic acid, malic acid, tyramine, isonicotinic acid, o-phosphoethanolamine, L-glutamine, salicylic acid and D-glucose. The invention also provides a kit for detecting the plasma small molecule metabolism biomarker composition, the spectrum peak intensity of the obtained plasma small molecule metabolism biomarker is detected, the risk score of whether each subject is MetS or pre-MetS is calculated, and then whether the subject is MetS or pre-MetS is predicted. According to the invention, efficient and rapid diagnosis of the metabolic syndrome and the preclinical stage thereof is realized.

The invention belongs to the field of catalyst preparation technology and application, and relates to preparation of a Pd / C catalyst and a method for synthesizing phenylacetic acid from benzyl chloride by using the Pd / C catalyst. The method comprises the following steps: S1, preparation of a Pd / C catalyst: preparing a high-dispersity, high-activity and stable catalyst by improving the process, obtaining a high conversion rate by only using 0.2% of the catalyst, and having excellent reusability; and S2, synthesizing phenylacetic acid: taking benzyl chloride and CO as raw materials, adding the prepared high-activity Pd / C catalyst, and optimizing a reaction process to obtain high-yield and high-purity phenylacetic acid. The prepared catalyst shows an excellent catalytic effect, the production method is simple in step and mild in reaction condition, the yield of the obtained phenylacetic acid is relatively high, the used solvent can be recycled, the cost is greatly saved, and the method is suitable for large-scale industrial production.

The invention discloses a quinolinone derivative and a preparation method thereof, and the quinolinone derivative comprises a 3-phenyl-6, 7-dimethoxy isoquinolin-1 (2H)-one derivative and a 3-phenyl-6, 7-dimethoxy quinolin-2 (1H)-one derivative which are shown in the structural general formulas of formula (I) and formula (II). Wherein 4, 5-dimethoxy-2-methyl benzaldehyde is synthesized firstly, then the 4, 5-dimethoxy-2-methyl benzaldehyde and substituted cyanophenyl are subjected to cycloaddition reaction under the action of potassium tert-butoxide and LiHMDS, and the 4, 5-dimethoxy-2-methyl benzaldehyde is obtained; the preparation method of the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide comprises the following steps: synthesizing 2-amino-4, 5-dimethoxybenzaldehyde, carrying out acylation reaction on the 2-amino-4, 5-dimethoxybenzaldehyde and substituted phenylacetic acid under the action of HATU to obtain 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide, and carrying out cyclization reaction on the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide under the action of K2CO3 to obtain the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide. The preparation method has the characteristics of mild reaction conditions, simplicity in operation, high efficiency, environment friendliness and the like.

The invention provides a phenylglycine derivative as well as a synthesis method and application thereof, and belongs to the field of preparation of phenylglycine derivatives. The 2-morpholine-2-phenylacetic acid derivative is obtained by taking a phenylboronic acid derivative as a substrate and carrying out Petasis'one-pot method 'reaction on the phenylboronic acid derivative, glyoxylic acid and morpholine in a solvent. The method has the advantages of high yield, high selectivity, mild conditions and environmental protection. The invention provides a new way for industrial production of phenylglycine, and provides a new way for developing phenylglycine and new functional materials thereof.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The invention belongs to the technical field of product separation in enzymatic synthesis of antibiotics, and particularly relates to a method for separating and purifying amoxicillin and phenylacetic acid in the production process of amoxicillin. An immobilized penicillin acylase mutant is used for catalyzing penicillin potassium to synthesize amoxicillin in one step, a set of method for separating amoxicillin and phenylacetic acid is developed for an obtained reaction mixture, and the technical scheme mainly comprises the following steps: firstly, separating the immobilized penicillin acylase mutant from a reaction solution through filtration; then, amoxicillin is separated out through crystallization; and then crystallizing, separating and recovering phenylacetic acid through toluene extraction, back extraction and the like. According to the separation method, the amoxicillin can be rapidly and efficiently separated, the yield of the amoxicillin is relatively high, and the average crystallization rate reaches 93.22%; meanwhile, the separation and recovery effects of phenylacetic acid are good; and the extraction agent toluene can be recycled.

The invention discloses an intermediate for preparing optically pure berbamine and spirosine and a preparation method of the intermediate. The intermediate is a compound (S)-1-(4-(5-(((R)-8-bromo-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1-yl) methyl)-2-hydroxyphenoxy) benzyl)-6-methoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-7-alcohol (20a) or a compound (S)-1-(3-(4-(((R)-8-bromo-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1 The preparation method comprises the following steps: firstly, carrying out a multi-step reaction on 5-bromovanillin, 4-hydroxyphenylacetic acid and 4-benzyloxy-3-methoxybenzaldehyde which are used as initial raw materials to obtain optical pure berbamine and spirosine, and then, carrying out a multi-step reaction on the optical pure berbamine and spirosine to obtain the optical pure berbamine and spirosine, and carrying out a reaction on the optical pure berbamine and spirosine to obtain the optical pure berbamine and spirosine. The synthesis route adopts a convergent synthesis mode, the synthesis efficiency is high, the reaction condition is mild, the safety is high, and the operation is simple and convenient.

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

The application belongs to the technical field of biological medicine, and particularly relates to a lactobacillus paracasei and application thereof. The lactobacillus paracasei ZY101 is preserved in the China General Microbiological Culture Collection Center, has a preservation number of CGMCC No. 32360, a preservation date of October 25, 2024, and an address of No. 3, Beichen West Road, Chaoyang District, Beijing. Compared with a commercial bacillus acidophilus, the apricot vinegar prepared by using the lactobacillus paracasei ZY101 has new substances including linalool, alpha-farnesene, 2-phenylacetic acid ethyl ester and geranylgeraniol, and further promotes the aroma of the apricot vinegar. Compared with the commercial bacillus acidophilus, the existing substances are obviously improved, and specifically include ethyl acetate, isoamyl acetate, ethyl octanoate, ethyl hexanoate, acetoin, methyl palmitate, gamma-deca-lactone, ethyl dodecanoate, delta-deca-lactone, trans-nerolidol and dihydro-beta-ionone.

The invention relates to a separation method of 2-methylphenylacetic acid-alpha-ketoxime isomers, and belongs to the technical field of pesticides. The specific method comprises the following steps: adding 2-methylphenylacetic acid-alpha-ketoxime serving as a raw material into n-butyl alcohol, adding an aqueous solution of sodium hydroxide while stirring, carrying out solid-liquid separation after full reaction, and acidizing the solid to obtain a Z configuration of 2-methylphenylacetic acid-alpha-ketoxime; and acidizing the liquid to obtain the 2-methylphenylacetic acid-alpha-ketoxime E configuration. According to the method disclosed by the invention, the Z-configuration disodium salt and the E-configuration disodium salt of the 2-methylphenylacetic acid-alpha-ketoxime are separated by utilizing the solubility difference of the Z-configuration disodium salt and the E-configuration disodium salt of the 2-methylphenylacetic acid-alpha-ketoxime in a specific solvent and a specific proportion range; performing simple acidizing treatment to obtain high-purity Z configuration and E configuration of the 2-methylphenylacetic acid-alpha-ketoxime; the purity of the two configurations is 97% or above, raw materials are provided for preparing kresoxim-methyl and trifloxystrobin of specific configurations, and mutual influence of drug effects is avoided.

The invention belongs to the field of medicines, and particularly provides a method for preparing an important intermediate compound N-(2-(cyclohex-1-ene-1-yl) ethyl)-2-p-methoxyphenylacetamide of dextromethorphan. According to the method, 2-(1-cyclohexenyl) ethylamine and p-methoxyphenylacetic acid are used as raw materials, N, N-carbonyldiimidazole is selected as a condensation reagent, reaction conditions are optimized, the reaction temperature is reduced, the reaction time is shortened, aftertreatment is simple, the product yield and purity are high, cost is low, and industrial production is facilitated.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The present invention relates to a synthetic method of 2-methyl-α-methoxyiminophenylacetic acid methyl ester, and the method flow comprises the following: Step 1: using o-methylphenylacetic acid or o-methylphenylacetamide or o-methylphenylacetic acid methyl ester as raw material, first directly oximating and esterifying with sodium nitrite in sulfuric acid in a solvent; Step 2: "one-pot method" hydrogenation of sodium hydroxide or potassium hydroxide to control pH value, and reacting with dimethyl sulfate to obtain 2-methyl-α-methoxyiminophenylacetic acid methyl ester. The present invention uses o-methylphenylacetic acid or o-methylphenylacetamide or o-methylphenylacetic acid methyl ester as raw material, and adopts safe and reliable sodium nitrite as oximation reagent, avoids using nitrite esters that are flammable and explosive, avoids using expensive methoxyamine hydrochloride, has safe and reliable reaction, low raw material cost, and adopts "one-pot method" in the operation process, has simple and smooth process, mild reaction conditions, and is suitable for industrialized amplification production.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

This invention provides a flavoring agent for enhancing the honey-sweet aroma of tobacco, comprising the following raw materials and their mass percentages: 0.2-0.3% 2,3-pentanedione, 0.45-0.55% phenylacetic acid, 0.45-0.55% phenethyl acetate, 0.25-0.4% phenylethanol, 0.45-0.6% methyl phenylacetate, 0.45-0.6% ethyl phenylacetate, 0.5-0.6% menthyl acetate, 0.15-0.25% geraniol, and the balance being propylene glycol. This invention belongs to the field of tobacco flavoring technology. By combining 2,3-pentanedione, phenylacetic acid, and phenethyl acetate in a specific mass ratio and conducting testing and evaluation, a flavoring agent suitable for enhancing the honey-sweet aroma of tobacco has been successfully developed. The composition is clearly defined, significantly improving the honey-sweet aroma of tobacco products, with a rich and long-lasting aroma, and good taste harmony.

The invention discloses a chitosan-based membrane as well as a preparation method and application thereof, and belongs to the technical field of packaging materials. The chitosan-based film has a double-layer structure consisting of an inner layer and an outer layer, the outer layer is a water-blocking antibacterial layer formed by a silver complex, and the inner layer is an antibacterial antioxidant layer formed by polyphenol; the silver complex is a complex which is formed by the reaction of pyrrole-2-formaldehyde-g-chitosan and silver acetate; the polyphenol is formed by grafting 3, 4-dihydroxy methyl phenylacetate on the chitosan. The silver complex water-blocking antibacterial layer is constructed on the outer layer, and the polyphenol antibacterial anti-oxidation layer is constructed on the inner layer, so that the double fresh-keeping mechanism of external protection and internal maintenance is realized, and the comprehensive performance and application potential of the material are remarkably improved.