134 results about "Phenylacetic acid" patented technology

The invention discloses a high-strength moisture-proof gypsum board and a preparation method thereof, and relates to the technical field of gypsum board preparation. The high-strength moisture-proof gypsum board is prepared by dipping the surface paper in the composite dipping liquid and then pouring the surface paper and the gypsum core with the waterproof agent, the composite dipping liquid comprises the methoxy vinyl ether copolymer and the epoxy polyoxymethylene dimethyl ether, and the methoxy vinyl ether copolymer is 2, 3, 5-trimethyl-1, 3-pentanediol monoisobutyrate. According to the present invention, epoxy polyoxymethylene dimethyl ether is prepared by reacting 2, 4-dimethoxymethoxyphenylacetic acid with 2-hydroxyethyl vinyl ether, and the epoxy polyoxymethylene dimethyl ether is prepared by terminating polyoxymethylene dimethyl ether with allyl and then reacting with phthalimide hexperoxy acid, such that the waterproofness and the mechanical property of the gypsum board are improved; the waterproof agent is prepared by reacting hydrogen-containing silicone oil and fluorine-containing hyperbranched amide polyurea urethane, so that the moisture resistance and bonding strength of the gypsum board surface paper are enhanced, and additional mechanical support is provided for the gypsum board.

The invention discloses a synthesis method of 2, 4, 5-trifluorophenylacetic acid, which comprises the following steps: by taking cheap and easily available o-chloronitrobenzene as a raw material, reacting with sodium nitrate in a sulfuric acid and trifluoroacetic acid system, separating generated 2, 4-dinitrochlorobenzene through melt crystallization, and continuing to synthesize 2, 4-dinitrochlorobenzene in methyl chloroacetate to obtain 2, 4, 5-trifluorophenylacetic acid. The method comprises the following steps: carrying out indirect aromatic nucleophilic substitution reaction on 2, 4-dinitrophenylacetic acid under the condition of sodium hydride to generate 5-chloro-2, 4-dinitrophenylacetic acid methyl ester, separating, carrying out fluorination reaction on the 5-chloro-2, 4-dinitrophenylacetic acid methyl ester and potassium fluoride under the action of a phase transfer catalyst, carrying out rectification separation to obtain 2, 4, 5-trifluorophenylacetic acid, and carrying out hydrolytic acidification on the 2, 4, 5-trifluorophenylacetic acid in a sodium hydroxide aqueous solution to obtain 2, 4, 5-trifluorophenylacetic acid. And the process route is safer, more environment-friendly, more efficient and lower in cost.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The invention discloses an intermediate for preparing optically pure berbamine and spirosine and a preparation method of the intermediate. The intermediate is a compound (S)-1-(4-(5-(((R)-8-bromo-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1-yl) methyl)-2-hydroxyphenoxy) benzyl)-6-methoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-7-alcohol (20a) or a compound (S)-1-(3-(4-(((R)-8-bromo-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1, 2, 3, 4-tetrahydroisoquinoline-1 The preparation method comprises the following steps: firstly, carrying out a multi-step reaction on 5-bromovanillin, 4-hydroxyphenylacetic acid and 4-benzyloxy-3-methoxybenzaldehyde which are used as initial raw materials to obtain optical pure berbamine and spirosine, and then, carrying out a multi-step reaction on the optical pure berbamine and spirosine to obtain the optical pure berbamine and spirosine, and carrying out a reaction on the optical pure berbamine and spirosine to obtain the optical pure berbamine and spirosine. The synthesis route adopts a convergent synthesis mode, the synthesis efficiency is high, the reaction condition is mild, the safety is high, and the operation is simple and convenient.

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

The application belongs to the technical field of biological medicine, and particularly relates to a lactobacillus paracasei and application thereof. The lactobacillus paracasei ZY101 is preserved in the China General Microbiological Culture Collection Center, has a preservation number of CGMCC No. 32360, a preservation date of October 25, 2024, and an address of No. 3, Beichen West Road, Chaoyang District, Beijing. Compared with a commercial bacillus acidophilus, the apricot vinegar prepared by using the lactobacillus paracasei ZY101 has new substances including linalool, alpha-farnesene, 2-phenylacetic acid ethyl ester and geranylgeraniol, and further promotes the aroma of the apricot vinegar. Compared with the commercial bacillus acidophilus, the existing substances are obviously improved, and specifically include ethyl acetate, isoamyl acetate, ethyl octanoate, ethyl hexanoate, acetoin, methyl palmitate, gamma-deca-lactone, ethyl dodecanoate, delta-deca-lactone, trans-nerolidol and dihydro-beta-ionone.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

This invention provides a flavoring agent for enhancing the honey-sweet aroma of tobacco, comprising the following raw materials and their mass percentages: 0.2-0.3% 2,3-pentanedione, 0.45-0.55% phenylacetic acid, 0.45-0.55% phenethyl acetate, 0.25-0.4% phenylethanol, 0.45-0.6% methyl phenylacetate, 0.45-0.6% ethyl phenylacetate, 0.5-0.6% menthyl acetate, 0.15-0.25% geraniol, and the balance being propylene glycol. This invention belongs to the field of tobacco flavoring technology. By combining 2,3-pentanedione, phenylacetic acid, and phenethyl acetate in a specific mass ratio and conducting testing and evaluation, a flavoring agent suitable for enhancing the honey-sweet aroma of tobacco has been successfully developed. The composition is clearly defined, significantly improving the honey-sweet aroma of tobacco products, with a rich and long-lasting aroma, and good taste harmony.

The invention discloses a chitosan-based membrane as well as a preparation method and application thereof, and belongs to the technical field of packaging materials. The chitosan-based film has a double-layer structure consisting of an inner layer and an outer layer, the outer layer is a water-blocking antibacterial layer formed by a silver complex, and the inner layer is an antibacterial antioxidant layer formed by polyphenol; the silver complex is a complex which is formed by the reaction of pyrrole-2-formaldehyde-g-chitosan and silver acetate; the polyphenol is formed by grafting 3, 4-dihydroxy methyl phenylacetate on the chitosan. The silver complex water-blocking antibacterial layer is constructed on the outer layer, and the polyphenol antibacterial anti-oxidation layer is constructed on the inner layer, so that the double fresh-keeping mechanism of external protection and internal maintenance is realized, and the comprehensive performance and application potential of the material are remarkably improved.

The application provides a method for promoting the absorption of calcium elements by pineapple fruits, which comprises the following steps: three months after the pineapple plant is induced to bloom and four months after the pineapple plant is induced to bloom, gauze is soaked in an amino oxyacetic acid aqueous solution or a pyrazine amide aqueous solution, the soaked gauze is applied to the connection between the pineapple fruit and the fruit stem for 2-5 hours; the gauze is secondly soaked in an indole-3-acetic acid aqueous solution, an indole-3-butyric acid aqueous solution, a phenylacetic acid aqueous solution or an alpha-naphthylacetic acid aqueous solution, and the soaked gauze is again applied to the connection between the pineapple fruit and the fruit stem for 2-5 hours; the gauze is thirdly soaked in a 6-benzylaminopurine aqueous solution, a kinetin aqueous solution, a thidiazuron aqueous solution or a forchlorfenuron aqueous solution, and the soaked gauze is again applied to the connection between the pineapple fruit and the fruit stem for 2-5 hours. The application can inhibit the formation of the pineapple fruit stem delimitation, promote the absorption of calcium by the fruits, reduce the incidence of pineapple water core disease from about 18% to about 0.6%, and significantly improve the income of fruit farmers.

The invention discloses a recombinant microorganism for producing hydroxytyrosol as well as a construction method and application of the recombinant microorganism. According to the recombinant microorganism, 3-deoxy-D-arabinoheptulose-7-phosphate synthetase aroGfbr, chorismate mutase / pre-benzoic acid dehydrogenase tyrAfbr, 4-hydroxyphenylacetic acid 3-hydroxylase HpaBC, phenylpyruvate decarboxylase ARO10 and alcohol dehydrogenase ADH6 are subjected to overexpression, and the recombinant microorganism can be used for preparing the recombinant microorganism. The genome of the gene naturally comprises a citrate synthase coding gene gltA and a tyrosine aminotransferase coding gene tyrB; the original promoter of the gltA and / or the original promoter of the tyrB are / is replaced by a time sequence promoter PrrnC-37. When the recombinant microorganism is used for producing hydroxytyrosol, the production efficiency can be improved, and the production cost of hydroxytyrosol can be reduced.

The invention relates to a preparation method of oxybutynin, and particularly provides a preparation method of a condensing agent di (2-pyrimidinyl) carbonate and oxybutynin. According to the preparation method, 2-cyclohexyl-2-hydroxyphenylacetic acid and 4, 4-diethylamino-2-butyne-1-alcohol are used as raw materials, di (2-pyrimidinyl) carbonate is used as a condensing agent, condensation reaction is performed to prepare oxybutynin, the reaction yield and the product purity can be remarkably improved, and the reaction conditions are milder.

The application discloses a synthesis method of 2,4,5-trifluorophenylacetic acid, which comprises the following steps: S1, 1,2,4-trifluorobenzene is subjected to a chloromethylation reaction to obtain 2,4,5-trifluorobenzyl chloride; and S2, 2,4,5-trifluorobenzyl chloride is subjected to an electrolysis reaction with carbon dioxide to synthesize 2,4,5-trifluorophenylacetic acid. The method optimizes the synthesis process of 2,4,5-trifluorophenylacetic acid, has a short synthesis route, low cost, mild conditions, green safety, simple post-treatment and purification process, and is very suitable for industrialized scale production.

The application belongs to the field of detection reagents, and particularly relates to a single-component luminol chemiluminescence substrate liquid and a preparation method thereof. The single-component luminol chemiluminescence substrate liquid comprises the following components: sodium acetate, sodium perborate, N-N dimethylacetamide, beta-cyclodextrin, luminol, 4-morpholinopyridine, p-acetylaminophenol, 4-hydroxyphenylacetic acid, phenothiazine-10-yl-propyl sulfonic acid sodium salt and isothiazolinone. The purpose of the application is to solve the technical defects that the luminol chemiluminescence substrate liquid in the prior art must be packaged in two components due to the instability of the luminous agent and the oxidizing agent in the liquid phase, leading to inconvenient use and easy introduction of operation errors, so as to provide a single-component luminol chemiluminescence substrate liquid and a preparation method thereof, which have high storage stability, high luminous performance and convenient use.

The invention discloses a lactobacillus paragasseri strain capable of converting anthocyanin to generate various active metabolites, inhibiting NF-kappa B and cGAS-STING signals and enhancing inflammatory response relieving, and belongs to the technical field of microorganisms and the technical field of medicines. The lactobacillus paragasseri CCFM1499 provided by the invention can be used for converting anthocyanin into various active substances such as homovanillic acid, cyanidin, 3 ', 4'-dihydroxyphenylacetic acid and the like; fermentation supernate obtained by fermenting anthocyanin through the lactobacillus paragasseri CCFM1499 has the following effects: (1) the capability of reducing inflammatory factors of cells is achieved; (2) the cell senescence phenotypic capability is relieved; (3) the cGAS-STING signal channel capability is inhibited; and (4) inhibiting the NF-kappa B signal path capability. The lactobacillus paragasseri CCFM1499 fermented anthocyanin provided by the invention can be used for preparing a product for relieving inflammatory response, and has a huge application prospect.

The application relates to a reagent combination for detecting depression, a manufacturing method, a detection system and application thereof, and belongs to the technical field of instrument detection. The reagent combination for detecting depression comprises a calibrator, a quality control sample and an extraction solution of a to-be-detected compound serving as a biomarker; wherein the to-be-detected compound is at least three kinds selected from 5-hydroxyanthranilic acid, methionine, gamma-aminobutyric acid, 3,4-dihydroxyphenylacetic acid, 2-picolinic acid, quinolinic acid, kynurenine, 5-hydroxytryptamine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, dopamine and norepinephrine. The reagent combination for detecting depression and the detection system can significantly improve the accuracy of diagnosis, are convenient to detect, have good repeatability of detection data, are high in specificity, and are accurate in clinical diagnosis results.

The application belongs to the technical field of pigeon feed, and particularly relates to application of 4-hydroxyphenylacetic acid in preparation of a milk pigeon feed additive. A method for improving the growth performance and immune performance of a milk pigeon is provided, which comprises: additionally adding 4-hydroxyphenylacetic acid in milk pigeon milk replacer. Experiments prove that, after 500-2000 mg / kg of 4-hydroxyphenylacetic acid is additionally added in the milk pigeon milk replacer, the growth performance and immune performance of the milk pigeon are obviously enhanced, and the survival rate of the milk pigeon is improved, which has important significance for the large-scale breeding of meat pigeons.

The present application relates to the field of microbial technology, and particularly to a Pichia kudriavzevii (Pichia kudriavzevii) strain ZB448 and application thereof. Pichia kudriavzevi The Pichia kudriavzevii strain ZB448 provided by the present application has rich ester aroma, especially high content of phenylacetic acid ethyl ester, phenylacetic acid ethyl ester, ethyl acetate and isobutyl acetate, and significantly reduced content of ethyl octanoate; the aroma characteristics generated are strong fruit aroma and honey aroma and weak wine aroma, and the overall aroma is more pleasant and coordinated. The strain is used for fermentation of wheat protein seasoning juice, can effectively increase the content of ester aroma components in the product, weaken the adverse odor of bran koji, increase the content of umami amino acids, so that the product achieves the effect of rich ester aroma, rich aroma, and improved umami, and significantly improves the overall flavor and quality of the product.

This invention is entitled "A Method for Preparing an Intermediate of Aericoxib," belonging to the field of pharmaceutical preparation technology. The technical problem to be solved is to provide a method for preparing an intermediate of Aericoxib that is simple to operate, uses readily available raw materials, and has simple post-processing. The key points of the technical solution are that the preparation method includes the following steps: (1) 2-bromo-1-(4-methanesulfonyl)acetophenone, hexamethylenetetramine and solvent are reacted, filtered, hydrochloric acid and methanol are added, and the reaction is continued to obtain 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride; (2) 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride, p-methylphenylacetic acid, base 1 and solvent are mixed, reacted, cooled to -5℃-15℃, base 2 and 1-bromopropane are added, and the reaction is continued to obtain the intermediate.

This invention belongs to the field of product separation technology in enzymatic antibiotic synthesis, and particularly relates to a method for separating and recovering amoxicillin products from a one-step synthesis catalyzed by a Kluyveromycin β-subunit G385 mutant penicillin acylase. This application uses an immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from potassium penicillin. A method for separating amoxicillin and phenylacetic acid is developed for the obtained reaction mixture. The technical solution mainly includes: firstly, separating the immobilized penicillin acylase mutant from the reaction solution by filtration; then separating amoxicillin by crystallization; and finally, separating and recovering phenylacetic acid by toluene extraction, back-extraction, etc. This separation method can rapidly and efficiently separate amoxicillin with a high yield, with an average crystallization rate of 93.22%; simultaneously, the separation and recovery of phenylacetic acid is good; and the extractant toluene can be recycled.

The present disclosure provides a cyclic Gd (III) complex with a chemical structure shown in formula I, where a ring structure of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is used as a parent ring, lipophilic groups R′ and R″ in formula I are respectively introduced to a α-position of phenylacetic acid (PAA) and a benzene ring structure, and a chiral group R in formula I is introduced to a DOTA macrocycle position. The chiral group R can increase the rigidity of a macrocyclic structure and improve the stability of the complex, and the lipophilic groups R′ and R″ can bind to hepatocellular organic anion transporting polypeptides (OATPs), thereby greatly improving the distribution of the cyclic Gd (III) complex as a contrast agent in the liver and gallbladder, that is, thereby providing excellent targetability.

This invention relates to an industrial preparation method for 2-methylphenylacetic acid, comprising the following steps: under an inert solvent, 2-methylhalobenzene and malonate diester undergo a coupling reaction in the presence of a catalyst and base A to obtain compound one; compound one is hydrolyzed and decarboxylated under the presence of base B to prepare 2-methylphenylacetic acid; the chemical structural formula of compound one is: [formula missing], where R is a C1-C8 alkyl group. Compared with existing technologies, this invention uses inexpensive raw materials, is simple to operate, can react under normal pressure, has relatively mild conditions, is safe and environmentally friendly, and is easy to industrialize.

The application discloses a compound flower and fruit fragrance type latent fragrance compound, a preparation method and application and an application method, and has the following general formula: wherein R represents or. In the technical scheme, 2-amino methyl benzoate is used as raw material, and two acylated derivatives are prepared through acylation reaction. The two compounds are stable in chemical properties, and can release 2-amino methyl benzoate and phenylacetic acid (cinnamic acid) when pyrolyzed at high temperature, and can be applied to cigarettes as stable fragrance precursors to improve smoke and highlight product characteristics.

The invention belongs to the technical field of electrochemistry, and particularly relates to an electrode applied to preparation of phenylacetic acid by electrochemical oxidation of beta-phenethyl alcohol and a preparation method and application thereof. The electrode comprises a substrate and a plating layer arranged on the surface of the substrate, and the plating layer comprises iron, cobalt and nickel. According to the electrode, beta-phenethyl alcohol can be converted into phenylacetic acid through high-selectivity electrochemical catalysis, the selectivity and the current efficiency of the product phenylacetic acid are both larger than 90%, side reactions such as oxygen evolution can be greatly inhibited in the electrolysis process, the oxygen content is smaller than 5%, and it is guaranteed that the electrolysis reaction is carried out safely.

The application discloses a synthesis process of guanfacine hydrochloride, and the guanfacine hydrochloride raw medicine is obtained through three chemical reactions of urea methylation, amide condensation and amination reaction and one step of salification and recrystallization by taking 2,6-dichlorobenzoic acid and urea as starting materials. The starting material of the application is urea with lower selection cost, and the advantages are that a genotoxic impurity is easy to detect and the workshop detection cost is reduced; the intermediate is O-methyl isourea p-toluenesulfonate, and the advantages are that the intermediate has high stability and the quality is easy to control; and the amination reaction is performed by using ammonium chloride instead of ammonia water, so that the reaction cost is reduced and the workshop operation is more convenient.

Provided in the present invention are a suspended triple inhalation aerosol composition and a preparation method therefor. The aerosol composition comprises fluticasone furoate, vilanterol trifenatate, glycopyrrolate, a diluent, a surfactant and a propellant; has higher drug-delivery efficiency and drug-delivery dose, and higher lung deposition; and has the effects of better ameliorating Mch-induced elevated pulmonary resistance and decreased pulmonary compliance, thereby facilitating improvement to medication safety and patient compliance.

The invention discloses a Lactobacillus paracasei strain capable of converting truffle to generate various active small molecules, regulating and controlling collagen synthesis of skin cells and resisting aging, and belongs to the technical field of microorganisms. The lactobacillus paracasei CCFM1493 obtained through screening can produce m-hydroxyphenylacetic acid and salicylic acid by fermenting white truffle, the content of protocatechuic acid and dihydrocaffeic acid is increased, the skin quality is improved by regulating skin cell collagen synthesis, oxidation resistance and aging resistance, and it can be seen that the lactobacillus paracasei CCFM1493 can be used for preparing the traditional Chinese medicine composition. The fermentation liquor of the white truffle fermented by the Lactobacillus paracasei (Lactobacillus paracasei) CCFM1493 has a huge application prospect in the preparation of a product for improving the skin quality.