11 results about "Methyl phenylacetate" patented technology

The present invention relates to a synthetic method of 2-methyl-α-methoxyiminophenylacetic acid methyl ester, and the method flow comprises the following: Step 1: using o-methylphenylacetic acid or o-methylphenylacetamide or o-methylphenylacetic acid methyl ester as raw material, first directly oximating and esterifying with sodium nitrite in sulfuric acid in a solvent; Step 2: "one-pot method" hydrogenation of sodium hydroxide or potassium hydroxide to control pH value, and reacting with dimethyl sulfate to obtain 2-methyl-α-methoxyiminophenylacetic acid methyl ester. The present invention uses o-methylphenylacetic acid or o-methylphenylacetamide or o-methylphenylacetic acid methyl ester as raw material, and adopts safe and reliable sodium nitrite as oximation reagent, avoids using nitrite esters that are flammable and explosive, avoids using expensive methoxyamine hydrochloride, has safe and reliable reaction, low raw material cost, and adopts "one-pot method" in the operation process, has simple and smooth process, mild reaction conditions, and is suitable for industrialized amplification production.

This invention provides a flavoring agent for enhancing the honey-sweet aroma of tobacco, comprising the following raw materials and their mass percentages: 0.2-0.3% 2,3-pentanedione, 0.45-0.55% phenylacetic acid, 0.45-0.55% phenethyl acetate, 0.25-0.4% phenylethanol, 0.45-0.6% methyl phenylacetate, 0.45-0.6% ethyl phenylacetate, 0.5-0.6% menthyl acetate, 0.15-0.25% geraniol, and the balance being propylene glycol. This invention belongs to the field of tobacco flavoring technology. By combining 2,3-pentanedione, phenylacetic acid, and phenethyl acetate in a specific mass ratio and conducting testing and evaluation, a flavoring agent suitable for enhancing the honey-sweet aroma of tobacco has been successfully developed. The composition is clearly defined, significantly improving the honey-sweet aroma of tobacco products, with a rich and long-lasting aroma, and good taste harmony.

The invention discloses a chitosan-based membrane as well as a preparation method and application thereof, and belongs to the technical field of packaging materials. The chitosan-based film has a double-layer structure consisting of an inner layer and an outer layer, the outer layer is a water-blocking antibacterial layer formed by a silver complex, and the inner layer is an antibacterial antioxidant layer formed by polyphenol; the silver complex is a complex which is formed by the reaction of pyrrole-2-formaldehyde-g-chitosan and silver acetate; the polyphenol is formed by grafting 3, 4-dihydroxy methyl phenylacetate on the chitosan. The silver complex water-blocking antibacterial layer is constructed on the outer layer, and the polyphenol antibacterial anti-oxidation layer is constructed on the inner layer, so that the double fresh-keeping mechanism of external protection and internal maintenance is realized, and the comprehensive performance and application potential of the material are remarkably improved.

The pilocarpine p-methyl phenylacetate crystal form A disclosed for the first time is good in solid stability, free of crystal transformation and convenient to store for a long time. And the preparation process is simple, good in reproducibility, stable and controllable, and beneficial to industrial large-scale production.

The utility model discloses continuous washing equipment for methyl phenylacetate production, which comprises a barrel shell, a first washing tank, a second washing tank and a third washing tank, the first washing tank, the second washing tank and the third washing tank are sequentially arranged in the barrel shell, the bottom end of the first washing tank is connected with the top end of the second washing tank through an electric valve, and the bottom end of the third washing tank is connected with the top end of the third washing tank. The bottom end of the second washing tank is connected with the top end of the third washing tank; through grooves are formed in the positions, located at the joint of the first washing tank and the second washing tank, of the barrel shell, the joint of the second washing tank and the third washing tank and the bottom of the third washing tank, of the barrel shell. Flow of the adjacent washing tanks can be achieved through gravity, a lifting pump does not need to be installed for conveying a solution, the cost is saved, meanwhile, the first washing tank, the second washing tank and the third washing tank are reasonably installed in the barrel shell, and the occupied space is saved.

The invention relates to the technical field of organic synthesis, and discloses a synthesis method of (E)-2-methyl-alpha-methoxyimino methyl phenylacetate. According to the invention, o-methyl phenylacetonitrile is used as a raw material, and a series of steps such as oximation, first methylation, alkaline hydrolysis, second methylation and acidic rearrangement are carried out to obtain (E)-2-methyl-alpha-methoxyimino methyl phenylacetate. According to the method provided by the invention, the byproduct salt amount is greatly reduced, and the atom utilization rate is greatly improved; the organic solvent dosage is reduced, and the equipment utilization rate is greatly improved; according to the method, methylation reaction conditions are optimized, high reaction activity is obtained while the use amount of a methylation reagent is reduced, meanwhile, excessive methane chloride needing to be recycled is greatly reduced due to the fact that the use amount of methane chloride is reduced, the tail gas treatment amount is small, equipment is relatively simple, and the operation cost is low; besides crystallization operation, the whole reaction process is gas-liquid or liquid-liquid reaction, so that the mass and heat transfer effect is improved, and subsequent continuous transformation is facilitated.

The invention provides a preparation method and application of methyl 2-hydroxyphenylacetate. The methyl 2-hydroxyphenylacetate is separated from a fermentation culture of streptomyces wetland 13-3 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No. 22830. According to the method, the compound methyl 2-hydroxyphenylacetate is obtained from streptomycete for the first time, verification proves that the methyl 2-hydroxyphenylacetate has broad-spectrum antibacterial activity on various plant pathogenic fungi, particularly, the inhibitory activity on aspergillus fumigatus, colletotrichum truncatum, rhizoctonia solani, verruca verrucosa and magnaporthe oryzae is higher than that of amphotericin B, and the methyl 2-hydroxyphenylacetate can be used for preparing antibacterial agent drugs and has broad-spectrum antibacterial activity. A novel natural antibacterial compound is provided for the fields of agriculture and medicine, and the method is simple and convenient to operate, high in purification efficiency and environment-friendly.

The invention discloses polysubstituted pentene diacid ester as well as a synthesis method and application thereof, and belongs to the technical field of medicine synthesis. The structure of the polysubstituted pentene diacid ester is # imgabs0 #. According to the method, the polysubstituted pentene diacid ester is synthesized from diazo-2-methyl fluorophenylacetate and bicyclo [1.1. 0] butane-1-benzyl formate, the reaction conditions are mild, the used reagents and raw materials are cheap and easy to obtain, and the catalytic efficiency is high. The polysubstituted pentene diacid ester synthesized by the invention shows excellent bacteriostatic activity on tomato early blight, wheat gibberella, phytophthora capsici and cucumber gray mold, and can be used as a plant bacteriostatic agent.

The invention belongs to the technical field of complexes and application thereof, and provides a side chain modified nitrosyl iron sulfide complex and a preparation method and application thereof. The side chain modified nitrosyl iron sulfur complex is a nitrosyl iron sulfur complex [Fe2 (-SL) 2 (NO) 4] taking [Fe2S2 (NO) 4] 2-as a raw material and halogenated hydrocarbon as a ligand, L is a ligand modified on an S atom, and the halogenated hydrocarbon is 3, 5-dimethoxybenzyl bromide, 3-bromomethylbenzonitrile, 4-bromomethylphenylacetate or 3-bromomethylphenylboronic acid. And the compound can be stably formed with the human serum albumin and can be used as a nitric oxide donor for preparation and can be applied as a nitric oxide donor. All the complexes can be recognized and combined with serum albumin, the crystal structure of the complex shows that the nitrosyl iron sulfur complex can be combined in the region of a serum albumin structural domain 1, and the formed complex also has the properties of light-induced nitric oxide release and obvious inhibition of human cervical cancer cell growth activity.

The invention provides a preparation method of 3-isochromone, and relates to the technical field of organic synthesis. Specifically, methyl phenylacetate and N, N-dimethylformamide are used as raw materials, and 3-isochromone is prepared through a Vilsmeier-Haack reaction; preferably, the methyl phenylacetate, the N, N-dimethylformamide and the phosphorus oxychloride are mixed, a Vilsmeier-Haack reaction is carried out, then an intramolecular condensation reaction is carried out, and the 3-isochromone is prepared. The method has the advantages of simple and easily available starting materials, short reaction steps and no use of highly toxic chemicals, provides a new route for expanding the synthesis method of 3-isochromone, and has a good application prospect.

The invention relates to the technical field of compound purification, and discloses a static melt crystallization purification method of 2-(((6-(trifluoromethyl)-2-pyridyl) oxy) methyl) methyl phenylacetate, which comprises the following steps: S1, first-stage static crystallization: the cooling rate is 0.5-5 DEG C / h, the crystallization temperature is 25-35 DEG C, the crystallization amount is controlled to be 60-90%, then segmental sweating purification is performed, and a product is extracted; and S2, secondary mother liquor recovery and crystallization: carrying out static crystallization at the cooling rate of 1-7 DEG C / h and the crystallization temperature of 20-35 DEG C, and then sweating and extracting a secondary crystallization product. According to the invention, through a gradient melt crystallization coupling segmented sweating technology, 94.6% of raw materials are purified to 99.7% or more (single impurity content is less than 0.1%, toluene residue content is less than 0.3%, and water content is less than 0.1%) at a single time; mother liquor is recycled, crystallized and purified to the raw material level and then reused, and the total yield breaks through 90% and is improved by 20% or above compared with solvent crystallization; and on the basis of residual liquid control of the lowest co-melting point, the waste liquid discharge amount is reduced by 50%. The method solves the problems of purity, yield and environmental protection bottlenecks of solvent crystallization within 12 hours, and is suitable for industrial continuous production.