12 results about "Ipratropium bromide" patented technology

The invention relates to the technical field of osmotic pressure testing, and particularly discloses an optimization system for osmotic pressure testing of an ipratropium bromide solution, which comprises a data acquisition module, a data processing module and a data processing module, the data recording module records the operation state data of the conductivity acquisition instrument in the use process, and the operation state of the conductivity acquisition instrument directly affects the accuracy of the conductivity data of the standard solution, so that the operation state of the conductivity acquisition instrument can be analyzed based on the data; the conductivity data can be corrected, so that the data is closer to a true value, the reliability of a quality analysis result of a standard solution is improved, the accuracy of a precision detection result of an osmotic pressure detection instrument and an osmotic pressure detection result of an ipratropium bromide solution is further improved, and the optimization of an osmotic pressure detection method is realized.

The invention belongs to the technical field of medicine. The invention relates to the field of eye drops, in particular to application of ipratropium bromide in the aspect of preventing or improving myopia and eye drops containing ipratropium bromide. The research proves that the single drug of the ipratropium bromide can effectively inhibit the growth of the ocular axis and the deterioration of the diopter, and the brand new medicinal value of the ipratropium bromide in the aspect of preventing and improving the myopia is disclosed for the first time. More importantly, the invention finds that the combination of the ipratropium bromide and the diquafosol sodium can generate a remarkable synergistic effect, and the curative effect of the combined preparation is far better than that of a single drug and even better than that of a clinical drug atropine. The invention provides a safe, effective and long-term brand new drug choice for myopia prevention and control, and has good application prospect and value.

Disclosed are medicinal compositions, and devices, methods and systems which provide ipratropium bromide carried by at least 1234ze(E) and ethanol.

Disclosed are medicinal compositions, and devices, methods and systems which provide ipratropium bromide carried by at least 1234ze(E) and ethanol.

1. Name of the designed product: packing box (ipratropium bromide). 2. Use of the designed product: the designed product is used for packing ipratropium bromide solution for inhalation. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The present invention relates to a metered dose inhaler device comprising a stable inhalable composition of ipratropium bromide, contained in a canister fitted with a metering valve, an actuator and a dose indicator. The present invention also relates to a process for preparing such a pharmaceutical composition and its use in the treatment of respiratory disorders such as for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema in a subject in need thereof (e.g., a human).

Disclosed are medicinal compositions, and devices, methods and systems which provide ipratropium bromide carried by at least 1234ze(E) and ethanol.

The present invention relates to a pressurized metered dose inhaler (pMDI) comprising: a container; a pharmaceutical formation under pressure in the container, said pharmaceutical formulation comprising: (i) about from about 75% by weight to about 87% by weight HFO-1234ze(E); (ii) from about 13% by weight to about 25% by weight of ethanol; and (iii) ipratropium bromide in solution in said ethanol and / or said HFO-1234ze(E); a normally closed valve on the container; and an actuator fluidly connected to the valve and having an orifice diameter of less than 0.5 mm, said valve being actuatable to an open position to release said pharmaceutical formulation to pass through said orifice and produce an aerosol spray containing ipratropium bromide in solution.

The invention belongs to the technical field of medicine synthesis processes, and particularly provides a preparation method of ipratropium bromide, one-pot synthesis is adopted, separation operation is not needed in the process, lithium tert-butoxide is adopted as a reaction raw material, the total yield of a reaction route and the purity of a product are remarkably improved, the purity of the prepared ipratropium bromide product can reach 99.95% or above, and the yield of the ipratropium bromide product can reach 99.95% or above. The method has the advantages of short production period, less output of three wastes, environmental protection, high process safety, low production cost, simple operation, mild reaction conditions, high purity and high yield, and is suitable for industrial production.

The present invention relates to a metered dose inhaler device comprising a stable inhalable composition of ipratropium bromide, contained in a canister fitted with a metering valve, an actuator and a dose indicator. The present invention also relates to a process for preparing such a pharmaceutical composition and its use in the treatment of respiratory disorders such as for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema in a subject in need thereof (e.g., a human).

The invention relates to the technical field of pH value measurement, in particular to a device and method for measuring the pH value of an ipratropium bromide solution for inhalation, the device comprises a host unit and a pH electrode probe connected with the host unit through a wire, and an embedded control seat is fixedly arranged in the host unit; the bottom of the solution cup and the embedded control seat are detachably mounted in a butt joint manner; an inert gas compression tank and a main gas valve are arranged in the host unit; a breaking control column is fixedly arranged at the bottom of the embedded control seat; according to the device for measuring the pH value of the ipratropium bromide solution for inhalation, the influence of carbon dioxide in air on the pH value of the ipratropium bromide solution can be greatly reduced under the working condition that the ipratropium bromide solution needs to be measured for a long time such as multiple times of measurement, and the measurement accuracy is improved.

This invention provides a method for determining impurities in ipratropium bromide inhalation solution, belonging to the field of pharmaceutical detection technology. The method involves preparing a test solution from the ipratropium bromide solution, using a mixture of ammonium acetate buffer and acetonitrile as mobile phase A and an acetonitrile mixture as mobile phase B, followed by isocratic elution at a volume ratio of 30:70 and high-performance liquid chromatography (HPLC) to detect impurities sulfur and butylated hydroxytoluene (BHT) in the ipratropium bromide solution. This invention employs HPLC, resulting in more accurate and consistent results with theoretical predictions. Furthermore, the method exhibits satisfactory recovery and specificity, high accuracy, and high precision. It provides a novel and accurate method for determining sulfur (S) and BHT in ipratropium bromide inhalation solution, enabling better quality control and evaluation of ipratropium bromide inhalation solutions.