2 results about "Phenylacetate" patented technology

The application relates to the technical field of catalytic materials, and relates to an organic photocatalytic material and a preparation method thereof.1, comprising the following steps: mixing modified N-hydroxy phthalimide phenylacetate, an aliphatic nitroalkane, 2,6-dimethylpyridine, a photocatalyst and a solvent, then irradiating under visible light, placing in an inert atmosphere, stirring for 2-8 hours, and obtaining a product through post-treatment to obtain a final product; the mass ratio of the modified N-hydroxy phthalimide phenylacetate, the nitro compound, the 2,6-dimethylpyridine, the photocatalyst and the solvent is 2-5:1-2:1-3:1:8-11. The visible light catalysis method can be used to synthesize the nitro compound under mild conditions, and further provides a green and efficient new path for the preparation of a nitrogen-containing drug intermediate.

This disclosure relates to crystalline and solvate forms of nucleoside reverse transcriptase translocation inhibitors (NRTTIs), and their pharmaceutical compositions, which are useful for the treatment and prevention of Retroviridae virus infections, including infections caused by the HIV virus. This disclosure particularly provides crystalline forms of (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purine-9-yl)-2-ethynyl-2-((2-phenylacetoxy)methyl)tetrahydrofuran-3-yl 2-phenylacetate, selected from crystalline form II, crystalline form III, crystalline form IV, and crystalline form V.