181 results about "Phenylacetate" patented technology

The present invention relates to use of ornithine in the manufacture of a medicament for use in combination with at least one of phenylacetate and phenylbutyrate for preventing or treating liver decompensation or hepatic encephalopathy. The invention also relates to use of at least one of phenylacetate and phenylbutyrate in the manufacture of a medicament for use in combination with ornithine for preventing or treating liver decompensation or hepatic encephalopathy.

The invention discloses a preparation method of 2-(4-haloethyl) phenyl-2-methyl propionic ester and a synthesis method of bilastine, which comprises the following steps of: carrying out acylation reaction on 2, 2-dimethyl phenylacetate and halogen acetyl halides under the action of catalyst, to generate 2-(4-halogen acetyl) phenyl-2-methyl propionic ester; carrying out kishner-wolff-huang reduction reaction on the 2-(4-halogen acetyl) phenyl-2-methyl propionic ester, to reduce the carbonyl so as to generate the 2-(4-haloethyl) phenyl-2-methyl propionic ester; having condensation reaction with 1-ethoxy ethyl-2-pyridine-4-group benzimidazole by taking the 2-(4-haloethyl) phenyl-2-methyl propionic ester as a midbody to obtain esterified bilastine; and hydrolyzing, to generate the bilastine. The novel synthesis method of the bilastine provided by the invention can easily obtain raw materials, and is simple to operate, lower in cost, environment-friendly, and completely suitable for the industrial production.

Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio, at an infusion rate of from 100 mL / hr to 400 mL / hr. In a further embodiment, herein is also disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetate and (phenylacetylglutamine or phenylacetylisoglutamine) in a 4:1 ratio, at an infusion rate of from 100 mL / hr to 400 mL / hr. Herein are also disclosed the pharmaceutical compositions used in the above methods.

Compositions and methods of treating anemia, cancer, AIDS, or severs beta -chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.

The invention relates to epoxy resin polymer mortar and a production process thereof. The mortar is prepared from the following components in parts by weight: 15-20 parts of epoxy resin slurry, 2-4 parts of an active diluent, 6-8 parts of a curing mixture and 70-80 parts of a base material which are mixed, stirred and mixed, wherein the epoxy resin slurry is prepared from bisphenol A epoxy resin E51, modified epoxy resin, organic bentonite and dioctyl phthalate; the active diluent is prepared from epoxy chloropropane, fatty alcohol and trichloropropane; the curing mixture is prepared from 85 parts of modified phenolic aldehyde amine, hydroxy-terminated liquid nitrile rubber, 2-(3, 4-expoy cyclohexyl) ethyl triethoxyl silane, lauryl phenylacetate and resorcinol; the base material is prepared from ordinary portland cement, quartz sands, hydrophobic expanded perlite, refined graphite powder and sericite powder. The epoxy resin polymer mortar provided by the invention not only has excellent mechanical property and wear resistance, but also has a good adhesive performance, and can be integrally formed with substrate concrete.

The invention relates to the process for purifying acrylic acid which comprises using novel organic extracting agent to separate acrylic acid from its water solution, then removing light compositions such as water and acetic acid by azeotropic fractional distillation, wherein the organic extracting agent comprises toluene, acetic ether, butyl acetate, butyl acetate, propionic ether, diisobutyl ketone, isophorone, methyl phenyl ether or their mixture, preferably the composite compound of toluene with isobutyl phenylacetate, the mass ratio of toluene and isobutyl phenylacetate is between 1:1-1:50, preferably 1:2-1:12. The process according to the invention can realize high acetic acid removing ratio.

Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.

The invention mainly discloses a synthetic method of p-hydroxyacetophenone. According to the synthetic method, phenol and acetic anhydride are taken as raw materials so prepare phenylacetate; under catalytic action of aluminium trichloride, o-dichlorobenzene is added for reaction, steam distillation is carried out, active carbon filtration is carried out, and crystallization is carried out so as to obtain p-hydroxyacetophenone; and then p-hydroxyacetophenone is also prepared via two times of circular reaction of o-dichlorobenzene layer and phenylacetate, wherein the o-dichlorobenzene layer contains o-hydroxyacetophenone and is obtained via layering of a product of the former reaction. Compared with the prior art, the synthetic method possesses following advantages: side product suppression assistant circulating method (three times of continuous operation, and two times of circulation) is adopted, o-dichlorobenzene containing o-hydroxyacetophenone is used in circulation process, generation of o-hydroxyacetophenone in subsequent process is reduced effectively, p-hydroxyacetophenone yield is increased by 10% at least, and HPLC detection purity is 99.7% or higher. The synthetic method is capable of increasing p-hydroxyacetophenone yield, realizing reasonable cyclic utilization of side product, and reducing production cost, and is suitable for industrialized production.

The invention discloses a method for synthesizing hydroxytyrosol. With 3,4-dialkoxy alkyl phenylacetate shown as the structural general formula (I) as raw material, sodium / alcohol is used for carrying out reduction to obtain the hydroxytyrosol, and R1, R2 and R3 are respectively selected from C1-C6 alkyl or C6H5CH2. Compared with a method reported by literature, the method disclosed by the invention has the advantages that raw materials are available, cost is low, operation is simple, requirement to production condition and equipment is low, and industrialization is easy to realize.

The present invention relates to use of ornithine in the manufacture of a medicament for use in combination with at least one of phenylacetate and phenylbutyrate for preventing or treating liver decompensation or hepatic encephalopathy. The invention also relates to use of at least one of phenylacetate and phenylbutyrate in the manufacture of a medicament for use in combination with ornithine for preventing or treating liver decompensation or hepatic encephalopathy.

The invention discloses a peach essence. The peach essence consists of the following ingredients: propanediol, hexanol, hexenyl phenylacetate, benzaldehyde, ethyl acetate, phenylacetic acid cis-3-ester hexane, methyl acetate, hexyl acetate, hexyl trans-2-ester hexane, ethyl maltol, leaf alcohol, hexanal, acetic acid, linalool, gamma-caprylolactone, theta-decalactone, gama-decalactone, gamma-undecalactone, 8-mercaptomenthone, 2-isopropyl-4-methylthiazole, beta- damascenone, ethyl caprate and ethyl benzoate. The peach essence is moderate in fragrance, saturated, thick, stable in quality, natural in flavor and approximat to the natural fragrance of peach.

Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels.wherein, X, R1, and R3 are as defined herein.

The invention relates to a preparation method of an M-choline receptor blocking agent of ipratropium bromide 1. The preparation method comprises the following steps of using ethyl phenylacetate as starting raw materials; performing reaction with isopropyl tropanol; generating phenylacetate isopropyl tropeine; then, performing substitution, reduction and addition reaction to obtain the ipratropium bromide. The method has the advantages that the operation is simple; safety and controllability are realized; the work protection is low; the preparation method is suitable for industrial production. The formula is shown as the accompanying drawing, and the molecular weight is 412.36.

The invention provides preparation methods for the drug clopidogrel used for resisting platelet aggregation and intermediates thereof. According to a technical scheme provided by the invention, reaction conditions are mild, the utilization rate of a brominating agent is high, usage of a high-toxicity brominating agent is avoided; and compared to the prior art, the preparation methods have the beneficial effects of low cost, low pollution, low energy consumption, high yield and the like, provide high purity intermediates for preparation of clopidogrel and effectively reduce preparation cost for clopidogrel products.

The invention discloses a honey essence having natural flavour of honey and a preparation method thereof; the honey essence is prepared from linalool oxide, glycerol triacetate, ethanol, propylene glycol, phenethanol, damascenone, ethyl maltol and honey base; the honey base is a composition of damascenone, rose geranium oil, 4-hydroxyl-2,5-dimethyl-3(2H) furanone, triethyl citrate, methyl anthranilate, vanillin, caproic acid, n-nonanoic acid, 2-acetylfuran, 2- methyl butyric acid, alpha-terpilenol, butyric acid, benzaldehyde, phenylethyl phenylacetate, phenethyl acetate, phenethyl butyrate and propylene glycol; the honey essence is prepared by mixing propylene glycol with ethyl maltol, heating, dissolving, cooling to room temperature and adding glycerol triacetate, ethanol, linalool oxide, phenethyl alcohol, damascenone and the honey base; and the honey essence disclosed by the invention has better honey sweet flavour.

The invention provides a honey-sweet type cigarette paper essence and a preparation method thereof. The cigarette paper essence comprises the components according to the total weight of 1000 parts: 1-4 parts of beeswax absolute oil, 2-5 parts of celery seed oil, 5-15 parts of ethyl vanillin, 30-50 parts of phenethyl phenylacetate, 0.5-2 parts of ethyl phenylacetate, 0.1-0.5 parts of ethyl caproate, 1-5 parts of delta-decalactone, 1-5 parts of gamma-nonanoic lactone, 5-15 parts of a cocoa extract, 5-15 parts of a coffee extract, 100-200 parts of propylene glycol, and the balance a 70% ethyl alcohol. The cigarette paper essence has the beneficial effects that: 1, the flavor is rich in hierarchy, can be coordinated with a tobacco original flavor, and can give cigarettes a unique style; 2, a small amount of addition of the essence can bring a prominent and lasting smell to the cigarettes; and 3, the loss of the aroma brought by reducing tar and harmful components is made up, a relatively good modification effect is played on the overall organoleptic characteristics of the cigarettes, and the quality of the cigarettes is facilitated to be improved.

The invention relates to the process for purifying acrylic acid which comprises using novel organic extracting agent to separate acrylic acid from its water solution, then removing light compositions such as water and acetic acid by azeotropic fractional distillation, wherein the organic extracting agent comprises toluene, acetic ether, butyl acetate, butyl acetate, propionic ether, diisobutyl ketone, isophorone, methyl phenyl ether or their mixture, preferably the composite compound of toluene with isobutyl phenylacetate, the mass ratio of toluene and isobutyl phenylacetate is between 1:1-1:50, preferably 1:2-1:12. The process according to the invention can realize high acetic acid removing ratio.

The invention provides a dihydric-2-acyl phenylacetate with a novel structure, a preparation method and application thereof, and relates to a compound containing the structure of the dihydric-2-acyl phenylacetate. The preparation method comprises the following steps: using dihydroxybenzoic acid 1 as a raw material, esterifying the dihydroxybenzoic acid 1, protecting hydroxyl group, reducing ester group to alcohol 4, and then treating the alcohol 4 by methylsulfonyl chloride and potassium cyanide in turn, obtaining cyanide 6, and then obtaining corresponding phenylacetate 8 by the action of alcohol and the cyanide 6 after the cyanide 6 is hydrolyzed into carboxylic acid; and obtaining an acidylation product (9) by the reaction of the phenylacetate 8 and R<2>CO2H under the action of trifluoroacetic anhydride or polyphosphoric acid, and finally removing the protected group to obtain the dihydric-2-acyl-phenylacetate CsA. Moreover, the dihydric-2-acyl-phenylacetate CsA can also be prepared by adopting an ester exchange method under acid catalysis. The related preparation method has the characteristics of easily obtained reagent, simple operation, high yield, and the like.

The invention belongs to the field of pharmaceutical chemicals and relates to a preparation method for L-ornithine phenylacetate. The preparation method comprises the following steps of: mixing L-ornithine aqueous solution with phenylacetic acid solution; stirring and reacting the mixture; and crystallizing the obtained L-ornithine phenylacetate solution to separate out L-ornithine phenylacetate in the form of crystal. The preparation method is a one-step reaction, has a simple and gentle process, provides effective reference for the high purity and industrialization of the L-ornithine and phenylacetic acid, has a low toxic and side effect of the product, and ensures the safety of clinical medication. Compared with the prior art, the preparation method provided by the invention has low cost, high yield, and high product purity, and is suitable for industrial production.

High-yield copper sulphide ore flotation agents are made from the following raw materials including by weight, 10-15 parts of engine oil, 9-13 parts of phenethyl phenylacetate oil, 2-3 parts of lime, 15-20 parts of O-isopropyl-N-sulfur ethyl carbamate, 4-6 parts of sodium sulphide, 4-6 parts of sodium mercaptoacetate, 24-27 parts of xanthate, 5-7 parts of chitosan, 2-3 parts of Turkey red oil, 1-2 parts of polyether modified silicone and 4-5 parts of activating agents. The high-yield copper sulphide ore flotation agents are good in copper collecting performance, high in copper yield, good in selectivity, good in rejection capability of other minerals, high in copper grade, stable in pH value, stable in foam and good in flocculation effect. The activating agents comprise nanometer jade powder and other constituents, are stable in dispersion, good in permeability and activation performance, long in duration time of the activation time and capable of improving the yield and grade of copper. The high-yield copper sulphide ore flotation agents can obviously improve the metal recovery rate of copper sulphide ore, make full and effective use of ore resources and create good economical and social benefits.

The invention discloses 7 alpha-hydroxysteroid dehydrogenase as well as a coding gene and application thereof. An amino acid sequence of the 7 alpha-hydroxysteroid dehydrogenase provided by the invention is shown as SEQ ID NO. 1, and a nucleotide sequence of the 7 alpha-hydroxysteroid dehydrogenase gene is disclosed and shown as SEQ ID NO. 2. The 7 alpha-hydroxysteroid dehydrogenase can catalyze asubstrate taurocholic acid (TCA) to generate taurine 7-ketone cholic acid (T7K-CA), catalyze a substrate glycocholic acid (GCA) to generate glycine 7-ketone cholic acid (G7K-CA), catalyze a substratetaurochenodeoxycholic acid (TCDCA) to generate taurine 7-ketone lithocholic acid (T7K-LCA), catalyze a substrate glycochenodeoxycholic acid (GCDCA) to generate glycine 7-ketone lithocholic acid (G7K-LCA) and catalyze a substrate ethyl benzoylformate (EB) to generate ethyl 2-hydroxy-2-phenylacetate, and has better catalytic activity, has a catalytic activity to TCDCA, GCDCA and EB 10, 5, and 3 times that of sardinia clostridium 7 alpha-HSDH, correspondingly, and has great industrial application value.

The invention provides a method for synthesizing 3-alkoxy-4-alkoxycarbonyl phenylacetate and 3-alkoxy-4-alkoxycarbonyl phenylacetic acid. The method for synthesizing 3-alkoxy-4-alkoxycarbonyl phenylacetate comprises: 3-alkoxy-4-methyl benzoate reacts with the chloro-carbonate on the effect of strong base in the organic solution at 190 deg.-0 deg. to obtain the product; the method of the 3-alkoxy-4-alkoxycarbonyl acetic ether cheesed hydrolysis to obtain the 3-alkoxy-4-alkoxycarbonyl phenylacetic acid.

The invention discloses a method for preparing phenylacetate. The method comprises the following steps of: 1, mixing phenol and acetic acid in a molar ratio of 1:1.1, andsimultaneously adding the mixture into pyridine propyl sulfonic acid ionic liquid, wherein the ratio of the pyridine propyl sulfonic acid ionic liquid to the mixture of the phenol and the acetic acid is 1ml:1.05mol; 2, heating the mixed solution in oil bath, wherein the temperature is controlled to be between 120 and 130 DEG C; and 3, refluxing for 2 to 6 hours, performing distillation to remove the unreacted phenol and acetic acid, and collecting the phenylacetate separated at the temperature of between 190 and 195 DEG C. The method has the advantages that: the pyridine propyl sulfonic acid ionic liquid is used as a catalyst; the use of a solvent is avoided; the operation is simple and safe; the production cost is low; and the industrialization of phenylacetate can be realized easily.

The invention discloses a method for preparing phenylacetate by using an ionic liquid and belongs to the field of organic chemical synthesis. According to the method, phenylacetate is prepared by taking phenol and acetic anhydride as starting raw materials and using the ionic liquid which is good in thermal stability, difficult to volatilize and recyclable as a catalyst and a solvent. In the method, no any other poisonous and harmful catalysts and volatile organic solvents are used, reaction condition is moderate, synthesis process is simple, requirement for equipment is low and yield is high. The method disclosed by the invention is an environment-friendly efficient new method for synthetizing phenylacetate.

The invention relates to single hydroxyl-2-acyl phenylacetic acid easter, a preparation method and the application thereof, which relates to a compound containing single hydroxyl-2-acyl phenylacetic acid easter structure, and provides single hydroxyl-2-acyl phenylacetic acid easter with novel structure, the preparation method and the application thereof. Single hydroxyl benzaldehyde 1 is used as raw material and is firstly converted into corresponding aryl benzene propanoic acid 2 by using Meldrum acid; under the effect of AlCl3, intramolecular acidylation happens to 2 to get compound 3; after passing through a protective hydroxyl, 3 is reacted with grignard reagent to get corresponding alkane coumarone 5 which is oxidized to get 2-acyl-phenylacetic acid compound 6; 6 is esterified by different sterols, and then a protecting group of 6 is removed to get the product single hydroxyl-2-acyl-phenylacetic acid easter CsM. The compound CsM can be used as potential anti cancer drug or other biological activity drugs.

The invention provides methoxyimino phenylacetate compounds containing nitrohydrazinecarboximidamide structures as well as a preparation method and an application of the methoxyimino phenylacetate compounds. The structural formula of each compound is represented as the formula I, wherein R1 is H, C1-C10 saturated or unsaturated aliphatic hydrocarbon, phenyl, substituted phenyl, pyridine-2-yl, substituted pyridine-2-yl, pyridine-3-yl, substituted pyridine-3-yl, pyridine-4-yl, substituted pyridine-4-yl, thiazole-2-yl, substituted thiazole-2-yl, furan-2-yl, substituted furan-2-yl, benzyl, substituted benzyl, phenethyl, substituted phenethyl, 2-hydroxy-1-naphthyl or 3-substituted phenyl propane-2-yl; R2 is hydrogen or C1-C10 alkyl. An insecticidal and bactericidal activity experiment proves that the compounds represented in the formula (I) have good biological activity, can effectively prevent crops from being invaded by insects and harmful bacteria and can be used as plant insecticidal and bactericidal agents.

The invention discloses a supported catalyst for diphenyl carbonate synthesis by reaction of phenylacetate and dimethyl carbonate and a preparation method thereof. The active components of the catalyst are molybdenum oxide and vanadium oxide, wherein the carrier of the catalyst is a molecular sieve, the charge capacity of the carrier is between 12.5 and 75 percent, and the ratio scope of the amounts of the molybdenum oxide and the vanadium oxide is (2.6:1)-(17:1). The catalyst has the characteristics of high catalytic activity, high selectivity, long service life and the like, and has high industrial application value.

The invention relates to essence with the fragrance of thick broad-bean sauce and a preparation method of the essence. The essence is prepared from furanone, methyl cyclopentenolone, ethyl vanillin, ethyl maltol, propanediol, 2-acetyl pyrrole, butyric acid, anisic aldehyde, 4-methyl-5-ethoxyl-thiazole, 4-methyl-5-acetoxy ethyl thiazole, ethyl myristate, phenylethyl phenylacetate, 4-guaethol, 2-acetyl furan, 3-methylmercapto-propanol, lactic acid, 2-methylpyrazine, 2,3,5-trimethylpyrazine, 2-acetyl thiazole, 3-methylmercapto-propanal, ethyl butyrate and glacial acetic acid. According to the essence, the specific property of the fragrance of the thick broad-bean sauce is ensured, and the essence has the joyful sour and sweet sauce fragrance, is lasting, comfortable, strong and stable in fragrance, and has the note which is the same as that of the characteristic fragrance of the thick broad-bean sauce. In addition, the heat resistance of the essence is higher than that of the fragrance of the thick broad-bean sauce, and the fragrance retention period is also longer than that of the fragrance of the thick broad-bean sauce. The method for preparing the essence is simple and is suitable for large-scale production, and the essence is easy to produce in a large scale.

The invention relates to a powerful glass detergent which is prepared from the following raw materials in parts by weight: 6-10 parts of ethylene glycol, 3-9 parts of triethylenediamine, 4-8 parts of zinc chloride, 6-9 parts of lauryl phenylacetate, 6-8 parts of alkanolamide, 5-10 parts of sodium lauryl sulfate, 5-8 parts of silicon dioxide, 5-9 parts of calcium silicate, 6-9 parts of polydimethylsiloxane, 5-8 parts of phenyl toluate, 3-9 parts of Gleditsia sinensis powder and 5-10 parts of nonylphenol polyethenoxy ether. The powerful glass detergent can remove stubborn stains on the glass, has certain bactericidal action, and reduces the generation of viruses and microbes.