16 results about "Nitroalkane" patented technology

The invention discloses a method for constructing a highly conjugated aromatic ring system from bio-based (Z)-3-hexene-2, 5-diketone, and the method comprises the following steps: preparing a 1, 3-dinitroalkane aromatic compound with high yield from a bio-based aldehyde substance in nitromethane through a nickel-based catalyst, and then carrying out ring opening on the 1, 3-dinitroalkane aromatic compound and electro-catalytic 2, 5-dimethylfuran to prepare the highly conjugated aromatic ring system from the bio-based (Z)-3-hexene-2, 5-diketone and the bio-based (Z)-3-hexene-2, 5-diketone. The high-conjugation biaromatic ring system is constructed through the reaction of 1, 5-diketone; the preparation method has the advantages that the yield is high, the greenization degree is high, and the obtained highly conjugated biaromatic ring system has high bio-based content (gt; 86%), and has a high application value.

The invention discloses a synthesis method of a novel fluorine-containing allyl tertiary nitro alkane compound, which comprises the following steps: by taking a gem-difluorocyclopropane derivative and sec-nitro alkane as raw materials, carrying out ring opening on gem-difluorocyclopropane under the catalysis of transition metal to generate a fluorine allyl-metal complex; and then reacting with sec-nitro alkane to obtain the straight-chain fluorine-containing allyl tert-nitro alkane compound. The method has obvious advantages in the aspects of synthesis conditions and practicability, has the advantages of simple synthesis steps, simplicity and convenience in operation, cheap and easily available raw materials, good compatibility to functional groups, high chemical selectivity, high reaction efficiency and the like, and is more in line with green and sustainable chemistry concepts; and reference and reliable technical support are provided for efficient synthesis of the fluorine-containing allyl tertiary nitro alkane compound.

The invention relates to a method for preparing a cycloheptatrienone derivative, and belongs to the technical field of bioengineering. The invention provides a method for preparing a cycloheptatrienone derivative, which is based on a framework editing strategy of biological catalysis and comprises the following steps of: performing biological catalysis on a substrate and an auxiliary substrate by using a phenol derivative as a substrate and nitroalkane as an auxiliary substrate and using multi-copper oxidase and / or a microorganism for producing the multi-copper oxidase as a catalyst to obtain the cycloheptatrienone derivative. The auxiliary substrate is used as a C1 unit to be inserted into the skeleton of the aromatic ring substrate for editing, so that the cycloheptatrienone derivative is generated. According to the method, multi-copper oxidase is used as a catalyst, nitroalkane which is simple, easy to obtain, safe and highly stable is used as a C1 unit, and a phenol derivative is successfully converted into the cycloheptatrienone derivative. According to the method, a single carbon insertion mediated skeleton editing biological catalysis strategy is constructed, the strategy breaks through the limitation of a traditional carbene insertion reaction, and the method has a great application prospect in skeleton modification in the field of chemical and biological catalysis.

The invention discloses a preparation method of a benzylsulfonyl fluoride compound, which comprises the following steps: taking benzylthiocyanate as a substrate, in a solvent, taking benzylthiocyanate shown as a formula (1) as a substrate, reacting under the action of an additive, an F source and a gas atmosphere, and obtaining the benzylsulfonyl fluoride compound shown as a formula (2) after the reaction is finished, in the formulas (1) and (2), R is selected from one or more of H, alkyl, aryl, halogen, cyano, nitryl, alkoxy, acyl and amido. According to the method disclosed by the invention, the target product can be synthesized by only 4-8 hours, so that the target product can be obtained with relatively high yield, and the method is relatively rapid and efficient. According to the synthesis method disclosed by the invention, the benzyl sulfuryl fluoride compound is synthesized from simple and easily available benzyl thiocyanate under relatively simple conditions, and the fluorine-containing building block compound which is widely applied to the fields of medicines, pesticides and petrochemical engineering is realized.

The invention discloses a method for synthesizing a chiral pyrazolone imine derivative based on an asymmetric aza-Henry reaction catalyzed by an organic catalyst, which comprises the following steps: placing a pyrazolone imine compound and a nitroalkane compound in a solvent, adding the organic catalyst, and reacting at-78-60 DEG C while stirring to prepare the target product chiral pyrazolone imine derivative. Or placing the pyrazolone imine compound and brominated nitromethane in a solvent, then adding an organic catalyst, carrying out a stirring reaction at-78 to 60 DEG C to prepare a chiral pyrazolone imine derivative, and further carrying out debromination to obtain the target product, namely the chiral pyrazolone imine compound. The asymmetric aza-Henry reaction of the pyrazolone imine compound and the nitroalkane compound or the bromo-nitromethane is successfully realized on the basis of the small organic molecule catalyst, and the asymmetric aza-Henry reaction has the advantages of low catalyst consumption, high reaction rate (the fastest reaction rate is 0.5 h), high enantioselectivity (the highest reaction rate reaches 96% ee), good universality of reaction substrates and the like.

The invention belongs to the technical field of organic compound preparation, and discloses a photochemical preparation method of a tetraphenylhexahydrotetrazine compound. The preparation method comprises the following steps: mixing an azobenzene compound, biborate, a carbon source and an organic solvent, wherein the carbon source comprises alkyl aldehyde or nitroalkane; and reacting under light irradiation, removing the organic solvent, and separating and purifying to obtain the compound. The tetraphenylhexahydrotetrazine compound with high yield can be prepared by taking an azobenzene compound as a raw material, taking aldehyde or nitroalkane as a carbon source, adding bis (borate), and carrying out illumination in the absence of a metal catalyst within the reaction time of less than 1 hour. Moreover, the preparation method disclosed by the invention shows wide functional group compatibility, so that various types of azobenzene compounds can be converted into tetraphenylhexahydrotetrazine compounds, and the application prospect is wide.

The application relates to the technical field of catalytic materials, and relates to an organic photocatalytic material and a preparation method thereof.1, comprising the following steps: mixing modified N-hydroxy phthalimide phenylacetate, an aliphatic nitroalkane, 2,6-dimethylpyridine, a photocatalyst and a solvent, then irradiating under visible light, placing in an inert atmosphere, stirring for 2-8 hours, and obtaining a product through post-treatment to obtain a final product; the mass ratio of the modified N-hydroxy phthalimide phenylacetate, the nitro compound, the 2,6-dimethylpyridine, the photocatalyst and the solvent is 2-5:1-2:1-3:1:8-11. The visible light catalysis method can be used to synthesize the nitro compound under mild conditions, and further provides a green and efficient new path for the preparation of a nitrogen-containing drug intermediate.

The invention discloses a preparation method and application of a urea triazole derivative which is simple and easy to operate, cheap and easily available in raw materials, high in reaction efficiency and good in inhibition effect on human liver cancer cells Huh-7, and belongs to the technical field of medicine synthesis. According to the key points of the technical scheme, the urea triazole derivative molecule has a structure, or R1 is hydrogen atom, fluorine, chlorine, bromine, iodine, nitryl, alkyl (such as methyl, ethyl or alkynyl) or alkoxy (such as methoxyl) and various substituent groups, R2 is phenyl derivative or benzyl derivative, and X is oxygen atom or sulfur atom. The invention designs and synthesizes a urea triazole derivative with a novel structure, and the compound has a good inhibition effect on human liver cancer cells Huh-7.

The invention discloses a method for selective fluoroallyl alkylation of difluorocyclopropane by using sec-nitro alkane, which comprises the following steps: by using sec-nitro alkane and gem-difluorocyclopropane as raw materials, carrying out ring-opening selective ring-opening reaction on the sec-nitro alkane and gem-difluorocyclopropane through transition metal catalysis to generate a branched chain type fluorine-containing allyl tertiary nitro compound. The method has obvious advantages in the aspects of synthesis conditions and practicability, has the advantages of simple synthesis steps, simplicity and convenience in operation, cheap and easily available raw materials, good compatibility to functional groups, regioselectivity, high reaction efficiency and the like, and also provides reference and reliable technical support for a branched chain type regioselective allylation method.

A method for the preparation of a 3-nitro-N—(C1-13 alkyl)phthalimide composition comprises reacting a 3-nitro phthalic acid to provide 3-nitro-phthalic anhydride, optionally in the presence of a solvent, and reacting 3-nitro-phthalic anhydride with a C1-13 alkylamine optionally in the presence of a solvent to provide the 3-nitro-N—(C1-13 alkyl)phthalimide composition comprising 3-nitro-N—(C1-13 alkyl)phthalimide and optionally, 4-nitro-N—(C1-13 alkyl)phthalimide. The 3-nitro-N—(C1-13 alkyl)phthalimide composition can have undetectable levels of 4-nitro-N—(C1-13 alkyl)phthalimide, and consequently, polyetherimides ultimately derived from the 3-nitro-N—(C1-13 alkyl)phthalimide composition can be enriched in 3,3′ linkages and / or exclude 3,4′ and 4′4 linkages. The polyetherimides disclosed can have improved flow and a decreased yellowness index.

The invention relates to the technical field of preparation of isoxazoline derivatives, in particular to preparation and application of an isoxazoline derivative containing an oxime ether structure, the structural formula of the isoxazoline derivative containing the oxime ether structure is shown as a general formula I. In the formula, R1, R2 and R3 are hydrogen, halogen, cyano, nitro, trifluoromethyl, alkoxy or alkyl; r4 is hydrogen, halogen, cyano, nitro, C1-C6 alkyl, substituted benzyl, naphthenic base or heterocyclic ring; the isoxazoline derivative containing the oxime ether structure, disclosed by the invention, can be used for preventing and treating major lepidoptera agricultural pests, such as plutella xylostella, spodoptera frugiperda, ostrinia nubilalis, helicoverpa armigera, mythimna septemmina and the like. The isoxazoline derivative containing the oxime ether structure disclosed by the invention can be used for preventing and treating major lepidoptera agricultural pests, such as the plutella xylostella, the spodoptera frugiperda, the ostrinia nubilalis, the helicoverpa armigera, the mythimna septemmina and the like.

The invention relates to the field of pesticide technology, and in particular a type of pyridyloxy carboxylic oxime derivative, preparation method, herbicidal composition and application thereof. The pyridyloxy carboxylic oxime derivative is represented by formula I,wherein, A, B each independently represent halogen, or alkyl or cycloalkyl with or without halogen; C represents hydrogen, halogen, alkyl or haloalkyl; Q represents halogen, cyano, cyanoalkyl, hydroxyalkyl, amino, nitro, formyl, alkyl with or without halogen and the like; R1 and R2 independently represent hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkenyl, cycloalkyl, alkoxy, acyloxy, alkylthio, or unsubstituted or substituted aryl, etc.; M represents nitro or NR3R4. The compound has excellent herbicidal activity and higher crop safety, especially good selectivity for key crops such as rice.

The present disclosure relates to a process for producing chiral β-nitro alcohol compounds. The invention relates in particular to an (S)-selective oxynitrilase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding β-nitro alcohol compound in the presence of a nitroalkane compound and an oxynitrilase.

The application discloses a DNA-targeted substitution 1H-pyrazolo[3,4-b]quinoline HDAC inhibitor and a preparation method and application thereof. The compound is a compound with a general formula (I) structure or a pharmaceutically acceptable salt. In the general formula (I), R is hydrogen, an alkyl group, halogen, a nitro group, an alkoxy group or a trifluoromethyl group; a linker is a substituted C1-C9 alkyl group, a C3-C8 cycloalkyl group, a C5-C10 aryl group, a single heterocyclic aryl group containing 5 or 6 ring atoms or a double heterocyclic aryl group having 8 to 15 ring atoms; wherein the heterocyclic aryl group contains 1-4 heteroatoms independently selected from O, S, N, oxidized S or oxidized N; a carbon atom or a nitrogen atom is a connecting point of a heteroaromatic ring structure and maintains a stable aromatic ring. The compound has strong inhibitory activity on HDAC and can effectively target DNA, and can prevent or treat related mammalian diseases caused by abnormal expression of HDAC and abnormal biological functions of DNA. The application also relates to a pharmaceutical use of a composition of the compound with the general formula I.

The application discloses a chromanone compound and application of the chromanone compound in prevention and treatment of bacterial canker disease of kiwi fruit, and a structural formula of the chromanone compound is shown in the following formula: wherein R is one or more of hydrogen, alkyl, alkenyl, alkynyl, nitro, alkoxy, cyano, amino, sulfonic acid group, halogenated alkyl, aryl, heteroaryl and halogen; and R' is alkyl or aryl. A synthesis method provided by the application uses cheap and easily obtained 2-hydroxyacetophenone as a basic raw material to perform conventional chemical synthesis, and the reaction can be completed under mild conditions without metal catalysts. The synthesis method has the advantages of simple reaction system, short reaction time, high yield, and the like, and can greenly synthesize the chromanone compound; meanwhile, the chromanone compound has obvious prevention and treatment effect on bacterial canker disease of kiwi fruit.

The invention discloses a preparation method of an aryl sulfonyl fluoride compound, which specifically comprises the following steps of: reacting aryl thiocyanate as shown in a formula (1) as a substrate in a solvent under the atmosphere of an additive, a fluorine source and gas, and obtaining the aryl sulfonyl fluoride compound as shown in a formula (2) after the reaction is finished, in the formulas (1) and (2), R is selected from one or more of H, alkyl, aryl, halogen, cyano, nitryl, alkoxy, acyl and amido. According to the method disclosed by the invention, the target product can be synthesized by only 4-8 hours, so that the target product can be obtained with relatively high yield, and the method is relatively rapid and efficient. According to the synthesis method disclosed by the invention, the aryl sulfuryl fluoride compound is synthesized from simple and easily available aryl thiocyanate under relatively simple conditions, and the fluorine-containing building block compound which is widely applied to the fields of medicines, pesticides and petrochemical engineering is realized.