379 results about "Pyrazolone" patented technology

A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi.

Provided herein are compounds of the formula (I):

as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): wherein A is a C?2-14#191 aryl group, B is a hydrogen atom, a C?1-6#191 alkyl group, a C?1-3#191 alkyl group substituted with one or more fluorine atoms or a C?2-14#191 aryl group, D is a hydrogen atom, a C?1-6#191 alkyl group, a C?1-3#191 alkyl group substituted with one or more fluorine atoms or a C?2-14#191 aryl group, and E is a C?2-14#191 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.

The invention discloses a method for determining sea cucumber polysaccharide content in a sea cucumber or a sea cucumber product. The method is characterized in that the sea cucumber or the sea cucumber product is enzymolyzed by protease; the sea cucumber polysaccharide produced by the enzymolysis is separated out by adopting alcohol precipitation; then tested solution is prepared by hydrolysis of trifluoroacetate; the tested solution is prepared into fucose standard water solution which is derived by 1-phenyl-3-methyl-5-pyrazolone; the peak area of fucose derivative in the obtained derivatives is measured by high performance liquid chromatography; and the sea cucumber polysaccharide content in the sea cucumber product is obtained by calculating with the fucose as a reference. The invention provides a simple, accurate, reliable and standardized quantitative analysis method for determining the sea cucumber polysaccharide in various sea cucumbers and sea cucumber products.

A thermal transfer ink is provided, which includes:

• • at least one dye (a);
  • at least one dye selected from the group including dye (b), dye (c) and a mixture thereof; and
  • a medium; wherein
  • (a) is a dye having a pyrazolone methine skeleton,
  • (b) is a dye having a quinophthalone skeleton, and
  • (c) is a dye having an aminopyrazole azo skeleton.

The invention relates to a method of combining PMP (1-Phenyl-3-Methyl-5-Pyrazolone) derivatization and IM-MS/MS (Ion Mobility Tandem Mass Spectrometry), which solves the problem that an actually mixed sugar sample cannot be analyzed easily, quickly and accurately in the prior art for identifying oligosaccharide isomers, and meanwhile, solves the problem that the compositions of monosaccharide residues of the sugar cannot be determined by utilizing a mass spectroscopy means. According to the method for quickly identifying the sugar, the effects on identifying sugar isomers by taking PMP and PHN (Phenylhydrazine) as derivatization reagents and combining the IM-MS/MS method are compared, the CCS (Collision Cross Section) value of a derivatization product is calculated theoretically for further proving that mixed extracts of the sugar can be qualitatively identified successfully by combining the PMP derivatization and the IM-MS/MS method, and meanwhile, the connection, structures and compositions of the sugar can be identified.

The invention discloses a cocoa powder adulteration detection method based on fingerprints. In order to establish the cocoa powder adulteration detection method, polysaccharide components in cocoa powder are extracted through the assistance of ultrasonic, fingerprints of the polysaccharide components of the cocoa powder can be obtained through the hydrolysis of sulfuric acid and the analysis of pre-column PMP(1-phenyl-3-methyl-pyrazolone) derivatization high performance liquid chromatography (HPLC), a hierarchical cluster analysis (HCA) method is used for implementing the cocoa powder adulteration identification test according to the relative peak area of the common characteristic peak. The result shows that the cocoa powder which is mixed with 15 percent or more of cocoa shells can be identified through the method. The method is stable and has high precision and good repeatability, is easy to control, the mass situation of cocoa powder polysaccharide on the integral characteristic appearance of chromatograph can be controlled, and a novel scientific method can be provided for the quality control and authentication identification of the cocoa powder.

The invention discloses a thiazole bipyrazolone compound as well as applications thereof in preparing a small molecular inhibitor of Bcl-2 family proteins and antitumor drugs, the thiazole bipyrazolone compound has the above structural formula, and the thiazole bipyrazolone compound has the activity for inhibiting the combination of Bcl-xL and natural substrate polypeptide (Bid BH3 polypeptide) in the micromole range, and can serve as the small molecular inhibitor of the Bcl-2 family proteins for inhibiting the anti-apoptosis activity thereof; and the compound shows a certain inhibitory activity to human breast cancer MDA-MB-231 cells and MCF-7 cells, and is expected to be developed into the antitumor drugs of targeted Bcl-2 family proteins.

The invention provides a type of fused heterocycle compounds containing pyrazolone rings, optical isomers, cis-trans-isomers or pharmaceutically acceptable salts of fused heterocycle compounds and applications of the fused heterocycle compounds, and the optical isomers, cis-trans-isomers or pharmaceutically acceptable salts of the fused heterocycle compounds. The fused heterocycle compounds have astructure represented by a formula (I) (shown in the description). The fused heterocycle compounds containing the pyrazolone rings, and the optical isomers, the cis-trans-isomers or the pharmaceutically acceptable salts of the fused heterocycle compounds have high killing activity to agriculture and forestry pests, health pests and the like, furthermore, and the compounds have a delayed action effect to pests such as red imported fire ants, so the pests can carry the drug to a nest, and the whole nest and an queen ant can be well killed; and the compounds have very good application prospects.

The invention discloses a rapid quantitative method for tea polysaccharide monosaccharide composition. The steps includes: (1) hydrolyzing tea polysaccharide with trifluoroacetic acid; (2) dissolving the hydrolyzed tea polysaccharid sample with ultra pure water to obtain a hydrolyzed polysaccharide solution, and adding trehalose to serve as the internal standard substance; (3) conducting derivatization on the internal standard containing hydrolyzed polysaccharide solution with 1-phenyl-3-methyl-5-pyrazolone (PMP); (4) at the same time of hydrolyzed polysaccharide derivatization, conducting derivatization on standard monosaccharide; and (5) carrying out high performance liquid chromatographic analysis, thus obtaining the content of each monosaccharide. The high performance liquid detection system conditions employed by the method include: octadecyl silane bonded silica gel is a chromatographic column of filler, the mobile phase is a buffer solution mixed according to certain ratio and an organic agent, the flow speed is 1.0ml/min, and the detection wavelength of an ultraviolet detector is 250nm. The method is simple, fast, convenient and, stable, achieves separation and analysis of monosaccharide within 20min, and improves the accuracy and precision of tea polysaccharide monosaccharide detection.

The invention discloses a pyrazolone pyrimidine compound as well as a preparation method and application thereof. The invention provides the pyrazolone pyrimidine compound shown as a formula I, and anenantiomer, a diastereomer, a tautomer, a crystal form, a medically acceptable salt, a solvent compound, a metabolite or a prodrug thereof. The inhibition activity of the compound on WEE1 kinase is high. The formula I is shown in the description.

The invention belongs to the field of pesticides, and particularly relates to weeding composition containing pyrazolone compounds and an application of the weeding composition. The weeding composition comprises an effective weeding quantity of an active component A, an active component B and a safener compound C, wherein the active component A is one of general formulae represented in the specification, R1 represents hydrogen atoms, R2 represents methyl, R3 represents ethyoxyl, R4 represents helium atoms, and R5, R6 and R7 represents alkyl and the like; the active component B is selected from one or more of compounds as follows: 1) a triazine compound: ametryn; 2) diphenyl ether compounds: oxyfluorfen and the like; the safener compound C is selected from one or more of compounds as follows: C1: isoxadifen-ethyl and the like. With the adoption of the composition, the problems about weeds including barnyard grass, eleusine indica, horseweed herb and the like during destructive weeding and sugarcane field weeding can be solved effectively, and the composition has the characteristics that the weeding spectrum is enlarged, the application amount is reduced, the composition is safe to crops, herbicide resistant weeds can be controlled and the like.

The invention provides a method and a detection kit for identifying a biomarker of cerebral infarction. The biomarker is free mannose and glucose obtained by high performance liquid chromatography based on pre-column 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization in serum. The detection method is the high performance liquid chromatography method based on the pre-column PMP derivatization. Thetechnical scheme has the advantages that the pretreatment is simple, the analysis time is short, the instrument price is reasonable, the requirements of conventional use are met, the operation stepsare simple and easy to learn, the accuracy of a detection result is high, a normal person and a cerebral infarction patient can be distinguished only by blood collection, the amount of the needed serum is extremely small, the blood collection amount is smaller than 1 mL, and the like. The obtained result shows that the analysis method can be used for rapidly determining the content of the free mannose and glucose in the serum of the cerebral infarction patient, so that the method has very important significance for researching a relation between the free mannose and glucose in the serum and the cerebral infarction, and looking for a novel cerebral infarction clinical detection marker.

The invention discloses a solvent orange 2A processing technique in the chemical engineering domain, which comprises the following steps: adopting 4-nitro-2-aminophenol and 1-phenyl-3-methyl-5-pyrazolone as basic raw material; coupling; complexing; substituting; adding composite solvent of amide in the alcohol ether solvent and complexing agent CRF; heating to 100 deg.c; adding azo A; heating to 138-150 deg.c directly for 2.5-3.5h; cooling to evolve in the water; filtering; washing through water to obtain the complex B.

The invention provides a new synthesis method for crizotinib. An atomic economic reaction is adopted to reduce environmental pollution. A high-optical purity raw material is obtained by chiral prolinol induced chiral reduction; a chiral centre is constructed through an SN2 substitution reaction; post-processing and purification difficulties caused by Mitsunobu reaction are overcome. Malononitrile derivative is constructed by adopting a coupling reaction of malononitrile and bromo-pyridinium derivative; N,N-dicarboamide derivatives are obtained by performing aminolysis on N,N-dimethylamine hydrochloride; in the N,N-dicarboamide derivatives, N,N-dimethylamine serving as an easy-to-leave group and hydrazine perform a ring closing reaction to construct a pyrazolone ring, so that an expected final product, namely crizotinib, is obtained. According to the method, though continuous steps are used, the reaction of each step is high, the optical purity is high, and the total yield is also high. In addition, raw materials used in the synthesis method are low in cost and easily obtained; the using amount of a catalyst is small; total cost is easy to control. An operating process is simple and convenient and easy to control, and is suitable for industrial production.

This invention relates to a quaternary antibacterial azo dye, characterizing: structural formula is indicated as formula(1), wherein: A is a quaternary group, B is a coupling group comprising aromatic ammonia group, pyridinone or pyrazolone. This invented dye can dye acrylic fibre according to the conventional cation staining, with the color fastness meeting the using requirement. The dye water solution and dyed acrylic fibre can kill or suppress Gram-positive bacteria and Gram-negative bacteria like Staphylococcus aureus and Escherichia coli.

The present invention is directed to quinolinone-pyrazolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

The invention relates to a method for quickly detecting pesticide residue of cyanogens-containing synthetic pyrethroids in tea. The method comprises the following steps of: leaching cyanogens-containing synthetic pyrethroids in tea in advance; removing interference components in the tea and then heating the pesticide residue of cyanogens-containing synthetic pyrethroids for full alkaline hydrolysis to generate cryanide ions; adding acid to generate HCN (Hydrocyanic Acid) gas; transferring, absorbing and measuring the concentration of a CN (Cyanide) ion by using an air suction device; and realizing accurate quantitative measurement by using thiocyanate-isonicotinic acid pyrazolone spectrophotometry development. According to the method, an alkaline hydrolysis reaction and HCN gas transfer are thoroughly realized by heating, stirring and extracting air, thus the detection sensitivity is high; and meanwhile, interference substances in the tea are eliminated so as to facilitate the accurate quantitative detection. In addition, the method has low cost, is realized by adopting simple equipment, is simple and convenient and is easy to popularize; and the strict on technical requirements is inferior to that of instrument analysis; and the method is a simple accurate analysis method for detecting pesticide residue of fresh leaves in the production of tea and analyzing the quality of finished tea.

The purpose of the present invention is to provide a novel medicinal agent and a novel method both of which can be used for treating ALS (amyotrophic lateral sclerosis), preventing the progression of the phase of ALS, treating a symptom associated with ALS, or preventing the progression of the phase of the symptom, and both of which can be particularly applied to patients who can be treated by the medicinal agent or the method highly effectively among ALS patients who are needed to be treated. According to the present invention, a medicinal agent which can be used for treating amyotrophic lateral sclerosis, preventing the progression of the phase of amyotrophic lateral sclerosis, treating a symptom associated with amyotrophic lateral sclerosis, or preventing the progression of the phase of the symptom is provided. The medicinal agent comprises 3-methyl-1-phenyl-2-pyrazolin-5-one or a physiologically acceptable salt thereof as an active ingredient, is administered in such a manner that a 14-day dosing period and a 14-day washout period are repeated alternately or in such a manner that a 14-days initial dosing period and a subsequent 14-day initial washout period are set and subsequently a dosing period in which the dosing is carried out for any 10 days of 14 days and a 14-day washout period are repeated alternately, and is administered to a patient who meets specific criteria.