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383 results about "Pyrazolone" patented technology
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Pyrazolone is 5-membered heterocycle containing 2 adjacent nitrogen atoms. It can be viewed as a derivative of pyrazole possessing an additional keto (=O) group.
Synergistic fungicidal mixtures for fungal control in cereals
ActiveUS20110082160A1Improve efficacyGood curative effectBiocideOrganic chemistryChlorothalonilIsopyrazam
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi.
Owner:CORTEVA AGRISCIENCE LLC
Synergistic fungicidal compositions containing a 5-fluoropyrimidine derivative for fungal control in cereals
InactiveUS20110053966A1Good curative effectOrganic active ingredientsBiocideBiotechnologyChlorothalonil
A fungicidal composition containing a fungicidally effective amount of a) a compound of Formula IA and / or IB and (b) at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, chlorothalanil, isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-isobutyryloxymethoxy-4-methoxypyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester, and (5,8-difluoroquinazolin-4-yl)-{2-[2-fluoro-4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethyl}-amine provides synergistic control of selected fungi.
Owner:DOW AGROSCIENCES LLC
Bicycle substituted pyrazolone azo derivative, preparation thereof and use in medicine
The invention relates to a dicyclo-substituted pyrazolone azo derivative expressed by general formula (I), or pharmaceutically acceptable salt, hydrate, solvent compound or ester thereof, a preparation method and medical application thereof.
Owner:SHANGHAI HENGRUI PHARM CO LTD
Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
Owner:F HOFFMANN LA ROCHE INC
Pyrazolone compounds and thrombopoietin receptor activator
InactiveUS20060069140A1Potent platelet increasing actionHigh affinityBiocideOrganic chemistryBULK ACTIVE INGREDIENTBiological activation
A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): wherein A is a C?2-14#191 aryl group, B is a hydrogen atom, a C?1-6#191 alkyl group, a C?1-3#191 alkyl group substituted with one or more fluorine atoms or a C?2-14#191 aryl group, D is a hydrogen atom, a C?1-6#191 alkyl group, a C?1-3#191 alkyl group substituted with one or more fluorine atoms or a C?2-14#191 aryl group, and E is a C?2-14#191 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
Owner:NISSAN CHEM IND LTD
Sea pumpkin and sea pumpkin product sea pumpkin polysaccharide content determination method
InactiveCN101285826AStrong absorption capacitySimple and fast operationComponent separationBiological testingHydrolysisPeak area
The invention discloses a method for determining sea cucumber polysaccharide content in a sea cucumber or a sea cucumber product. The method is characterized in that the sea cucumber or the sea cucumber product is enzymolyzed by protease; the sea cucumber polysaccharide produced by the enzymolysis is separated out by adopting alcohol precipitation; then tested solution is prepared by hydrolysis of trifluoroacetate; the tested solution is prepared into fucose standard water solution which is derived by 1-phenyl-3-methyl-5-pyrazolone; the peak area of fucose derivative in the obtained derivatives is measured by high performance liquid chromatography; and the sea cucumber polysaccharide content in the sea cucumber product is obtained by calculating with the fucose as a reference. The invention provides a simple, accurate, reliable and standardized quantitative analysis method for determining the sea cucumber polysaccharide in various sea cucumbers and sea cucumber products.
Owner:OCEAN UNIV OF CHINA
Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
Owner:ABBOTT LAB INC
Method of processing a photographic element containing electron transfer agent releasing couplers
InactiveUS6929905B2Shorten development timeEasy to shapePhotoprinting processesMulticolor photographic processingArylChemical compound
A method of processing a silver bromoiodide photographic element comprising contacting the photographic element with a color developer for less than 120 seconds; wherein the photographic element comprises a support and more than one dye forming unit, and wherein the dye forming unit closest to the support contains an electron transfer agent releasing compound represented by the formula:CAR-(L)n-ETAwherein:CAR is a carrier moiety which is capable of releasing -(L)n-ETA on reaction with oxidized developing agent;L is a divalent linking group, n is 0, 1, or 2; andETA is a releasable 1-aryl-3-pyrazolidinone electron transfer agent having a calculated log partition coefficient (c log P) greater than or equal to 2.40 bonded to L or CAR through either the nitrogen atom in the 2-position or the oxygen attached to the 3-position of the pyrazolidinone ring.
Owner:EASTMAN KODAK CO
Ink for thermal transfer, sheet for thermal transfer, and thermal transfer recording method using the same
InactiveUS6866706B2Improve performanceMonoazo dyesLiquid surface applicatorsPhotochemistryThermal transfer
A thermal transfer ink is provided, which includes:at least one dye (a);at least one dye selected from the group including dye (b), dye (c) and a mixture thereof; anda medium; wherein(a) is a dye having a pyrazolone methine skeleton,(b) is a dye having a quinophthalone skeleton, and(c) is a dye having an aminopyrazole azo skeleton.
Owner:MITSUBISHI CHEM CORP
Bicyclic pyrazolone compound, and use method and applications thereof
The invention provides a type of substituted bicyclic pyrazolone compounds which can be used for inhibiting the activities of receptor tyrosine kinases especially the activities of Axl, Mer, c-Met and Ron kinases. The invention also provides medicine compositions comprising the type of compounds, and applications of the compound and the medicine compositions in drug preparation. The medicines can be used for preventing and treating proliferative diseases or reducing the severity of the diseases.
Owner:ZHONGSHAN INNOVATION BIOPHARMACEUTICAL CO LTD
Method for quickly identifying sugar
InactiveCN105699478AAccurate identificationAccurate analysisPreparing sample for investigationMaterial analysis by electric/magnetic meansSpectroscopySugar
The invention relates to a method of combining PMP (1-Phenyl-3-Methyl-5-Pyrazolone) derivatization and IM-MS / MS (Ion Mobility Tandem Mass Spectrometry), which solves the problem that an actually mixed sugar sample cannot be analyzed easily, quickly and accurately in the prior art for identifying oligosaccharide isomers, and meanwhile, solves the problem that the compositions of monosaccharide residues of the sugar cannot be determined by utilizing a mass spectroscopy means. According to the method for quickly identifying the sugar, the effects on identifying sugar isomers by taking PMP and PHN (Phenylhydrazine) as derivatization reagents and combining the IM-MS / MS method are compared, the CCS (Collision Cross Section) value of a derivatization product is calculated theoretically for further proving that mixed extracts of the sugar can be qualitatively identified successfully by combining the PMP derivatization and the IM-MS / MS method, and meanwhile, the connection, structures and compositions of the sugar can be identified.
Owner:CHANGCHUN UNIV OF CHINESE MEDICINE
Cocoa powder adulteration detection method based on fingerprints
The invention discloses a cocoa powder adulteration detection method based on fingerprints. In order to establish the cocoa powder adulteration detection method, polysaccharide components in cocoa powder are extracted through the assistance of ultrasonic, fingerprints of the polysaccharide components of the cocoa powder can be obtained through the hydrolysis of sulfuric acid and the analysis of pre-column PMP(1-phenyl-3-methyl-pyrazolone) derivatization high performance liquid chromatography (HPLC), a hierarchical cluster analysis (HCA) method is used for implementing the cocoa powder adulteration identification test according to the relative peak area of the common characteristic peak. The result shows that the cocoa powder which is mixed with 15 percent or more of cocoa shells can be identified through the method. The method is stable and has high precision and good repeatability, is easy to control, the mass situation of cocoa powder polysaccharide on the integral characteristic appearance of chromatograph can be controlled, and a novel scientific method can be provided for the quality control and authentication identification of the cocoa powder.
Owner:SHANDONG TIANMEI BIO CO LTD
Quantitative detection method of polysaccharide containing uronic acid
ActiveCN105675779ALess susceptible to interferenceLow costComponent separationUronic acidSugar derivatives
The invention discloses a quantitative detection method of polysaccharide containing uronic acid. The method comprises the following steps: preparing a standard polysaccharide solution and a sample solution to be tested; hydrolyzing polysaccharide in the standard solution and the sample solution to be tested so as to obtain hydrolyzed residue; derivatizing the residue with 1-phenyl-3-methyl-5-pyrazolone to prepare a sugar derivative; carrying out chromatographic analysis on the sugar derivative by the utilization of a high performance liquid chromatograph and a triple quadrupole linear ion trap mass spectrometer; determining which kind of polysaccharide containing uronic acid the sample to be tested is according to the chromatogram; and preparing a standard curve of chromatographic peak area and polysaccharide concentration according to the chromatogram of the standard polysaccharide disaccharide derivative obtained by high performance liquid chromatography-mass spectrum, and calculating content of polysaccharide containing uronic acid in the sample to be tested by the utilization of peak area of the sample to be tested. According to the method provided by the invention, quantitative detection of polysaccharides can be accurately carried out, and effective means is provided for quality control of products such as medicines, health product and the like of the polysaccharides.
Owner:DALIAN POLYTECHNIC UNIVERSITY
Thiazole couplet pyrazolone series compound and application of the same as Bcl-2 family protein antagonist
InactiveCN101343268ANovel structureHigh cytotoxic activityOrganic active ingredientsOrganic chemistryThiazoleMda mb 231
The invention discloses a thiazole bipyrazolone compound as well as applications thereof in preparing a small molecular inhibitor of Bcl-2 family proteins and antitumor drugs, the thiazole bipyrazolone compound has the above structural formula, and the thiazole bipyrazolone compound has the activity for inhibiting the combination of Bcl-xL and natural substrate polypeptide (Bid BH3 polypeptide) in the micromole range, and can serve as the small molecular inhibitor of the Bcl-2 family proteins for inhibiting the anti-apoptosis activity thereof; and the compound shows a certain inhibitory activity to human breast cancer MDA-MB-231 cells and MCF-7 cells, and is expected to be developed into the antitumor drugs of targeted Bcl-2 family proteins.
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Fused heterocycle compounds containing pyrazolone rings and applications thereof
ActiveCN108129481AEnhance killing activityGood killing effectBiocideOrganic chemistryPyrazoloneRed imported fire ant
The invention provides a type of fused heterocycle compounds containing pyrazolone rings, optical isomers, cis-trans-isomers or pharmaceutically acceptable salts of fused heterocycle compounds and applications of the fused heterocycle compounds, and the optical isomers, cis-trans-isomers or pharmaceutically acceptable salts of the fused heterocycle compounds. The fused heterocycle compounds have astructure represented by a formula (I) (shown in the description). The fused heterocycle compounds containing the pyrazolone rings, and the optical isomers, the cis-trans-isomers or the pharmaceutically acceptable salts of the fused heterocycle compounds have high killing activity to agriculture and forestry pests, health pests and the like, furthermore, and the compounds have a delayed action effect to pests such as red imported fire ants, so the pests can carry the drug to a nest, and the whole nest and an queen ant can be well killed; and the compounds have very good application prospects.
Owner:SOUTH CHINA AGRI UNIV
Method for determining and correcting cyanide
InactiveCN102564982AReduce riskReduce storageColor/spectral properties measurementsChloramine BChloramine
The invention discloses a method for determining and correcting cyanide. The method is characterized by comprising the following steps of: 1) putting 10 milliliters of distillate in a colorimetric tube which has a volume of 25 milliliters and is provided with a plug; 2) adding 5 milliliters of phosphate buffer solution into the tube, mixing uniformly, quickly adding 0.2 milliliter of chloramine solution, immediately inserting the plug, mixing uniformly and placing for 3 to 5 minutes; 3) adding 5 milliliters of isonicotinic acid-pyrazolone mixed solution into the tube, uniformly mixing, adding water to dilute until mixture reaches a marked line, shaking uniformly, and placing in an aqueous solution at the temperature of between 25 and 35 DEG C for 40 minutes; and 4) determining absorbance by using a cuvette with height of 1cm, and using reagent blank as reference at the wave length of 638nm, and finding out the corresponding cyanide content from the standard curve. By using an intermediate medium, the cost of purchasing, storing and managing toxic and dangerous chemicals is reduced, and potential unsafe factors of the toxic and dangerous chemicals in using operation can be reduced.
Owner:SHANXI TAIGANG STAINLESS STEEL CO LTD
Substituted pyrazolone compounds and methods of use
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Owner:BEIJING FINDCURE BIOSCIENCES LTD
Laser ray transmitting colored thermoplastic resin composition and method of laser welding
InactiveUS7153384B2High fastnessMaintain good propertiesLamination ancillary operationsOnium based azo dyesArylHydrogen atom
Laser ray transmitting colored thermoplastic resin composition containing a dis-azo salt forming dye consisting of an anionic component from a dis-azo acid dye and an organic ammonium component, said acid dye being represented by Formula (1) below,R1—N═N-E-N═N—R2; (1)E: (2), (3), (4); R1, R2: aryl, pyrazolone; one or more of E, R1, R2 have sulfonic acid group,R3, R4: hydrogen atom, alkyl, sulfonic acid group,R5, R6: hydrogen atom, sulfonic acid group,R15: sulfonic acid group.Method of laser welding wherein a contact portion of a laser ray transmitting material comprising the laser ray transmitting colored thermoplastic resin composition above and a laser ray absorbing material is welded by irradiating laser ray so that the laser ray passes through the laser ray transmitting material and is absorbed in the laser ray absorbing material with the laser ray transmitting material and the laser ray absorbing material in contact with each other.
Owner:ORIENT CHEM INDS
Application of pharmaceutical composition in preparation of medicine for treating sepsis
InactiveCN104546832AImprove efficacyHydroxy compound active ingredientsAntipyreticDiseaseInjury brain
The present invention relates to a use of a pharmaceutical composition in the manufacture of medicament for treating related diseases caused by endotoxemia. The pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one or pharmaceutically acceptable salt thereof and borneol. The diseases include, but are not limited to, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, sepsis related disseminated intravascular coagulation, acute lung injury, acute respiratory distress syndrome, multiple organ failure syndrome, septic brain injury and inflammatory lung injury caused by other reasons, including but not limited to bacterial pneumonia.
Owner:YANTAI YENEPHARMA BIOMEDICAL
Rapid quantitative method for tea polysaccharide monosaccharide composition
InactiveCN105136951AEasy to separateMonosaccharide peaks are sharpComponent separationMonosaccharide compositionFiller Excipient
The invention discloses a rapid quantitative method for tea polysaccharide monosaccharide composition. The steps includes: (1) hydrolyzing tea polysaccharide with trifluoroacetic acid; (2) dissolving the hydrolyzed tea polysaccharid sample with ultra pure water to obtain a hydrolyzed polysaccharide solution, and adding trehalose to serve as the internal standard substance; (3) conducting derivatization on the internal standard containing hydrolyzed polysaccharide solution with 1-phenyl-3-methyl-5-pyrazolone (PMP); (4) at the same time of hydrolyzed polysaccharide derivatization, conducting derivatization on standard monosaccharide; and (5) carrying out high performance liquid chromatographic analysis, thus obtaining the content of each monosaccharide. The high performance liquid detection system conditions employed by the method include: octadecyl silane bonded silica gel is a chromatographic column of filler, the mobile phase is a buffer solution mixed according to certain ratio and an organic agent, the flow speed is 1.0ml / min, and the detection wavelength of an ultraviolet detector is 250nm. The method is simple, fast, convenient and, stable, achieves separation and analysis of monosaccharide within 20min, and improves the accuracy and precision of tea polysaccharide monosaccharide detection.
Owner:HUAZHONG AGRI UNIV
Pyrazolone pyrimidine compound as well as preparation method and application thereof
PendingCN109810111AStrong inhibitory activityOrganic chemistryAntineoplastic agentsMetaboliteEnantiomer
The invention discloses a pyrazolone pyrimidine compound as well as a preparation method and application thereof. The invention provides the pyrazolone pyrimidine compound shown as a formula I, and anenantiomer, a diastereomer, a tautomer, a crystal form, a medically acceptable salt, a solvent compound, a metabolite or a prodrug thereof. The inhibition activity of the compound on WEE1 kinase is high. The formula I is shown in the description.
Owner:SHANGAI PHARMA GRP CO LTD
Weeding composition containing pyrazolone compounds and application of weeding composition
ActiveCN106106506AReduce the amount of applicationSignificantly active aloneBiocideDead animal preservationCompound cHerbicide resistant
Owner:QINGDAO KINGAGROOT RESISTANT WEED MANAGEMENT CO LTD
Method and detection kit for identifying biomarker of cerebral infarction
InactiveCN109342597AThe pre-processing process is simpleEasy to handleComponent separationBlood collectionMedicine
The invention provides a method and a detection kit for identifying a biomarker of cerebral infarction. The biomarker is free mannose and glucose obtained by high performance liquid chromatography based on pre-column 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization in serum. The detection method is the high performance liquid chromatography method based on the pre-column PMP derivatization. Thetechnical scheme has the advantages that the pretreatment is simple, the analysis time is short, the instrument price is reasonable, the requirements of conventional use are met, the operation stepsare simple and easy to learn, the accuracy of a detection result is high, a normal person and a cerebral infarction patient can be distinguished only by blood collection, the amount of the needed serum is extremely small, the blood collection amount is smaller than 1 mL, and the like. The obtained result shows that the analysis method can be used for rapidly determining the content of the free mannose and glucose in the serum of the cerebral infarction patient, so that the method has very important significance for researching a relation between the free mannose and glucose in the serum and the cerebral infarction, and looking for a novel cerebral infarction clinical detection marker.
Owner:THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound
ActiveCN111471047AEasy to synthesizeAtom economy is highOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsArylAcyl group
The invention discloses a method for selectively synthesizing a pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound, and belongs to the technical field of organic chemistry. Starting from a 1-aryl pyrazolidone compound 1 and an alkynyl cyclobutanol compound 2, the pyrazolo[1,2-a] pyrazolone compound 3 or 2-acyl indole compound 4 is synthesized with high selectivity by changing the reaction temperature, solvent and additive types under the catalysis of a dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer. The method has the advantages of simple and easily available raw materials, simplicity and convenience in operation, mild conditions, good selectivity, wide substrate application range and the like.
![Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound](https://images-eureka.patsnap.com/patent_img/24ba3190-d604-49af-a639-d45bd9ddb998/FDA0002501308420000011.png "Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound")
![Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound](https://images-eureka.patsnap.com/patent_img/24ba3190-d604-49af-a639-d45bd9ddb998/BDA0002501308430000021.png "Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound")
![Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound](https://images-eureka.patsnap.com/patent_img/24ba3190-d604-49af-a639-d45bd9ddb998/BDA0002501308430000031.png "Method for selectively synthesizing pyrazolo[1,2-a] pyrazolone or 2-acyl indole compound")
Owner:HENAN NORMAL UNIV
Process for preparing solvent orange 2A
InactiveCN1952016AImprove solubilityIncrease polarityComplex metal azo dyesAlcoholSubstitution reaction
The invention discloses a solvent orange 2A processing technique in the chemical engineering domain, which comprises the following steps: adopting 4-nitro-2-aminophenol and 1-phenyl-3-methyl-5-pyrazolone as basic raw material; coupling; complexing; substituting; adding composite solvent of amide in the alcohol ether solvent and complexing agent CRF; heating to 100 deg.c; adding azo A; heating to 138-150 deg.c directly for 2.5-3.5h; cooling to evolve in the water; filtering; washing through water to obtain the complex B.
Owner:南通市争妍新材料科技有限公司
Synthesis process for compound crizotinib
The invention provides a new synthesis method for crizotinib. An atomic economic reaction is adopted to reduce environmental pollution. A high-optical purity raw material is obtained by chiral prolinol induced chiral reduction; a chiral centre is constructed through an SN2 substitution reaction; post-processing and purification difficulties caused by Mitsunobu reaction are overcome. Malononitrile derivative is constructed by adopting a coupling reaction of malononitrile and bromo-pyridinium derivative; N,N-dicarboamide derivatives are obtained by performing aminolysis on N,N-dimethylamine hydrochloride; in the N,N-dicarboamide derivatives, N,N-dimethylamine serving as an easy-to-leave group and hydrazine perform a ring closing reaction to construct a pyrazolone ring, so that an expected final product, namely crizotinib, is obtained. According to the method, though continuous steps are used, the reaction of each step is high, the optical purity is high, and the total yield is also high. In addition, raw materials used in the synthesis method are low in cost and easily obtained; the using amount of a catalyst is small; total cost is easy to control. An operating process is simple and convenient and easy to control, and is suitable for industrial production.
Owner:甘肃皓骏药业有限公司
Process for producing asymmetric hypomethyl dye
The reaction of pyrazolones and methyleneindolines with orthoformates is an ideal one-step method for the preparation of asymmetric methine dyes.
Owner:BAYER AG
Antibiotic azo dye comprising quaternary ammonium salt group and its preparation and uses
InactiveCN1880378AThe synthesis method is simpleThe synthesis process is simpleMonoazo dyesDyeing processEscherichia coliQuaternary ammonium cation
This invention relates to a quaternary antibacterial azo dye, characterizing: structural formula is indicated as formula(1), wherein: A is a quaternary group, B is a coupling group comprising aromatic ammonia group, pyridinone or pyrazolone. This invented dye can dye acrylic fibre according to the conventional cation staining, with the color fastness meeting the using requirement. The dye water solution and dyed acrylic fibre can kill or suppress Gram-positive bacteria and Gram-negative bacteria like Staphylococcus aureus and Escherichia coli.
Owner:DALIAN UNIV OF TECH +1
Quinolinone-pyrazolone m1 receptor positive allosteric modulators
The present invention is directed to quinolinone-pyrazolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Owner:MERCK SHARP & DOHME LLC
Rapid Quantitative Detection Method of Cyanopyrethroid Pesticide Residues in Tea
InactiveCN102262089AImprove detection accuracyImprove stabilityMaterial analysis by observing effect on chemical indicatorPreparing sample for investigationAlkaline hydrolysisIsonicotinic acid
The invention relates to a method for quickly detecting pesticide residue of cyanogens-containing synthetic pyrethroids in tea. The method comprises the following steps of: leaching cyanogens-containing synthetic pyrethroids in tea in advance; removing interference components in the tea and then heating the pesticide residue of cyanogens-containing synthetic pyrethroids for full alkaline hydrolysis to generate cryanide ions; adding acid to generate HCN (Hydrocyanic Acid) gas; transferring, absorbing and measuring the concentration of a CN (Cyanide) ion by using an air suction device; and realizing accurate quantitative measurement by using thiocyanate-isonicotinic acid pyrazolone spectrophotometry development. According to the method, an alkaline hydrolysis reaction and HCN gas transfer are thoroughly realized by heating, stirring and extracting air, thus the detection sensitivity is high; and meanwhile, interference substances in the tea are eliminated so as to facilitate the accurate quantitative detection. In addition, the method has low cost, is realized by adopting simple equipment, is simple and convenient and is easy to popularize; and the strict on technical requirements is inferior to that of instrument analysis; and the method is a simple accurate analysis method for detecting pesticide residue of fresh leaves in the production of tea and analyzing the quality of finished tea.
Owner:HUAZHONG AGRI UNIV
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