32 results about "Hydrazone" patented technology

This invention discloses a method for preparing 4-(trifluoromethylsulfinyl)pyrazole compounds, comprising: dissolving terminal alkyne in n-hexane under nitrogen atmosphere, adding anhydrous zinc chloride, and reacting trifluoromethylsulfinyl chloride to obtain α-trifluoromethylalkynyl sulfoxide; adding benzoyl chloride dropwise to a CH2Cl2 solution of phenylhydrazine and triethylamine under nitrogen atmosphere to obtain acylhydrazine; adding carbon tetrachloride to a suspension of acylhydrazine and triphenylphosphine in acetonitrile to obtain hydrazone chloride; and reacting α-trifluoromethylalkynyl sulfoxide, hydrazone chloride, potassium carbonate, and anhydrous ethanol at room temperature to obtain 4-(trifluoromethylsulfinyl)pyrazole compounds. This invention uses inexpensive and readily available raw materials, the entire reaction route is mild and simple to operate, does not require stringent reaction conditions, and most of the reaction process is carried out at room temperature. The product yield is high, and the prepared trifluoromethylalkynyl sulfoxide pyrazole structure has multiple derivatization sites, showing good application prospects.

This invention discloses a hydrazone-linked fluorine-substituted covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalysis technology. The material is synthesized by hydrazone condensation of 1,3,5-trifluoro-2,4,6-tris(4-formylphenyl)benzene and terephthalohydrazide, denoted as F-TPDH-COF. A one-step solvothermal synthesis is employed, resulting in a mild, environmentally friendly, low-cost, and easily scalable process. The material obtained by this invention utilizes hydrazone bonds to achieve proton enrichment in acidic media, and fluorine atoms regulate the electronic structure to improve charge separation efficiency. Under pH=2 conditions, the photocatalytic hydrogen peroxide production rate reaches as high as 5825.2 μmolg. ‑1 h ‑1 Its activity and stability are significantly better than most existing COF photocatalytic materials, and it can be used for efficient photocatalytic preparation of hydrogen peroxide in acidic systems, showing good prospects for industrialization.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

This invention relates to the field of polymer fine chemical materials and the synthesis technology of special functional waterborne coatings, specifically to an aldehyde-capturing self-healing waterborne coating and its preparation method. The invention discloses an aldehyde-capturing self-healing waterborne coating and its preparation method. This coating uses a side-chain carboxylated ketone-containing waterborne polyurethane-acrylate composite emulsion as the core film-forming material, forming dynamic hydrazone crosslinks with adipic acid dihydrazide, and introducing an epoxy-amine permanent crosslinking network. The side-chain carboxyl groups are derived from maleic anhydride grafted and undergo ring-opening transformation upon contact with water, and are covalently fixed to the polymer side chains, preventing the migration of small molecule acids and ensuring coating storage stability. After the coating cures, environmental moisture triggers the dissociation of side-chain carboxyl groups, releasing protons and catalyzing the dynamic exchange of hydrazone bonds, achieving room-temperature self-healing. Excess hydrazone groups in the coating capture aldehyde pollutants, and the newly generated hydrazone bonds introduce polar groups and crosslinking sites, enhancing network stability.

This invention provides a biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold, its preparation method, and its application, relating to the technical field of tissue engineering scaffolds. The biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold comprises, from the inside out, a cementum repair layer, a periodontal ligament repair layer, and an alveolar bone repair layer; the cementum repair layer and the alveolar bone repair layer include a mineralized hydrogel layer; wherein the raw materials for preparing the mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and hydroxyapatite; the alveolar bone repair layer includes a non-mineralized hydrogel layer; wherein the raw materials for preparing the non-mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and fibrin I. This invention precisely matches the mechanical and biological requirements of each layer of the periodontal complex through a three-layer structure, a reversibly hydrazone-regulated viscoelastic gradient, and a differentiated biochemical microenvironment of nHAp / FBN1.

The application relates to the technical field of pharmaceutical chemistry, and discloses a sulfuryl hydrazone compound, a preparation method thereof and anti-tumor application. The compound is synthesized from isatin derivatives and sulfuryl hydrazine through two-step nucleophilic substitution-elimination reaction, has a chemical structure as shown in formula (I), and is characterized by 1H NMR, 13C NMR and HRMS. The sulfuryl hydrazone compound has significant inhibitory activity on A549 (lung cancer), HepG2 (liver cancer) and Hela (cervical cancer) three human cancer cell strains, the value of some compounds is as low as 0.03 micromole / L, the compound can induce cell apoptosis by mediating ROS generation in tumor cells, inhibiting the NF-kappa B signal pathway and activating Caspase-3 activity, and can effectively inhibit cancer cell migration and colony formation. The compound has a mild synthesis process, simple operation and wide substrate applicability, can be used as a potential anti-tumor active ingredient, can be used for preparing drugs for resisting lung cancer, liver cancer, cervical cancer and other tumors, and can provide new candidate compounds and technical support for cancer treatment.

The present application belongs to the technical field of animal model construction, and relates to a insomnia animal model construction method and application with the characteristics of body deficiency, fever and emotional irritability. The application of uncoupling agent as a modeling agent in the construction of insomnia animal model with the characteristics of body deficiency, fever and emotional irritability; the uncoupling agent is carbonic acid cyanide-4-trifluoromethoxy benzyl hydrazone, carbonyl cyanide m-chlorophenyl hydrazone or benzalazoline. The present application uses mice as model animals, uses uncoupling agent as a modeling agent, and suspends or dissolves the modeling agent, then gives the mice intragastric administration once a day, and lasts for 1-4 weeks, to construct a "deficiency and irritability insomnia" insomnia animal model with the characteristics of body deficiency, fever and emotional irritability. The present application has a high degree of consistency with the traditional Chinese medicine theory, and can be well used for the screening and evaluation of anti-insomnia chemical drugs, anti-insomnia traditional Chinese medicine compounds and anti-insomnia health care products.

The present application relates to the field of drug delivery technology and chronic kidney disease treatment, in particular, a kidney tissue targeted chronic kidney disease treatment drug nano delivery system, which solves the problems of poor targeting, low bioavailability, obvious side effects of existing chronic kidney disease treatment drugs, and insufficient responsiveness and poor safety of existing nano delivery systems. The system comprises a double-responsive nano carrier, an anti-kidney fibrosis drug and a targeting mediation layer. The double-responsive nano carrier is based on methoxy polyethylene glycol modified chitosan-polylactic acid copolymer, contains pH-sensitive hydrazone bonds and redox-sensitive disulfide bonds, and has a core-shell structure. The surface of the carrier is covalently connected with CD13 receptor affinity peptides, and is coated with a polylysine modified hyaluronic acid targeting mediation layer. The drug is pirfenidone or mycophenolate mofetil, which is covalently combined with the carrier through a disulfide bond. The system can realize precise enrichment of kidney lesions and double-responsive controlled drug release, improve the treatment effect, and reduce systemic and local toxicity.

The application provides a dendrimer prodrug and a nano-assembly thereof, and belongs to the technical field of antitumor drugs. The application constructs a dendrimer prodrug Epi-DBP shown in formula I by bridging PEG and Epi dendrimer conjugate through a borate ester bond. An IDO inhibitor NLG919 is loaded in the hydrophobic cavity of the Epi-DBP to form a nano-assembly NLG919@Epi-DBP. The nano-assembly NLG919@Epi-DBP has a stable nano structure and can be enriched at a tumor tissue. In an acidic environment of a tumor cell, a hydrazone bond is broken to cause the release of Epi and NLG919. Experimental results show that the NLG919 in the NLG919@Epi-DBP has excellent synergistic antitumor effect with the Epi-DBP. The application constructs an IDO inhibition combined with chemotherapy nano platform based on a dendrimer, realizes the remodeling of a tumor immune microenvironment while synergistically performing chemotherapy to enhance the antitumor effect, and has a wide application prospect.

This invention discloses a low-temperature resistant solvent-free polyurethane adhesive and its preparation method, belonging to the technical field of polyurethane adhesives. The adhesive comprises component A and component B. Component A includes the following raw materials in parts by weight: 10-30 parts epoxidized castor oil, 15-35 parts polyether polyol, 5-15 parts bisphenol A type liquid epoxy resin, 20-30 parts epoxy silane-modified nano-hydroxyapatite, and 0.1-0.5 parts catalyst. Component B includes the following raw materials in parts by weight: 30-50 parts isocyanate, 10-20 parts polyether polyol, 5-15 parts terminal aminosiloxane, and 4-10 parts vanillin polyethylene glycol hydrazone. The vanillin polyethylene glycol hydrazone is obtained by the condensation reaction of vanillin and polyethylene glycol dihydrazide. The polyurethane adhesive of this invention introduces multiple flexible chain structures with synergistic effects, enabling the adhesive to possess good toughness under low-temperature conditions.

This invention relates to a kit and application for improving the stability of CY5 signals in direct amplification PCR systems of blood samples, belonging to the field of gene detection technology. The invention provides a CY5-modified probe carrying a protecting group, which is formed by coupling an activated protecting group containing ester and hydrazone bonds with a CY5-modified probe. It also provides a PCR detection method using the aforementioned CY5-modified probe carrying a protecting group for non-disease diagnosis or treatment purposes. The probe designed in this invention can break ester bonds at the high temperature (90-95℃) of the PCR reaction. Simultaneously, as the temperature increases, the pH changes; for every 10℃ increase in temperature, the pKa value decreases by approximately 0.3. Under suitable pH conditions, the protecting group itself breaks, further reducing the steric hindrance effect of the probe and releasing the target probe. This solves the problems of severe signal interference, low detection sensitivity, and poor specificity of CY5 fluorescent probes in direct amplification PCR of blood samples.

A hydrazone compound, a pharmaceutical composition thereof and application thereof. Specifically, provided are compounds as shown in formula (III) or pharmaceutically acceptable salts thereof. The compounds have one or more of the following advantages: good water solubility; lower cytotoxicity; good inhibitory activity on Arf1 activation; strong anti-tumor immunity and induction thereof.

The invention relates to a polymer for treating a surface, which polymer comprises n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups for controlling surface-initiated reversible-deactivation radical polymerization (SIRDRP), wherein m is an integer equal to or greater than 3. The groups for controlling SIRDRP are selected from groups which comprise an initiator and groups which comprise a chain transfer agent (CTA). The reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups. The carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D): wherein R1 is H or –S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for SIRDRP. The invention also relates to a treated substrate having a surface suitable for SIRDRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIRDRP, bonded to the reacted polymer.

This invention discloses a dibenzylamine-bridged DASA molecular switch for salicylaldehyde hydrazone and its preparation method. The DASA molecule has the structure 4-((benzyl((1E,3Z)-5-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidine-5(2H)-ylidene)-4-hydroxypentan-1,3-dien-1-yl)amino)methyl)-N′-((E)-2-hydroxybenzylene)benzoylhydrazide, which is prepared by reacting the donor (E)-4-((benzylamino)methyl)-N′-(2-hydroxybenzylene)benzoylhydrazide with the acceptor 5-(furan-2-methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione in methanol. Its advantages include: exhibiting excellent negative photochromic behavior in moderately strong aprotic polar solvents such as dichloromethane and acetonitrile; undergoing reversible linear-ring isomerization under visible light irradiation; showing significant changes in absorption peaks; and exhibiting good cyclic fatigue resistance. Furthermore, the introduced salicylaldehyde hydrazone group enhances its responsiveness to acids, bases, and metal ions, enabling reversible switching in various protic and aprotic solvents and selective recognition of different metal ions, thus showing broad application prospects in colorimetric sensing and metal ion detection.

This invention discloses a photocatalytic anti-mildew coating of titanium dioxide and its preparation method. The coating consists of Ni-N4 single-atom shell modified titanium dioxide, 2-hydroxypropionamide, film-forming resin, dispersant, leveling agent, anti-settling agent, defoamer, and deionized water. The Ni-N4 single-atom shell modified titanium dioxide forms a dynamic hydrazone network in situ on the titanium dioxide surface, and the Ni-N4 single-atom structure is constructed through heat treatment with nickel acetate assistance, significantly improving the separation efficiency and dispersibility of photogenerated carriers. The 2-hydroxypropionamide molecules form a stable hydrogen bond network in the system, enhancing the coating's density and long-term stability. The coating obtained by this invention exhibits excellent performance in dispersibility, density, anti-mildew properties, resistance to damp heat, and photocatalytic properties. This invention solves the problems of easy agglomeration, loose coating, and poor anti-mildew performance of traditional titanium dioxide, demonstrating strong innovation and application prospects.

The application discloses an antitumor composition of arsenic trioxide and artesunate for enhancing the drug efficacy of arsenic trioxide, and discloses GA modified pH responsive arsenic trioxide-artesunate double-drug nanoliposome including the composition, the double-drug nanoliposome including glycyrrhetinic acid-polyethylene glycol-hydrazone-distearyphosphatidyl ethanolamine polymer, cholesterol, artesunate and calcium arsenate nanoparticles; the glycyrrhetinic acid-polyethylene glycol-hydrazone-distearyphosphatidyl ethanolamine and cholesterol form nanoliposome, and the nanoliposome is loaded with artesunate and calcium arsenate nanoparticles; the calcium arsenate nanoparticles contain arsenic trioxide, and a preparation method and application in preparing antitumor drugs are disclosed. The application first co-loads the highly toxic traditional Chinese medicine arsenic trioxide and artesunate to play a synergistic effect, realizes the attenuation and efficiency enhancement of arsenic trioxide through targeted modification delivery and tumor microenvironment response release, and has a good clinical application prospect.

The invention discloses an oleanolic acid acylhydrazone derivative as well as a preparation method and application thereof. The oleanolic acid acylhydrazone derivatives have a structural formula shown in the following formula I. In the structural formula, R is selected from halogen-substituted pyridine and hydroxyl-substituted naphthyl. The invention provides a series of oleanolic acid acylhydrazone derivatives with novel structures, and the oleanolic acid acylhydrazone derivatives have relatively good inhibition effects on human breast cancer cells MDA-MB-231 and human pancreatic cancer cells Mia paca-2, and can be used for preparing an anti-cancer drug. The compound can be used for preparing anti-tumor drugs.

This invention discloses a class of imidazo[1,2-]azoline containing a hydrazone structure. a Preparation methods and applications of pyridine derivatives, this invention uses imidazo[1,2- a Using the pyridine skeleton as the parent structure, a series of imidazo[1,2-] hydrazone fragments were introduced to design and synthesize a series of imidazo[1,2-] hydrazone-containing structures. a Pyridine derivatives. In vitro activity results showed that these compounds had excellent inhibitory activity against plant pathogenic fungi (such as *Botrytis cinerea*, *Colletotrichum gloeosporioides*, *Colletotrichum sorghum*, *Colletotrichum tea*, *Alternaria alternata*, and *Rhizoctonia solani*), and some of the target compounds also showed good inhibitory activity against plant pathogenic bacteria.

The application belongs to the technical field of mass spectrometry, and particularly relates to application of 2-hydrazinylpyrazine as a reactive matrix in MALDI-TOF-MS analysis of carbohydrates and a method. 2-hydrazinylpyrazine is an organic small molecule with a hydrazine group, can specifically react with the aldehyde group at the reducing end of carbohydrates to generate a hydrazone derivative, significantly improve ionization efficiency and move the target molecule to the high mass region, and avoid matrix interference. The application also provides a matrix system comprising 2-hydrazinylpyrazine and alpha-cyano-4-hydroxycinnamic acid propyl ester and a layered spotting method, wherein the derivatization reaction solution is first spotted, and then alpha-cyano-4-hydroxycinnamic acid propyl ester solution is overlaid after drying, which significantly improves the uniformity of crystallization, eliminates the "sweet spot effect", and improves the detection reproducibility. The method of the application can directly analyze carbohydrates in complex biological samples without purification and enrichment, and can obtain rich fragment ions in tandem mass spectrometry analysis, and successfully distinguish isomers.

The application discloses a charge transport layer coating with low visible light transmittance and a preparation method thereof, and belongs to the field of organic photoconductive drums. The charge transport layer coating comprises 1-5 parts of 9-anthracene formaldehyde diphenyl hydrazone, 5-10 parts of a silicone leveling agent, 60-120 parts of N,N'-diphenyl-N,N'-di(p-tolyl)benzidine, 100-150 parts of a carbonic acid resin, 500-800 parts of a tetrahydrofuran solution and 0.2-0.5 parts of tertiary amyl binaphthylquinone. The charge transport layer coating adds tertiary amyl binaphthylquinone, which can be uniformly dispersed in the charge transport layer solution, so that the solution changes from colorless and transparent to red-brown. When the charge transport layer solution is coated on the surface of a charge generation layer of a photosensitive drum to form a charge transport layer, the visible light transmittance can be reduced under the condition of guaranteeing electrical characteristics, the risk that the surface charging potential of the photosensitive drum is attenuated under light can be effectively reduced, and the service life and printing quality of the photosensitive drum are improved.

The present application provides a resin composition, and a pellet and a molded article. The resin composition contains (A) a polyacetal resin, and contains (B) an aliphatic carboxylic acid hydrazide and / or an aliphatic hydrazone in an amount of 0.005 to 0.3 parts by mass per 100 parts by mass of (A) the polyacetal resin, and (C) a urea compound represented by formula (N) in an amount of 0.02 to 0.3 parts by mass, the (C) urea compound containing a silicon-containing compound in a proportion such that the silicon atom content in the (C) urea compound is greater than 0 mass% and is 0.007 mass% or less.

A method for preparing trifluoromethyl-substituted 1,2,4-triazole hydrazone derivatives is disclosed, relating to the field of organic synthesis. This invention uses readily available and inexpensive trifluoromethylhydrazone chloride and N-cyano-N-aryl-p-toluenesulfonamide as starting materials. Under alkaline conditions, derivatives containing trifluoromethyl, 1,2,4-triazole rings, and hydrazone structures are constructed in one step via a tandem cyclization and nucleophilic substitution reaction. This process requires no catalysts, metal reagents, or additional oxidants, features mild reaction conditions, simple operation, low equipment requirements, excellent atom economy, high starting material conversion rate, few byproducts, and is easy to scale up and promote. It provides a practical and economical synthetic route for the development of potentially bioactive trifluoromethyltriazole hydrazone compounds.

This invention belongs to the field of biomedical technology, specifically relating to a bispecific antibody photoimmunoassay inhibitor, its preparation method, and its application. The bispecific antibody photoimmunoassay inhibitor is composed of a bispecific antibody against EGFR and HER3 linked to a photosensitizer. The photosensitizer includes dihydroporphyrin e6, IR700, verteporfin, and / or hematoporphyrin monomethyl ether. The near-infrared photosensitizer is coupled to the Fc segment or constant region of the bispecific antibody via hydrazone bonds or disulfide bonds. This bispecific antibody photoimmunoassay inhibitor can simultaneously target EGFR and HER3, precisely killing tumor cells through phototherapy, and has broad application prospects in tumor treatment.

This invention belongs to the field of biopharmaceutical nanoparticle formulations and provides an anti-AQP5 arginine deiminase nanocarrier complex and its preparation method. The invention utilizes a PLGA-PEG-maleimide copolymer to self-assemble into core-shell nanoparticles with a particle size of 50-200 nm. The shell layer is cross-linked by pH-sensitive hydrazone bonds formed by diacylhydrazide and glutaraldehyde, maintaining structural and storage stability under neutral conditions. Under acidic tumor / endosome environments, it can partially dissociate to release and restore the protein conformation. The anti-AQP5 antibody-arginine deiminase is covalently fixed to the shell surface via thio-maleimide addition, achieving a synergistic effect of high protein loading and enzyme activity maintenance, long PEGylation cycling and AQP5-mediated active targeting, and a dynamic balance between stable encapsulation and acid-triggered deactivation. In vitro uptake by AQP5-highly expressing tumor cells is significantly superior to non-targeting carriers, and the in vivo plasma half-life is significantly prolonged, making it suitable for tumor metabolic therapy.

This invention belongs to the field of organic chemical synthesis technology, specifically relating to an N-aminohydrazone derivative and its preparation method. The N-aminohydrazone derivative has the general structural formulas I and II, where Formula I is [formula missing], and Formula II is [formula missing], wherein Ar- is phenyl, substituted phenyl, aryl, or heteroaryl; in Formula I, the two R'; together constitute morpholino, piperidin-1-yl, or 2-phenylhydrazine derivative; in Formula II, R'; is morpholino, piperidin-1-yl, or 2-phenylhydrazine derivative; R" is ethyl, isopropyl, tert-butyl, or benzyl; and R';';'; is H or phenyl. Formula I is prepared using aldehyde hydrazone compounds and azodicarboxylic acid ester compounds as reactants, employing a "one-pot two-step" method. Using aldehyde hydrazone compounds and azodicarboxylic acid ester compounds as reactants, a photocatalyst and a metal catalyst are added to the reaction system to prepare Formula II. The N-aminohydrazone derivative provided by this invention has a novel structure, good functional group compatibility, mild preparation conditions, and simple operation.

This invention belongs to the field of pesticides and fungicides, and discloses the synthesis and application of a hydrazone compound. The hydrazone compound has the structure shown in Formula I. The hydrazone compound of this invention has the advantages of novel structure, low toxicity, and high-efficiency fungicidal activity, and has great application prospects as a fungicide.