1137 results about "Hydrazone" patented technology

The invention discloses a method for determining content of volatile carbonyl compound in main stream smoke of cigarette. 2, 4-dinitrophenylhydrazine is utilized to gather volatile carbonyl compound in main stream smoke of cigarette, so as to form hydrazone compound, and the content of the hydrazone compound is determined by a high performance liquid chromatograph by adopting external standard method; and the high performance liquid chromatograph adopts chromatographic column. The determination method of the invention adopts chromatographic column, has excellent separating effect on nitro substituted arene derivative, especially on hydrazone compound formed after reaction of 2, 4-dinitrophenylhydrazine and volatile carbonyl compound, and meanwhile chromatographic analysis condition is optimized, thus achieving complete separation of volatile carbonyl compound and interfering component in main stream smoke of cigarette and improving accuracy of determination.

The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the like. The methods of the invention provide several improvements over existing methods, including the ability to synthesize efficiently and under mild conditions α-aryl and α-vinyl products from a wide range of starting materials, including ketones, esters, hydrazones, and imines. Furthermore, the methods of the invention may be used in an asymmetric sense, i.e. to produce enantiomerically-enriched chiral α-aryl and α-vinyl products.

Charge transport compounds are described that have a multiple number of hydrazone-bridged heterocyclic groups (especially julolidine, carbazole and/or triarylmethane groups) connected by a central bridging group. An example of charge transport compounds are those having the following generic formula:(R-Q)n-Y Formula Iwherein R is selected from the group consisting of julolidine ring groups, carbazole ring groups, and triarylmethane ring groups; Q comprises an aromatic hydrazone linking group, such as Y comprises a bridging group between R-Q- groups, such as a bond, carbon atom, nitrogen atom, oxygen atom, sulfur atom, a methylene group; Z is an aryl group, preferably a phenyl group or naphthyl group; X is a linking group, preferably amethylene group, and for example having the formula -(CH2)m- (branched or linear), where m is an integer between 0 and 20, inclusive, and one or more of the methylene groups is optionally replaced by an oxygen atom, a carbonyl group, urethane, urea, an ester group, a -NR6 group, a CHR7 group, or a CR8R9 group where R6, R7, R8, and R9 are, independently, H, an alkyl group, or aryl group; and n is an integer between 2 and 6, inclusive. An organic photoreceptor includes that compound and (b) a charge generating compound; and (c) an electrically conductive substrate.

A functionalized polymer includes a directly bonded moiety, which can be located at a terminus of the polymer, defined by the formula —NH—NR¹R² where R¹ and R² independently are substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, allyl, aralkyl, alkaryl, or alkynyl groups, or together form a substituted or unsubstituted alkylene, alkenylene, cycloalkylene, cycloalkenylene, or arylene group. The functionalized polymer can be provided by reacting a living polymer with a hydrazone. Such polymers can be used in the production of compositions that include particulate fillers.

Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.

The invention relates to a dual-sensitivity amphiphilic polysaccharide-doxorubicin conjugate.According to the conjugate, hydrophobic antitumor drug doxorubicin is introduced in a polysaccharide framework through a connecting arm containing a disulfide bond and a hydrazone bond, so that the polysaccharide-doxorubicin conjugate has an amphiphilic property, can be self-assembled into a nano-micelle in water and directly used for tumor treatment, and can also be physically loaded with an antitumor drug to be used for antitumor treatment.The conjugate is mainly characterized in that after the nano-micelle reaches a focus, the disulfide bond in the connecting arm can be degraded specifically by high-concentration reduction substances in focus cells, and meanwhile the hydrazone bond in the connecting arm can be degraded in a special pH environment of the focus, so that the micelle is degraded, the drug is quickly released, and the treatment effect is improved; the antitumor drug is loaded in two modes of chemical conjugation and physical package, and therefore the joint treatment effect is achieved.The polysaccharide conjugate and a pharmaceutical composition can be used for injection or oral administration or external administration, can remarkably improve antitumor activity, and provides a new thought for development of the antitumor drug.

To realize an electrophotographic photoreceptor excellent in abrasion resistance, the photosensitive layer of the photoreceptor comprises a polyester resin containing a repeating structural unit represented by the formula (1) and a hydrazone compound.

(In the formula (1), Ar¹ to Ar⁴ each represents, independently of each other, an arylene group which may have a substituent. X¹ represents a bivalent group (including a single bond) and X² represents a bivalent group (including a single bond) with 3 or less atoms.)

The invention relates to a hydrazone bond-connected chiral covalent organic framework bonded silica gel stationary phase and an application thereof. The stationary phase is prepared by a method comprising the following steps: uniformly mixing a hydrazide chiral precursor, 1,3,5-benzenetricarboxaldehyde and ammoniated silica gel in an organic solvent in an inert atmosphere, carrying out a reaction under the catalysis of acetic acid, and filtering, washing and drying the obtained reaction product to obtain the chiral covalent organic framework bonded silica stationary phase. The structure of the hydrazide chiral precursor is represented by formula (I) shown in the description, a mass ratio of the ammoniated silica gel to the hydrazide chiral precursor is (2-12):1, and molar ratio of the hydrazide chiral precursor to the 1,3,5-benzenetricarboxaldehyde is 1:(0.5-2). The chiral covalent organic framework-bonded silica gel stationary phase is uniform in particle size; and the stationary phase has the advantages of high column efficiency, moderate column pressure and good separation effect on cis-trans isomers and position isomers when used in high performance liquid chromatography, and also has the advantages of definite structure, simple preparation method and good batch reproducibility.

The invention relates to a bifunctional polyethylene glycol and adriamycin conjugate and a preparation method thereof. The bifunctional polyethylene glycol and adriamycin conjugate is prepared in the following steps: modifying methoxy polyethylene glycol which serves as a raw material through hydroformylation, carrying out a reductive amination reaction on the modified methoxy polyethylene glycol and disulfide-bond containing dihydrazide to generate terminal-hydrazide polyethylene glycol, and carrying out a reaction on the terminal hydrazide of the terminal-hydrazide polyethylene glycol and the ketone carbonyl of the adriamycin to generate a hydrazone bond to obtain the bifunctional polyethylene glycol and adriamycin conjugate. The bifunctional polyethylene glycol and adriamycin conjugate provided by the invention can adapt to the reductive acidic environment in a cancer cell to release drugs rapidly to improve the cancer treatment effect and reduce the drug resisting possibility of the cancer cell, and in addition, the bifunctional polyethylene glycol and adriamycin conjugate can be self-assembled into a nano particle in a water phase to be able to circulate for a long time in blood to improve the pharmacokinetics of the doxorubicin. The method for preparing the bifunctional polyethylene glycol and adriamycin conjugate has the advantages of simple process, mild reaction conditions, high drug carrying rate and low cost, and the raw materials are easy to obtain. The bifunctional polyethylene glycol and adriamycin conjugate has potential application values in the aspects of targeted delivery of drugs, controlled release of drugs and improvement of clinical cancer resisting and treating effects.

The invention discloses a convenient, rapid and economical method for massively preparing abiraterone acetate. According to the method, dehydroepiandrosterone acetate is used as a starting material, a keto carbonyl group is converted to hydrazone, and the abiraterone acetate is directly synthesized through iodination and Suzuki coupling reaction. According to the method, the operation is simple and convenient, the total yield of the three-step reaction is 34.7%, the product purity is 98.5%, the column chromatography separation purification is not required in the postprocessing, and the method is suitable for industrial production.

A compound represented by the following formula (I):

wherein R¹ represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R² represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R³ represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof.

Water-borne cross-linking polymeric compositions and related embodiments, such as methods of making and using the compositions, as well as products formed with said compositions are described. For example, the water-borne composition may comprise polymers incorporating cross-linking functionality such as, but not limited to, carbonyl or epoxy functionality, and a blocked cross-linking agent, for example, a hydrazone. The cross-linking functionality does not react with the blocked cross-linking agent; however, the blocked cross-linking agent is capable of reacting with the alternative form cross-linking agent such as, but not limited to, a hydrazide, to yield a cross-linked polymer. The alternative form cross-linking agent may be formed in an equilibrium reaction including the blocked cross-linking agent.

The aim of the invention is to improve the cleaning performance of washing and cleaning agents against stains from polysaccharide-containing food residue. This is substantially achieved by incorporating a combination of peroxide bleaching agents with specific acyl hydrazones.

The present invention provides 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues suitable for use as an in vivo iron chelators, the PCIH analogue having Formula 1:

wherein R1 is an aromatic or heterocyclic group and R2 is either H or OH; isomers thereof or salts thereof; pharmaceutical compositions containing the analogues; and uses of the analogues in the treatment of iron-overload diseases.

An object of the invention is to improve the photosensitivity characteristics, characteristics on repeated use and stability of a photoreceptor. A photosensitive layer formed on a conductive support of a photoreceptor contains crystalline oxotitanylphthalocyanine having major peaks in an X-ray diffraction spectrum at Bragg angles (2theta±0.2°) of 7.3°, 9.4°, 9.6°, 11.6°, 13.3°, 17,9°, 24.1° and 27.2°, wherein a peak bundle formed by overlapping the peaks at 9.4° and 9.6° is the largest peak, and the peak at 27.2° is the secondary largest peak as a charge generating substance. Furthermore, it contains a bisamine compound, an N,N'-bisenamine compound, a styryl compound, an amine-hydrazone compound, a benzofuran-bishydrazone compound, a bisenamine compound, a benzofuran-bishydrazone compound or a benzofuran-bis-cyclic hydrazone compound represented by the particular structural formulae as a charge transporting substance.

The invention relates to a medicine for killing solenopsis invicta buren and the use method thereof. The medicine comprises 0.0025%-5.0000% of insecticidal active constituent according to mass percent, which is selected from one of or the mixture of the following component: fipronil, fluorine insects amines, spinosad, Arab-Israeli (Iraq) ivermectin, vants hydrazone, imidacloprid, rotenone, matrine, Yanggakdo twisting glycosides, cicuta alkali, boric acid; 15%-25% of glucide, 10%-25% of thickening agent, 0.005%-6% of menstruum, 0.01%-0.03% of preservative and the rest of water. The use method of the solenopsis invicta buren baits is that: pouring suitable quantity baits agent into a container with nozzle, and diluting the baits agent with water, then agitating the anthill lightly, and sprinkling the water-based baits agent on the body surface of the ergates and the soil above the anthill surface after a mass of ergates come out of the anthill. The manufacturing process of the medicine is simple, the cost is lower, and the use method is suitable for large-scale spraying.

The invention discloses a double-targeting polypeptide-antibody-drug conjugate, and a prepared method and antineoplastic application thereof. The double-targeting polypeptide-antibody-drug conjugate structurally includes four components of (A), tumor specificity targeting polypeptide; (B), an antineoplastic drug; (C), a mitochondria target functional group; and (D), hydrazone bonds used for connecting the polypeptide and the antineoplastic drug. The tumor specificity targeting polypeptide is connected with the antineoplastic drug by a connecting arm comprising the hydrazone bonds; the antineoplastic drug is connected with the mitochondria target functional group by chemical bonds; and the tumor specificity targeting polypeptide is suitable for targeting the conjugate to a tumour cell and marker protein LAPTM4B carried on the surface of the tumour cell is used as a specificity target. A molecular target is combined with an organelle target, selective uptake of the drug in the tumour cell can be increased, an acting site of a DOX drug can be transferred form cell nucleus to mitochondria, and therefore the condition that the tumour cell is killed by drug resistance is avoided.

The invention provides antineoplastic prodrugs with structures represented by formulas (I), (II), (V), (VI), (VII), or (VIII), and a preparation method thereof. According to the invention, polyethylene glycol or polyethylene glycol monomethyl ether is adopted as a carrier, and anthracycline antineoplastic drugs are bonded on the carriers through ester bonds, amide bonds or hydrazone bonds, such that the antineoplastic prodrugs are obtained. According to the antineoplastic prodrugs provided by the invention, polyethylene glycol or polyethylene glycol monomethyl ether is adopted as a carrier, such that the drug-loading of the anthracycline antineoplastic drugs is improved, toxic and side-effects are reduced, and the bioavailability is improved. Polyethylene glycol or polyethylene glycol monomethyl ether has good biocompatibility and biodegradation property. When polyethylene glycol or polyethylene glycol monomethyl ether is used as an antineoplastic prodrug carrier, no harm is brought to human bodies. With polyethylene glycol or polyethylene glycol monomethyl ether, anthracycline antineoplastic drug dissolvability and circulation period in human bodies can be improved. Therefore, the method assists in improving the performances of anthracycline antineoplastic drugs.

The invention belongs to the field of medicinal chemistry and discloses pyrimidotriazole compounds containing hydrazine bonds as well as a preparation method and an application of the pyrimidotriazole compounds in drug preparation. The general formula I of the compounds is shown in the specification. The compounds have remarkable inhibition and killing functions on multiple tumor cells such as MGC-803, MCF-7 and EC-109, can serve as candidate or lead compounds for further development and are applied to preparation of an anti-tumor drug.

The invention relates to a functional reactive dye for a zinc ion probe, and a preparation method and application thereof. The dye has a structural formula as described in the specification. The preparation method comprises the following steps: subjecting rhodamine B and hydrazine hydrate to a heating reflux reaction so as to obtain rhodamine B hydrazide; subjecting methyl p-aminobenzoate and hydrazine hydrate to a heating reflux reaction, dissolving a product in a solvent, adding salicylaldehyde drop by drop and then carrying out a heating reflux reaction so as to obtain salicylaldehyde-4-aminobenzoyl hydrazone; and dissolving cyanuric chloride in a solvent, adding an acid binding agent, adding rhodamine B hydrazide drop by drop at a temperature in a range of -5 to 5 DEG C, carrying out a reaction under stirring so as to obtain a concentration product, dissolving the concentration product in a solvent, adding the acid binding agent, adding salicylaldehyde-4-aminobenzoyl hydrazone drop by drop and carrying out a reflux reaction with temperature controlled so as to obtain the functional reactive dye. The functional reactive dye has good selectivity on zinc ions, is convenient to use in sewage treatment and exerts good usage effect.

The invention provides a preparation method for amycin pro drug and application thereof; the method is as follows: potassium permanganate and polyethylene glycol are oxidized and reacted to generate polyethylene glycol diacid; by EDCI catalyzing effect, polyethylene glycol diacid and hydrazinoformic acid butyl ester are reacted and then BOC protective group is drawn off to generate polyethylene glycol maleic hydrazide intermediate product; by EDCI catalyzing effect, the intermediate product is drawn into 13-carbonyl of amycin to obtain target compound amycin-polyethylene glycol diacid hydrazone bond linker. The pro drug can strength anti-tumor effect of amycine, reduces toxic and side effect of medicine, increases targeting effect, and provides new idea for the development of anti-tumor medicines.