Medicinal uses of hydrazones

a technology of hydrazone and hydrazone, which is applied in the field of medicinal uses of hydrazone, can solve the problems of lack of oxygen supply, tissue damage, health problems affecting hundreds of millions of people, etc., and achieve the effects of increasing the transcription of hif-1 target genes, and increasing the biological activity of hif-1
US20040053977A1Inactive Publication Date: 2004-03-18ALMSTEAD JI IN KIM +3
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ALMSTEAD JI IN KIM
Publication Date
2004-03-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compounds having a structure according to Formula (I): are effective in a method of increasing erythroproietin and vascularization of tissue in a subject in need thereof.
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Description

[0001] This application is a Divisional of application Ser. No. 10 / 134,890, filed Apr. 29, 2002, which claims priority under Title 35, United States Code 119(e) from Provisional Application Serial No. 60 / 288,765, filed May 4, 2001.

[0002] This invention is directed to compounds that are useful in methods of treating hypoxia related disorders. The invention is also directed to pharmaceutical compositions comprising the compounds.

[0003] Ischemic cardiac disease and peripheral vascular disease are major health problems affecting hundreds of millions of people worldwide. Ischemia results when there is a lack of oxygen supply. It is estimated that about half of the deaths that occur in the United States each year alone are caused by ischemic heart disease. This invention relates, in part, to methods for the treatment of such diseases and pharmaceutical compositions in the treatment thereof.

[0004] Oxygen is essential for an organism's survival, given its role in essential metabolic process...

Claims

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