How to Increased vascularization patent retrieval - Eureka

Enhancement of angiogenesis to grafts using cells engineered to produce growth factors

ActiveUS20050002915A1Great ease of implantationSupport growthBiocidePeptide/protein ingredientsSecreted growth factorAngiogenesis Modulating Agents

The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular endothelial growth factor (VEGF), in conjunction with constructs for replacing or augmenting organ functions. In one aspect of he invention, the genetically engineered cells can be immature cells that are capable of differentiating and assimilating into the target region. The methods of the present invention can be used to enhance vascularization locally at a target site in need of repair, growth, or implantation through the incorporation of autologous cells which have been genetically engineered to secrete a growth factor or angiogenesis modulating agent.

Enhancement of angiogenesis to grafts using cells engineered to produce growth factors

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Owner:WAKE FOREST UNIVERSITY

Methods of enhancing drug delivery and effectiveness of therapeutic agents

ActiveUS20120076862A1Promote absorptionConvenient treatmentPowder deliveryHeavy metal active ingredientsDiseaseCo administration

The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as “the drug uptake capability”). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.

Owner:ABRAXIS BIOSCI LLC

Medicinal uses of hydrazones

InactiveUS6660737B2Increasing endogenous EPO and vascularizationIncreased vascularizationBiocideNervous disorderGynecologyHydrazone

Compounds having a structure according to Formula (I):are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.

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Owner:THE PROCTER & GAMBLE COMPANY

Methods and compositions for modulating hair growth or regrowth

InactiveUS20070036742A1Inhibit synthesisIncreased vascularizationBiocideCosmetic preparationsAstaxanthinRed Clover

The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and / or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.

Owner:ACCESS BUSINESS GRP INT LLC

Devices having a textured surface

ActiveUS7645475B2Good adhesionReduce capsular contractionEnvelopes/bags making machineryLayered productsPolymerMaterials science

A method for forming a randomly textured surface on an implantable device such as soft tissue prosthesis. The textured surface has numerous cavities, interstices and passageways or tunnels and is thus referred to as a microporous surface texture. The surface is formed by two or more applications of polymeric particles and a polymeric dispersion.

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Owner:MENTOR WORLDWIDE

Methods of enhancing drug delivery and effectiveness of therapeutic agents

InactiveUS20140017323A1Uptake of the therapeutic agent to a target tissuePromote absorptionBiocideOrganic active ingredientsDiseaseNanoparticle

The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as “the drug uptake capability”). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.

Owner:ABRAXIS BIOSCI LLC

Compositions And Methods For Lipo Modeling

InactiveUS20090317376A1Conducive to survivalReduce adverse metabolic consequence of obesityBiocidePeptide/protein ingredientsFat graftingNK1 receptor antagonist

Methods for lipomodeling by peripherally administering a modulator of a Y receptor are provided. Methods may comprise reduction of a fat depot by administering a Y receptor antagonist proximally and / or directly to the site of the fat depot. Other methods comprise increasing or stabilizing a fat depot or fat graft by administering a Y receptor agonist proximally and / or directly to the site of the fat depot or fat graft. Also provided are methods for stimulating wound healing by administering a Y receptor agonist proximally to a wound site.

Compositions And Methods For Lipo Modeling

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Owner:GEORGETOWN UNIV

Long-acting hormone and growth factor compositions and uses thereof

InactiveUS7442684B2Improve fertilityIncrease egg productionPeptide/protein ingredientsPeptide preparation methodsSerum igeHalf-life

This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.

Long-acting hormone and growth factor compositions and uses thereof

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Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK

Vascularization Inhibitors

InactiveUS20130236889A1Increased vascularizationPeptide/protein ingredientsMicrobiological testing/measurementCXCR4Knockout animal

This invention provides a therapeutic agent for inhibiting neovascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, and a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4.Based on the finding that vascularization is suppressed in CXCR4 knockout mice, it becomes possible to prepare a therapeutic agent for suppressing vascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, each of which comprises as the effective ingredient, a substance that inhibits the action of CXCR4, as well as to prepare a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. Methods for treatment are made possible that use these therapeutic agents.

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Owner:KISHIMOTO TADAMITSU +2

Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells

ActiveUS20110218396A1Improve efficiencyEasy to integrateNon-surgical orthopedic devicesPenis implantsSexual impotenceTissue integration

The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and / or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.

Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells

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Owner:UNIV OF LOUISVILLE RES FOUND INC +1

Medicinal uses of dihydropyrazoles

InactiveUS6878729B2Increasing endogenous EPO and vascularizationIncreased vascularizationBiocideOrganic chemistryGynecologyBlood vessel

Compounds having a structure according to Formula (I):are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.

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Owner:PROCTER & GAMBLE CO

Fluid dispenser

ActiveUS20130218066A1Speed up the repair processPromotes collagen synthesisElectrotherapyDiagnosticsActuatorRadiation

A fluid dispenser comprising:a fluid reservoir (1); anda body (6) receiving:a dispenser member (3) that is connected to the reservoir (1);an actuator member (4) for actuating the dispenser member (3);a dispenser and diffuser head (7) forming a fluid dispenser orifice (73) and an application wall (74) for applying the fluid coming from the dispenser orifice (73) onto the skin;a module (5) comprising at least one source of radiation (51), such as an LED, each emitting monochromatic light of 400 nm to 700 nm, and having an anti-inflammatory action and / or a stimulating action for stimulating skin-regeneration metabolisms;characterized in that the dispenser and diffuser head (7) comprises a source housing (78), and in that the body (6) comprises a module housing (65) wherein the module (5) is received, this module housing (65) communicating with the source housing (78) so that the source of radiation (51) extends in the source housing (78) of the head (7).

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Owner:APTAR FRANCE SAS

Medicinal uses of hydrazones

InactiveUS20040053977A1Increasing endogenous EPO and vascularizationIncreased vascularizationBiocideNervous disorderGynecologyHydrazone

Compounds having a structure according to Formula (I): are effective in a method of increasing erythroproietin and vascularization of tissue in a subject in need thereof.

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Owner:ALMSTEAD JI IN KIM +3

Compositions and methods for treatment of peripheral vascular disease

InactiveUS20130210726A1Improve and more effective treatmentRestore blood flowBiocideOrganic active ingredientsPeptideVascular disease

The present invention relates to compositions and methods for the treatment of peripheral vascular disease (PVD). In particular, the invention provides compositions and methods for treatment of critical limb ischemia, and related diseases, disorders or conditions, based on the use of angiotensin-(1-7) peptides or functional equivalents, analogs or derivatives, angiotensin-(1-7) receptor agonists, ACE2 and/or ACE2 activators.

Compositions and methods for treatment of peripheral vascular disease

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Owner:TARIX PHARMA LTD

Vaginal rejuvenation

InactiveUS20050187429A1Enhances vascularizationEnhances tissue ingrowthSurgical adhesivesObstetrical instrumentsDistal thirdOrgasmic platform

A tissue reinforcement therapy to make the vaginal vault smaller and possibly increase and / or restore sexual gratification is described. The therapy involves augmenting the distal third of the vagina, the orgasmic platform, the external vaginal opening and the perineal area with an injectable in situ polymerizing liquid.

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Owner:PROMETHEAN SURGICAL DEVICES

Method for building vascularized tissue engineering periosteum

ActiveCN107648669AReduce integration timeShorten the healing processElectro-spinningTissue regenerationBiologyNanofibrous membrane

The invention provides a method for building a vascularized tissue engineering periosteum. The method is characterized by comprising the following steps: 1, preparing a macromolecular micro / nano-fibermembrane by an electrostatic spinning method; 2, inoculating seed cells to the nano-fiber membrane, performing cultivation in vitro and performing directional induction for a period of time; 3, implanting a seed cell / nano-fiber membrane composite body subjected for in-vitro directional induction for a period of time in vivo, performing in-vivo vascularization for a period of time and then takingout to obtain the tissue engineering periosteum. By the method, the rejection reaction of an autologous tissue can be effectively reduced and the vascularization degree of the tissue engineering periosteum can be greatly increased; furthermore, the tissue engineering periosteum is vascularize in vivo in advance, so that the integration time of a blood vessel at the defect position and a blood vessel of the implanted tissue engineering periosteum can be shortened, the healing process of the bone defect is shortened, and the method has a very wide application prospect in the fields of wound healing and tissue engineering.

Method for building vascularized tissue engineering periosteum

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Owner:WUHAN UNIV

Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device

InactiveUS20190030374A1Increased vascularizationImprove retentionUltrasound therapyDiagnosticsElectricityControl signal

The present invention relates to an apparatus and an implantable ultrasound generating treating device and to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, and comprising several ultrasound generating transducers (20) which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers (20) each have one or several operating frequencies.characterized in that the transducers comprise at least:characterized in that the group of transducers consists of several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers.

Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device

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Owner:UNIV PIERRE & MARIE CURIE +2

Decompressive thermogenic bandage

InactiveUS20080003274A1Stimulate and improve tissueStimulate increased blood flowPlastersMedical applicatorsDiseaseChemical reaction

An apparatus is disclosed that allows for the delivery of medications and or chemicals for treatment of tissue through permeable dermal patch positioned inside a vessel for use in treating of any particular disease or aliment. The vessel self-adheres through activation of a chemical heater which may be activated by a pull tab exterior of the vessel. Initiation of the chemical reaction generates heat sufficient to raise the air temperature inside the vessel to allow the vessel to auto-generate a vacuum for wound treatment and to aid in sterilization of the wound site. The heated air expands and is evacuates through a one-way valve exterior of the vessel. Cooling of the interior air generates a vacuum inside the vessel to create a suction that holds the vessel in place. Increases blood flow to the treated tissue area, stimulated by the vacuum, facilitates improved delivery of the medication or pharmacological composition to the user. Application of vacuum to the treated tissue disinfects the tissue while providing a bacterial infiltration barrier.

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Owner:KAISER DANIEL E

Methods and compositions for modulating hair growth or regrowth

ActiveUS8197865B2Inhibit synthesisIncreased vascularizationBiocideCosmetic preparationsRed CloverOleoresin

The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention include extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, lichochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof.

Methods and compositions for modulating hair growth or regrowth

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Owner:ACCESS BUSINESS GRP INT LLC

Methods and Compositions for Modulating Hair Growth or Regrowth

ActiveUS20110059192A1Reduce or removeIncrease synthesisBiocideCosmetic preparationsCamellia sinensisSalvia

The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention include extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, lichochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof.

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Owner:ACCESS BUSINESS GRP INT LLC

Inhibiting vascularization using antibodies to CXCR4 and SDF-1

InactiveUS8119126B2Prevent proliferationPrevent invasionPeptide/protein ingredientsAntibody ingredientsCXCR4Knockout animal

This invention provides a therapeutic agent for inhibiting neovascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, and a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4.Based on the finding that vascularization is suppressed in CXCR4 knockout mice, it becomes possible to prepare a therapeutic agent for suppressing vascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, each of which comprises as the effective ingredient, a substance that inhibits the action of CXCR4, as well as to prepare a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. Methods for treatment are made possible that use these therapeutic agents.

Inhibiting vascularization using antibodies to CXCR4 and SDF-1

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Owner:CHUGAI PHARMA CO LTD +1

Fluid dispenser

ActiveUS8818500B2Speed up the repair processPromotes collagen synthesisElectrotherapyWriting connectorsActuatorAnti-inflammatory analgesics

A fluid dispenser including a fluid reservoir and a body receiving a dispenser member that is connected to the reservoir and an actuator member for actuating the dispenser member; a dispenser and diffuser head forming a fluid dispenser orifice and an application wall for applying the fluid coming from the dispenser orifice onto the skin; a module having a source of radiation emitting monochromatic light of 400 nm to 700 nm and having anti-inflammatory action and / or a stimulating action for stimulating skin-regeneration metabolisms. The dispenser and diffuser head include a source housing and the body includes a module housing communicating with the source housing so that the source of radiation extends in the source housing of the head.

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Owner:APTAR FRANCE SAS

Enhancement of angiogenesis to grafts using cells engineered to produce growth factors

ActiveUS8940292B2Increased vascularizationSupport growthBiocidePeptide/protein ingredientsImmature cellsGenetically engineered

The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular endothelial growth factor (VEGF), in conjunction with constructs for replacing or augmenting organ functions. In one aspect of the invention, the genetically engineered cells can be immature cells that are capable of differentiating and assimilating into the target region. The methods of the present invention can be used to enhance vascularization locally at a target site in need of repair, growth, or implantation through the incorporation of autologous cells which have been genetically engineered to secrete a growth factor or angiogenesis modulating agent.

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Owner:WAKE FOREST UNIV HEALTH SCI INC

Hybrid fibrin-microgel constructs for tissue repair and regeneration

InactiveUS20150290362A1Increased vascularizationMaintain mechanical propertiesBiocidePharmaceutical non-active ingredientsFiberTissue repair

Composite constructs of polymer matrices and polymeric microgels, and methods of making and using thereof, are described. The addition of the microgels to polymeric matrices retains the overall mechanical properties of the matrices and enables cell spreading, invasion and vascularization. Using fibrin as a model system, composite fibrin constructs with microgels are described, in which microgels form unique interconnected pockets within the fibrin matrix. The microgel assembly is driven by the polymerization dynamics of fibrin, and the architecture of these interconnected pockets can be tuned. The composite constructs support cell spreading, migration and infiltration more efficiently than do control matrices. The composite constructs can be used attract cells and / or to deliver therapeutic, diagnostic, nutraceutical, prophylactic and cosmetic agents to a desired site.

Hybrid fibrin-microgel constructs for tissue repair and regeneration

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Owner:GEORGIA TECH RES CORP

Ccl20-specific antibodies for cancer therapy

InactiveUS20110123542A1Inhibiting and reducing and growthInhibiting and reducing tumor progressionImmunoglobulins against cytokines/lymphokines/interferonsAntibody ingredientsTreatment fieldCancer therapy

The invention is directed to the field of cancer therapy, specifically to the use of anti-CCL20 antibodies for the treatment of neoplastic disorders. The invention provides compositions and methods useful for the treatment of CCR6 and CX-CR4 expressing tumors.

Ccl20-specific antibodies for cancer therapy

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Owner:HADASIT MEDICAL RES SERVICES & DEVMENT

Portable device for cleaning and massaging the skin

InactiveUS20100122410A1Easy to useCleansing and massaging skinBathsDouchesBiomedical engineeringFluid supply

The invention concerns a portable device (10) for cleaning and massaging the skin, comprising means (18, 22) for being fixed on a person's body part, means (26) for being connected to fluid supply means (28), and means (20, 30, 32) for circulating fluid connected to the connecting means (26) and designed to extend around and / or along the person's body part, said circulating means (20, 30, 32) comprising orifices (34, 36) or nozzles (38) for spraying fluid on said person's body part.

Portable device for cleaning and massaging the skin

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Owner:GOURDIN HERVE

Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells

ActiveUS8727965B2Promote formationIncreased vascularizationNon-surgical orthopedic devicesPenis implantsTissue integrationCavernous tissue

The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and / or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.

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Owner:UNIV OF LOUISVILLE RES FOUND INC +1

Tissue vascularization promoting gene-chitosan nanometer granula complex

InactiveCN1565650ALarge specific surface areaHigh expressionSurgerySkeletal/connective tissue cellsVascular tissueGrowth promoting

The invention relates to a tissue vascularization promoting gene-chitosan nanometer particle complex, and belongs to tissue engineering field. The invention inoculates cardiac cell by type 1 collagen of pcDNA#-[3.1]-hVEGF gene-chitosan nanometer particle complex, then transplants them to injured cardiac tissue after in vitro cultivation thereof. Slow releases in vivo and transfects peripheral cardiac cell to obtain target gene expression. Expressed product hVEGF can promote the regeneration of vascular tissue. The growth promoting function of cardiac vessel is intense since the nanometer carry high quantity of gene due to its small volume and specific surface area.