13 results about "Amentoflavone" patented technology

The invention provides a pharmaceutical composition for preventing and / or treating pancreatic cancer and application, and belongs to the technical field of biological medicine. According to the pharmaceutical composition, through combination of amentotaxus biflavone and gemcitabine, the prevention and treatment effect of gemcitabine or amentotaxus biflavone on pancreatic cancer can be further improved, and the pharmaceutical composition has a synergistic interaction effect. Research results show that the combination of amentoflavone and gemcitabine not only can significantly inhibit the growth of pancreatic cancer cells, but also can inhibit the migration ability of pancreatic cancer cells. The pharmaceutical composition disclosed by the invention provides more choices for clinically preventing and treating pancreatic cancer.

The invention relates to the field of material science and engineering, and particularly discloses a screening method of an anti-macrobrachium rosenbergii iridovirus natural compound based on an MCP protein target. The method comprises the following steps: constructing a three-dimensional structure of a virus major capsid protein MCP and determining an active pocket; performing structure pretreatment on the natural compound library; by taking the active pocket as a target spot, performing multiple rounds of virtual screening through molecular docking to obtain a candidate compound with binding energy less than or equal to-10.0 kcal / mol; and establishing a macrobrachium rosenbergii artificial infection model, determining the virus inhibition rate and protection rate of the candidate compound, and screening the active compound. The eugenol, the amentoflavone, the polyphyllin II and the solamargine screened by the method show a remarkable antiviral effect in an in-vivo injection test and breeding verification. According to the method, accurate screening from target spot prediction to in-vivo verification is realized.

The invention relates to the technical field of medicines, in particular to a compound composition for preventing alopecia and promoting hair growth and application thereof. The invention provides a compound composition for preventing hair loss and promoting hair growth. The compound composition is prepared from the following raw materials in parts by weight: 1-5 parts of amentoflavone and 1-10 parts of unodil. The invention provides an application of amentoflavone and unodil in hair loss prevention and hair growth. An in-vitro cell experiment shows that after the amentoflavone and the unodil are combined, the proliferation of human primary dermal papilla cells can be promoted. A preclinical animal experiment shows that after the amentoflavone and the unodil are locally used, the hair growth speed is increased, and the hair density is increased.

The invention relates to the technical field of medicines, and finds that a natural product amentoflavone can be used as a GPR35 (G-protein coupled receptor 35, GPR35) receptor agonist and application thereof, the compound is amentoflavone, has GPR35 receptor agonist activity, is a GPR35 receptor agonist, can be used for treating thromboembolic diseases, spring conjunctivitis, intracranial embolism, primary sclerosing cholangitis and myocardial infarction, and can be used for treating various diseases such as thromboembolic diseases, spring conjunctivitis, intracranial embolism, primary sclerosing cholangitis and myocardial infarction. Therefore, a novel GPR35 receptor stimulant seedling compound with a clear action target can be provided for the related diseases.

The invention discloses an application of sciatin in preparation of a product for improving cell viability, resisting cell aging, resisting oxidation or inhibiting senescence-related secretory phenotype (SASP) inflammatory factors. According to the application disclosed by the invention, the anti-aging activity of the sciaflavone is evaluated by constructing an IMR-90 cell model for inducing aging by chemotherapy. Experimental results show that the vitality of senescent cells can be remarkably improved at the concentration of 10 mu M, and the enhancing effect is 40% or above. More importantly, the sciaflavones can significantly reduce the level of reactive oxygen species (ROS) in senescent cells, and the average inhibition level reaches 75.0%. Meanwhile, the sciaflavin has a regulating or inhibiting effect on secretion of SASP inflammatory factors IL-6 and IL-8 in senescent cells. The results jointly prove that the sciaflavones have the potential of relieving the cell senescence state and support the application of the sciaflavones in preparation of anti-aging products.

The invention discloses a method for detecting amentoflavone in a juniper extract, and relates to the related field of juniper extract detection. The molecularly imprinted fiber test paper is combined with a photoacoustic acoustic microcavity detection technology, so that the detection of amentoflavone shows the comprehensive advantages of high sensitivity, high selectivity and quick response, on one hand, a specific recognition cavity is formed on the fiber surface by a molecularly imprinted polymer layer, and the specific recognition cavity is formed on the surface of the fiber; the test paper has an obvious selective adsorption effect on amentoflavone, and the interference of other polyphenol components in the juniper berry extract is obviously reduced; and on the other hand, the photoacoustic acoustics microcavity can amplify the photothermal conversion process of the adsorbed molecules, so that a weak thermal-acoustic signal is effectively enhanced, and the detection sensitivity far higher than that of a traditional spectrum method is obtained.

The invention provides application of amentotaxus biflavone in preparation of a medicine for treating bladder cancer, and provides application of amentotaxus biflavone in preparation of a medicine for treating bladder cancer, which has the advantages that by increasing the concentration of amentotaxus biflavone, the number of bladder cancer cells is gradually reduced, the cells are shrunk, nuclear shrinkage of different degrees is caused, the activity, proliferation, invasion and migration of bladder cancer T24 cells and bladder cancer 5637 cells are inhibited, and the bladder cancer is treated. The PI3K / AKT / NF-kappa B pathway promotes the expression of a pro-apoptosis gene Bax in bladder cancer cells, inhibits the expression of an apoptosis inhibitor gene Bcl-2, inhibits the proliferation of the bladder cancer cells by inducing G1 phase retardation of the bladder cancer cells, induces and reduces the expression of PI3K, AKT and NF-kappa B proteins in cell nucleuses through the PI3K / AKT / NF-kappa B pathway, and induces the apoptosis of the bladder cancer cells. The invention belongs to the field of medicine.

The invention relates to the technical field of pharmaceutical preparations, and discloses an application of angelica keiskei chalcone in preparation of an intervention drug for metabolism-related fatty liver diseases, and the intervention drug comprises the following raw materials: an angelica keiskei chalcone extract, a methacrylic acid-methyl methacrylate copolymer, L-arginine, nicotinamide and L-tartaric acid. The preparation process adopts a fluid phase change coprecipitation method. In the liquid preparation stage, L-arginine is utilized to realize preliminary solubilization of chalcone. Nicotinamide and chalcone construct a charge transfer complex to inhibit chemical degradation of active components in an alkaline environment. In the coprecipitation stage, L-tartaric acid constructs a spatial multidentate cross-linked network in a polymer matrix, locks the amorphous state of drug molecules, and cuts off a recrystallization channel. In the post-treatment stage, pre-cooled acid washing liquid is adopted for replacing and washing waste salt, and powder is prevented from absorbing moisture and deliquescing. The in-vitro dissolution rate, the chemical stability and the physical stability of long-term storage of the chalcone are effectively improved.

The application belongs to the field of medicine and chemical industry, and relates to a biflavonoid compound and an extraction method and application thereof. A structural formula of the biflavonoid compound is as shown in formula 1: The biflavonoid compound is prepared through a series of steps such as crushing, extraction, concentration, extraction, column chromatography, HPLC and drying, and has high purity. The anti-HCC activity of the C-O-C bonded biflavonoid compound is better than that of reported C-C bonded amentoflavone and C-O-C bonded taxifolin, and therefore the biflavonoid compound has high potential for preparing hepatocellular carcinoma drugs.

The application discloses a detection method of amentoflavone in juniper extract, and relates to the field of juniper extract detection. The application combines molecular imprinting fiber test paper with photoacoustic acoustic microcavity detection technology, so that the detection of amentofavone has the comprehensive advantages of high sensitivity, high selectivity and rapid response. On one hand, the molecular imprinting polymer layer forms a specific recognition cavity on the surface of the fiber, so that the test paper has obvious selective adsorption effect on amentofavone, and the interference of other polyphenol components in the juniper extract is significantly reduced. On the other hand, the photoacoustic acoustic microcavity can amplify the light-heat conversion process of the adsorbed molecules, so that the weak heat-acoustic signal is effectively enhanced, and the detection sensitivity is much higher than that of the traditional spectroscopy.

According to the application of amentotaxus biflavone in preparation of the drug for the sensitivity of the bladder cancer to the cis-platinum, the amentotaxus biflavone synergistically improves the activity and proliferation of the cis-platinum in inhibiting bladder cancer T24 cells and bladder cancer 5637 cells through the specific cytotoxic effect of the amentotaxus biflavone on the T24 cells and the 5637 cells, so that the sensitivity of the bladder cancer to the cis-platinum is enhanced, and the sensitivity of the bladder cancer to the cis-platinum is improved. The compound is used for preparing medicines for treating bladder cancer and belongs to the field of medicines.

The present invention relates to a composition for promoting muscle cell differentiation, or preventing or treating muscle diseases, the composition comprising amentoflavone as an active ingredient. It was confirmed that amentoflavone promotes the differentiation of muscle cells by regulating the expression of muscle-specific markers and promoting creatine kinase activity, and therefore the composition can be effectively used as a composition for promoting muscle cell differentiation, producing cultured meat, or preventing, treating or ameliorating muscle diseases.

The invention discloses an application of amentotaxus biflavone in preparation of a medicine for treating viral sepsis, the amentotaxus biflavone has high affinity to two targets of leukotriene A4 hydrolase (LTA4H) and leukotriene B4 Receptor 1 (Leukotriene B4 Receptor 1, BLT1), can simultaneously inhibit the activity of the LTA4H and the BLT1, and can be used for preparing a medicine for treating the viral sepsis, so that the amentotaxus biflavone can be used for preparing a medicine for treating the viral sepsis. According to the present invention, the virus infection is blocked, the generation of the inflammatory mediator leukotriene B4 mediated by LTA4H is blocked, the inflammatory reaction is amplified by BLT1, the survival rate of the influenza virus infected sepsis mouse model is improved, and the application can be used for preparing the drug for treating viral sepsis.