20 results about "Iridoid" patented technology

The invention belongs to the technical field of natural pharmaceutical chemistry, and particularly relates to a novel iridoid compound, namely, uncarcinin, separated from wingceltis, a pharmaceutically acceptable isomer of the novel iridoid compound, a wingceltis extract containing the novel iridoid compound, and a preparation method and application of the novel iridoid compound. The chemical structure of the utazonine is shown as a formula I, and the absolute configuration of the utazonine is (1S, 3S, 3aR, 4R, 7aS). The invention also provides a method for extracting the compound or the extract from the stem of the wingceltis, and purifying by combining pH gradient extraction with silica gel column chromatography, semi-preparative high performance liquid chromatography and gel chromatography to obtain the compound or the extract. The wingceltis cycline, the isomer of the wingceltis cycline, the wingceltis extract containing the wingceltis cycline or the pharmaceutical composition show remarkable gastric mucosa protection activity in an in-vitro cell model, particularly, the protection rate of the wingceltis cycline to ethanol-induced human gastric mucosa epithelial cell (GES-1) injury at the concentration of 50 mu M can reach 5.21%, and the wingceltis cycline, the isomer of the wingceltis cycline, the wingceltis extract containing the wingceltis cycline or the pharmaceutical composition show definite gastric mucosa protection activity.

The application belongs to the technical field of medicine, and particularly relates to a new iridoid compound extracted from Patrinia scabiosaa Fisch, a preparation method and application of the iridoid compound, a structure formula of the iridoid compound is shown as formula (I), and the preparation method of the iridoid compound is provided in detail. 50 The iridoid compound has inhibiting proliferation effects on HL-60 and THP-1 cells, and IC values are 67.53 micromoles and 59.31 micromoles respectively. The iridoid compound can be used for preparing medicines for treating leukemia, and has wide application prospects.

The invention discloses a capsule preparation for supporting mood health and improving depression and hormone balance, and relates to the technical field of health food. The capsule preparation comprises the following active components and auxiliary materials in parts by weight: the active components: 3-6 parts of a Malaysia flaxseed extract (containing 12% of lignan), 2-5 parts of Singago pumpkin seed concentrated powder (containing 4mg / g of zinc), 1-3 parts of Indonesia sesame essence (containing lignan), 2-4 parts of a sunflower seed extract (containing vitamin E), 1-3 parts of an olive leaf extract (containing 0.5% of an olive split iridoid compound) and an angelica sinensis extract (containing 0.5% of an olive split iridoid compound). 2-5 parts of Hypericum perforatum (flavonoid gt; 2.5%) 3-7 parts. Through scientific and reasonable formula design, various active components with synergistic effects are organically combined, the dual effects of emotion regulation and hormone balance can be achieved from multiple targets and multiple ways, the content of effective components is stable, bioavailability is high, taking is convenient, safety is high, and the actual requirements of consumers can be met.

This invention discloses an cycloene ether terpene with antioxidant activity and its application. The cycloene ether terpene with antioxidant activity has the structure shown in formula (I). Experiments have shown that the cycloene ether terpene with antioxidant activity shown in formula (I) of this invention has significant antioxidant activity and can be used in the preparation of antioxidant drugs or cosmetics.

The invention discloses a quality detection method of a coptis-gardenia medicine pair. According to the quality detection method, analysis conditions such as optimal mobile phase composition, elution procedure, mass spectrum, flow velocity and chromatographic column are screened through a large number of experiments. The chemical components of the coptis chinensis-gardenia medicine pair are analyzed and identified by adopting a UPLC-Q-TOF / MS technology, 99 components are identified, 41 coptis chinensis and 60 gardenia are common, and alkaloids, phenylpropanoids, iridoids, organic acids and flavonoids are taken as main components. On the basis, the UPLC-PDA (Ultra Performance Liquid Chromatography-Personal Digital Assistant) technology is used for carrying out content determination on the main effect components of the coptis-gardenia medicine pair, such as genipin 1-O-gentiobioside, geniposide, coptisine, epiberberine, cotetrandrine, jateorhizine, berberine hydrochloride and palmatine hydrochloride. Systematic methodology investigation and content determination prove that the method is good in precision, stability and repeatability, and reliable technical support is provided for quality control of coptis chinensis-gardenia medicine pairs and basic research of pharmacodynamic substances.

The present invention relates to the technical field of medical technology, and specifically to an iridoid dimer, a preparation method, and an application thereof. The structural formula of the iridoid dimer is shown in Formula I: The present invention separates and obtains the iridoid dimer from a thermal conversion product of swertiamarin, and verifies the pharmacological activity of the iridoid dimer through cell experiments. The new iridoid dimer compound exhibits excellent anti-inflammatory effects, has a significant inhibitory effect on NO production, can effectively reduce the expression of pro-inflammatory factors TNF-α, IL-1β, and IL-6, can reduce the inflammatory response caused by overexpression of inflammatory factors, and can be used as a lead compound for the development of new anti-inflammatory drugs; the preparation steps of the new iridoid dimer skeleton compound provided by the present invention are easy to control, simple, and rapid, laying a foundation for the development of the medicinal value of the iridoid dimer compound.

A secoiridoid that can resist myocardial cell damage and is extracted from brown bellflower tree, with the molecular formula C 17 H 20 O7, is extracted, isolated and identified as avelladoid I (Avd I) from the water extract of the dried endothelium of brown bellflower tree. It can improve the viability of myocardial cells, reduce the LDH level in damaged myocardial cells, and reduce the abnormally elevated level of inflammatory factors in damaged cells, proving that Avd I can improve myocardial cell damage and relieve myocardial cell inflammatory damage, with significant social and economic benefits.

The present invention discloses an iridoid compound, a preparation method, a pharmaceutical composition, and an application thereof, belonging to the field of pharmaceutical chemistry technology. Based on the traditional Chinese medicine small molecule genipin, the present invention designs a GSK-3β compound containing an iridoid structure, which has a certain therapeutic effect on Alzheimer's disease and can also enhance the specificity and effectiveness of the compound, reduce toxic side effects, and prevent drug resistance. Furthermore, the compound of the present invention has good GSK-3β inhibitory activity and has important practical value in the field of anti-Alzheimer's disease.

The application belongs to the field of medicine and relates to a use of a Nanshanhuagen extract in the preparation of a medicine for treating pulmonary fibrosis, wherein the Nanshanhuagen extract is an effective part of anthraquinones, anthraquinone glycosides and iridoid compounds. The above-mentioned effective part for resisting pulmonary fibrosis is first discovered, the active ingredients are clear, the effect of treating pulmonary fibrosis is comprehensive, the effect of treating pulmonary fibrosis is obviously superior to that of the prior art, and the Nanshanhuagen extract can produce a synergistic effect with a chemical medicine for resisting pulmonary fibrosis. According to specific effective compounds in the above-mentioned extract, it is found that the compounds have a synergistic effect, and a corresponding medicine composition for treating pulmonary fibrosis is disclosed.

The invention discloses an anti-aging compound which is a new compound extracted from fructus forsythiae and is named as cyclic pentacarbazide acid ester. The invention also discloses a preparation method of the forsythia suspensa extract, which comprises the following steps: extraction: carrying out reflux extraction on a dried medicinal material by using an ethanol water solution, filtering, and recovering under reduced pressure to remove a solvent, so as to obtain the forsythia suspensa extract; according to the present invention, the pure product of the cyclocardioside acid ester is obtained through the steps of macroporous resin separation, C18 separation, gel purification and target fraction collection, and the experiment results of Caenorhabditis elegans show that the cyclocardioside acid ester can prolong the life cycle of the Caenorhabditis elegans, and the cyclocardioside acid ester and the Caenorhabditis elegans have significant anti-aging effects.

The invention belongs to the technical field of medicines, and particularly discloses an application of an iridoid compound in a Parkinson's disease neuroprotective medicine, which is specifically characterized in that an alpha-Syn plasmid is transfected into a mouse dopaminergic neuron MES23.5 cell to establish an alpha-Syn overexpressed PD cell model, and 8-O-acetyl shanzhiside methyl ester is added to intervene the PD cell. Results prove that 8-O-acetyl shanzhiside methyl ester can improve cell viability and reduce cytotoxicity by reducing mitochondrial damage of PD cells, and has a neuroprotective effect on PD damaged neurons; a PD mouse model is established by utilizing MPTP intraperitoneal injection, intervention is carried out through intragastric administration of 8-O-acetyl shanzhiside methyl ester, and a result proves that 8-O-acetyl shanzhiside methyl ester can effectively improve the athletic ability of a PD mouse. The results show that the 8-O-acetyl shanzhiside methyl ester can effectively play a neuroprotective role on PD, and has a good clinical application prospect.

The application discloses a mutant of iridoid synthetase with improved specificity and enzyme activity and application thereof. The mutant of iridoid synthetase is obtained by mutation of wild-type iridoid synthetase NmISY2 derived from Nepeta mussinii. The mutant has higher catalytic activity to 8-oxogeranial, and the enzyme activity to geranial is obviously decreased. The ratio of the enzyme activity of the mutant to 8-oxogeranial and geranial is up to 293 times, which is greatly improved compared with the parent iridoid synthetase. The mutant can be used for heterologous synthesis and in-vitro synthesis of iridoid compounds and derivatives, and has a good application prospect.

The application relates to a water extract of Zhizi Chi Tang, granules and application and preparation method thereof. Zhizi Chi Tang dry extract powder is mixed with a diluent to obtain a base material; a wetting agent is added into the base material to obtain soft material; the soft material is sieved through a first sieve screen to obtain wet granules; the wet granules are dried to obtain dry material; and the dry material is whole-granulated through a second sieve screen to obtain dry granules. The water extract of Zhizi Chi Tang contains at least iridoid, isoflavone, organic acid, crocin and other substances, and has remarkable efficacy on the treatment of depression. The application reforms the dosage form of Zhizi Chi Tang by means of modern scientific research technology and method, adopts wet granulation as a granulation technology, and selects and optimizes the types of auxiliary materials and the proportion of medicine and auxiliary materials by taking the granulation of soft material, granule hardness, granule appearance, and granule yield as indexes, and the drying temperature of the granules is investigated to optimize the better forming process of the Zhizi Chi Tang granules.

The invention relates to acanthopanax, schisandra chinensis and poria cocos paste for treating insomnia and a preparation method of the acanthopanax, schisandra chinensis and poria cocos paste. The acanthopanax, schisandra chinensis and poria cocos paste is prepared from the following raw materials in parts by weight: 150-250 parts of an acanthopanax extract, 100-180 parts of a schisandra chinensis extract, 180-220 parts of a poria cocos extract, 80-120 parts of a spina date seed extract, 50-80 parts of a polygala tenuifolia extract, 60-100 parts of a tuber fleeceflower stem polysaccharide extract, 00-300 parts of xylitol and 10-20 parts of sodium carboxymethyl cellulose. The traditional Chinese medicine composition has the beneficial effects that through GABA receptor alpha2 subunit expression and 5-HT1A double-target synergistic effect, the limitation of a single medicine on the tranquilizing effect is broken through, and slow-wave sleep is synergistically prolonged; the traditional Chinese medicine is used for treating insomnia, especially for heart-spleen deficiency and liver-kidney deficiency syndromes. A synergistic sedative mechanism of tenuigenin and iridoid of tuber fleeceflower stem is introduced, so that the problem of poor effect of a traditional ointment formula on phlegm-heat disturbing heart type insomnia is solved; the pachymaran and the tenuigenin reduce the level of cortisol at night and reduce the awakening frequency by inhibiting excessive activation of an HPA axis.

The invention discloses an iridoid compound with anti-aging activity in rhododendron simsii as well as a preparation method and application of the iridoid compound, and belongs to the technical field of natural product chemistry. According to the present invention, the two iridoid compounds such as pacyodiridoid A and splendoside with anti-aging activity are separated from the rhododendron simsii for the first time, and the experiment results show that in the caenorhabditis elegans model, the two compounds can improve the physiological status of caenorhabditis elegans from multiple dimensions, can significantly improve the anti-oxidative stress ability of caenorhabditis elegans, and can provide the anti-aging activity for the caenorhabditis elegans, such that the anti-aging activity of the caenorhabditis elegans can be significantly improved, and the anti-aging activity of the caenorhabditis elegans can be significantly improved; the two compounds have obvious effects in the aspects of aging-related indexes (life, exercise ability and food intake) and growth and development indexes, fully prove that the two compounds have excellent anti-aging activity, lay a new material basis and theoretical basis for the research of an anti-aging mechanism, and open up a new direction for the development of novel anti-aging drugs at the same time. According to the present invention, the structure of the compound pachypodidoid A is novel, such that the new lead compound is provided for the research and the development of the anti-aging drug, and the important application value is provided;

To provide a hair composition that improves the properties of damaged hair. To provide a method for performing hair treatment using a hair composition that improves the properties of damaged hair. [Solution] A hair composition comprising the following components (A) and (B). (A) At least one iridoid compound selected from iridoids and secoiridoids. (B) Monovalent or polyhydric alcohols with 6 or fewer carbon atoms.

The present invention provides a method for detecting and separating the chemical constituents of Cassytha filiformis. By using ultra-high performance liquid chromatography combined with a specific mobile phase and elution program, the present invention can separate 44 compounds from Cassytha filiformis. Further, by using the analysis method of ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometer, 42 compounds can be quickly identified therefrom, including 13 flavonoid compounds, 8 triterpenoid compounds, 4 proanthocyanidin components, 9 iridoids, 6 phenolic acids and 2 other types of structures. The results show that Cassytha filiformis contains a variety of bioactive components, has strong ecological significance and high development and utilization value. The present invention enriches the chemical constituents of Cassytha filiformis, lays a foundation for the research on its pharmacological activities and development and utilization, and at the same time provides a new preparation method for 42 compounds, enriching the sources of the compounds.

The present invention belongs to the field of medical technology, and specifically relates to three iridoid compounds with anti-inflammatory activity, as well as preparation methods and applications thereof. The present invention provides a preparation method for three new iridoid compounds extracted from the leaves of the rhizome of the Chinese twig. The three new iridoid compounds all exhibit excellent anti-inflammatory effects, have a significant inhibitory effect on NO production, can effectively reduce the expression of pro-inflammatory factors TNF-a and IL-6, can reduce the inflammatory response caused by the overexpression of inflammatory factors, and can be used as lead compounds for the development of new anti-inflammatory drugs.

The present invention relates to two iridoid compounds Xylanchinoid A (1) and Xylanchinoid B (2) extracted from the rhizome of *Gelsemium elegans* and their preparation methods and applications, belonging to the field of pharmaceutical technology. Compounds 1 and 2 have inhibitory effects on the cytokines TNF- α , IL-6 and IL-1 β secreted by LPS-induced macrophages RAW264.7, can form a pharmaceutical composition with a pharmaceutically acceptable carrier, and can be used for the development of anti-inflammatory drugs.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine compound preparation for reducing blood sugar and blood fat and a preparation method thereof.The monarch drug raw radix astragali has the effects of invigorating the spleen, tonifying qi and strengthening the root, the monarch drug cimicifugae foetidae-radix bupleuri is matched to construct a qi activity lifting hub, and the limitation that a traditional blood sugar reducing prescription purely nourishes yin and clears heat is broken through; a composite scheme of fire depression and simultaneous elimination of phlegm and blood stasis is adopted, iridoid components in cimicifugae foetidae promote M2 polarization of macrophages and reduce IL-1beta expression, a'body fluid production promoting and thirst quenching 'component taking puerarin as a carrier is combined with raw and cooked rehmannia root verbascoside to form an intestinal GLP-1 secretion enhancement effect, and meanwhile, the composition also has the characteristic of enhancing bioavailability; by optimizing the monarch, minister, assistant and guide relationship of the raw radix astragali, rhizoma atractylodis, rhizoma atractylodis macrocephalae and other medicinal materials, an intervention path of tonifying qi and yin and detoxifying and activating blood is established.