12 results about "Iridoid" patented technology

The invention belongs to the technical field of natural pharmaceutical chemistry, and particularly relates to a novel iridoid compound, namely, uncarcinin, separated from wingceltis, a pharmaceutically acceptable isomer of the novel iridoid compound, a wingceltis extract containing the novel iridoid compound, and a preparation method and application of the novel iridoid compound. The chemical structure of the utazonine is shown as a formula I, and the absolute configuration of the utazonine is (1S, 3S, 3aR, 4R, 7aS). The invention also provides a method for extracting the compound or the extract from the stem of the wingceltis, and purifying by combining pH gradient extraction with silica gel column chromatography, semi-preparative high performance liquid chromatography and gel chromatography to obtain the compound or the extract. The wingceltis cycline, the isomer of the wingceltis cycline, the wingceltis extract containing the wingceltis cycline or the pharmaceutical composition show remarkable gastric mucosa protection activity in an in-vitro cell model, particularly, the protection rate of the wingceltis cycline to ethanol-induced human gastric mucosa epithelial cell (GES-1) injury at the concentration of 50 mu M can reach 5.21%, and the wingceltis cycline, the isomer of the wingceltis cycline, the wingceltis extract containing the wingceltis cycline or the pharmaceutical composition show definite gastric mucosa protection activity.

The application belongs to the technical field of medicine, and particularly relates to a new iridoid compound extracted from Patrinia scabiosaa Fisch, a preparation method and application of the iridoid compound, a structure formula of the iridoid compound is shown as formula (I), and the preparation method of the iridoid compound is provided in detail. 50 The iridoid compound has inhibiting proliferation effects on HL-60 and THP-1 cells, and IC values are 67.53 micromoles and 59.31 micromoles respectively. The iridoid compound can be used for preparing medicines for treating leukemia, and has wide application prospects.

The invention discloses a capsule preparation for supporting mood health and improving depression and hormone balance, and relates to the technical field of health food. The capsule preparation comprises the following active components and auxiliary materials in parts by weight: the active components: 3-6 parts of a Malaysia flaxseed extract (containing 12% of lignan), 2-5 parts of Singago pumpkin seed concentrated powder (containing 4mg / g of zinc), 1-3 parts of Indonesia sesame essence (containing lignan), 2-4 parts of a sunflower seed extract (containing vitamin E), 1-3 parts of an olive leaf extract (containing 0.5% of an olive split iridoid compound) and an angelica sinensis extract (containing 0.5% of an olive split iridoid compound). 2-5 parts of Hypericum perforatum (flavonoid gt; 2.5%) 3-7 parts. Through scientific and reasonable formula design, various active components with synergistic effects are organically combined, the dual effects of emotion regulation and hormone balance can be achieved from multiple targets and multiple ways, the content of effective components is stable, bioavailability is high, taking is convenient, safety is high, and the actual requirements of consumers can be met.

This invention discloses an cycloene ether terpene with antioxidant activity and its application. The cycloene ether terpene with antioxidant activity has the structure shown in formula (I). Experiments have shown that the cycloene ether terpene with antioxidant activity shown in formula (I) of this invention has significant antioxidant activity and can be used in the preparation of antioxidant drugs or cosmetics.

The invention discloses a quality detection method of a coptis-gardenia medicine pair. According to the quality detection method, analysis conditions such as optimal mobile phase composition, elution procedure, mass spectrum, flow velocity and chromatographic column are screened through a large number of experiments. The chemical components of the coptis chinensis-gardenia medicine pair are analyzed and identified by adopting a UPLC-Q-TOF / MS technology, 99 components are identified, 41 coptis chinensis and 60 gardenia are common, and alkaloids, phenylpropanoids, iridoids, organic acids and flavonoids are taken as main components. On the basis, the UPLC-PDA (Ultra Performance Liquid Chromatography-Personal Digital Assistant) technology is used for carrying out content determination on the main effect components of the coptis-gardenia medicine pair, such as genipin 1-O-gentiobioside, geniposide, coptisine, epiberberine, cotetrandrine, jateorhizine, berberine hydrochloride and palmatine hydrochloride. Systematic methodology investigation and content determination prove that the method is good in precision, stability and repeatability, and reliable technical support is provided for quality control of coptis chinensis-gardenia medicine pairs and basic research of pharmacodynamic substances.

The present invention relates to the technical field of medical technology, and specifically to an iridoid dimer, a preparation method, and an application thereof. The structural formula of the iridoid dimer is shown in Formula I: The present invention separates and obtains the iridoid dimer from a thermal conversion product of swertiamarin, and verifies the pharmacological activity of the iridoid dimer through cell experiments. The new iridoid dimer compound exhibits excellent anti-inflammatory effects, has a significant inhibitory effect on NO production, can effectively reduce the expression of pro-inflammatory factors TNF-α, IL-1β, and IL-6, can reduce the inflammatory response caused by overexpression of inflammatory factors, and can be used as a lead compound for the development of new anti-inflammatory drugs; the preparation steps of the new iridoid dimer skeleton compound provided by the present invention are easy to control, simple, and rapid, laying a foundation for the development of the medicinal value of the iridoid dimer compound.

The application belongs to the field of medicine and relates to a use of a Nanshanhuagen extract in the preparation of a medicine for treating pulmonary fibrosis, wherein the Nanshanhuagen extract is an effective part of anthraquinones, anthraquinone glycosides and iridoid compounds. The above-mentioned effective part for resisting pulmonary fibrosis is first discovered, the active ingredients are clear, the effect of treating pulmonary fibrosis is comprehensive, the effect of treating pulmonary fibrosis is obviously superior to that of the prior art, and the Nanshanhuagen extract can produce a synergistic effect with a chemical medicine for resisting pulmonary fibrosis. According to specific effective compounds in the above-mentioned extract, it is found that the compounds have a synergistic effect, and a corresponding medicine composition for treating pulmonary fibrosis is disclosed.

The application discloses a mutant of iridoid synthetase with improved specificity and enzyme activity and application thereof. The mutant of iridoid synthetase is obtained by mutation of wild-type iridoid synthetase NmISY2 derived from Nepeta mussinii. The mutant has higher catalytic activity to 8-oxogeranial, and the enzyme activity to geranial is obviously decreased. The ratio of the enzyme activity of the mutant to 8-oxogeranial and geranial is up to 293 times, which is greatly improved compared with the parent iridoid synthetase. The mutant can be used for heterologous synthesis and in-vitro synthesis of iridoid compounds and derivatives, and has a good application prospect.

The application relates to a water extract of Zhizi Chi Tang, granules and application and preparation method thereof. Zhizi Chi Tang dry extract powder is mixed with a diluent to obtain a base material; a wetting agent is added into the base material to obtain soft material; the soft material is sieved through a first sieve screen to obtain wet granules; the wet granules are dried to obtain dry material; and the dry material is whole-granulated through a second sieve screen to obtain dry granules. The water extract of Zhizi Chi Tang contains at least iridoid, isoflavone, organic acid, crocin and other substances, and has remarkable efficacy on the treatment of depression. The application reforms the dosage form of Zhizi Chi Tang by means of modern scientific research technology and method, adopts wet granulation as a granulation technology, and selects and optimizes the types of auxiliary materials and the proportion of medicine and auxiliary materials by taking the granulation of soft material, granule hardness, granule appearance, and granule yield as indexes, and the drying temperature of the granules is investigated to optimize the better forming process of the Zhizi Chi Tang granules.

The invention discloses an iridoid compound with anti-aging activity in rhododendron simsii as well as a preparation method and application of the iridoid compound, and belongs to the technical field of natural product chemistry. According to the present invention, the two iridoid compounds such as pacyodiridoid A and splendoside with anti-aging activity are separated from the rhododendron simsii for the first time, and the experiment results show that in the caenorhabditis elegans model, the two compounds can improve the physiological status of caenorhabditis elegans from multiple dimensions, can significantly improve the anti-oxidative stress ability of caenorhabditis elegans, and can provide the anti-aging activity for the caenorhabditis elegans, such that the anti-aging activity of the caenorhabditis elegans can be significantly improved, and the anti-aging activity of the caenorhabditis elegans can be significantly improved; the two compounds have obvious effects in the aspects of aging-related indexes (life, exercise ability and food intake) and growth and development indexes, fully prove that the two compounds have excellent anti-aging activity, lay a new material basis and theoretical basis for the research of an anti-aging mechanism, and open up a new direction for the development of novel anti-aging drugs at the same time. According to the present invention, the structure of the compound pachypodidoid A is novel, such that the new lead compound is provided for the research and the development of the anti-aging drug, and the important application value is provided;

To provide a hair composition that improves the properties of damaged hair. To provide a method for performing hair treatment using a hair composition that improves the properties of damaged hair. [Solution] A hair composition comprising the following components (A) and (B). (A) At least one iridoid compound selected from iridoids and secoiridoids. (B) Monovalent or polyhydric alcohols with 6 or fewer carbon atoms.

The present invention belongs to the field of medical technology, and specifically relates to three iridoid compounds with anti-inflammatory activity, as well as preparation methods and applications thereof. The present invention provides a preparation method for three new iridoid compounds extracted from the leaves of the rhizome of the Chinese twig. The three new iridoid compounds all exhibit excellent anti-inflammatory effects, have a significant inhibitory effect on NO production, can effectively reduce the expression of pro-inflammatory factors TNF-a and IL-6, can reduce the inflammatory response caused by the overexpression of inflammatory factors, and can be used as lead compounds for the development of new anti-inflammatory drugs.