54 results about "Coptis chinensis" patented technology

This invention discloses a Zhishu Yangwei tablet for chronic gastritis and its granule dry-compression tableting process, relating to the field of traditional Chinese medicine preparation technology. The Yangwei tablet is made from the following raw materials in parts by weight: Codonopsis pilosula 35-45 parts, stir-fried Atractylodes macrocephala 18-22 parts, Poria cocos 18-22 parts, Glycyrrhiza uralensis 8-12 parts, Amomum villosum 18-22 parts, Lindera strychnifolia 18-22 parts, Salvia miltiorrhiza 45-55 parts, roasted Aucklandia lappa 18-22 parts, Paeonia lactiflora 18-22 parts, stir-fried Citrus aurantium 18-22 parts, Magnolia officinalis 28-32 parts, Lilium brownii 35-45 parts, and stir-fried chicken gizzard lining 18- 22 parts, dried plum 45-55 parts, Coptis chinensis 8-12 parts, hawthorn 35-45 parts, magnesium stearate 5-7 parts, sucrose 28-32 parts; This invention uses low-temperature dynamic extraction technology to replace the traditional high-temperature decoction process, effectively reducing the decomposition loss of heat-sensitive active ingredients such as tanshinone IIA and ursolic acid, and improving the bioavailability of the drug. It also uses membrane concentration and spray drying technology to replace the traditional atmospheric pressure concentration and oven drying process, shortening the production cycle, reducing energy consumption, and avoiding the degradation of active ingredients caused by prolonged heating of materials.

This invention discloses a pharmaceutical composition and its preparation method for treating atrophic gastritis, precancerous lesions of the stomach, and stomach cancer, belonging to the field of traditional Chinese medicine preparation technology. The pharmaceutical composition is prepared by a specific two-step microbial fermentation process using Astragalus membranaceus, Hericium erinaceus, Curcuma zedoaria, Actinidia chinensis root, Camptotheca acuminata fruit, Hedyotis diffusa, Coptis chinensis, Taraxacum mongolicum, Viola yedoensis, Corydalis yanhusuo (processed with vinegar), Phellodendron chinense, Solanum nigrum, Scutellaria baicalensis, Panax notoginseng, Zingiber officinale, Piper cubeba, Cuttlebone, Fritillaria thunbergii, roasted soybean, and red yeast rice. This invention significantly improves the bioavailability of the active pharmaceutical ingredients through the synergistic effect of the multifunctional groups of traditional Chinese medicine and the enhanced effect of microbial fermentation. It can systematically reverse gastric mucosal atrophy and intestinal metaplasia, effectively improve microcirculation, and inhibit Helicobacter pylori, while also exhibiting good safety. This provides a novel and effective treatment for the aforementioned gastric diseases.

This invention belongs to the field of veterinary drug technology, specifically a method for preparing a stress-relieving oral liquid. The specific steps of this method are as follows: weighing the Chinese herbal medicine slices, soaking and pre-treatment, heating and extraction, filtering the extract, vacuum concentration, and preparing the oral liquid. This method uses a low-temperature vacuum concentration process to prepare a Gardenia jasminoides extract after the Chinese herbal medicine extraction, avoiding the destruction of the active ingredients by high temperatures and maximizing the retention of the effective active substances of Coptis chinensis, Scutellaria baicalensis, and Gardenia jasminoides. In the subsequent compounding process, pharmaceutical-grade anhydrous glucose and sodium salicylate are selected as excipients to form a stable and homogeneous system with the compound small molecule peptides and the Gardenia jasminoides extract. This system is free of easily separated, precipitated, or turbid components, effectively tolerating the high temperature and humidity environment of farms, the bumpy rides of long-distance transportation, and the requirements of long-term storage, preventing rapid degradation of the active ingredients of the Chinese herbal medicine, and ensuring the stable efficacy of the oral liquid.

This invention provides a traditional Chinese medicine composition for treating skin trauma, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition of this invention comprises the following raw materials in parts by weight: Astragalus membranaceus 20-30 parts, Piper kadsura vine 20-30 parts, Dragon's blood 10-20 parts, Rheum palmatum 3-8 parts, Coptis chinensis 3-8 parts, Phellodendron chinense 3-8 parts, Angelica sinensis 8-15 parts, Panax notoginseng 1-5 parts, Angelica dahurica 5-10 parts, Rehmannia glutinosa 5-10 parts, Scrophularia ningpoensis 3-8 parts, Aucklandia lappa 1-5 parts, Paeonia suffruticosa 5-10 parts, Rosin 3-8 parts, Vespa nidus 10-15 parts, and Carbonized human hair 1-5 parts. The various medicinal materials of this invention interact and complement each other, possessing the effects of promoting diuresis and reducing swelling, promoting tissue regeneration and detoxification, anti-inflammatory and analgesic effects, and activating blood circulation and removing blood stasis. It can reduce tissue swelling and redness, effectively prevent infection of burn wounds, and improve wound healing speed. It has significant therapeutic effects on skin trauma caused by burns and scalds, with no toxic side effects.

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

This invention provides a compound drug for treating melioidosis, its preparation method, and its application. The drug comprises active components of traditional Chinese medicine, a bioactive preparation, and a pharmaceutically acceptable carrier. The active components of traditional Chinese medicine are primarily extracts of Scutellaria baicalensis, Coptis chinensis, Fagopyrum dibotrys, and Polygonum cuspidatum. The bioactive preparation includes polymyxin B, homoserine lactonease, and recombinant human β-defensin 3. The components work synergistically to construct a comprehensive intervention system covering all pathological stages, including biofilm disruption, sterilization, anti-endotoxin activity, intracellular bacterial clearance, immune regulation, and tissue repair. This system can effectively disrupt bacterial biofilms, kill multidrug-resistant strains, neutralize endotoxins, and eliminate latent intracellular bacteria, addressing the core pain points of existing melioidosis treatments, such as strong drug resistance, significant toxic side effects, and high recurrence rates. The preparation process of this invention is carried out under low-temperature and sterile conditions throughout, which fully preserves the stability of the active ingredients, making it suitable for industrial production. The drug can be prepared in various dosage forms, covering all clinical subtypes of melioidosis, and possesses clinical application value and promising prospects for widespread application.

The application discloses a spleen-targeting nanoassemblies of active ingredients of Sanhuang Xiexin Decoction, a preparation method and application thereof, and belongs to the technical field of biological medicine, and comprises spleen-targeting exosomes and nanoassemblies containing active ingredients of Sanhuang Xiexin Decoction, wherein the nanoassemblies containing active ingredients of Sanhuang Xiexin Decoction are loaded on the spleen-targeting exosomes; and the active ingredients of Sanhuang Xiexin Decoction are three active ingredients corresponding to three traditional Chinese medicines, i.e., rhubarb, Coptis chinensis and Scutellaria baicalensis. The application has the beneficial effects that based on three key active components of Sanhuang Xiexin Decoction, the nano delivery system of the carrier-free pure medicine of three active ingredients of traditional Chinese medicine compound is developed for the first time through a chemical self-assembly technology, support is provided for the development of a new dosage form of the nano preparation of the traditional Chinese medicine compound, and the spleen immune function disorder-mediated diseases have a good targeted treatment effect.

The application relates to the technical field of traditional Chinese medicine preparation, and particularly discloses a compound traditional Chinese medicine preparation for targeting egg duck and goose egg cytoplasmic disease, which comprises the following components: white head, Coptis chinensis, Huangqi, Phellodendron amurense, wine Danpi, bran-fried peach kernel, Chinese perilla, pomegranate peel, liquorice, honeysuckle, Andrographis, figwort, emblic, ginger, fried atractylodes, fried safflower, Xianhecao, spiny amaranth, and Poria cocos. Through the combination of monarch, minister, assistant and messenger, the core effects of heat-clearing and detoxifying, blood-cooling and dysentery-stopping, and dampness-drying and insect-killing of the medicines are synergistically exerted, the pathogenesis characteristics of the egg cytoplasmic disease are accurately targeted, blood stasis and blood circulation are promoted to eliminate the swelling of the lesion, and the intestinal mucosa damage is repaired to stop bleeding, the symptoms of hematochezia, diarrhea and oviduct inflammation of the egg duck and goose caused by the egg cytoplasmic disease are effectively relieved, the problems of the decreased antibiotic effect, drug residue, bacterial flora disorder and food safety risk are effectively solved, and the compound traditional Chinese medicine preparation has the remarkable progress of drug resistance, safety, no residue, intestinal protection and green environmental protection.

This utility model provides a simple device for collecting Coptis chinensis seeds, including a collection cylinder, which is mainly formed by folding an outer outer piece, a lower guide piece, and an upper guide piece. The two ends of the outer outer piece along its length are detachably connected by connectors to form the outer outer cylinder. The lower guide piece is connected to the lower edge of the outer outer piece along its width, folded inwards, and detachably connected by connectors, forming a lower guide cylinder. The lower guide cylinder has a frustum-shaped structure, with its lower end connected to the outer outer piece and its upper end forming a central hole fitted onto the plant stem. The upper guide piece is connected to the upper edge of the outer outer piece along its width, folded inwards, and detachably connected by connectors, forming an upper guide cylinder. The upper guide cylinder has an inverted frustum-shaped structure, with its upper end connected to the outer outer piece and its lower end located between the walls of the outer outer cylinder and the lower guide cylinder, and closer to the lower guide cylinder than the outer outer cylinder. This device is easy to assemble and disassemble, significantly reducing the workload of seed collection, saving seed collection costs, and preventing seed loss due to falling.

The application provides a traditional Chinese medicine preparation for treating dry eye, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation comprises the following components in parts by weight: 8-12 parts of chrysanthemum, 8-12 parts of cassia seed, and 8-12 parts of Coptis chinensis / Scutellaria baicalensis. The compatibility and synergistic effect of chrysanthemum, cassia seed and Coptis chinensis / Scutellaria baicalensis in the traditional Chinese medicine preparation, and the drug administration mode of atomization fumigation can make the drug directly act on the ocular surface, improve the local drug concentration, compared with the existing method of simply using sodium hyaluronate eye drops, the preparation can effectively improve the ocular surface inflammation, improve the tear film stability, and fundamentally relieve the core symptoms such as dryness and fatigue of dry eye.

This invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and its application, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for treating chronic atrophic gastritis provided by this invention is made from the following raw materials in parts by weight: 15-25 parts of Salvia miltiorrhiza, 8-16 parts of Curcuma zedoaria (processed with vinegar), 2-6 parts of Eupolyphaga sinensis, 10-20 parts of Codonopsis pilosula, 8-16 parts of Dendrobium nobile (dried), 5-15 parts of Pinellia ternata (processed), 1-5 parts of Evodia rutaecarpa (processed), and 1-5 parts of Coptis chinensis. It has the effects of promoting blood circulation and removing blood stasis, strengthening the spleen and replenishing qi, nourishing yin and benefiting the stomach, inhibiting bacteria and inflammation, and regulating immunity. It is suitable for chronic atrophic gastritis, especially those with gastric blood stasis combined with stomach yin deficiency or spleen and stomach weakness. It can significantly repair the gastric mucosa and reverse atrophic intestinal metaplasia, and is safe and reliable, providing a new traditional Chinese medicine treatment for chronic atrophic gastritis.

A traditional Chinese medicine composition for antitrichomonal and antipruritic purposes and feminine wipes using the same composition. This composition, consisting of Agrimonia pilosa and Coptis chinensis, is low in production cost, safe and effective, odorless, and has a simple formulation. Feminine wipes based on this composition can therefore be conveniently applied for antitrichomonal and / or antipruritic purposes and are easily scalable for mass production.

This invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for treating intestinal injury. The traditional Chinese medicine composition comprises: 50-150 parts of ginseng, 60-180 parts of polygonatum, 40-90 parts of atractylodes, 30-58 parts of sophora flavescens, 60-180 parts of ophiopogon japonicus, 60-110 parts of rehmannia glutinosa, 40-90 parts of polygonum multiflorum, 60-180 parts of cornus officinalis, 40-90 parts of poria cocos, 35-58 parts of eupatorium fortunei, 35-58 parts of coptis chinensis, 35-90 parts of anemarrhena asphodeloides, 35-58 parts of epimedium, 40-110 parts of salvia miltiorrhiza, 60-180 parts of kudzu root, 80-140 parts of litchi seed, and 40-90 parts of lycium chinense root bark. The above-mentioned traditional Chinese medicine composition can inhibit the expression of TNF, AGE-RAGE, TLR and IL-17 and the infiltration of macrophages. It also helps to regulate the proliferation and differentiation of intestinal cells, restore beneficial bacteria in the intestine, and significantly improve the barrier function of the intestine, thereby effectively improving the damaged intestinal function.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition, preparation, preparation method, and application for treating polycystic ovary syndrome (PCOS). The traditional Chinese medicine composition for treating PCOS comprises the following raw materials in parts by weight: 10-15 parts of Cuscuta chinensis, 10-15 parts of Lycium barbarum, 10-20 parts of Taxillus chinensis, 10-15 parts of Angelica sinensis, 10-15 parts of Achyranthes bidentata, 10-15 parts of Ligusticum chuanxiong, 10-15 parts of Alisma plantago-aquatica, 10-15 parts of Nelumbo nucifera leaf, 10-15 parts of Gynostemma pentaphyllum, 10-20 parts of Salvia miltiorrhiza, 5-10 parts of Euonymus alatus, 5-10 parts of Coptis chinensis, and 5-10 parts of Glycyrrhiza uralensis. Its core treatment principle is to tonify the kidney and spleen, promote blood circulation, and resolve phlegm, and it is used to treat PCOS.

This invention belongs to the field of gastric disease treatment, specifically relating to a traditional Chinese medicine composition for treating chronic atrophic gastritis with intestinal metaplasia and its preparation method. The traditional Chinese medicine composition for treating chronic atrophic gastritis with intestinal metaplasia comprises the following raw materials in parts by weight: Agrimonia pilosa 10-15 parts, Cyperus rotundus 8-10 parts, Scutellaria barbata 10-15 parts, Lobelia chinensis 10-15 parts, Patrinia scabiosaefolia 13-17 parts, Scutellaria baicalensis 7-11 parts, Hedyotis diffusa 10-15 parts, Prunella vulgaris 10-15 parts, Hedyotis diffusa 5-7 parts, Perilla frutescens 8-10 parts, Coptis chinensis 5-7 parts, Angelica sinensis 5-7 parts, etc. This invention focuses on the core pathogenesis of damp-heat in the spleen and stomach and stagnation of gastric collaterals. The Chinese herbal composition has the effects of clearing heat and removing dampness, regulating qi and harmonizing the stomach, nourishing blood and unblocking collaterals. Clinically, it can significantly improve the OLGA / OLGIM stage of patients with chronic atrophic gastritis with intestinal metaplasia, with a total effective rate of 65.1%, providing a safe and effective Chinese medicine solution for precancerous lesions of the stomach.

A fermented natural substance having nitric oxide metabolites fixated and stabilized therein is produced by a process including adding a fermentative strain to nitrogen-containing natural substance and carrying out fermentation by a batch fermentation process. The nitrogen-containing natural substance is at least one selected from the group consisting of lettuce, Sedum sarmentosum, spinach, blueberry, dandelion, pomegranate, cabbage, garlic, Morinda citrifolia, onion, soybean, bean sprout, mulberry leaf, Momordica charantia, Rubus coreanus, Houttuynia cortada, aronia, Humulus japonicus, Coptis chinensis, hijiki, hooker chive, mushrooms, calamus, wild spinach (Seomcho), Chinese cabbage, kelp, apple, mugwort, orange, salmon testis, abalone shell, shellfish shell, cricket, silkworm, Rehmannia glutinosa, and Shipjeondaebo-tang. to Bacillus sp., Bifidobacterium sp., Enterococcus sp., or Lactobacillus sp.

This invention relates to the field of granule preparation technology, and discloses a Coptis chinensis preparation for treating gastrointestinal damp-heat stagnation and its preparation method. First, the preparation components, including total alkaloids of Coptis chinensis, volatile oil of Aucklandia lappa, dry extract powder of excipient medicinal materials, chitosan, and pectin, are determined according to specific weight ratios. For different components, supercritical CO2 extraction, dynamic cyclic extraction combined with near-infrared online monitoring technology, and standardized water decoction process are used to accurately extract and prepare the preparation. Then, a chitosan-pectin nano-targeted delivery system is constructed, and colon-targeted nanoparticles are obtained by modifying colonic epithelial cell-targeting peptides. These nanoparticles are then obtained by vacuum freeze-drying and fluidized bed microsphere granulation. Simultaneously, the volatile oil of Aucklandia lappa is treated with β-cyclodextrin inclusion complex. Finally, the nanoparticles are mixed with the volatile oil inclusion complex, dry extract powder of excipient medicinal materials, enteric-coated excipients, and fillers to prepare a thermosensitive bio-ink. A thermosensitive gel framework preparation is then obtained using semi-solid extrusion 3D printing technology.

The present application relates to the medical technology field, specifically to a traditional Chinese medicine external preparation developed for the special environment of high altitude, which is used for preventing and treating sleep disorders caused by the low oxygen environment of high altitude. The main drugs are Coptis chinensis and Cinnamomum cassia, which are mixed in a certain proportion, extracted, freeze-dried and prepared into a gel plaster, and then the plaster can play the effect of improving sleep disorders through transdermal administration.

The application belongs to the field of traditional Chinese medicines, and relates to an antifungal traditional Chinese medicine composition and application. The antifungal traditional Chinese medicine composition is prepared from Sophora flavescens, Coptis chinensis, Phellodendri chinensis, Chinese toon, Cortex Meliae, Cortex Dictamni and Cnidium monnieri. The application provides the antifungal traditional Chinese medicine composition and application which has remarkable bacteriostatic effect, no obvious side effect, can repair skin barrier and is not easy to produce drug resistance.

This invention belongs to the field of traditional Chinese medicine technology, specifically disclosing a traditional Chinese medicine composition for treating insomnia due to deficiency of heart and liver blood, and its application. It consists of the following raw materials in parts by weight: 8-12 parts of Cistanche deserticola (processed with wine), 8-12 parts of stir-fried Ziziphus jujuba seeds, 4-6 parts of ginseng, 8-12 parts of stir-fried Atractylodes macrocephala, 10-14 parts of Poria cocos, 5-7 parts of licorice root, 5-7 parts of Angelica sinensis, 12-18 parts of Astragalus membranaceus, 10-14 parts of Scutellaria baicalensis, 5-7 parts of Coptis chinensis, 10-14 parts of Rehmannia glutinosa, 2-4 parts of cinnamon bark, and 10-14 parts of Phellodendron chinense. Compared with existing technologies, this invention's traditional Chinese medicine composition comprehensively replenishes qi and blood, strengthens the spleen and calms the mind, clears and drains excess fire, warms the kidneys and guides fire back to its source, and is balanced in its warming and cooling properties, replenishing without stagnation, clearing without coldness, and warming without dryness, thus effectively treating insomnia due to deficiency of heart and liver blood.

This invention discloses a method and detection method for increasing the content of dehydrocarbaverine in Coptis chinensis under drought stress, belonging to the field of medicinal plant cultivation and quality control technology. This method aims to solve the technical problem of unstable content and difficulty in ensuring the quality of the core active ingredient dehydrocarbaverine in artificially cultivated Coptis chinensis due to a lack of scientific basis for water management. The key technical solution involves selecting robust Coptis chinensis plants, stopping watering to subject them to natural drought stress treatment for six to eighteen days, and harvesting the plants at the end of the stress treatment. This method is mainly used to directionally increase the content of the active ingredient dehydrocarbaverine in the artificial cultivation of Coptis chinensis through scientifically controlled drought treatment, thereby effectively improving the quality and industrial value of the medicinal material. The detection method establishes a set of chromatographic separation and quantitative analysis conditions specifically designed for dehydrocarbaverine in the Coptis chinensis matrix.

The application provides a traditional Chinese medicine composition for gastroesophageal reflux disease, a preparation method and a quality control method. The traditional Chinese medicine composition is prepared from the following components: Coptis chinensis, prepared pinellia, bamboo shavings, dried tangerine or orange peel, fried Fructus Aurantii Immaturus, and Poria cocos. The traditional Chinese medicine composition provided by the application is strictly matched in terms of monarch, minister, and assistant, and has definite clinical curative effect.

This invention discloses a low-irritation, antibacterial, and repairing dual-effect topical composition for allergic skin problems and its preparation method. The composition is a compound of herbal extracts such as Coptis chinensis and Sophora flavescens, and plant essential oils such as clove oil and tea tree oil. An essential oil phospholipid nano-dispersion is prepared by ultrasonic emulsification of phospholipids, followed by cross-linking with a polysaccharide encapsulation material to construct a double-layer microcapsule structure, and finally spray-dried. The composition exhibits pH-responsive release characteristics, with accelerated release of active ingredients under acidic conditions, and maintains stability and antibacterial activity over a wide temperature range of -18℃ to 100℃. This invention effectively solves the problems of poor dispersibility and easy inactivation due to temperature sensitivity of natural active ingredients through a double-layer encapsulation system, achieving broad-spectrum and highly effective antibacterial activity (antibacterial rate > 99.7%), while maintaining a skin irritation index below 0.15. It combines low irritation with highly effective antibacterial and repairing effects, and the preparation process is simple and controllable, making it suitable for sensitive skin care and personal care products.

This invention discloses a suppository for treating endometritis in cattle and sheep, its preparation method, and its application, belonging to the field of veterinary drug preparation technology. The suppository uses Salvia miltiorrhiza, Coptis chinensis, Forsythia suspensa, Carthamus tinctorius, Borneol, and Astragalus membranaceus as active ingredients. Coptis chinensis and Forsythia suspensa clear damp-heat, while Salvia miltiorrhiza and Carthamus tinctorius unblock stagnation. Astragalus membranaceus replenishes postpartum qi deficiency, promotes blood circulation, enhances blood circulation, strengthens the body's resistance to pathogens, prevents inflammation recurrence, harmonizes the cold properties of other herbs, and reduces side effects. Borneol, with its pungent and penetrating properties, guides the medicine directly to the lesion, promotes mucosal repair, increases mucosal permeability, relieves pain and itching, and synergistically provides anti-inflammatory and analgesic effects, improving the user experience. It is suitable for local suppository administration, aligning with the principles of traditional Chinese veterinary medicine for endometritis, simultaneously exerting the effects of clearing heat and dampness, promoting blood circulation and removing blood stasis, and tonifying qi and strengthening the body, addressing both the symptoms and the root cause. By adding a matrix and excipients and combining vaginal administration to treat endometritis in cattle and sheep, the local drug concentration is concentrated for rapid onset of action, achieving a balance between effectiveness, convenience, and safety.

This application belongs to the technical field of traditional Chinese medicine pastes, specifically relating to a preparation process for traditional Chinese medicine pastes that improves anti-sanding, taste masking, and flowability. This process utilizes lemon juice to catalyze the hydrolysis of sucrose, stably controlling the sucrose conversion rate at over 95%, thus eliminating the risk of sanding at the source. Furthermore, it combines the physical barrier mechanisms of β-cyclodextrin and microcrystalline cellulose to form a triple anti-sanding barrier of chemical conversion, physical inclusion, and steric hindrance. Simultaneously, the efficient inclusion of β-cyclodextrin in Coptis chinensis alkaloids effectively masks the taste; and the "microsphere bearing" effect of microcrystalline cellulose solves the problem of sticking to the sides and spoon.

This application relates to the field of traditional Chinese medicine pharmaceutical technology, and discloses a traditional Chinese medicine for treating diabetic neuropathy and its preparation method. The traditional Chinese medicine is prepared from Coptis chinensis, Corydalis yanhusuo, Schisandra chinensis, Cornus officinalis, Astragalus membranaceus, and Cinnamomum cassia. The preparation method includes: low-temperature differential pretreatment of the raw materials; gas-phase assisted mechanical activation of components A and C under pressurized carbon dioxide environment, utilizing in-situ generation of carbamate intermediates in the gas phase to reduce lattice energy; subsequently, component B is added and pulsed milling is performed, directionally assembling into a hydrophobic ion-pair complex through a thermodynamically driven ligand substitution reaction; finally, the pressure and temperature are increased in situ to convert the reaction medium into a supercritical fluid for integrated extraction. This invention achieves the transformation of the active ingredient from a hydrophilic to a lipophilic chemical form through a gas-phase activation and stepwise substitution strategy, enabling it to effectively penetrate the blood-nerve barrier. Simultaneously, the low-temperature, anaerobic environment throughout the process effectively avoids the degradation of heat-sensitive components.

This invention discloses a traditional Chinese medicine mouthwash, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The mouthwash is prepared from the following raw materials in parts by weight: 8-20 parts Rehmannia glutinosa, 8-15 parts Lonicera japonica, 6-15 parts Scutellaria baicalensis, 5-8 parts Coptis chinensis, 10-20 parts Forsythia suspensa, 10-25 parts Gypsum fibrosum, 5-10 parts Mentha haplocalyx, 3-6 parts Stevia repens, 4-8 parts honey, and 10-20 parts Crataegus pinnatifida. It has the effects of clearing heat and detoxifying, relieving pain and stopping bleeding, is non-irritating, does not produce drug resistance, and has no toxic side effects on the human body. It has anti-inflammatory and antibacterial effects, while preventing the occurrence and development of oral diseases. It utilizes the basic thinking of traditional Chinese medicine to apply the compatibility of natural herbs, and the raw materials are abundant, readily available, low in cost, and the preparation method is simple, suitable for industrial production. It has a significant and definite therapeutic effect on gingival redness, swelling, bleeding, purulent discharge, alveolar bone resorption, and loose teeth caused by kidney yin deficiency and excessive stomach fire.

This invention discloses a traditional Chinese medicine composition for the prevention and / or treatment of herpes and / or its complications. By weight, the composition comprises: 8-14 parts of Sophora flavescens, 5-11 parts of Bistorta officinalis, 9-15 parts of Rheum palmatum, 0.5-6 parts of Coptis chinensis, 1-7 parts of Forsythia suspensa, 1-7 parts of Taraxacum mongolicum, 1-7 parts of Viola yedoensis, 1-7 parts of Paeonia lactiflora, 1-7 parts of Paeonia suffruticosa, 1-7 parts of Gardenia jasminoides, 3-9 parts of Rehmannia glutinosa, 1-7 parts of Chrysanthemum indicum, 1-7 parts of Lonicera japonica, 1-7 parts of Atractylodes lancea, 0.5-6 parts of Phellodendron chinense, 0.5-1.5 parts of Cicadae periostracum, 2-8 parts of Smilax glabra, 1-7 parts of Anemarrhena asphodeloides, 1-7 parts of Ophiopogon japonicus, 0.5-6 parts of Alisma plantago-aquatica, and 1-7 parts of Gypsum fibrosum. The complications are pain and / or inflammation. This traditional Chinese medicine composition is safe, effective, and has a simple and efficient preparation method with controllable quality. It also exhibits significant analgesic and anti-inflammatory effects and can treat shingles and its sequelae.

This invention belongs to the field of quality control technology, specifically relating to a quality control method for a compound traditional Chinese medicine preparation containing rhubarb. The quality control method of this invention uses thin-layer chromatography (TLC) to identify rhubarb, Viola yedoensis, Kochia scoparia, Cnidium monnieri, Coptis chinensis, or Dictamnus dasycarpus in a rhubarb antipruritic lotion. The method uses a developing solvent with a volume ratio of toluene, acetone, ethyl acetate, and formic acid of 8-10:1-3:1-2:0.1-2 to separate and extract the components to be analyzed from numerous effective drug components. While ensuring identification accuracy, this method allows for the identification of 4-6 traditional Chinese medicine components using a single TLC plate, exhibiting high stability and repeatability. This invention offers the technical advantages of requiring less sampling, simplifying quality testing, and greatly improving detection efficiency.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating hyperuricemia complicated with metabolic syndrome, its preparation method, and its application. The traditional Chinese medicine composition comprises the following components in parts by weight: Codonopsis pilosula 3-6 parts, Astragalus membranaceus 12-18 parts, Bupleurum chinense 1-5 parts, Citrus reticulata peel 1-5 parts, Citrus aurantium peel 3-6 parts, Scutellaria baicalensis 1-5 parts, Nelumbo nucifera leaf 3-6 parts, Crataegus pinnatifida 3-6 parts, Anemarrhena asphodeloides 12-18 parts, Coptis chinensis 1-3 parts, Polygonatum sibiricum 3-6 parts, Pueraria lobata 28-35 parts, Schisandra chinensis 1-5 parts, Smilax glabra 28-35 parts, Cimicifuga foetida 1-5 parts, processed chicken gizzard lining 5-10 parts, Lycopus lucidus 3-6 parts, Atractylodes lancea 3-6 parts, Phellodendron chinense 3-6 parts, and Liquidambar formosana 3-6 parts. The traditional Chinese medicine composition of this invention follows the theory of traditional Chinese medicine compatibility, and synergistically achieves the effects of strengthening the spleen and soothing the liver, resolving phlegm and drying dampness, clearing heat and removing blood stasis. By effectively reducing the levels of blood uric acid, triglycerides, systolic blood pressure and diastolic blood pressure, and regulating key indicators such as high-density lipoprotein, it significantly improves the clinical symptoms of patients with hyperuricemia and metabolic syndrome. Moreover, it has good safety in clinical application and no obvious adverse reactions.