Traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis

Abstract

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis, relates to the technical field of traditional Chinese medicines, and particularly aims to solve the problem of relatively narrow application prospects of treatment means applied to GERD at present in the background technology. Comprising rhizoma bletillae, calcined concha arcae, rhizoma pinelliae preparata, caulis bambusae in taeniam, fructus aurantii immaturus, pericarpium citri reticulatae, liquorice, poria cocos, coptis chinensis, fructus evodiae, platycodon grandiflorum and radix curcumae, and the traditional Chinese medicine composition is superior to western medicines, effective in treatment of the gastroesophageal reflux disease, small in side effect and economical and practical.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis. Background Art

[0002] Gastroesophageal reflux disease (GERD) refers to a disease in which gastric contents reflux into the esophagus and cause reflux-related symptoms and / or complications. The causes of GERD are diverse, mainly related to weakened defense mechanisms, including transient relaxation of the lower esophageal sphincter (see Expert Consensus on Diagnosis and Treatment of Gastroesophageal Reflux Disease in Traditional Chinese Medicine (2017)). GERD has many clinical manifestations. Heartburn and acid reflux are the most common typical symptoms of GERD, and chest pain is also a common symptom. Other atypical symptoms include upper abdominal pain, burning sensation in the upper abdomen, bloating, belching, nausea and other indigestion symptoms, or accompanied by throat discomfort, dysphagia, and sleep disorders. In addition, GERD can also be accompanied by extraesophageal symptoms, including cough, throat symptoms, asthma, and dental erosion, and complications include upper gastrointestinal bleeding and esophageal stenosis (see Expert Consensus on Gastroesophageal Reflux Disease (2014)).

[0003] The "Chinese Consensus on Multidisciplinary Diagnosis and Treatment of Gastroesophageal Reflux Disease" points out that the pathogenesis of GERD is diverse, and multiple factors and multiple sites are involved in the occurrence of GERD. Irreversible anti-reflux function or structural disorders (such as significant relaxation of the esophagus, etc.) are the main causes of GERD chronicity; gastroesophageal hypodynamic state is the main dynamic feature of GERD and is also a common inducing or aggravating factor for gastroesophageal reflux; psychological states such as anxiety and depression can enhance patients' sensitivity to GERD symptoms and lead to a further decline in their quality of life, forming a vicious cycle; gastroesophageal reflux disease is always accompanied by varying degrees of visceral hypersensitivity and strong tissue reactivity. Possible mechanisms for the generation of extraesophageal symptom syndrome include direct effects of reflux on the airway or simple involvement of extraesophageal organs.

[0004] Drug treatment is the first-line treatment for GERD. Drug treatment for GERD often needs to take into account other comorbidities, such as functional gastrointestinal disease, chronic gastritis, bile reflux, visceral hypersensitivity and intestinal flora imbalance. Commonly used drugs include acid inhibitors, antacids, gastrointestinal prokinetic drugs, mucosal protectants, bile binders, neuromodulators and so on. Nowadays, the treatment methods used for GERD are constantly updated, such as anti-reflux surgery, anti-anxiety, music therapy, etc., but the application prospects of these treatment methods are relatively narrow. For example, PPI, which is the mainstay of GERD treatment, also has symptoms that cannot be resolved in up to 40% of GERD patients with suspicious symptoms. Therefore, the development of Chinese medicine preparations has become an effective measure for the treatment of gastroesophageal reflux disease. Traditional Chinese medicine has a unique understanding of the pathogenesis of GERD. Traditional Chinese medicine believes that the liver and gallbladder are slack in dredging, the spleen fails to move, and the lungs fail to purify, resulting in the loss of harmony and descent of the stomach, gastric qi reflux, and esophageal invasion, which is the basic pathogenesis of GERD. As a comprehensive treatment method, traditional Chinese medicine treats the disease by combining disease differentiation with syndrome differentiation and treatment, and has certain unique advantages.

[0005] Therefore, there is an urgent need to design a Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis that is superior to Western medicine, is effective in treating gastroesophageal reflux disease, has few side effects, and is economical. Summary of the invention

[0006] In view of the problems existing in the above-mentioned prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis, which has the effects of clearing away heat and resolving phlegm, relieving adverse reactions and harmonizing the stomach, and assisting in antacidity, and can effectively treat gastroesophageal reflux and chronic gastritis.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] A Chinese medicine composition comprises the following Chinese medicine raw materials: Bletilla striata, calcined Corrugated Paper, Pinellia tuber, Rhizoma Anemarrhenae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Licorice, Poria, Coptis chinensis, Evodia rutaecarpa, Platycodon grandiflorum, and Curcuma aromatica.

[0009] Preferably, the Chinese medicine composition comprises the following Chinese medicine raw materials in parts by weight: 10-15g of Bletilla striata, 20-30g of calcined Corrugated Paper, 10-12g of Pinellia ternata, 10-12g of Rhizoma Anemarrhenae, 10-15g of Immature Citrus aurantium, 10-12g of Citrus reticulata, 3-6g of Licorice, 15-20g of Poria, 6-9g of Coptis chinensis, 3-5g of Evodia rutaecarpa, 10-12g of Platycodon grandiflorum, and 10-12g of Curcuma aromatica.

[0010] Bletilla striata, the traditional Chinese medicine Bletilla striata has the effects of astringing, stopping bleeding, reducing swelling and promoting tissue regeneration.

[0011] Calcined corrugated seeds have the effects of eliminating phlegm and removing blood stasis, softening and dispersing nodules, reducing acid and relieving pain, treating trauma, and treating gastritis.

[0012] Ginger and Pinellia have the effects of warming the middle, resolving phlegm, relieving adverse effects and stopping vomiting.

[0013] Bamboo shavings have the effects of clearing away heat and resolving phlegm, relieving restlessness and stopping vomiting, and calming the fetus.

[0014] Zhishi has the effects of breaking up qi, eliminating stagnation, resolving phlegm and relieving abdominal distension.

[0015] Tangerine peel has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm.

[0016] Licorice has the effects of replenishing qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving pain, and alleviating the properties of medicine.

[0017] Poria has the effects of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind and tranquilizing the nerves.

[0018] Coptis chinensis has the effects of clearing away heat and dampness, purging fire and detoxifying.

[0019] Evodia rutaecarpa has the effects of dispelling cold and relieving pain, relieving adverse qi and stopping vomiting, and promoting yang and stopping diarrhea.

[0020] Platycodon grandiflorum has the effects of clearing the lungs, relieving sore throat, removing phlegm and discharging pus.

[0021] Curcuma has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood.

[0022] The second object of the present invention is to provide a use of a Chinese medicine composition in preparing a drug for treating gastroesophageal reflux.

[0023] The third object of the present invention is to provide a use of a Chinese medicine composition in preparing a medicine for treating chronic gastritis.

[0024] Preferably, the dosage form of the drug is an oral dosage form, and the oral dosage form is granules, tablets, capsules, pills, syrups, powders, pastes, pellets, suspensions, emulsions, sustained-release preparations or controlled-release preparations.

[0025] The third object of the present invention is to provide a method for preparing a Chinese medicine granule, comprising:

[0026] S1. Take appropriate amounts of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus aurantium, Citrus reticulata, Licorice root, Poria cocos, Platycodon grandiflorum, and Curcuma zedoariae, add 10 times the amount of water, and soak in cold water for 2 hours;

[0027] S2. Decoction for 150 min and filter, add 1000-1500 ml of water to the residue, decoct for 120 min and filter again;

[0028] S3. The filtrates from the two filtrations are mixed and concentrated under negative pressure to an extract-like state;

[0029] S4. Take the amount of Bletilla striata, Evodia rutaecarpa, Coptis chinensis and calcined corrugated seeds, dry them at 80°C, crush them, and pass them through an 80-mesh sieve to obtain a fine powder;

[0030] S5. The extract obtained in step S2 is then mixed with the fine powder of the drug and the starch and stirred to obtain a soft drug material;

[0031] S6. Pass the drug soft material through a 12-mesh sieve to obtain drug wet granules, and dry the wet granules at 80° C. to obtain drug dry granules.

[0032] Preferably, in step S1, the amounts of pinellia tuber, bamboo shavings, immature bitter orange, tangerine peel, liquorice, poria, platycodon and turmeric are: pinellia tuber 12g, bamboo shavings 12g, immature bitter orange 15g, tangerine peel 12g, liquorice 6g, poria 15g, platycodon 12g, turmeric 12g.

[0033] Preferably, in step S4, the amounts of Bletilla striata, Evodia rutaecarpa, Coptidis chinensis and calcined Corundum truncatum are: 15 g Bletilla striata, 3 g Evodia rutaecarpa, 6 g Coptidis chinensis and 30 g calcined Corundum truncatum.

[0034] The beneficial effects of the present invention are as follows: the present invention discloses a Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis. Compared with the prior art, the present invention has the following improvements:

[0035] In the Chinese medicine composition of the present invention, Bletilla striata is sweet, bitter and slightly cold, mainly enters the liver and stomach meridians, has the functions of astringent hemostasis, swelling and tissue regeneration, and Corrugated seeds are salty and flat in nature, enter the liver and stomach meridians, have the functions of eliminating phlegm and removing blood stasis, softening and dispersing nodules, and reducing acid and relieving pain, and the two are the main drugs, which can treat stomachache, acid vomiting, and noisy stomach. Pinellia is a holy medicine for eliminating phlegm, and Tangerine peel regulates qi and eliminates phlegm. The two drugs can be used together to dry dampness and eliminate phlegm; Bamboo Shavings is sweet and cool, clears heat and eliminates phlegm, and is an important medicine for Shaoyang visceral heat and phlegm heat. Citrus aurantium is slightly cold, regulates qi and removes phlegm, eliminates accumulation and eliminates lumps, and the two drugs have the function of clearing heat and eliminating phlegm, and these four drugs are the ministerial drugs. Poria strengthens the spleen and eliminates dampness, and Curcuma promotes qi and relieves depression. The two drugs can promote qi and eliminate dampness; Coptis chinensis is bitter and cold, and Evodia rutaecarpa is pungent and warm. The two drugs are used together to form "Zuojin Pills", which have the function of clearing the liver and descending the stomach, and these four drugs are adjuvant drugs. Platycodon grandiflorum is a medicine for boats, which keeps the medicine in the middle burner to prevent the bitter cold from falling directly into the lower burner. Licorice harmonizes the other medicines, and the two medicines are the guiding medicines. The treatment principle is to soothe the liver and promote qi, strengthen the spleen and dry dampness, and harmonize the stomach and lower qi.

[0036] The Chinese medicine composition of the present invention targets the three major pathological factors of gastroesophageal reflux and chronic gastritis to reduce qi, resolve phlegm and eliminate blood stasis, and has the effects of soothing the liver and promoting qi, strengthening the spleen and drying dampness, harmonizing the stomach and reducing qi to cure the root cause. It can quickly relieve the main symptoms of gastroesophageal reflux disease patients such as acid reflux and heartburn, has a definite therapeutic effect, has no obvious adverse reactions and is highly safe. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 The present invention is a flow chart for preparing the Chinese medicine composition;

[0038] Figure 2 This is a typical case electronic gastroscopy report 1 of the present invention;

[0039] Figure 3This is the electronic gastroscopy report 2 of the typical case of the present invention;

[0040] Figure 4 This is the third typical case electronic gastroscopy report of the present invention. DETAILED DESCRIPTION

[0041] In order to enable those skilled in the art to better understand the technical solution of the present invention, the technical solution of the present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0042] Gastroesophageal reflux disease belongs to the category of "acid swallowing", "regurgitation", "noise", "epigastric pain" and other diseases in traditional Chinese medicine. Professor Huang Yahui believes that the main causes and pathogenesis of this disease are emotional disorders, liver failure to release, and qi disorder; improper diet, excessive smoking and drinking, damage to the spleen and stomach, internal dampness, and long-term heat accumulation, resulting in dampness and heat accumulation in the middle jiao; long-term illness and damage to the spleen, as well as surgery, spleen weakness, soil congestion and wood depression, liver and stomach disharmony, the above factors cause phlegm, qi, heat, and accumulation in the esophagus, and the descent of stomach qi is blocked. The spleen qi should rise but does not rise, and the stomach qi should fall but does not fall. The liver does not rise with the spleen, and the gallbladder does not fall with the stomach, resulting in stomach qi going up and attacking the esophagus, causing upper abdominal pain, chest pain, acid reflux, heartburn, belching, etc., forming this disease. In addition, stomach qi does not descend, water and moisture cannot be transformed, and they gather into phlegm and turbidity, which soaks in the lungs, and the lungs fail to descend, resulting in cough, asthma, sore throat and other symptoms. The disease is located in the esophagus and stomach, and is closely related to the liver, gallbladder, spleen and lungs. The nature of the disease is deficiency of the root and excess of the symptoms, or a mixture of deficiency and excess. The root deficiency is mainly spleen and stomach deficiency; the pathogenic excess is the symptoms, mainly qi stagnation, food stagnation and phlegm coagulation.

[0043] A Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis, the Chinese medicine composition is prepared from the following formula: 10-15g of Bletilla striata, 20-30g of calcined Corrugated seeds, 10-12g of Pinellia tuber, 10-12g of Rhizoma Anemarrhenae, 10-15g of Fructus Aurantii Immaturus, 10-12g of Pericarpium Citri Reticulatae, 3-6g of Licorice, 15-20g of Poria, 6-9g of Coptis chinensis, 3-5g of Evodia rutaecarpae, 10-12g of Platycodon grandiflorum, and 10-12g of Curcuma aromatica 。

[0044] Embodiment 1:

[0045] A traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis is prepared from the following formula: 15g of Bletilla striata, 30g of calcined Corrugated seeds, 12g of Pinellia ternata, 12g of Rhizoma Anemarrhenae, 15g of Immature Citrus aurantium, 12g of Citrus reticulatae, 6g of Licorice, 15g of Poria, 6g of Coptis chinensis, 3g of Evodia rutaecarpa, 12g of Platycodon grandiflorum and 12g of Curcuma aromatica.

[0046] Preparation method:

[0047] S1. Take eight herbs including Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus aurantium, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Poria, Platycodon grandiflorum and Curcuma aromatica according to their amounts, add 10 times the amount of water, and soak in cold water for 2 hours;

[0048] S2. Decoction for 150 min and filter, add water (1000-1500 ml) to the residue and decoct for 120 min before filtering again;

[0049] S3. The filtrates from the two filtrations are mixed and concentrated under negative pressure to an extract-like state;

[0050] S4. Take 4 herbs including Bletilla striata, Evodia rutaecarpa, Coptis chinensis and calcined Corrugated seeds according to the amount, dry at 80°C, grind and pass through an 80-mesh sieve to obtain fine powder;

[0051] S5. The extract obtained in step S2 is then mixed with the fine powder of the drug and an appropriate amount of starch and stirred to obtain a soft drug material;

[0052] S6. Passing the drug soft material through a 12-mesh sieve to obtain drug wet granules, and drying the wet granules at 80° C. to obtain drug dry granules;

[0053] S7. The dry drug particles are then sterilized by irradiation and bagged to make semi-finished products. Finally, they are made into finished products after quality inspection and external packaging.

[0054] Embodiment 2:

[0055] The difference between Example 2 and Example 1 is that, on the basis of Example 1, the Chinese medicine composition prepared in Example 1 is used to compare clinical treatment with the corresponding Western medicine rabeprazole + domperidone tablets, thereby obtaining that the Chinese medicine composition of the present invention is better than rabeprazole + domperidone in the treatment of gastroesophageal reflux and chronic gastritis; the specific process is as follows:

[0056] Determine the treatment and control groups

[0057] A total of 80 patients with gastroesophageal reflux disease who were admitted to our hospital from July 2012 to January 2013 and met the diagnostic criteria for gastroesophageal reflux disease were selected and randomly divided into two groups: the Jiwa Fanliu San group (treatment group) had 40 cases, including 24 males and 16 females, aged 34 to 74 years old, with an average age of 54 years old and an average course of disease of 3.6 months; the Rabeprazole + Motilium tablets group had 40 cases, including 22 males and 18 females, aged 36 to 70 years old, with an average age of 53 years old and an average course of disease of 3.4 months; there were no significant differences in gender, age and course of disease between the two groups (P>0.05), and they were comparable.

[0058] Treatment

[0059] Treatment group: Jiwa Fanliu San (the Chinese medicine composition of the present invention) was given for treatment. The dosage was adjusted according to the symptoms, specifically: for patients with obvious heartburn, add 9g of Coptis chinensis and 3g of Evodia rutaecarpa; for patients with obvious acid regurgitation, add 15g of Cuttlebone and 15g of Calcined Oyster; for patients with obvious chest pain, add Corydalis yanhusuo, Pollen Typhae and Platycodon grandiflorum; for patients with obvious gastric distension, add Radish Seed and Citron; for patients with obvious stomach cold, add 6g of Amomum villosum and 6g of Dry Ginger; for patients with obvious hiccups, add 12g of Inula flower and 15g of Ochre; for patients with dry mouth, add 12g of Anemarrhena and 12g of Radix Ophiopogonis; for patients with bitter mouth, add 10g of Bupleurum and 10g of Radix Scutellariae. One dose per day, decoct in water to obtain about 300ml of juice, take twice a day in the morning and evening.

[0060] Control group: 10 mg of rabeprazole sodium enteric-coated capsules were given once a day before meals in the morning; 10 mg of metoclopramide tablets were given 3 times a day before meals. Both groups were treated for four weeks as a course of treatment, and two courses of treatment were continued. During the treatment period, other drugs related to the treatment of this disease were stopped, and sweet, sour, spicy, cold and indigestible foods were avoided, smoking and drinking were stopped, and emotions were relaxed.

[0061] Diagnostic criteria and efficacy evaluation criteria

[0062] The diagnostic criteria of Western medicine refer to the "Chinese Consensus on Gastroesophageal Reflux Disease (2006, Sanya)". The diagnostic criteria of traditional Chinese medicine and the evaluation criteria of efficacy: refer to the "Consensus on the Diagnosis and Treatment of Gastroesophageal Reflux Disease in Traditional Chinese Medicine (2009, Shenzhen)" issued by the Spleen and Stomach Disease Branch of the Chinese Association of Traditional Chinese Medicine.

[0063] Clinical efficacy

[0064] 1. Comparison of clinical efficacy

[0065] The records and evaluations of single symptoms (typical reflux symptoms such as acid reflux, heartburn, pain or discomfort behind the sternum, belching and reflux) are shown in Table 1. Among them, markedly effective means that the original symptoms disappeared; effective means that the original symptoms improved by 2 levels; improved means that the original symptoms improved by 1 level; ineffective means that the original symptoms did not improve or worsened.

[0066] Table 1 Comparison of clinical efficacy between the two groups

[0067]

[0068] Note: There was a significant difference in the therapeutic effects between the two groups (P < 0.05), and the therapeutic effect of the treatment group was better than that of the control group.

[0069] 2. Comparison of inflammation under gastroscopy

[0070] The improvement of esophageal mucosal inflammation under gastroscope before and after treatment was based on the Los Angeles Classification (LA Classification) developed by the World Gastroenterology Congress in Los Angeles, USA in 1994, as shown in Table 2. Among them, cure means that the esophageal mucosa under endoscopy is normal; marked effect means that the inflammation under endoscopy has not disappeared, and the score difference before and after treatment is 2 points; effective means that the inflammation under endoscopy has not disappeared, and the score difference before and after treatment is 1 point; ineffective means that the inflammation under endoscopy has not disappeared, and the score difference before and after treatment is 0 points or a negative value.

[0071] Table 2 Comparison of criteria for determining inflammation under gastroscopy

[0072]

[0073] Note: There was a significant difference in the therapeutic effects between the two groups (P<0.05), and the therapeutic effect of the treatment group was better than that of the control group.

[0074] 3. Comparison of adverse reactions

[0075] Specifically, the records and statistics of symptoms of bitter mouth and dry mouth, abdominal pain and diarrhea, and anal swelling are shown in Table 3;

[0076] Table 3 Comparison of adverse reactions between the two groups

[0077]

[0078] Note: There is a significant difference between the two groups, P < 0.01.

[0079] Embodiment 3:

[0080] Example 3 is a typical case record of taking the Chinese medicine composition in Example 1 and the related gastroscopy report, such as Figure 2-4 As shown, specifically:

[0081] 1. Name: Wang, male, 45 years old, from Xincheng District, Xi'an, no history of herbal allergies. On February 21, 2024, he was treated in the outpatient clinic of Huang Yahui, director of the Department of Spleen and Stomach, Xi'an Traditional Chinese Medicine Hospital. Main complaint: acid reflux and heartburn for 3 months. Current medical history: The patient complained of acid reflux and heartburn after getting angry 3 months ago, chest and flank distension, noisy feeling in the epigastric region, hiccups, dry mouth, bitter mouth, sticky and uncomfortable stool, once a day, normal urination. Past history: healthy. Allergy history: denied. Physical examination: clear consciousness, general spirit, no obvious abnormality of skin and mucous membranes, superficial lymph nodes were not touched, no obvious abnormality was found in the head and neck, chest, heart and lungs, and abdomen, physiological reflexes existed, and pathological reflexes were not elicited. No obvious abnormality was found in the specialist physical examination. Tongue diagnosis: red tongue, yellow and greasy fur. Pulse diagnosis: stringy and slippery. Diagnosis: gastroesophageal reflux disease (liver and stomach stagnation and heat syndrome). Treatment method: Clearing away heat and resolving phlegm, lowering adverse reactions and harmonizing the stomach, with antacid as the main method, oral administration of the drug of the present invention (3g / time, 3 times / day) for 2 months and then re-examination. Re-examination on April 21, 2024, the patient reported that the above symptoms improved significantly after taking the drug for 2 months. Doctor's advice: Relax emotions, follow up if discomfort occurs.

[0082] 2. Name: Wang * Feng, gender: male, age: 35 years old, first visit date: May 28, 2024, main complaint: epigastric distension and pain for 1 year, current medical history: epigastric distension and pain without obvious cause 1 year ago, worse after meal, no systematic diagnosis and treatment, now for further diagnosis and treatment of integrated Chinese and Western medicine, current symptoms: epigastric distension and pain, worse after meal, occasional belching, heartburn, back pain, dry mouth, bitter mouth, moderate amount of gray and white sticky sputum in the throat, difficult to cough up, good appetite, poor rest at night, formed stool, 1 time / day, small amount, accompanied by a feeling of incomplete defecation, regular urination. Pale tongue, white fur, stringy pulse.

[0083] Past medical history: denied history of "diabetes", "hypertension", "coronary heart disease" and other medical history. Allergy history: denied history of drug and food allergies. Physical examination: clear consciousness, regular facial features, no obvious abnormalities in skin and mucous membranes, no superficial lymph nodes were palpable, no obvious abnormalities were found in the head and neck, thorax, heart and lungs, and abdomen, physiological reflexes were present, pathological reflexes were not elicited, and no obvious abnormalities were found in the specialist physical examination. Auxiliary examinations: electronic gastroscopy: cardia inflammation; chronic atrophic gastritis (C1) with erosion; inflammation of the duodenal bulb.

[0084] Western medicine diagnosis: 1. Chronic gastritis; 2. Gastroesophageal reflux, such as Figure 2 As shown, TCM diagnosis: stomachache (liver-stomach disharmony syndrome) treatment: soothing the liver and stomach, promoting qi and relieving pain. Oral administration of the drug of the present invention (3g / time, 3 times / day), after 3 months of follow-up, all symptoms were relieved, and reexamination of gastroscopy showed chronic non-atrophic gastritis. It is recommended that the patient avoid wind and cold, be cautious in diet, and continue to take the drug for 2 weeks to consolidate the therapeutic effect, and follow up if discomfort occurs.

[0085] 3. Name: Zhang * Hai, Gender: Male, Age: 50 years old, Date of first diagnosis: July 9, 2024; Chief complaint: Dull pain in the epigastric region for 2 weeks, Current medical history: Dull pain in the epigastric region occurred 2 weeks ago without obvious cause, no systematic diagnosis and treatment, now seeking further diagnosis and treatment of integrated Chinese and Western medicine in the outpatient clinic, Current symptoms: Dull pain in the epigastric region, worse after meals, acid reflux, heartburn, conscious fever in the hands and feet, poor appetite, shallow sleep, formed stool, 1 time / day, accompanied by difficulty in defecation, feeling of incomplete defecation, and regular urination.

[0086] Past medical history: denied history of "diabetes", "hypertension", "coronary heart disease", etc. Allergy history: denied history of drug and food allergies. Physical examination: clear consciousness, regular facial features, no obvious abnormalities in skin and mucous membranes, no superficial lymph nodes were palpable, no obvious abnormalities were found in the head and neck, thorax, heart and lungs, and abdomen, physiological reflexes were present, and pathological reflexes were not elicited. No obvious abnormalities were found in the specialist physical examination.

[0087] Auxiliary examinations: Electronic gastroscopy: cardia inflammation; chronic atrophic gastritis (C1) with erosion; duodenal bulb inflammation.

[0088] (2022.3.1 Xi'an Traditional Chinese Medicine Hospital) Western medicine diagnosis: 1. Cardiac inflammation; 2. Chronic atrophic gastritis; 3. Duodenal bulbitis. Traditional Chinese medicine diagnosis: stomachache (liver-stomach disharmony syndrome), treatment: soothing the liver and stomach, promoting qi and relieving pain. Oral administration of the drug of the present invention (3g / time, 3 times / day), follow-up after 1 month, all symptoms were relieved, reexamination of gastroscopy showed chronic non-atrophic gastritis, it is recommended that the patient avoid wind and cold, be cautious in diet, continue to take this drug for 2 weeks to consolidate the therapeutic effect, and follow up if discomfort occurs.

[0089] 4. Name: Liu * Li, gender: female, age: 39 years old, first visit: June 29, 2024; Chief complaint: epigastric distension and pain with hiccups for 8 months, current medical history: epigastric distension and pain without obvious cause 8 months ago, obvious in the morning and after meals, accompanied by hiccups, no systematic diagnosis and treatment, now seeking further diagnosis and treatment of integrated Chinese and Western medicine in the outpatient clinic. Current symptoms: epigastric distension and pain, obvious in the morning and after meals, frequent hiccups, acid reflux, heartburn, dry mouth, bitter mouth, dry throat, chest tightness, shortness of breath, spontaneous sweating, unformed stool, 7 days / time, difficult defecation, regular urination, normal appetite. Red tongue, white fur, stringy pulse.

[0090] Past medical history: denied history of diabetes, hypertension, coronary heart disease, etc. Allergy history: denied history of food or drug allergy. Physical examination: clear consciousness, regular facial features, no obvious abnormality in skin and mucous membranes, no superficial lymph nodes were palpable, no obvious abnormality in head and neck, thorax, heart, lungs and abdomen, physiological reflexes were present, and pathological reflexes were not elicited. No obvious abnormality was found in the specialist physical examination.

[0091] Auxiliary examination: Electronic gastroscopy: reflux esophagitis (LA); chronic atrophic gastritis (C1), (2024.6.29 Xi'an Traditional Chinese Medicine Hospital). Western medicine diagnosis: 1. Reflux esophagitis; 2. Chronic atrophic gastritis. Traditional Chinese medicine diagnosis: stomachache (liver-stomach disharmony syndrome);

[0092] Treatment: Soothe the liver and regulate qi to relieve pain, lower qi and soothe the stomach to stop hiccups. Oral administration of the drug of the present invention (3g / time, 3 times / day), after 2 months of follow-up, all symptoms were relieved, and a gastroscopy review showed chronic atrophic gastritis, and the examination report was as follows Figure 3 As shown, it is recommended that patients avoid wind and cold, be careful with their diet, continue to take this medicine for 2 weeks to consolidate the therapeutic effect, and follow up if any discomfort occurs.

[0093] 5. Name: Qian*Li, Gender: Female, Age: 52, Date of first diagnosis: July 25, 2024

[0094] Chief complaint: intermittent epigastric distension for 20 years. Current medical history: Epigastric distension appeared 20 years ago without obvious cause, worse after meals, no systematic diagnosis and treatment, now seeking further diagnosis and treatment of integrated Chinese and Western medicine, current symptoms: epigastric distension, worse after meals, accompanied by epigastric pain, hiccups, acid reflux, heartburn, dry mouth, bitter mouth, poor appetite, poor appetite, chest tightness and shortness of breath after meals, poor sleep, shallow sleep and easy awakening, bowel movements once every 4-5 days, dry, labored defecation, adjustable urination. Red tongue, white fur, stringy pulse.

[0095] Past medical history: denied history of "diabetes", "hypertension", "coronary heart disease", etc. Allergy history: denied history of drug and food allergies. Physical examination: clear consciousness, regular facial features, no obvious abnormalities in skin and mucous membranes, no superficial lymph nodes were palpable, no obvious abnormalities were found in the head and neck, thorax, heart and lungs, and abdomen, physiological reflexes were present, and pathological reflexes were not elicited. No obvious abnormalities were found in the specialist physical examination.

[0096] Auxiliary examinations: 1. Electronic gastroscopy: reflux esophagitis (LA), cardia inflammation, chronic non-atrophic gastritis with erosion. 2. Pathological examination: chronic inflammation of cardia mucosa, (2024.7.5 Xi'an Municipal Traditional Chinese Medicine Hospital). 3. Carbon 14 breath test: Hp (+), DPM = 150. (2024.7.25 Xi'an Municipal Traditional Chinese Medicine Hospital)

[0097] Western medicine diagnosis: 1. Reflux esophagitis; 2. Chronic non-atrophic gastritis; 3. Cardiac inflammation; 4. Helicobacter pylori infection. Traditional Chinese medicine diagnosis: Stomach bloating (liver-stomach disharmony syndrome)

[0098] Treatment: Soothe the liver and regulate qi, harmonize the stomach and relieve bloating. Orally take the drug of the present invention (3g / time, 3 times / day), re-examine after 2 months, all symptoms are relieved, re-examination of gastroscopy indicates chronic non-atrophic gastritis, the examination report is as follows Figure 4 As shown, it is recommended that patients avoid wind and cold, be careful with their diet, continue to take this medicine for 2 weeks to consolidate the therapeutic effect, and follow up if any discomfort occurs.

[0099] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A Chinese medicine composition, characterized in that: The weight proportions of the Chinese medicinal raw materials include: 10-15g of Bletilla striata, 20-30g of calcined Corrugated Paper, 10-12g of Pinellia ternata, 10-12g of Rhizoma Anemarrhenae, 10-15g of Immature Citrus aurantium, 10-12g of Citrus reticulatae, 3-6g of Licorice, 15-20g of Poria, 6-9g of Coptis chinensis, 3-5g of Evodia rutaecarpa, 10-12g of Platycodon grandiflorum, and 10-12g of Curcuma aromatica.

2. A Chinese medicine composition according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is an oral dosage form, and the oral dosage form is granules, tablets, capsules, pills, syrups, powders, pastes, pellets, suspensions, emulsions, sustained-release preparations or controlled-release preparations.

3. A method for preparing a Chinese medicine composition according to any one of claims 1 to 2, characterized in that: include: S1. Take appropriate amounts of Pinellia tuber, Rhizoma Anemarrhenae, Immature Citrus aurantium, Citrus reticulata, Licorice root, Poria cocos, Platycodon grandiflorum, and Curcuma zedoariae, add 10 times the amount of water, and soak in cold water for 2 hours; S2. Decoction for 150 min and filter, add 1000-1500 ml of water to the residue, decoct for 120 min and filter again; S3. The filtrates from the two filtrations are mixed and concentrated under negative pressure to an extract-like state; S4. Take the amount of Bletilla striata, Evodia rutaecarpa, Coptis chinensis and calcined corrugated seeds, dry them at 80°C, crush them, and pass them through an 80-mesh sieve to obtain a fine powder; S5. The extract obtained in step S2 is then mixed with the fine powder of the drug and the starch and stirred to obtain a soft drug material; S6. Pass the drug soft material through a 12-mesh sieve to obtain drug wet granules, and dry the wet granules at 80° C. to obtain drug dry granules.

4. Use of the Chinese medicine composition according to claim 3 in preparing a drug for treating gastroesophageal reflux.

5. Use of the Chinese medicine composition according to claim 3 in preparing medicine for treating chronic gastritis.

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