49 results about "Gluconolactone" patented technology

The invention relates to a method for continuously synthesizing a dapagliflozin intermediate, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: mixing 5-bromo-2-chloro-4 '-ethoxydiphenylmethane, a photocatalyst and THF (tetrahydrofuran), introducing the mixture into an ultraviolet light catalytic micro-channel for pre-activation to generate an aryl free radical intermediate, namely a pre-activation solution, carrying out contact reaction on the pre-activation solution and a THF solution of 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone in a low-temperature coupling area of a micro-reactor, and carrying out purification, purification and purification to obtain the aryl free radical intermediate. The reaction liquid is introduced into a dynamic quenching zone and is mixed with supercritical CO2 on line, an intermediate I is obtained through supercritical fluid extraction and separation, and the photocatalyst is recycled; the method has the advantages of high reaction efficiency, convenience in catalyst recovery and simplicity in product separation.

The invention relates to a polyacid composite oil-controlling and acne-removing gel and a preparation method thereof, and belongs to the technical field of skin care products. The polyacid composite oil-controlling and acne-removing gel is prepared from the following components in percentage by mass: 2% of salicylic acid, 3%-4% of glycolic acid, 0.5%-1.5% of mandelic acid, 0.5%-1.0% of lactobionic acid, 0.5%-1.0% of gluconolactone, 1.2%-1.6% of microcrystalline cellulose (and) sphingomonas fermentation product extract (and) cellulose gum, 2%-5% of butanediol, 0.3%-0.5% of asiaticoside-II, 0.5%-1.5% of centella asiatica, 0.5%-1.5% of vitamin E and the balance of water. And the balance of deionized water. By adding micro-crystalline cellulose (and) sphingomonas fermentation extract (and) cellulose gum, system stability under compounding of five organic acids is realized, semitransparent gelatinous texture is obtained, the composition is suitable for point coating use mode, impression is not affected, oil-controlling and acne-removing effects are improved under the condition of low organic acid content, and the composition belongs to skin-care polyacid products and has a broad market prospect. The mild oil control and acne removal effects are realized, and the cream is suitable for oil-sensitive skin crowds.

The invention provides a polymorphic zinc and organic acid composition for targeted scalp barrier repair as well as a preparation method and application of the polymorphic zinc and organic acid composition. The composition is prepared from the following components in percentage by mass: 1 to 80 percent of yeast / zinc fermentation product, 1 to 20 percent of polyaspartic acid chelated zinc, 0.5 to 20 percent of gluconolactone, 0.5 to 6 percent of hydroxydecanoic acid, 1 to 10 percent of succinyl glycan and the balance of water or other pharmaceutically / cosmetically acceptable carriers. Wherein the mass ratio of the yeast / zinc fermentation product to the polyaspartic acid chelated zinc is (1: 1)-(8: 1); the mass ratio of the hydroxydecanoic acid to the gluconolactone is (1: 0.5)-(1: 3). The invention provides an efficient, mild and multi-effect synergistic nursing composition, and the composition realizes a three-in-one scalp regulation mechanism of barrier repair, mild bacteriostasis and long-acting moisturizing through unique component synergy.

The invention relates to the technical field of antibacterial agents, in particular to a compound antibacterial agent of a plant polyphenol complex and a preparation method of the compound antibacterial agent. The compound antibacterial agent is prepared from the following raw materials in parts by weight: 20-30 parts of moutan bark extract, 20-30 parts of folium mori, 20-30 parts of a carrier, 10-20 parts of jerusalem artichoke extract, 10-20 parts of coptis chinensis extract, 2-4 parts of a tackifier and 1-3 parts of a microbial agent. According to the invention, paeonol in moutan bark, chlorogenic acid in mulberry leaves, berberine in coptis chinensis and inulin polyphenol in jerusalem artichoke can be combined with lipid of bacterial cell membranes, so that membrane permeability is increased, microbial metabolic enzymes are interfered, energy metabolism and biosynthesis are blocked, free radicals are removed, and antibacterial effects of other components are enhanced; folium mori is hydrolyzed through beta-glucosidase to release free polyphenol, gluconolactone adjusts the acid environment to promote polyphenol dissolution, and the antibacterial effect of the composite antibacterial agent is effectively improved.

The present invention relates to a composition, preferably cosmetic, comprising: - at least one thiopyridinone compound chosen from the compounds of formula (I), the tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: - at least niacinamide or one of its derivatives; - at least gluconolactone; - a surfactant system comprising (i) at least one N-acyl-amino surfactant and (ii) at least one amphoteric surfactant; and - at least one non-associative crosslinked copolymer of acrylic acid and / or methacrylic acid, or one of their esters.

The invention discloses a preparation method of modified mineral powder for adjusting and controlling the viscosity of concrete. The preparation method of the modified mineral powder comprises the following steps: placing vertical mill mineral powder in a hydrochloric acid solution for ultrasonic treatment and infiltration to obtain activated mineral powder; preparing a sodium alginate solution and a calcium chloride cross-linking solution, adding the activated mineral powder into the sodium alginate solution to obtain a mineral powder suspension, and dropwise adding the mineral powder suspension into the calcium chloride cross-linking solution to react to obtain calcium alginate coated mineral powder; the preparation method comprises the following steps: dissolving sodium citrate, glucolactone and active nano silicon dioxide in water to form precursor sol; and adding the calcium alginate coated mineral powder into the precursor sol to obtain the modified mineral powder. The modified mineral powder prepared by the method disclosed by the invention realizes double effects of morphology regularization and viscosity controllability, and has an adjusting and optimizing effect on the viscosity problem of concrete when being applied to the concrete; and the method improves the activity of the mineral powder and the bonding strength of interfaces of the mineral powder and other components at the same time, so that the compactness and the overall strength of the concrete are improved.

The invention discloses a flue gas desulfurization composite synergist and a preparation method thereof, and relates to the technical field of flue gas desulfurization. The desulfurization composite synergist is prepared from the following raw materials in parts by weight: 5 to 10 parts of citric acid, 20 to 30 parts of binary acid, 15 to 20 parts of sodium formate, 15 to 20 parts of sodium salt, 12 to 18 parts of magnesium salt, 2 to 4 parts of surfactant, 2 to 4 parts of pH buffering agent and 5 to 10 parts of calcium oxide. The preparation method comprises the following steps: carrying out a ring-opening reaction on 3-(2-aminoethylamine) propyl methyl dimethoxy silane and glucolactone to obtain an intermediate 1, and then carrying out a two-step quaternization reaction to synthesize the novel surfactant. The prepared desulfurization composite synergist has a good desulfurization effect and is suitable for limestone-gypsum wet flue gas desulfurization.

The invention provides a micro-ecological preservative composition suitable for sensitive skin. The preparation method comprises the following steps: firstly, carrying out reflux extraction on artemisia apiacea through 60% ethanol, then adding lactobacillus plantarum and saccharomyces cerevisiae for fermentation to obtain artemisia apiacea fermentation liquor powder, and then compounding phenoxyethanol and gluconolactone to obtain the micro-ecological preservative composition. Experiments prove that the micro-ecological preservative composition does not excessively inhibit / promote proliferation of propionibacterium acnes, disturbance and damage to resident bacterial colonies of skin are reduced, and the micro-ecological preservative composition has a certain repairing effect on a micro-ecological barrier. Phenoxyethanol and natural preservatives (sweet wormwood herb fermentation liquor powder and gluconolactone) have a certain synergistic preservative effect, so that the dosage of phenoxyethanol can be reduced, and the irritation and scorching risks of high use concentration of phenoxyethanol to sensitive skin are reduced.

The invention discloses a pore cleaning mud mask and a preparation method thereof, belongs to the technical field of cosmetics, and particularly relates to a pore cleaning mud mask. Comprising 14 to 18 parts of kaolin, 7 to 9 parts of Manny root ice river mud, 4.5 to 5.5 parts of Amazon white mud, 10 to 12 parts of wheat germ oil, 43 to 47 parts of tea water, 0.1 to 0.14 part of a phellinus linteus extract, 1 to 2 parts of swertia mileensis powder, 2 to 4 parts of lactobionic acid, 0.08 to 0.12 part of salicylic acid and 0.4 to 0.6 part of gluconolactone. The pore cleaning mud mask provided by the invention is uniform in particle size distribution, uniform in mixing and capable of keeping the state of the mud mask moist and not dry in the use process, the cleaning strength of controlling oil, dredging pores and resisting inflammation is improved, meanwhile, skin sensitivity caused by excessive cleaning is avoided, and the cleaning effect is good. The invention provides a novel cleaning mud mask formula for realizing the goal of cleaning pores and an efficient and stable preparation method of the novel cleaning mud mask formula.

The invention relates to an allergy-relieving acne-removing composition and a preparation method and application thereof, and the allergy-relieving acne-removing composition comprises the following raw materials in parts by mass: 1-10 parts of VB-IP, 5-20 parts of hydroxyethyl urea, 1-5 parts of coated salicylic acid, 2-10 parts of wild soybean, 1-5 parts of clerodendranthus spicatus, 1-5 parts of rosewood seeds, 1-10 parts of lactobionic acid, 1-10 parts of gluconolactone, 1-10 parts of mandelic acid, 1-10 parts of glycollic acid, 1-5 parts of octyl dodecyl glucoside and 1-5 parts of cetearyl glucoside. 0.5 to 2 parts of phenoxyethanol and 5 to 30 parts of deionized water; the composition comprises the following components: a wild soybean fermentation extract, a clerodendranthus spicatus fermentation extract and a rosewood seed fermentation extract. Compared with the prior art, the formula is stable, penetration can be promoted, cutin renewal can be accelerated, a sebum film can be repaired, sebum can be adjusted, and the acne removing and skin care effects are good.

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a glucolactone crystal with controllable product granularity, which comprises the following steps: carrying out ultrasonic induced nucleation on a gluconic acid concentrated solution to generate a seed crystal, then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h, stirring by adopting a Taylor flow stirrer while cooling, and then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h to obtain the glucolactone crystal with controllable product granularity. A 45-degree four-blade axial Taylor flow stirring paddle is assembled below the Taylor flow stirrer, the rotating speed is 200-400 rpm, the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer is 0.4-0.8, after the cooling procedure is completed, solid-liquid separation is conducted, crystals are collected, and a glucolactone crystal product is obtained after drying treatment. The number of fine grains is controlled by changing the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer and the stirring speed, glucolactone crystal products with different granularities are obtained, the process is stable, the granularity of the glucolactone crystals can be effectively controlled, and the granularity of the crystal products can be finely adjusted according to actual product requirements.

The present disclosure discloses a composition for hair growth comprising Larix europea wood extract, Camellia sinesis leaf extract, Pisum sativum sprout extract, Curcuma longa (Turmeric) callus conditioned media, Hamamelis virginiana (Witch Hazel), Rosmarinus officinalis Leaf Oil, Glycerin, Glycine, Zinc Chloride, Sodium Metabisulfite, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Saccharide Isomerate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Biotinoyl Tripeptide- 1, Alpha Glucosyl Hesperidin, Caffeine, Hydrolyzed Pea Protein, Polyalkylene Glycol Mono Butyl Ether, Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Niacinamide, Arginine, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, and water is added to the composition until the desired volume is achieved. A method for preparing the composition for hair growth is also provided.

Methods and compositions suitable for treating acne, disrupting biofilms, and / or killing bacteria contained in biofilms are provided. [Solution] A particular method involves contacting skin requiring such treatment with a composition comprising two α-hydroxy acids and a polyhydroxy acid. Another particular method involves applying a composition comprising a first α-hydroxy acid, a second α-hydroxy acid, and a polyhydroxy acid to a surface having a biofilm. A particular composition is a. Glycolic acid in an amount of approximately 0.1% to 7.5% by weight, b. Approximately 0.1% to 5% by weight of gluconolactone, c. Approximately 0.1% to 5% by weight of mandelic acid, d. Glycol and, e. Salt-resistant thickening polymer, It contains, and the total amount of glycolic acid, gluconolactone, and mandelic acid is less than about 15% by weight of the total composition.

The invention discloses a preparation method of high-strength elastic double-network-structure double-gel used for stabilizing astaxanthin and used as a low-fat food (light and comfortable triangle) sandwich, and belongs to the technical field of food. The preparation method comprises the following steps: (1) heating and stirring glyceryl monostearate in edible oil to obtain oleogel; (2) heating and dissolving gelatin and sodium alginate in water to obtain a gelatin-sodium alginate aqueous solution; and (3) mixing the oil gel with the gelatin-sodium alginate aqueous solution, adding calcium carbonate and gluconolactone, stirring to prepare a uniform and stable emulsion, and refrigerating and standing to obtain the high-strength elastic double-gel with the double-network structure. The gelatin-calcium alginate double gel entrapped with astaxanthin provided by the invention has good mechanical properties and microstructure, healthy grease'light and comfortable triangle 'created on the basis of an oil-water double gel system reduces the grease content of the whole system, the functional component astaxanthin is loaded, and functional guarantee is provided for preparation of novel low-fat food sandwich.

The invention discloses a novel organic foliar iron fertilizer formula as well as an application method and application thereof. The formula of the novel organic foliar iron fertilizer comprises ferrous gluconate, D-glucolactone and vitamin c, wherein the mass ratio of the ferrous gluconate to the D-glucolactone to the vitamin c is 22.5: 20: 1. After a nonionic surfactant is added into the formula, and then the formula is added into water to be sprayed to plant leaves growing in alkaline soil, the chlorophyll content and the photosynthetic efficiency of the leaves can be remarkably improved, and the yield of crops, especially yellow peaches, can be improved. The foliar iron fertilizer is low in formula cost, simple in preparation process and obvious in effect in a short time, and has a wide application prospect.

The present disclosure discloses a composition for anti-graying hair comprising Aloe barbadensis Leaf Extract, Camellia sinensis leaf extract, Rosmarinus officinalis Leaf Oil, Hamamelis virginiana (Witch Hazel), Neopicrorhiza scrophulariiflora root extract, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Polyalkylene Glycol Mono Butyl Ether, Ethylhexylglycerin, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Propylene Glycol, Biotin, Hyaluronic Acid, Saccharide Isomerate, Alpha Glucosyl Hesperidin, Dimethyl Isosorbide, Mandarin peel paste, N-Acetyl L-Tyrosine, Pentylene Glycol, Gluconolactone, Propanediol, and water is added to the composition until a desired volume is achieved. The method for preparing the composition for anti-gray hair is also provided.

The invention belongs to the technical field of biochemical energy batteries, and discloses an implantable biochemical energy battery array, a chip and application. Comprising a plurality of biochemical energy power generation units which are mutually connected through a microfluidic channel to form a biochemical energy power generation array, the power generation array is connected in series and in parallel to form a battery array, and glucose fluid flows through the microfluidic channel. The power generation unit comprises a positive electrode, a biochemical decomposition chamber and a negative electrode, carrier materials of hexokinase HK, glucose 6-phosphate dehydrogenase G6PD, glucose 6-phosphate lactonase PGLS and glucose 6-phosphate dehydrogenase 6PGDH are fixed in the biochemical decomposition chamber, and the negative electrode is coated with an artificial film assembled with NADPH transhydrogenase and mitochondrial respiratory chain compound protein. According to the invention, glucose is used as fuel of the cell for continuous power generation, and the flexible array biochemical energy cell which is miniaturized, high in load, long in endurance, capable of being shaped and high in energy density can be provided.

The application discloses a Chlorella protein hydrolysate-based oil gel and a preparation method and application thereof in the field of plant-based food, and the preparation method comprises the following steps: using or not using a protease to hydrolyze Chlorella protein to obtain Chlorella protein hydrolysate, and dispersing the Chlorella protein hydrolysate in water to form a Chlorella protein hydrolysate suspension; after using gluconolactone to induce the Chlorella protein hydrolysate suspension to form a hydrogel, diluting the hydrogel with water, and performing one-time high-speed shearing treatment to obtain a Chlorella protein hydrolysate microgel particle dispersion; adding the Chlorella protein hydrolysate microgel particle dispersion into liquid edible vegetable oil, and performing secondary high-speed shearing treatment to obtain a coarse emulsion; adding an edible polysaccharide solution into the coarse emulsion, and performing three-time high-speed shearing treatment to obtain a Chlorella protein hydrolysate-based oil-in-water emulsion; and removing water in the Chlorella protein hydrolysate-based oil-in-water emulsion to obtain the Chlorella protein hydrolysate-based oil gel. The Chlorella protein hydrolysate-based oil gel has good texture performance and oil retention.

An electroless ruthenium plating bath contains at least a ruthenium compound, a reducing agent, and a stabilizer. The reducing agent is hydrazines. The stabilizer includes a hydroxylamine compound and an organic compound having a hydroxyl group. The hydroxylamine compound is either or both of hydroxylamine sulfate and hydroxylamine chloride. The organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

This invention belongs to the field of cosmetics and discloses a shampoo for cleansing the scalp and hair. It comprises the following components by weight percentage: 0.1-2% compound acid, 0.1-1% compound soft water, 10-30% surfactant, 0.1-5% conditioning agent, 0.1-10% moisturizer, 0.1-2% soothing and oil-controlling active ingredients, 0.5-1% preservative, 0.2-2% fragrance, and the balance being water. The compound acid is composed of gluconolactone, capryloyl glycine, and succinic acid, and the compound soft water is composed of sodium phytate, inositol hexaphosphate, tetrasodium glutamate diacetate, and disodium EDTA. This shampoo, through the selection of compound acids and the combination of compound soft water, along with the soaking application method, achieves a perfect balance between the effectiveness of cleansing the scalp and hair and gentleness, providing a comfortable daily shampooing experience similar to hot spring soft water, and improving the scalp environment to reduce hair loss.

Composition comprising a thiopyridinone compound, niacinamide and gluconolactone The present invention relates to a composition, preferably cosmetic, comprising: - at least one thiopyridinone compound chosen from the compounds of formula (I), the tautomers of formula (I'), their salts, their solvates such as their hydrates, their optical isomers, their racemates and their mixtures; - at least niacinamide or one of its derivatives; - at least gluconolactone; - a surfactant system comprising (i) at least one N-acyl-amino surfactant and (ii) at least one amphoteric surfactant; and - at least one non-associative crosslinked copolymer of acrylic acid and / or methacrylic acid, or one of their esters. Figure for abstract: none

The invention belongs to the technical field of biomedicine and individual physiological function prediction intervention, and relates to a method for evaluating individual physiological functions and health intervention, in particular to a method for evaluating individual aging age groups based on metabolite combinations and application. According to the present invention, any one or a combination of a plurality of small molecule plasma metabolites of the following five metabolites such as Maltose / Lactase, Phenylacetylglutamine, Gluconolactone, AMP and Maltotriose is adopted to deduce the aging stage of an individual; the metabolite-based composition can better predict and deduce the aging stage of an individual, is expected to be applied to clinical practice for evaluating the aging process of a subject, and has positive significance for further establishing measures for promoting healthy aging and intervening aging.

The application discloses an environment-friendly anti-dissolution gel foam extinguishing agent, which is composed of a foaming agent, a gelling agent, a crosslinking agent and a flame retardant, wherein the foaming agent is alkyl polyglycoside APG0810, the gelling agent is kappa-carrageenan, the crosslinking agent is gluconolactone, and the flame retardant is tributyl phosphate. Compared with existing foam extinguishing agents, the anti-dissolution gel foam extinguishing agent has longer storage stability, fewer component types, better anti-dissolution and better extinguishing performance. In addition, the anti-dissolution gel foam extinguishing agent has lower manufacturing cost, simple preparation process and is more convenient for large-scale industrial production.

The invention provides attapulgite modified gel. The attapulgite modified gel is prepared from the following raw materials: attapulgite, pregabalin, sodium alginate, carboxymethyl cellulose, calcium carbonate and D-glucolactone. The attapulgite, the sodium alginate and the carboxymethyl cellulose are mixed and cross-linked, the unique layer chain crystal structure of the attapulgite endows the gel with excellent adhesion and mechanical properties, so that the gel can be tightly attached to skin or tissues, and meanwhile, the attapulgite, the sodium alginate and the carboxymethyl cellulose have a synergistic effect to construct a stable three-dimensional network with a pore structure; the pregabalin hydrogel prepared by the preparation method disclosed by the invention is favorable for improving the continuous release performance of the gel to pregabalin, reducing the burst release phenomenon of pregabalin in application, prolonging the drug effect time of the hydrogel and meeting clinical treatment requirements.

Described herein is a personal care composition comprising: a cosmetically acceptable carrier; an antiperspirant component, the antiperspirant component comprising a gluconolactone or an acid thereof; and optionally, a thickening agent. Also described herein are methods of making and using these compositions.

The present invention discloses a method for selectively synthesizing an empagliflozin intermediate. By selectively hydrogenating and reducing gluconolactone to chiral hemiacetal, and then directly performing a dehydroxy arylation coupling reaction with an aryl halide compound under the action of a catalyst to obtain an intermediate compound Ⅳ of empagliflozin. The beneficial effects of the present invention are as follows: Through the selective synthesis of chiral hemiacetal and the direct dehydroxy arylation coupling reaction, the selectivity of the gluconolactone connection reaction is effectively increased, the reaction steps of the overall route are reduced, and the generation of reaction by-products can be effectively reduced; in addition, the synthesis method of the present invention is simple to operate, the product is easy to process, the product yield and purity are relatively high, the raw materials are easily available, and it is suitable for industrial scale-up production.

The invention discloses a preparation method of rice protein peptide-sodium alginate composite hydrogel, which is characterized in that rice protein peptide obtained by treatment under different enzymolysis conditions is mixed with sodium alginate, nano calcium carbonate and glucolactone for reaction, and gel is formed through cross-linking action. According to the method, the preparation method of the peptide gel is successfully improved, and the gel prepared by compounding the rice protein peptide obtained by treatment under different enzymolysis conditions with sodium alginate has the advantages of simple preparation method process, moderate gel speed, easiness in control, strong gel water binding capacity, relatively strong gel strength and thermal irreversibility.

The invention discloses a polyether amine nonionic surfactant, preparation thereof and application of the polyether amine nonionic surfactant in laser cutting protection liquid. A methyl gluconate intermediate is formed by controllable ring opening of D-anhydrous gluconolactone in an organic solvent, then the methyl gluconate intermediate and a primary amine group of polyether amine M1000 are subjected to an amidation condensation reaction, the glycosyl-polyether amine nonionic surfactant with an amphiphilic structure is successfully constructed, meanwhile, the reaction process is easy to operate, and the preparation method is suitable for industrial production. The reaction condition is mild, the content of byproducts is low, and excellent wetting ability, easy-to-clean property and heat-resistant stability are achieved. And compounding with water-soluble resin, an organic solvent, an ultraviolet absorbent and water to obtain the easy-to-clean and high-stability laser cutting protection liquid. The laser cutting protection liquid can significantly improve wettability, thermal oxidation resistance stability and residue cleaning efficiency in chip wafer processing, and is suitable for precision processing fields such as semiconductor wafer scribing and the like.

The application discloses a glycosylation modified polyethylene imine and application thereof as an anti-tuberculosis drug. The glycosylation modified polyethylene imine provided by the application is obtained by reacting polyethylene imine with gluconolactone, and one or more amino groups on the polyethylene imine are modified with a gluconolactone group L (HOCH2(CHOH)4CO-). Further, the anti-tuberculosis activity, cytotoxicity and stability of the glycosylation modified polyethylene imine are verified through a series of experiments, and the experimental results show that the toxicity of the gluconolactone modified polyethylene imine to normal cells is obviously reduced, the polyethylene imine has high inhibitory activity to tubercle bacillus, and the polyethylene imine has good stability, so the polyethylene imine has great clinical application potential as a new anti-tuberculosis drug.

The invention relates to a cleaning and acne removing composition and application thereof. The cleaning and acne removing composition comprises gluconolactone, glycolic acid, pyrrolidone carboxylic acid and glycolipid. The invention creatively finds that gluconolactone, glycolic acid, pyrrolidone carboxylic acid and glycolipid have a remarkable synergistic effect in the aspects of cleaning and removing acnes, the four components are mutually matched and synergistic, the cleaning and acne removing performance of the composition can be remarkably improved, meanwhile, the composition has an itching relieving effect, and the using skin feeling is improved.