530 results about "Methylene Dichloride" patented technology

The invention relates to an antibacterium nano fiber material and a preparation method thereof; the material comprises polymer superfine fiber and antibacterial agent, and the weight ratio is 60 to 98: 2 to 40; the preparation method comprises the following steps: (1) the antibacterial agent is dissolved in distilled water to prepare solution; the polymer superfine fiber is dissolved in methylene dichloride or chloroform organic solvent, emulsifier is added to be mixed evenly, to obtain solution which is dispersed evenly; (2) the two types of solution are mixed to obtain even water-in-oil W/O latex, and then electrostatic spinning is conducted to the latex, to obtain the antibacterium nano fiber material. The nano fiber material has good ventilation property and filterability, still has bacteriostasis and sterilization functions for a long time after stably releasing the antibacterial agent, has simple preparation method, adopts the biodegradable and bioabsorbable polymer as carrier materials, can be absorbed by the human body after fully releasing, is not left, does not need secondary operation and has no side effect.

The invention relates to a preparation method of monodisperse polylactic acid (PLA) microballoon spheres, which includes: (1) the PLA is dissolved in methylene dichloride so as to be taken as a dispersed phase and polyvinyl alcohol is dissolved in water so as to be used as a continuous phase; (2) two solutions are respectively put into injectors and the injectors are arranged on two boost pumps and connected with a microchannel reactor, and then the flow velocities of the dispersed phase and the continuous phase are adjusted to ensure that liquid drops with uniform size are continuously generated at the joint of the two phases; (3) the generated liquid drops are collected in the aqueous solution of the polyvinyl alcohol and a variable frequency oscillator is adopted to assist the volatilization of a solvent so as to ensure that the liquid drops are solidified to spheres; and (4) the spheres are washed by ionized water for a plurality of times and arranged in an oven for drying to obtain the monodisperse PLA microballoon spheres. The monodisperse PLA microballoon spheres prepared by the invention have a smooth surface and a particle size ranging from 200 Mum to 1000 Mum; a reaction device has simple and easy preparation process and controllable dimension of microchannels. The size of the prepared microballoon spheres can be conveniently adjusted and controlled and the variable frequency oscillator is adopted for quickening the solidification process of the PLA microballoon spheres, with low cost and less time consumption.

The invention relates to a method for detecting multiple residual solvents in a medicament. According to the method, by utilizing a gas chromatographic method, nine organic solvents including methanol, ethanol, acetonitrile, acetone, isopropanol, methylene dichloride, ethyl acetate, tetrahydrofuran and triethylamine in the medicament are simultaneously detected, the sensitivity and the precision are high, and the repeatability is good; by utilizing a standard addition method, other standard substances do not need to serve as internal standard substances, only pure substances of to-be-measured components are needed, the accuracy requirement on the sampling volume is low, and the operation is simple; by utilizing a headspace sampling method, a direct solution sample is prevented from interfering the detection and polluting a chromatographic column; by utilizing a temperature programming method, low-boiling-point organic solvents and high-boiling-point organic solvents can be effectively separated.

The invention relates to a preparation method of a fluorescent molecular probe for detecting sulfite ions through naked eyes and fluorescence ratio as well as the application of the fluorescent molecular probe in detecting sulfite ions. The fluorescent molecular probe is prepared by condensing 4-hydroxy naphthalimide serving as raw material and acetylpropionic acid in refluent methylene dichloride. The synthesis is simple and convenient, and the reaction conditions are mild. The probe molecule provided by the invention has higher sensitivity, stable fluorescence performance, higher synthesis yield and good selectivity, and furthermore, the response range of the probe is 0-1500 mu m, the detection limit is 6 mu m; the detection range is wide, the lower detection limit is low, and the probe is suitable for naked eye detection. Meanwhile, the florescence-ratio detection is adopted to avoid errors caused by exciting light intensity, probe concentration and environment factors of an off-on type probe which detects ions only depending on the change of fluorescence intensity and the probe disclosed by the invention is not influenced by anions such as F<->, Cl<->, Br<->, I<->, HPO4<2->, SO4<2->, NO<3->, AcO<->, ClO<4->, N<3-> and HCO<3->. Even interfering ions exist, the probe has very good response to sulfite ions. Therefore, the fluorescent molecular probe has practical application value in the fields of biochemistry, environmental science and the like.

The invention provides a method for preparing a Salen-metal complex. The method comprises the following steps of: under the argon atmosphere, adding ligands(II), sodium methoxide, absolute methanol soluble ligands(II) and sodium methoxide into a reactor in sequence; stirring the mixture for 2 minutes, and adding 1mol/L cobalt acetate anhydrous/ methanol solution dropwise, wherein the molar ratio of the ligands(II) to sodium methoxide to cobalt acetate is 1:1:1; and making the mixture reacted at the room temperature for 24 hours, adding anionic salt which has the same molar weight as the cobalt acetate, stirring the mixture for three days in the air, stopping the reaction, concentrating the mixture, performing dissolution and filtration by adding methylene chloride, drying the filtrate by anhydrous sodium sulfate overnight, filtering the mixture, concentrating under reduced pressure, and drying the mixture under the vacuum condition to obtain the Salen-metal complex. The Salen-metal complex prepared by the method has the advantages of simple method, low cost and high catalytic efficiency.

The invention discloses a method for extracting multifunctional sulforaphane from broccoli sprouting vegetable. The method comprises: fresh broccoli sprouting vegetable which grows for 6-10 days is taken as raw material, and is then crushed to be 100 meshes of sieve after being frozen and dried; after that, 100 parts by weight of the processed material is taken to be added with de-ionized water, methylene dichloride, 0.001-0.003 parts by weight of Vc and 0.1-0.3 parts by weight of Na2S, the pH value is adjusted to be 4-6, and the mixed solution is hydrolyzed for 6-10h at 15-35 DEG C; finally, the sulforaphane is obtained after being filtered, washed and purified. As the broccoli sprouting vegetable which grows for 6-10 days is taken as raw material, the method can effectively increase the production rate of the sulforaphane and plays the role of activation for using myrosase to hydrolyze sulpho-glucoside by adding the Vc; meanwhile, sodium sulfide is added for overcoming the interference of Fe in the material, thus improving the production rate of the sulforaphane. The obtained sulforaphane has multiple functions such as cancer resistance, oxidation resistance and the like as well as good application prospect.

The invention relates to an electrophoresis particle of polymer dye (pigment) for electronic ink and a preparation method thereof, and belongs to technology of electrophoresis particle preparation. The electrophoresis particle uses dye as an initial raw material, and is prepared according to the following proportion that: the mass ratio of the dye to acryloyl chloride is 1:1-10; the mass ratio of the dye to styrene is 1:1-20; the mass ratio of the dye to divinylbenzene is 1:0.5-10; and the mass ratio of the dye to an initiator AIBN is 1:0.01-0.05. The preparation method comprises the following steps: carrying out functionalized modification on dye acidylation by acryloyl chloride in methylene dichloride to lead the dye to carry a polymerizable functional group; then, leading the dye to perform a polymerization reaction with styrene in ethanol for 4 to 12 hours by taking AIBN as the initiator and the divinylbenzene as a cross-linking agent to prepare the particle with particle diameter of between 200 and 300nm. The electrophoresis particle and the preparation method have the advantages of simple process, accessible raw materials, even particle diameter of the prepared colorful electrophoresis particle and good degree of sphericity. The electrophoresis particle of the organic polymer dye (pigment) not only maintains the advantages of bright color and proper density of the organic dye, but also overcomes the defects uneven shape of the organic dye particle, poor movement effect in disperse liquid under the action of an electric field.

The invention discloses a method for winding a cardo-containing polyaryletherketone or polyarylethersuifone resin matrix composite, which comprises the following steps that: N-methylpyrrolidone, chloroform, N,N-dimethyl acetamide, morpholine or methylene dichloride and other solvents are used to prepare a PEK-E or PES-C resin solution at a certain concentration; continuous fibers are impregnated with gum and the solvent is removed to prepare a prepreg; during winding, the prepreg is first pre-heated to a certain temperature before reaching a mandrel, and then wound on the surface of the mandrel in a longitudinal direction, circumferential direction or alternately in the two directions under the action of a certain tensile force; and at the same time, the prepreg is further heated to promote the rise matrix to be fused quickly to adhere winding layers and finally consolidates and cools to form a compact winding structure. The method of the invention can manufacture high-performance thermoplastic composite winding members which are light in weight, high in strength and high temperature-resistance, and can meet the needs of petrochemical, sports, building and aerospace fields and other fields.

The invention provides oxidation resistant dimethyl silicon oil based magnetic fluid and a preparation method thereof; the dimethyl silicon oil based magnetic fluid is prepared by nano-magnetic particles, a surface modifier and carrier fluid, and the carrier fluid is the dimethyl silicon oil. The preparation method of the dimethyl silicon oil based magnetic fluid comprises the following steps: preparing the nano-magnetic particles; treating the nano-magnetic particles in an activated way; preparing the nano-magnetic particles which are modified by the surface modifier; adding the modified nano-magnetic particles which are purified into methylene dichloride, dispersing and filtering the mixture to obtain the methylene dichloride based magnetic fluid; adding the magnetic fluid into the dimethyl silicon oil to be stirred and dispersed, heating the mixture and maintaining the temperature between 50 and 90 DEG C, separating and precipitating the mixture to obtain the dimethyl silicon oil based magnetic fluid. The dimethyl silicon oil based magnetic fluid in the invention has the advantages of high stability, low temperature resistance and high temperature resistance. The preparation method is simple, high in efficiency and low in requirement on equipments, thus being easy to be applied in various fields and having wide application prospect.

The invention relates to a preparation method for thiamethoxam. The preparation method comprises the following specific steps of: dissolving 3-methyl-4-nitroimidotetrahydro-1,3,5-oxadiazine and 2-chlorine-5-chloromethyl thiazole into a polar aprotic organic solvent, adding potassium iodide serving as a catalyst and potassium carbonate serving as an acid binding agent, stirring at normal temperature or in a heating way for 8 hours, and detecting whether reaction is fully completed through TLC (Thin Layer Chromatography), wherein a reaction system always keeps in yellow suspension state; and evaporating the organic solvent out, adding methylene dichloride into residues for immersion cleaning, filtering inorganic salts out, obtaining an organic phase which is a deep yellow transparent solution, evaporating the methylene dichloride to dryness, and recrystallizing the crude product by using methylbenzene to obtain maize-yellow thiamethoxam, wherein the yield is 85 percent and the purity is 98 percent. The preparation method has the advantages: the affinity substitution process is stable and quick, the tendency of a side reaction is lowered greatly, the bottleneck of the requirement on the purity of the 2-chlorine-5-chloromethyl thiazole is overcome, the problem of black color of the product is solved completely, and the product yield is greatly increased.

The invention belongs to the technical field of medicines and discloses melittin complex nanoparticles for oral administration and a preparation method thereof. Water-soluble melittin and an amphiphilic substance are dissolved into a hydrosolvent A to form a hydrophobic protein ion pairing complex; the complex and a suitable polymer material are dissolved into a nonaqueous solvent B; an emulsion solvent diffusion method in a liquid phase is adopted to wrap the complex into the polymer material; and microparticles with the particle diameter between 10 and 1000nm are formed after the solvent is volatilized. The hydrosolvent A is distilled water, double distilled water, deionized water, physiological saline, or a phosphate buffer solution or an acetate buffer solution or a Tris buffer solution with the pH value of between 1 and 11; and the nonaqueous solvent B is a single or mixed solvent of alcohol, acetone, ethyl acetate, methylene dichloride, chloroform and dimethyl sulfoxide. The complex has high fat solubility, and the encapsulation rate of the nanoparticles is more than 90 percent. The preparation process is mild and can assure the biological activity of medicines. The preparation method is suitable to prepare oral administration preparations.

The present invention relates to an electrochemistry synthetic method of tetributyl tribromide of ammonium and belongs to the field of chemical formulation preparing technology. Sadi synthetic method in accordance with the present invention is as follow: dissolving tetrabutyl ammonium bromide in a aqueous solution of bromium salts such as ammonium bromide, potassium bromide or sodium bromide, magnetic-stirring it until reaching a entire solubilization, and then restirring it after adding organic solvent such as methylene dichloride or acetonitrile therein; putting the solution into an electrolytic tank of non-diaphragm type, selecting platinum meshwork as cathode and anode, inputting a constant electrical current for electroanalysis; electrolyzing for 3 hours under normal temperature and magnetic stirring to obtain tetributyl tribromide of ammonium in oil phase finally; washing the oil phase with distilled water, evaporating the organic solvent off and exposing it to air for a period of time, after the product solidifies, washing it with water, performing a recrystallization with methanol to obtain high-purity tetributyl tribromide of ammonium solid.

The invention discloses a glue removing agent for LED (light emitting diode) encapsulation residue glue. The glue removing agent is basically prepared from the following ingredients in percentage by weight: 30 to 80 percent of solvents, 10 to 60 percent of diluting agents, 5 to 10 percent of penetrating agents, 0.1 to 5 percent of metal protecting agents, 0.1 to 5 percent of catalysts and 0.1 to 0.5 percent of surface active agents. The product can be used for removing silica gel and epoxide resin encapsulation glue remained by an LED encapsulation material on equipment; the effect is good; no corrosion is left on the equipment; toxicity on the human body is low; compared with conventional methylene dichloride, carbon tetrachloride, tetrachloroethylene, acetone, toluene, xylene and vinyl acetate, the effect is equivalent; the consumption is low; the environment-friendly effect is achieved; the use is convenient.

The invention discloses a method for extracting rose essential oil from rose dregs and belongs to an extract method of essential oil, in particular relates to a method for extracting rose essential oil by using the organic solvent extraction and molecular distillation technology. The method comprises the following steps of: firstly, soaking and extracting the rose dregs by using petroleum ether and methylene dichloride as the mixed solvent; secondly, filtering the solution, condensing the filtrate, adding absolute ethyl alcohol, freezing and filtering the filtrate, removing the vegetable wax, condensing the filtrate to get the condensed solution; and thirdly, removing the residual solvent, vegetable wax, pigment and the like by a molecular distillation device to finally obtain the rose essential oil. The invention provides a new technology for the sufficient utilization of the rose and the improvement of the economic benefit of the rose processing enterprises.

The invention discloses a polylactic-co-glycolic acid (PLGA)/calcium carbonate compound microsphere with a porous shell and a preparation method for the compound microsphere. The preparation method comprises the following steps of: a, dissolving PLGA in a methylene dichloride organic solvent to obtain a PLGA oil phase; adding calcium carbonate powder to the PLGA oil phase; stirring and performing ultrasonic treatment to obtain organic/inorganic uniform mixed liquid; b, dissolving glucolactone in polyvinyl alcohol (PVA) aqueous solution to obtain acid PVA aqueous solution; c, dispersing the mixed liquid obtained in the step a into the acid PVA aqueous solution obtained in the step b under the condition of stirring to obtain oil-in-water single emulsion; d, continue stirring under the condition of reduced pressure to enable methylene dichloride in an oil phase drop to volatilize to obtain solidified compound microspheres; and e, collecting the microspheres in the step d; washing by using deionized water; and performing freeze drying. A pore-forming agent is not introduced by the method disclosed by the invention, thus, a porous structure exists on the surface of the prepared compound microsphere, and the compound microsphere is in favor of cell growth.

The invention discloses a preparation method of vonoprazan fumarate. The preparation method includes: S1, dissolving 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde (I) in organic solvent, mixing with methylamine alcohol solution for 6-8h to generate imine, reducing with metal borohydride for 1-2h, and performing post-treatment to obtain a compound according to a formula II; S2, dissolving the compound prepared in the step S1 according to the formula II, in organic solvent, performing ice bathing and mixing with Boc anhydride to allow reaction for 1-2h, and performing post-treatment to obtain a compound according to a formula III; S3, dissolving the compound prepared in the step S2 according to the formula III, in organic solvent, adding sodium hydride and crown ether, adding 3-pyridine sulfuryl chloride, mixing for reaction for 1-2h, and performing post-treatment to obtain a compound according to a formula IV; S4, reacting the compound prepared in the step S3 according to the formula IV, in trifluoroacetic acid and methylene dichloride solution to obtain a compound according to a formula V; and S5, dissolving the compound prepared in the step S4 according to the formula V, in organic solvent to be salified with fumaric acid, thereby obtaining the vonoprazan fumarate (VI). The preparation method has few side reactions and high intermediate purity and allows simple post-treatment.

The invention discloses a process for producing methane chloride by chlorination reaction heat. The process comprises a hydrochlorinate process and a chlorination process, wherein the chlorination process comprises the following steps that: after methane chloride gas prepared by the hydrochlorinate process and subchloride gas separated from mixture of a chlorination reaction are mixed and preheated, the methane chloride gas and the subchloride gas are mixed with chlorine and are introduced to a chlorination reactor to react; reaction mixture exchanges heat with raw material gas mixture of the methane chloride and the subchloride through a heat exchanger to preheat the raw material gas mixture, meanwhile, after the reaction mixture self is cooled, the reaction mixture enters a quenching tower to be cooled and washed, and enters a separating column to be separated; chlorine hydride gas and the subchloride gas are separated from gas vaporized from the top of the separating column through condensing separation, and are used as raw materials of the hydrochlorinate process and the chlorination process to be recycled; and methylene dichloride, methenyl trichloride and carbon tetrachloride are obtained from a mixed liquid obtained from the bottom of the separating column through rectifying separation. The process sufficiently and effectively reclaims mass high-grade heat energy carried by the mixture of high-temperature chlorination reaction, can greatly save energy, and reduce production cost.

The invention discloses a garden rubbish utilization method based on hydrothermal carbonization and solid biomass fuel. Through hydrothermal treatment of garden rubbish, solid products (hydrothermal biochar powder) and liquid byproducts (with light oil as a main ingredient) are utilized respectively, wherein the solid products are conveniently transported and stored for a long distance because of high heat value, good burning performance and low water content and then are mixed with crushed and dried garden rubbish in the proportion being 7:3, and the solid formed biomass fuel is prepared after compacting. The liquid byproducts are subjected to methylene dichloride extraction and rotary evaporation, and light oil is obtained. Both the solid products and the liquid byproducts of the garden rubbish can be used, so that the utilization efficiency of the garden rubbish is improved, resource waste is avoided, secondary pollution is small, the whole technological process is simple, the reaction conditions are relatively mild, the operation cost is low, and the solid biomass fuel has certain social meaning and higher economic value.

The invention relates to an alkylaryl sulfonate type hyperbranched polymer surface active agent and a preparation method thereof. The surface active agent is an anionic-nonionic surface active agent. The preparation process is that organic solvent and thionyl chloride are added in a flask, then sulfobenzoic acid monosodium salt is added to be reacted until hydrogen chloride and sulfur dioxide gas are not escaped, DMF is added, stirring reaction is performed under the temperature of 60 DEG C, the organic solvent is added for dilution after cooling, a certain amount of normal hexane is added, and after the temperature is cooled to below 25 DEG C, a filtered and separated pale yellow crystal is placed so as to obtain a midbody after being dried; and hydroxyl-terminated hyperbranched polymer which is one third of molar weight of the midbody is placed in a reactor, methylene dichloride is added under the room temperature, triethylamine is added to serve as catalyst, stirring reaction is performed, and after reaction is ended, evaporation, extraction and filtration are performed to obtain the alkylaryl sulfonate type hyperbranched polymer surface active agent. The alkylaryl sulfonate type hyperbranched polymer surface active agent has higher surface activity and lower CMC (Critical Micelle Concentration) and good emulsion stability, facilitates biodegradation, and is environmental protection.

The invention relates to a method for processing oily sludge through a supercutical fluid. The method comprises the steps of extracting the fuel oil from a routine preprocessed oily sludge due to the mutual effect of the supercutical fluid and a carrying agent under a certain temperature and pressure, wherein the extracting temperature is 35-80 DEG C, the pressure is 15-50 MPa, the separation temperature of a separator is 20-45 DEG C and the separation pressure is normal pressure-5 MPa; the supercutical fluid is supercritical carbon dioxide; and the carrying agent is one or more mixtures of methylene dichloride, ethyl acetate, acetone, petroleum ether and acetonitrile. The method has the following advantages that by adopting the method for processing the oily sludge through the supercutical fluid, the oily sludge is processed through a supercutical fluid extracting technology; the method is simple in process flow, high in processing efficiency, low in investment running cost and complete in oily sludge treatment; and the processed sludge can reach the national emission standard, the secondary pollution cannot be caused in the treatment process and the method is an environment-friendly green treatment process.