19 results about "Methylene Dichloride" patented technology

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

The invention belongs to the technical field of biomedicine synthesis, and particularly relates to the technical field of chemical synthesis of natural drugs / prodrugs for controlling metabolic abnormalities such as blood sugar and blood fat. The invention provides a preparation method of a cholic acid derivative. The preparation method comprises the following steps: adding benzyl bromide into an alkaline solution containing cholic acid to obtain benzyl cholate; the method comprises the following steps: adding a dichloromethane solution containing acyl chloride into a dichloromethane solution containing benzyl cholate and 4-dimethylaminopyridine under protective gas to obtain a colorless oily product; and introducing hydrogen into the absolute ethyl alcohol in which the colorless oily product is dissolved to obtain the cholic acid derivative. The chemical synthesis of the cholic acid derivative is realized.

A method for producing α-amino acid poly(ester amides), poly(ester ureas), and copolymers thereof by interfacial polycondensation comprises the following steps: (a) preparing a first solution by mixing bis(α-amino acid)-, ω-alkylene diester di-p- toluenesulfonate salt, and anhydrous sodium carbonate in water; (b) preparing a second solution by dissolving an aliphatic dicarboxylic acid chloride, or triphosgene, or a mixture of triphosgene with aliphatic dicarboxylic acid chlorides and / or a mixture of triphosgene with aliphatic diisocyanates in methylene chloride; (c) cooling both the first and the second solutions; (d) adding the second solution to the first at a rate of 2350–2400 mL / min under stirring at 680–700 rpm; (e) adding 4.0–4.5 L of distilled water to the resulting reaction mixture in the reactor; (f) adding 10–12 L of distilled water to the polymer solution in the distillation / washing unit while simultaneously performing azeotropic distillation of methylene chloride and washing the polymer; and (g) drying the obtained polymer.

This invention provides a composition that inhibits the tyrosinase enzyme involved in melanin production and also inhibits the action of collagen-degrading enzymes, thereby promoting collagen synthesis and achieving sufficient effects of skin whitening and elasticity improvement without inducing skin irritation due to skin allergies. [Solution] A composition having skin whitening and skin elasticity improving effects, according to one embodiment of the present invention, contains ginger extract as an active ingredient, and the ginger extract can be extracted using methylene chloride.

The utility model belongs to the technical field of methylene methyldisulfonate production, and particularly relates to a methylene methyldisulfonate production system which comprises an esterification kettle, an extraction tank, a primary centrifugal machine, a crystallization kettle, a secondary centrifugal machine and a spiral conveyor which are sequentially connected, and the top of the extraction tank and the top of the crystallization kettle are both connected to a dichloromethane elevated tank; the top of the extraction tank is further connected to a tube pass upper opening of the condenser through a pipeline, a tube pass lower opening of the condenser is connected to a liquid inlet of the esterification kettle through a pipeline, a liquid discharging opening of the primary centrifugal machine is connected to a primary mother liquor tank, and a liquid discharging opening of the secondary centrifugal machine is connected to a secondary mother liquor tank. The production system is reasonable in structural arrangement, methylene methyldisulfonate in the esterification liquid is extracted by using dichloromethane instead of water, the output of wastewater is greatly reduced, severe heat release is avoided in the treatment process, and the safety risk is greatly reduced.

This invention provides a composition that inhibits the tyrosinase enzyme involved in melanin production and also inhibits the action of collagen-degrading enzymes, thereby promoting collagen synthesis and achieving sufficient effects of skin whitening and elasticity improvement without inducing skin irritation due to skin allergies. [Solution] A composition having skin whitening and skin elasticity improving effects, according to one embodiment of the present invention, contains ginger extract as an active ingredient, and the ginger extract can be extracted using methylene chloride.

The invention discloses a method for preparing an alpha-hydroxyl ester compound by utilizing lignite residue catalysis, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: S1, mixing water and an aryl diazo ester compound, then adding acetonitrile in an air atmosphere, and stirring; s2, adding lignite residues as a catalyst to catalyze a reaction, reacting at room temperature for 1 h, heating to 80 DEG C, and continuously reacting for 8-10 h; s3, stopping the reaction when the reaction is detected to be complete by TLC; and S4, filtering the reaction liquid, washing a filter cake with dichloromethane until the filter cake is colorless, carrying out reduced pressure concentration on the filtrate to remove volatile components, and carrying out silica gel column chromatography separation to obtain the alpha-hydroxyl ester compound. According to the method, the lignite residues are used as the catalyst which is wide in source, low in cost and easy to obtain, and other transition metals or complex ligands do not need to be additionally introduced in the reaction; the reaction conditions are mild, the yield is good, gram-scale reaction can be realized, and the method has industrial prospects; meanwhile, waste resources can be recycled, and the development themes of green chemistry and green environmental protection are met.

The present application relates to a kind of preparation methods of waste tobacco extract, waste tobacco is crushed, enzymolysis, organic solvent ultrasonic extraction obtains methylene chloride extract S1 and ethyl acetate extract S2;After enzymolysis treatment, tobacco powder is fermented, subcritical water extraction, heavy metal adsorption and nanofiltration membrane filtration, nanofiltration membrane permeate is concentrated to obtain concentrated extract, concentrated extract is carried out molecular distillation, the light component and heavy component of molecular distillation are collected, the light component is water extract S3, and the heavy component is water extract S4;Concentrated extract is obtained by concentrating the cut-off liquid, and is recorded as water extract S5;The waste tobacco extract is one or more than two of methylene chloride extract S1, ethyl acetate extract S2, water extract S3, water extract S4 and water extract S5.The extract contains a large amount of tobacco native substance, has strong tobacco style characteristics, and higher safety, and it is applied to cigarette, can significantly improve the sensory quality of cigarette.

The utility model belongs to chemical organic synthesis equipment technical field discloses a kind of synthesis device of methyl acetate, reaction kettle, plate and frame filter press, distillation kettle, stainless steel condenser, product receiving kettle, methylene chloride receiving kettle and vacuum pump;The outlet valve of the bottom of the reaction kettle is connected to the inlet end of the plate and frame filter press by pipeline;The outlet end of the plate and frame filter press is connected to the inlet end of the distillation kettle by pipeline;The outlet end of the top of the distillation kettle is connected to the inlet end of the stainless steel condenser by pipeline;The outlet end of the stainless steel condenser is connected to T type control valve;The first outlet end of the T type control valve is connected to the inlet end of the methylene chloride receiving kettle by pipeline;The second outlet end of the T type control valve is connected to the inlet end of the product receiving kettle by pipeline;The inlet end of the top of the product receiving kettle is connected to the vacuum pump by pipeline.

This invention discloses a method for synthesizing and applying propyl 4-{[(1R)-1-phenylethyl]amino}-5-(methoxycarbonyl)-1,2,3,6-tetrahydropyridine-1-carboxylate, belonging to the field of pharmaceutical preparation technology. Specifically, the method involves: removing the tert-butyloxycarbonyl group from 1-tert-butyl 4-oxopiperidinium-1,3-dicarboxylate methyl ester under oxaloyl chloride conditions; reacting the obtained intermediate with ethyl chloroformate in dichloromethane solvent to prepare compound 2; and then reacting compound 2 with the amino group of (R)-(+)-1-phenylethylamine via a nucleophilic substitution reaction to prepare propyl 4-{[(1R)-1-phenylethyl]amino}-5-(methoxycarbonyl)-1,2,3,6-tetrahydropyridine-1-carboxylate. The compound exhibits good lipid-lowering activity and can be used as a potential lipid-lowering drug for the treatment of related diseases. Furthermore, the synthesis method is simple, efficient, and low-cost, and the prepared product has high purity, making it easy to achieve large-scale industrial production.

The invention relates to the technical field of medical chemistry, and discloses a tirapazamine derivative, a preparation method of the tirapazamine derivative comprises the following steps: S1, dissolving tirapazamine and an alkaline substance in a solvent, and adding alkyl acyl chloride for reaction until raw materials are completely converted; s2, after the reaction in the S1 is finished, performing rotary evaporation to remove the solvent, adding dichloromethane for dissolving, washing with a saturated saline solution, drying with anhydrous sodium sulfate, and finally evaporating to remove the solvent to obtain a crude product; and S3, carrying out column chromatography purification on the crude product to obtain the tirapazamine derivative. The invention also discloses an application of the tirapazamine derivative in preparation of medicines for treating tumors. Through molecular structure modification and prodrug design strategies, RTPZ is fully dissolved and dispersed in an embolic agent iodized oil, slow and controlled release of drugs in the iodized oil is realized, more lasting drug exposure is provided, and RTPZ shows stronger hypoxia selective cytotoxicity in vitro, so that RTPZ has a better anti-tumor effect.

An anion exchange membrane is made by mixing 2 trifluoromethyl ketone [nominal] (1.12 g, 4.53 mmol), 1 biphenyl (0.70 g, 4.53 mmol), methylene chloride (3.0 mL), trifluoromethanesulfonic acid (TFSA) (3.0 mL) to produce a pre-polymer. The pre-polymer is then functionalized to produce an anion exchange polymer. The pre-polymer may be functionalized with trimethylamine in solution with water. The pre-polymer may be imbibed into a porous scaffold material, such as expanded polytetrafluoroethylene to produce a composite anion exchange membrane.

To provide a membrane for purifying a biological fluid.SOLUTION: A membrane comprising at least one poly (aryl ether sulfone) (PAES) polymer comprising repeating units (RPAES) of formula (I) wherein each R1 is independently at each occurrence an alkyl having 1 to 5 carbon atoms and R is an alkyl having 1 to 10 carbon atoms or a cycloalkyl having 5 to 8 carbon atoms, wherein the weight-average molecular weight (M w) of the PAES is in the range of 70,000g / mole to 200,000g / mole as determined by size exclusion chromatography using methylene chloride as the mobile phase.SELECTED DRAWING: Figure 1

The invention provides a preparation method and application of a zirconium-based metal-organic framework adsorption material, and relates to the technical field of adsorbents. The method comprises the following steps: firstly, mixing zirconium tetrachloride, N, N '-bis (5-isophthalic acid) naphthalimide and a solvent, obtaining a zirconium-based metal-organic framework material by adopting a solvothermal method, then washing the obtained organic framework material, carrying out solvent exchange in dichloromethane, and drying to finish activating treatment; and finally, mixing the activated material, carboxyl benzo 12-crown-4-ether (CB-12C4E) and a solvent, carrying out constant-temperature reaction, cooling, filtering and drying to obtain the adsorption material CB-12C4E (at) Zr-NDI-scu-MOF. According to the method, more crown ether molecules are anchored through ligand exchange by utilizing Zr-NDI-scu-MOF with high porosity, so that a stronger lithium ion adsorption effect is shown, and the method has high adsorption capacity and relatively good selectivity and is suitable for efficiently and selectively recovering lithium ions from lithium ion solutions with complex components and various concentrations.

The invention discloses a preparation method of a biodegradable polycarbonate polymer, and belongs to the field of organic synthesis and polymer materials. According to the method, 2-propinyl-2-methyl trimethylene carbonate (MPMC) is taken as a starting raw material, polyethylene glycol-3400 is taken as an initiator, stannous octoate is taken as a catalyst, ring-opening polymerization reaction is carried out at 110 DEG C under a vacuum condition, and the reaction time is 20 hours. And after the reaction is finished, reducing the temperature of the system, and adding dichloromethane to dissolve the generated polymer, thereby finally obtaining the amphiphilic polyethylene glycol-polycarbonate diblock copolymer. The method for efficiently constructing the polycarbonate diblock copolymer by the specific route is reported for the first time. The method is clear and controllable in reaction condition, the obtained product is clear in structure, high in yield and excellent in reproducibility, a stable and reliable new way is provided for preparation of degradable functional polymer materials, and the method has a remarkable industrial application prospect.

This invention discloses a self-curing epoxy resin of triazine derivatives and polyetheramine, its preparation method, and its applications. It relates to the technical field of self-catalytic curing agent synthesis and epoxy resin preparation. The preparation method includes the following steps: adding cyanuric chloride to a solvent, adding an aliphatic amine, reacting, removing the solvent, then adding an alkali and dichloromethane and stirring to react. After the reaction is complete, washing and freeze-drying yield the triazine derivative; mixing the triazine derivative with polyetheramine, then adding epoxy resin, and curing to obtain the self-curing epoxy resin of triazine derivatives and polyetheramine. This preparation method not only significantly reduces the curing temperature but also achieves synergistic enhancement of rigidity and flexibility by adjusting the rigid curing agent of the triazine derivative and the flexible curing agent of the polyetheramine.