The application relates to the technical field of intelligent targeted
magnetic response micro robots, and discloses a
polyphenol-modified magnetic
liquid metal-based micro intelligent antibacterial
robot and a preparation method thereof.The preparation method comprises the following steps: dissolving
polyphenol and an
aminoglycoside antibiotic in water, performing a
Schiff base reaction to obtain a precursor solution; adding magnetic
liquid metal particles into the precursor solution, centrifugally collecting the
solid phase after reaction to obtain a precursor; and soaking the precursor in a high
agglutinin affinity
sugar solution, stirring and reacting, and then centrifugally collecting the
solid phase to obtain the
polyphenol-modified magnetic
liquid metal-based micro intelligent antibacterial
robot.The application utilizes the multiple
hydrogen bonds of natural polyphenol and the coordination effect of the magnetic liquid
metal surface to form a stable interface network, thereby providing a stable support for
sugar ligand fixation; meanwhile,
tobramycin participates in polyphenol
network construction in the form of a
Schiff base interaction, realizes the pH-responsive release of the antibiotic, combines and stabilizes
mannose, and finally obtains an intelligent targeted antibacterial micro
robot.