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Preparing method of nano-magnetic polymer composite microsphere

A nano-magnetic and composite microsphere technology, which is applied in medical engineering, material science and engineering and biological fields, can solve the problems of large magnetic microsphere particle size, low magnetic particle microencapsulation rate, and limited application, and achieve strong magnetic response sexual effect

Active Publication Date: 2011-08-03
PETROCHINA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the magnetic microspheres synthesized by the above method have problems such as large particle size (mostly submicron) and wide distribution.
At the same time, none of the above methods can fundamentally avoid the formation of uncoated magnetic particles and non-magnetic polymer microspheres, so the microencapsulation rate of magnetic particles is low, which limits its application in the fields of biology and medicine.

Method used

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  • Preparing method of nano-magnetic polymer composite microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1) Hydrophilic ultrafine Fe 3 o 4 Preparation of particle ferrofluid

[0042] Preparation of Fe by Chemical Co-precipitation 3 o 4 The ingredients and dosage contained in the particles are:

[0043] FeCl 3 ·6H 2 O 54.04g

[0044] FeCl 2 4H 2 O 19.88g

[0045] Deionized water 1200ml

[0046] Oleic acid 20g

[0047] 25% ammonia water 150ml

[0048] The preparation process is: FeCl 3 ·6H 2 O, FeCl 2 4H 2Dissolve O in 600ml of deionized water, and add to 2L reactor after dissolving; nitrogen gas is passed under stirring condition, and oleic acid is added; after stirring for 5-10 minutes, 25% ammonia water is added dropwise at room temperature; keep at room temperature for 1 hour, and heat up to 90°C , keep stirring at 90°C for 1 hour; cool down and discharge.

[0049] 2) The ingredients and parts by weight of the nano-magnetic seed emulsion are:

[0050] Styrene 100 parts

[0051] Hydrophilic ultrafine Fe 3 o 4 Particle magnetic fluid 540 parts

[0052...

Embodiment 2

[0063] 1) Hydrophilic ultrafine Fe 3 o 4 Preparation of particle ferrofluid

[0064] Preparation of Fe by Chemical Co-precipitation 3 o 4 The ingredients and dosage contained in the particles are:

[0065] FeCl 3 ·6H 2 O 54.04g

[0066] FeCl 2 4H 2 O 19.88g

[0067] Deionized water 1200ml

[0068] Oleic acid 20g

[0069] 25% ammonia water 150ml

[0070] The preparation process is: FeCl 3 ·6H 2 O, FeCl 2 4H 2 Dissolve O in 600ml of deionized water, and add to 2L reactor after dissolving; nitrogen gas is passed under stirring condition, and oleic acid is added; after stirring for 5-10 minutes, 25% ammonia water is added dropwise at room temperature; keep at room temperature for 1 hour, and heat up to 90°C , keep stirring at 90°C for 1 hour; cool down and discharge.

[0071] 2) The ingredients and parts by weight of the nano-magnetic seed emulsion are:

[0072] Styrene 100 parts

[0073] Hydrophilic ultrafine Fe 3 o 4 Particle magnetic fluid 540 parts

[007...

Embodiment 3

[0085] 1) Hydrophilic ultrafine Fe 3 o 4 Preparation of particle ferrofluid

[0086] Preparation of Fe by Chemical Co-precipitation 3 o 4 The ingredients and dosage contained in the particles are:

[0087] FeCl 3 ·6H 2 O 54.04g

[0088] FeCl 2 4H 2 O 19.88g

[0089] Deionized water 1200ml

[0090] Oleic acid 20g

[0091] 25% ammonia water 150ml

[0092] The preparation process is: FeCl 3 ·6H 2 O, FeCl 2 4H 2 Dissolve O in 600ml of deionized water, and add to 2L reactor after dissolving; nitrogen gas is passed under stirring condition, and oleic acid is added; after stirring for 5-10 minutes, 25% ammonia water is added dropwise at room temperature; keep at room temperature for 1 hour, and heat up to 90°C , keep stirring at 90°C for 1 hour; cool down and discharge.

[0093] 2) The ingredients and parts by weight of the nano-magnetic seed emulsion are:

[0094] Methyl methacrylate 100 parts

[0095] Hydrophilic ultrafine Fe 3 o 4 Particle magnetic fluid 500 p...

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Abstract

The invention relates to a preparing method ofa nano-magnetic polymer composite microsphere, which comprises the following steps: preparing a hydrophilic Fe3O4 magnetic liquid particle by using a chemical co-precipitation method; dissolving initiating agents and emulsifying agents by weight part into ionized water to prepare water phase, adding the hydrophilic Fe3O4 magnetic liquid particle and adding a monomer to obtain nano-magnetic seed emulsion through polymerization; dissolving initiating agents by weight part into ionized water, adding the nano-magnetic seed emulsion and then adding a monomer to obtain nano-magnetic polymer composite microsphere emulsion through polymerization; the emulsifying agents are sodium lauryl sulfate, sodium dodecyl sulfate or sodium dodecyl benzene sulfonate; the initiating agents are potassium peroxydisulfate, ammonium persulphate or sodium peroxydisulfate; the initiating agents are potassium peroxydisulfate, ammonium persulphate or sodium peroxydisulfate; the hydrophobic monomer is styrene or methyl methacrylate or a mixture of the styrene and the methyl methacrylate; the nano-magnetic polymer composite microspheres prepared by adopting a seed emulsion polymerization method have the superparamagnetism, have stronger magnetic responsiveness, have no uncoated magnetic particle and contain magnetic polymer microspheres and are narrow to distribute.

Description

Technical field: [0001] The invention belongs to the fields of material science and engineering and biological and medical engineering, and particularly relates to a preparation method of nanometer (particle diameter ≤ 100nm) magnetic polymer composite microspheres. Background technique: [0002] The physical coating method is the earliest method used to prepare magnetic composite microspheres. It uses in-situ chemical precipitation of iron ions and produced by iron ions. The magnetic composite microspheres prepared by this method have been applied in the fields of nucleic acid purification, DNA separation, enzyme immobilization and the like. However, this method can only prepare hydrophilic magnetic composite microspheres, and the application field is greatly limited, and the obtained magnetic composite microspheres have many insurmountable problems such as extremely irregular morphology, extremely wide particle size distribution, and easy leakage of magnetic particles. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/42H01F1/11B01J13/02
Inventor 陆书来黄金霞陈万友
Owner PETROCHINA CO LTD
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