35 results about "Sulforaphane" patented technology

The invention belongs to the technical field of health-care products, and particularly relates to a fermented composition beneficial to enhancing immunity and a preparation method thereof. The fermentation composition for improving immunity is prepared by taking yeast beta-glucan, an elderberry extract, glucoraphanin, sea cucumber peptide, inulin and a traditional Chinese medicine zymolyte as fermentation raw materials, firstly inoculating bacillus coagulans and staphylococcus xylosus for aerobic fermentation, and then inoculating bifidobacterium longum for anaerobic fermentation, the aerobic fermentation stage and the anaerobic fermentation stage have a synergistic effect, so that the fermentation speed can be increased, the fermentation time can be shortened, and richer nutrient substances can be provided, and therefore, the composition has an excellent effect of enhancing the immunity; the fermentation composition is applied to preparation of capsules helpful for enhancing immunity, is helpful for enhancing human immunity, and can solve the problem that active substances in existing health-care products are difficult to effectively absorb by human bodies, so that the effect of enhancing immunity is influenced.

The present invention relates to sulforaphane glycoconjugate compounds, as well as to the synthesis and therapeutic uses thereof for treating inflammatory diseases.

The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a milk thistle extract or powder. The invention also relates to the combination of a sulforaphane or a derivative thereof and a milk thistle extract or powder. The invention also relates to the combination of a broccoli extract or powder and a milk thistle extract or powder. The invention provides compositions and methods relating to these combinations.

A composition including a Moringa plant component for treating, preventing, reducing the occurrence of, decreasing the symptoms associated with, and / or reducing secondary recurrences of cancer in a subject is provided. The composition may comprise a Moringa plant component in an amount of 1 mg to 1750 mg, and sulforaphane or a sulforaphane derivative in an amount of 1 mg to 50 mg. Alternatively, the composition may comprise a Moringa plant component in an amount of 150 mg to 1500 mg sulforaphane precursor in an amount of 1 mg to 50 mg. The Moringa plant component can be Moringa leaf extract containing 10 mg of moringin per 1000 mg of the Moringa leaf extract. The composition may also include at least one of a mushroom extract or powder and a broccoli extract or powder.

The present invention is characterized by being a novel sulforaphane derivative comprising a complex of sulforaphane (1-isothiocyanato-4-[methylsulfinyl]butane (SFN)) and cysteine persulfide (CysSnH, n=2, 3, 4, or 5) or glutathione persulfide (GSnH or GSnG, n=2, 3, 4, or 5).

The invention discloses a chitosan modified turmeric-broccoli exosome hybrid nasal spray and application thereof, and belongs to the technical field of biological medicine and drug delivery. The nasal spray is formed by dispersing double plant exosome-lipidosome hybrids in a carrier for nasal cavities. The preparation method comprises the following steps: fusing curcumin carried by a turmeric exosome and sulforaphane carried by a broccoli bud exosome with a pH response liposome membrane containing 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine, and modifying by chitosan to form a three-layer structure; the preparation method comprises the steps of exosome extraction, ultrasonic drug loading, liposome hybridization, chitosan coating and preparation blending. The nasal spray is high in entrapment efficiency and uniform in particle size, the chitosan enhances nasal adhesion, inflammation targeted drug release is achieved through pH response, the brain targeting efficiency and stability are excellent, and the adaptability to children is good. The curcumin and sulforaphane are used for targeted therapy of children autism spectrum disorder neuroinflammation, anti-inflammation and anti-oxidation are achieved through synergism of curcumin and sulforaphane, the curative effect is remarkable, and a new scheme is provided for treatment of related diseases.

This invention belongs to the field of biomedical technology and relates to the application of OSM inhibitors in the preparation of drugs for the prevention or treatment of calcific aortic valve disease. This invention reveals for the first time that OSM drives osteogenic differentiation and calcified nodule formation of valvular interstitial cells through the OSM-OSMR-JAK2 / JAK3-STAT3-RUNX2 signaling axis, which is the core pathogenic mechanism leading to calcific aortic valve disease. This invention utilizes anti-OSM neutralizing antibodies or sulforaphane to effectively block this signaling axis, significantly inhibiting macrophage infiltration, valvular calcification, and improving hemodynamic abnormalities. This invention provides a precise target and a novel strategy for the modification therapy of calcific aortic valve disease, solving the technical problem of the ineffectiveness of traditional broad-spectrum anti-inflammatory therapy in valvular calcification.

This invention relates to broccoli rich in sulforaphane and indole-3-methanol, its preparation method, and its applications, belonging to the field of food technology. To increase the content of sulforaphane and indole-3-methanol in broccoli, this invention provides a broccoli rich in sulforaphane and indole-3-methanol and its preparation method. This invention utilizes expression vectors or recombinant bacteria overexpressing the BoSULTR1;1 and BoSULTR1;2 genes to prepare transgenic broccoli plants. Nutrient content determination results of the above transgenic broccoli plants show that the BoSULTR1;1 and BoSULTR1;2 genes increase the content of sulforaphane and indole-3-methanol in broccoli by increasing the content of the precursor substances sulforaphane and brassinosteroides. This invention achieves the goal of simultaneously increasing the content of sulforaphane and indole-3-methanol in broccoli, significantly improving the nutritional value of broccoli, and can be applied to the production of foods beneficial to health.

Described herein are methods of treating a human child including administering to the human child a compound selected from epigallocatechin gallate (EGCG), or a derivative thereof selected from epicatechin (EC), epigallocatechin (RGC) and epicatechin gallate (ECG), sulforaphane, olive oil, phylloquinone, quercetin, safranal, hydroxtyrosol, menaquinone-4, menaquinone-7, oleocanthal, peptide Ins-1 B9-23 19CAM22R-E, peptide Ins-1 B12-23-19CAM, peptide Ins-1 B12-23 19CAM22R-E, or a combination of any of the foregoing, wherein administration of the treatment is started between birth and six months of age. Also described are methods of treating a pregnant human or a nursing human mother who has recently given birth to an infant. Further described are insulin B chain mimotope peptides.

The present invention relates to a nutritional targeting composition which comprises a component 1 providing glucoraphanin, a component 2 providing myrosinase and magnesium stearate and which efficiently releases sulforaphane to activate NRF2 targets. The present invention also relates to the use of the composition in the preparation of products for preventing or treating diseases or conditions which can be prevented or treated by using sulforaphane.

The application discloses application of sulforaphane in preparation of an antienterovirus drug and belongs to the technical field of medicines, wherein the sulforaphane can inhibit the expression of viral proteins, inhibit viral genome replication and inhibit the production of virus particles to achieve the purpose of resisting enteroviruses; specifically, the sulforaphane can inhibit the replication of enteroviruses by up-regulating the content of p53 proteins. In addition, the sulforaphane can also be used for reducing the cell morphological damage caused by enteroviruses.

The invention discloses a method for increasing the content of sulforaphane in broccoli through magnetic field assisted blanching, and belongs to the technical field of food processing. The method for improving the content of sulforaphane in broccoli through magnetic field assisted blanching comprises the following steps: (1) preparing raw materials; (2) magnetic field assisted blanching pretreatment; (3) cooling and structure keeping treatment; (4) carrying out enzymatic incubation based on a magnetic field-assisted blanching regulation state; and (5) obtaining the broccoli product with high sulforaphane content. Exogenous enzymes, chemical reagents or additives are not introduced in the process, and the activity of endogenous myrosinase and the catalytic hydrolysis path of the endogenous myrosinase are regulated by synchronously applying a physical regulation means in the blanching pretreatment process, so that the generation level of sulforaphane in a treated sample is improved. The method is suitable for a food processing system, has the advantages of mild process conditions, strong controllability, high safety and easiness in industrial amplification, and has a wide application prospect in the field of food processing.

The invention relates to the technical field of aquaculture feed additives, and discloses a sulforaphane-containing weever anti-stress powder additive as well as a preparation method and application thereof. The natural plant extract sulforaphane, the high-quality protein source, the compound vitamins and the mineral substances are scientifically proportioned, so that the survival rate and the meat quality of the perches under the adverse conditions of high temperature, low oxygen, transportation and the like can be remarkably improved. The feed additive adopts a low-temperature granulation process, can effectively maintain the stability of active ingredients, and ensures that the active ingredients do not lose efficacy in a long-term storage process.

The invention discloses an anti-inflammatory and anti-aging face cream and a preparation method thereof, and belongs to the technical field of cosmetics. The face cream disclosed by the invention is prepared from the following components in percentage by weight: 5.0 to 20.0 percent of broccoli fermentation filtrate, 0.05 to 0.2 percent of andrographolide encapsulated by nano-liposome, 0.5 to 5.0 percent of a skin barrier repairing agent and a matrix. Sulforaphane (greater than or equal to 400 mg / kg) in broccoli is enriched through a lactic acid bacteria fermentation technology, and the stability and the smell of the broccoli are improved; the problem that andrographolide is difficult to dissolve and easy to crystallize is solved through embedding of nano-liposome (the particle size is 40-80 nm, and the encapsulation efficiency is larger than or equal to 85%), and the transdermal property of andrographolide is improved. The two are combined to synergistically activate an Nrf2 antioxidant pathway and inhibit an NF-kappa B inflammation pathway, and the two pathways intervene in inflammatory aging. Human body tests show that after the face cream is used for 4 weeks, the depth of wrinkles can be remarkably reduced (28.6%), the level of skin inflammatory factors TNF-alpha can be reduced (50.4%), and the face cream is free of any irritating reaction, has an excellent anti-aging effect and extremely high safety and is particularly suitable for sensitive skin.

The present invention relates to a nutritional targeting composition which comprises a component 1 providing glucoraphanin, a component 2 providing myrosinase and magnesium stearate and which efficiently releases sulforaphane to activate NRF2 targets. The present invention also relates to the use of the composition in the preparation of products for preventing or treating diseases or conditions which can be prevented or treated by using sulforaphane.

The present disclosure discloses a Lactobacillus plantarum ZUST49 and a bacterial agent, and use thereof, and belongs to the technical field of microorganisms. An aspect of the present disclosure provides a Lactobacillus plantarum ZUST49 and a bacterial agent containing the Lactobacillus plantarum ZUST49, and another aspect provides use of the Lactobacillus plantarum ZUST49 and the bacterial agent containing the Lactobacillus plantarum ZUST49. The Lactobacillus plantarum ZUST49 of the present disclosure may convert glucoraphanin into sulforaphane, especially in a human or animal intestinal environment. After an enteric probiotic preparation prepared from the strain of the present disclosure is orally taken, the Lactobacillus plantarum ZUST49 may efficiently convert the glucoraphanin into the sulforaphane in an intestinal tract, which not only solves a problem that stability of the sulforaphane cannot be improved in the prior art, but also effectively exerts a probiotic effect.

The invention belongs to the technical field of biomedical engineering, and particularly relates to an induction system for improving somatic cell reprogramming efficiency and a reprogramming method. The induction system comprises a carrier for expressing Oct4, Sox2 and Klf4 transcription factors, and sulforaphane. According to the induction system, on the basis of a classical four-factor reprogramming system, a c-Myc factor with a tumorigenic risk is removed, only Oct4, Sox2 and Klf4 three-factor expression vectors are reserved, and a natural antioxidant sulforaphane with the concentration of 2 [mu] M is innovatively introduced, so that the tumorigenic hidden danger caused by c-Myc is fundamentally avoided, the safety pain point of a traditional four-factor system is solved, and the induction system has the advantages of being simple in structure and convenient to operate. And by adding the sulforaphane, the reprogramming efficiency of the MEFs to the pluripotent iPSCs is improved by 6 times, and the high efficiency of reprogramming is realized.

The present invention relates to a nutrition targeting composition comprising a component 1 providing sulforaphane glucosinolate, a component 2 providing myrosinase and magnesium stearate for efficient release of sulforaphane activating the NRF2 target, and the use of said composition for the preparation of a product for the prevention or treatment of a disease or condition that can be prevented or treated with sulforaphane.

Compositions and methods for converting at least one glucosinolate to an isothiocyanate using Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and / or Pediococcus pentosaceus M2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucoraphanin, to isothiocyanates, such as sulforaphane, leads to the stimulation of the Nrf2 / Keap pathway and phase II enzymes, providing chemoprotective and anti-inflammatory effects. Accordingly, provided herein are compositions comprising Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and / or Pediococcus pentosaceus M2_H12, or active variants thereof, for administration to subjects for increasing isothiocyanate (e.g., sulforaphane) production, increasing the expression of genes regulated by the Nrf2 transcription factor, including phase II enzymes, decreasing inflammation, and treating or preventing an inflammatory disorder or a cancer. The composition can comprise at least one glucosinolate or a plant, plant part or an extract thereof comprising glucosinolate(s).

The invention relates to the technical field of animal breeding, in particular to application of sulforaphane in low-temperature preservation of goat semen, which comprises the goat semen and a diluent for low-temperature preservation, and the sulforaphane with proper concentration is added into the diluent for low-temperature preservation of the goat semen, so that the low-temperature preservation of the goat semen is realized. The goat sperm motility rate, activity, plasma membrane intact rate and acrosome intact rate can be effectively improved, the total antioxidant capacity (T-AOC) level in the sperms is effectively improved, and the content of reactive oxygen species (ROS) and malondialdehyde (MDA) in the sperms is effectively reduced. The low-temperature preserved goat semen still has high sperm motility, motility, plasma membrane integrity, oxidation resistance and the like after long-time low-temperature preservation and has good fertilization ability, and the purposes of long-term preservation and introduction and propagation of high-quality breeding ram semen are achieved.

The present invention relates to crystalline complexes of sulforaphane and alpha-cyclodextrin; pharmaceutical compositions comprising the complexes; methods for their manufacture; and the use of said complexes as a medicament.

The invention discloses a compound composition for moistening lung and protecting throat based on turnip and a preparation method thereof. The composition comprises a turnip active component, tremella polysaccharide, modified propolis nanoparticles, fucoidan, a loquat leaf extract and a menthol-cyclodextrin inclusion compound. In the preparation process, firstly, glucosinolate in turnip is efficiently converted into active substances such as sulforaphane through glucosinase; then designing and synthesizing modified propolis nanoparticles to embed propolis flavonoids and phenolic acids, so as to improve the stability and bioavailability of the propolis flavonoids and phenolic acids; finally, all the components are integrated, and the final product is prepared through the processes of gel compounding, spray drying and the like. The raphanin content of the product reaches 9.17 mg / g, the diameters of inhibition zones on staphylococcus aureus and streptococcus pneumoniae reach 17.6 mm and 16.97 mm respectively, the inhibition rate of mouse cough reaches up to 57.14%, and the problems that a traditional product is unstable in active ingredient and single in effect are solved.

The invention belongs to the field of aquaculture, and discloses a mitochondrial nutrition composition targeting a Micropterus salmoides SelP gene as well as a preparation method and application thereof. The mitochondrial nutritional composition comprises the following components in parts by weight: 1-25 parts of sulforaphane; 1 to 30 parts of ester type catechin; and 1 to 15 parts of phosphatidylcholine. According to the present invention, the micro encapsulation method is adopted to make full use of different biological structures of the raw materials to perform scientific compatibility so as to achieve the synergistic effect, and the mitochondrial nutrition composition targeting the Micropterus salmoides SelP gene is prepared, and the composition can enhance the mitochondrial function of the Micropterus salmoides liver by down-regulating the SelP expression so as to improve the survival rate of the Micropterus salmoides. The micropterus salmoides feed additive improves carbohydrate tolerance of micropterus salmoides and growth performance of fish bodies, can promote deposition of selenium in the fish bodies, and can be applied to the field of micropterus salmoides culture.

The invention relates to a nutrition targeting composition which comprises a component 1 for providing glucoraphanin, a component 2 for providing myrosinase, vitamin C and magnesium stearate and is capable of efficiently releasing sulforaphane and activating an NRF2 target spot. The invention also relates to the use of said composition for the preparation of a product for the prevention or treatment of diseases or conditions that can be prevented or treated with sulforaphane.

The application discloses a water extract of broccoli seeds for improving bioavailability of sulforaphane and a preparation process thereof. 2+ The application introduces phytic acid and zinc gluconate to construct a synergistic regulation system, uses the directional chelation of phytic acid to effectively deprive the essential cofactor of the ring sulfur designated protein, fundamentally blocks the generation path of the inactive nitrile, and uses the allosteric activation effect of zinc ions and the pH stability of gluconate to significantly enhance the catalytic efficiency of myrosinase.

A sulforaphane supplement in gummy form, including an active ingredient composition comprising sulforaphane, glucoraphanin, and myrosinase. The supplement including a matrix structure in which sulforaphane, glucoraphanin, and myrosinase are disposed in pores and immobilized therein.

The application provides a full-effect protection and prevention repair composition for acne skin and application thereof, and belongs to the technical field of cosmetics. The repair composition of the application is compounded with sulforaphane, lactoferrin, bromelain, madecassic acid lactone and guaiacum extract as active ingredients. The five substances can synergistically act together from multiple aspects, enhance the skin protection, improve the skin light damage, reduce the oxidative stress level, reduce the influence of stress hormone cortisol, and improve the emotional positivity, so as to achieve the effects of preventing acne, smoothing the skin and enhancing the barrier function.

A skincare composition includes a substance having a predetermined amount of one or more cruciferous vegetables, the predetermined amount of the one or more cruciferous vegetables including stabilized glucoraphanin and active myrosinase in a stable state; exposing the substance to a liquid activator causes a chemical reaction between the stabilized glucoraphanin and the active myrosinase to create sulforaphane in an active product; and applying the activated product to a skin surface allows the sulforaphane to act upon the skin surface.

The invention discloses pickled beetle rich in glucoraphanin and sulforaphane and a preparation method of the pickled beetle, and belongs to the technical field of food processing. The preparation method comprises the following steps: blanching the beetles, carrying out freeze thawing ultrasonic treatment on the beetles, adding ascorbic acid into fermentation liquor to activate myrosinase, and finally inoculating lactic acid bacteria to ferment the beetles, so that the contents of glucoraphanin and sulforaphane in the beetles are increased; meanwhile, compared with fresh beta, the storage time of the pickled beta is prolonged, the flavor of the beta is improved, and the pickled beta is rich in bioactive substances such as glucoraphanin and sulforaphane and rich in nutrition.