72 results about "Gallate" patented technology

A nutraceutical composition, consisting of Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

The utility model relates to the technical field of waste gas absorption devices, and discloses a waste gas absorption device for preparing amyl gallate, which comprises a middle shell, a square shell arranged in the middle shell, and activated carbon arranged in the square shell; the metal plate is arranged at the upper end of the square shell, and a magnet is mounted at the lower end of the square shell; the reset spring is arranged in the lower end of the square shell, pulling plates are arranged on the two sides of the exterior of the reset spring, an inserting rod is fixedly arranged on one side of the exterior of each pulling plate, the inserting rods penetrate through the square shell and extend into the middle shell, and limiting holes are formed in the positions, close to the two sides of the inserting rods, of the interior of the middle shell; and the connecting shell is arranged on one side of the exterior of the middle shell, a front shell is arranged on the side, deviating from the connecting shell, of the exterior of the middle shell, and a fan is installed in the front shell. The mode that the new square shell ejects out of the old square shell to replace the activated carbon is adopted, so that waste gas absorption work does not need to be stopped in the activated carbon replacement process.

The invention belongs to the technical field of pharmacotherapeutics, and particularly relates to application of theaflavin-3 '-gallate and a medicine prepared from theaflavin-3'-gallate. The theaflavin-3 '-gallate is used as a KEAP1-NRF2 inhibitor and is competitively combined with the KEAP1 to destroy the inhibition effect of the KEAP1 on the NRF2, so that the content of the NRF2 is increased, and the expression of downstream NQO1 and GCLC is improved. Besides, the theaflavin-3 '-gallate protects the liver function by inhibiting the increase of the contents of AST and ALT, and reduces the oxidative stress and lipid accumulation of the liver, so that the theaflavin-3'-gallate has the potential to become a medicine for treating the ethanol-induced liver injury.

The invention belongs to the technical field of biomedical materials, and provides a piezoelectric anti-inflammatory fibrous membrane / hydrogel composite dressing and a preparation method thereof, and the preparation method comprises the following steps: purifying bacterial cellulose to remove residual strains and other components; carrying out hydroxylation surface treatment on barium titanate; uniformly mixing the purified bacterial cellulose hydroxylated barium titanate, and performing vacuum filtration to obtain a bacterial cellulose / hydroxylated barium titanate composite fiber membrane; the preparation method comprises the following steps: preparing a polydopamine solution, then adding epigallocatechin-3-gallate, acrylamide, N, N-methylene bisacrylamide and tetramethylethylenediamine, and fully stirring to obtain a hydrogel precursor; and finally, putting the obtained composite fiber membrane into a mold, and pouring the hydrogel precursor to obtain the composite fiber membrane / hydrogel composite dressing. The prepared dressing can promote wound healing through self power supply, ultrasound and application of mechanical stimulation, can also provide a moist environment, reduce inflammatory response of wounds and provide excellent oxidation resistance, and thus the wound healing effect of the dressing is improved.

The invention belongs to the technical field of medicines, and particularly provides a novel application of a theaflavin compound in preparation of a product for inhibiting dipeptidyl peptidase-4 (DPP-4), and the theaflavin compound is one or more of theaflavin-3-gallate (TF2A), theaflavin-3 '-digallate (TF3) and theaflavin (TF). The research systematically proves that TF2A, TF3 and TF have new application of inhibiting DPP-4 for the first time: in-vitro enzymology and fluorescence experiments show that theaflavin can inhibit DPP-4 and interact with DPP-4, and molecular docking further shows possible binding configuration and key action sites of theaflavin. In vivo, the activity of DPP-4 in serum and different tissues of high-fat diet mice can be reduced, serum glucagon-like peptide-1 (GLP-1) can be up-regulated, and glycometabolism and inflammatory phenotype can be improved. Therefore, the theaflavin compound disclosed by the invention can be applied to preparation of products for inhibiting DPP-4, and has a good development prospect.

The invention discloses a preparation method and application of sodium gallate-polyphenol chitosan antibacterial hydrogel, firstly, gallic acid and sodium acetate are used as raw materials, a high-purity sodium gallate complex 5-carboxyl-2, 3-sodium dihydroxyphenolate is prepared at normal temperature and normal pressure, then a polyphenol compound and chitosan are cross-linked through Schiff base reaction, and the sodium gallate-polyphenol chitosan antibacterial hydrogel is obtained. And finally, carrying out rotary evaporation treatment, so that the sodium gallate is loaded in the polyphenol chitosan hydrogel system to obtain the antibacterial hydrogel. Sodium gallate is used as a functional component, uniform loading of sodium gallate in a polyphenol chitosan hydrogel system is realized through dual effects of physical adsorption and chemical bonding, the loading mechanism can effectively avoid aggregation and burst release of sodium gallate, stable release of antibacterial components is ensured, and the antibacterial property of the hydrogel is improved. The slow release time of the antibacterial hydrogel under the conditions that the pH values are 5.5 and 7.2 respectively exceeds 24 hours; and the antibacterial hydrogel has an inhibition effect on both gram-positive bacteria and gram-negative bacteria.

This invention discloses a method for preparing alkyl gallate without a dehydrating agent, belonging to the field of chemical reaction auxiliary technology. By optimizing the raw material ratio of the reaction system, precisely controlling the reaction environment parameters and the condensate separation rate, this invention utilizes the azeotropic properties of alcohol and water to achieve efficient separation of the water generated in the reaction. It can promote the forward esterification reaction without adding any dehydrating agent, achieving the same or even better water separation and reaction promotion effects without the need for a dehydrating agent. This invention eliminates the need for a dehydrating agent, and the synthesized methyl gallate, ethyl gallate, propyl gallate, octyl gallate, and lauryl gallate can reach a maximum content of 99.2%, with a stable product yield of 50-57g. This effectively reduces production costs, avoids the pollution problems caused by dehydrating agents, simplifies the production process, and possesses both green environmental protection and promising prospects for industrial-scale application.

In the present specification, disclosed is a method for preparing a gallocatechin gallate (Gallocatable Gallate), which comprises the steps of: preparing a gallocatechin gallate (Gallocatable Gallate; the present invention relates to uses of a composition for enhancing liver health or for auxiliary protection against chemical liver injury, in particular to uses of a composition for enhancing liver health or for auxiliary protection against chemical liver injury, such as GCG, isoquercitrin, IQC, and to the preparation of a composition for enhancing liver health or for auxiliary protection against chemical liver injury. In one aspect, the composition of the present invention can include a composite component of gallocatechin gallate and isoquercitrin to effectively reduce oxidative stress and chronic inflammatory response occurring in the process of lipid accumulation in liver tissue to improve liver health, and is applied to prevention, improvement or treatment of various liver diseases such as hepatitis, cirrhosis, liver cancer and the like.

Provided herein are compositions, methods, systems and / or kits for preventing and / or treating neoplasms using at least one modulator selected from quercetin, sodium phenyl butyrate and epigallocatechin-3-gallate in combination with one or more anti-cancer agents. The compositions, methods, systems and / or kits are used to prevent and / or treat neoplasms that are resistant to the one or more anti-cancer agents when administered alone. Also provided are nanoformulations based on nanoparticles with one or more anti-cancer agents and / or one or more modulators for preventing and / or treating neoplasms.

The invention relates to a preparation process of near-infrared fluorescent powder, in particular to nickel-containing near-infrared fluorescent powder and a preparation method thereof, a certain amount of barium carbonate, gallium oxide, nickel oxide and isopropanol are taken to be prepared into turbid liquid, and the nickel-containing barium gallate-based near-infrared fluorescent powder is prepared through the steps of grinding, drying, grinding, pressing, heat treatment, cooling, grinding and the like. Under the excitation of 635 nm light, the fluorescent powder presents ultra-wide band near-infrared luminescence composed of 1050-1400 nm light emission derived from matrix defects and 1300-1800 nm light emission of Ni < 2 + > ions; the light-emitting diode light source is more suitable for compact special near-infrared fluorescent powder conversion light-emitting diode light source design for high-resolution deep biological tissue imaging diagnosis equipment. Similarly, due to no ionizing radiation ultra-wide band NIR-II region emission, the system can be used in various biological tissue situations such as fat, muscle, endothelium and the like, and then development of multipurpose imaging diagnostic analysis technologies and equipment which are suitable for family daily medical treatment and are friendly and safe to special groups such as children, pregnant women, old people and the like can be promoted.

The invention relates to a preparation method of a natural product (‑) gallocatechin‑7‑gallate and its enantiomer (+) gallocatechin‑7‑gallate and their racemates and their use as a medicine for preventing and treating coronavirus infection, and belongs to the pharmaceutical field. The invention is innovative in that: research has found that (‑) gallocatechin‑7‑gallate and its enantiomers and their racemates have the effect of resisting the new coronavirus SARS‑CoV‑2; having the effect of resisting the coronavirus HCoV‑229E; its new coronavirus M pro / 3CL pro The inhibitory effect is an important mechanism for its antiviral effect. It is expected to become a clinical drug for the prevention and treatment of coronavirus infection.

The invention discloses an ionic liquid transmucosal delivery system based on polyphenol modification. A preparation method comprises the following steps: S1, preparing polyphenol modified ionic liquid by adopting aromatic folic acid, polyphenol A and choline bicarbonate; the polyphenol A is gallic acid or caffeic acid; s2, polyphenol B is dissolved in ultrapure water, a biomacromolecule medicine is added, freeze drying is performed after ultrasonic treatment, and polyphenol-biomacromolecule nanoparticles are obtained; the polyphenol A is epigallocatechin-3-gallate, and the polyphenol B is epigallocatechin-3-gallate or tannic acid; s3, adding the polyphenol-biomacromolecule nanoparticles into the ionic liquid, and performing ultrasonic treatment to obtain the ionic liquid transmucosal delivery system based on polyphenol modification. According to the drug delivery system, polyphenol participates in ionic liquid construction, more intermolecular interaction force sites are provided for the ionic liquid, the charge property of the ionic liquid is reduced, and meanwhile, polyphenol-biomacromolecule nanoparticles are constructed to prolong the in-vivo action time of the drug.

The invention provides an alkyl gallate epoxy curing agent as well as a preparation method and application thereof. The alkyl gallate epoxy curing agent has good corrosion inhibition performance, and can improve the adhesion and antibacterial property of a coating; the coating also has a strong adhesion effect, and the formed coating has an excellent dry adhesion effect; in some cases, based on a good hydrophobic effect given by long-chain alkyl contained in the alkyl gallate epoxy hardener, the alkyl gallate epoxy hardener also has good adhesive force in a high-humidity environment, so that the alkyl gallate epoxy hardener is particularly suitable for being used on equipment in the humid environment such as a marine environment.

The invention belongs to the technical field of crystal form drug molecules, and particularly relates to baricitinib-maleic acid-gallate. After the three components form the salt, the solubility of baricitinib can be remarkably enhanced, the oral bioavailability is improved, and the salt has a very high patent medicine value and a relatively good application prospect in the medical industry.

A composition for colouring hair, particularly eyebrows and eyelashes, comprising a first component containing gallic acid or gallates and a plant extract from walnut shell, nettle leaf or red vine le

The invention discloses a theaflavin nano-composite with whitening and moisturizing effects, which is mainly prepared from theaflavin as an active component, an encapsulation carrier and a synergistic component, and has a core-shell structure with theaflavin as a core and a three-dimensional network formed by the encapsulation carrier as a shell, the purity of the theaflavin is not lower than 80%, and the mass ratio of the theaflavin-3-gallate to the theaflavin-3 '-gallate is 1: (0.8-1.2); the encapsulation carrier comprises modified silk fibroin, activated tamarind seed polysaccharide and self-assembly oligopeptide with pH responsiveness, and a three-dimensional network is formed through reaction; the synergistic interaction components are 2-o-ethyl ascorbic acid and eugenol. The invention also discloses a preparation method and application of the compound. The theaflavin nano-composite prepared by the invention has the advantages of high stability, good bioavailability, capability of quickly releasing active matters on the surface of skin in a weakly acidic environment, and realization of whitening and moisturizing effects.

The present invention provides compositions and methods for activating physiological health defenses. The invention, comprising combinations of, and methods of providing and administering, (1) anthocyanins; (2) β-(1-3,1-6)-D-glucan; (3) chlorogenic acid; (4) curcumin; (5) epigallocatechin-3-gallate (EGCG); (6) genistein; (7) hydroxytyrosol; (8) lycopene (including both cis- and trans-isomers); (9) Lactobacillus reuteri, Akkermansia mucinophila, and / or Ruminoccocus sp. bacteria; (10) omega-3 polyunsaturated fatty acid (PUFA); (11) quercetin; and (12) proanthocyanidins, relieves and alleviates numerous deleterious health conditions and / or to support mammalian physiological health defenses including (but not limited to) angiogenesis, regeneration, microbiome, DNA protection, immunity, metabolism, and adaptive thermogenesis.

A method of enhancing the quality of a skin scar by topical application of an agent for improving scar quality is characterised in that said agent is pre-emptively applied to a potential surgical cutaneous site in advance of surgery, including surgery involving use of lasers. The topical agent may be a polyphenol, such as (-)-epigallocatechin-3-gallate (EGCG). Use of such a topical agent in advance of surgery leads to significant beneficial effects on dermal scarring by reducing mast cells, angiogenesis, skin thickness and simultaneously increasing elastin content. The topical agent may be applied directly or incorporated in a dressing, such as in a dermal patch comprising an adhesive silicone sheet, and can be worn both in the lead up to surgery and post-operatively.

The present invention provides a double-grid gel composite inhibitor for inhibiting coal spontaneous combustion and a preparation method thereof, which effectively combines three major inhibition systems of physical inhibition, chemical inhibition and nano flame retardancy, and belongs to the technical field of preparation of composite inhibitors for inhibiting coal spontaneous combustion. The physical inhibitors are hyaluronic acid and polyethylene glycol; the chemical inhibitor is epigallocatechin gallate; and the nano flame retardant is nano-attapulgite. By using a solution polymerization method, hyaluronic acid and polyethylene glycol are made into a double-grid gel, and are grafted and copolymerized with the natural chemical inhibitor epigallocatechin gallate, and finally polymerized with the modified nanomaterial attapulgite to obtain a new double-grid gel composite inhibitor. Compared with traditional inhibitors, the inhibitor has the advantages of low preparation cost, good moisture retention and fluidity, high thermal stability, high environmental protection performance, etc., and has great practical significance for the field of coal mine fire prevention and extinguishing and coal mine safety production.

The application discloses a kind of double ester type catechins compound and preparation method, steps are as follows: tea is mixed with methanol aqueous solution, and tea extract is obtained by ultrasonic extraction;Tea extract is continuously carried out reverse phase liquid chromatography separation, and finally double ester type catechins compound is obtained by collecting specific eluent and the distillate of specific time period, which is obtained epigallocatechin-3,4'-di- O -gallate and gallocatechin-3,4'-di- O -gallate is first purified by separation, and double ester type catechins compound has high purity.

A 3D-printed cervical plug. A 3D-printed cervical plug support is filled with a nanocomposite hydrogel. The nanocomposite hydrogel is a supramolecular nanocomposite formed by self-assembly of (-)-epigallocatechin-3-gallate and metal ions in a hydrogel.

The application discloses an EPA liposome and a preparation method and application thereof, and particularly relates to the technical field of cosmetics. The EPA liposome is prepared through self-assembly of liposomes by using the following raw materials in parts by mass: microalgae oil EPA 1-4 parts, epicatechin-3-gallate 1-2 parts, alpha-tocopherol 0.2-1 part, ginsenoside Rg3 0.02-0.1 part, lipids 2-10 parts, emulsifier 1-10 parts, and water is supplemented to 100 parts. The EPA liposome realizes the stable effect of EPA in a composite system such as a cosmetic skin care product, enhances the in-situ antioxidant and protective functions of EPA and slows down the autoxidation of EPA, improves the bioavailability and enhances the anti-aging effect through the synergy of the contained efficacy substances and the design of the nano-liposome.

A heterogeneous catalytic process for manufacturing alkyl gallates / digallates (e.g., esters of gallic acid) from gallic acid (e.g., 3,4,5-trihydroxy benzoic acid) and corresponding C1-C20 alkyl alcohol / diol in the presence of a non-halogenated, hydrophilic, strong cationic ion exchange resin, with high purity and higher yields. The process is devoid of neutralization and de-colorization steps and is free of toxic solvents and is suitable to synthesize higher alkyl gallates which are otherwise difficult to obtain by conventional methods.

This invention relates to the field of scale inhibition technology, and proposes a scale inhibitor for soda ash mother liquor and its preparation method. The scale inhibitor for soda ash mother liquor comprises the following components by weight: 50-75 parts polyacrylic acid, 30-50 parts polyepoxysuccinic acid, 5-12 parts surfactant, 2-16 parts sodium gallate, 1-10 parts sodium lactate, 1-7 parts stabilizer, 0.5-4.5 parts dispersant, and 30-50 parts water. This technical solution solves the problem of low scale inhibition rate in existing soda ash mother liquor scale inhibitors.

The disclosure relates to crystalline Form X of epigallocatetchin-3-gallate, compositions containing Form X, and methods of using Form X. The disclosure also relates to methods of making crystalline Form X of epigallocatetchin-3-gallate.

The gas-liquid separation condensing device comprises a condensing tower, a trigger switch and an electric control liquid discharge pipe, an exhaust pipe is arranged at the upper end of the condensing tower, a refrigerant inlet pipe and a refrigerant outlet pipe are installed at the upper end and the lower end of the side of the condensing tower respectively, a sleeve is arranged on the outer wall of the upper end of the refrigerant outlet pipe, and the refrigerant inlet pipe and the refrigerant outlet pipe are communicated through a pipeline. An air inlet pipe is arranged at the lower end of the side, away from the refrigerant inlet pipe, of the condensing tower, a trigger switch is mounted on the lower surface of the end of the air inlet pipe in the condensing tower, an electric control liquid discharging pipe is arranged on the surface of the condensing tower below the air inlet pipe, and a square rod is fixedly connected to the inner wall of the lower end of the condensing tower on the side of the electric control liquid discharging pipe. The outer wall of the square rod is sleeved with a floating plate, and a positioning pipe is fixedly installed at the upper end of the square rod. According to the gas-liquid separation condensing device for the amyl gallate reaction, condensate is conveniently prevented from being accumulated on the condensing structure, so that the normal work of the device is prevented from being influenced, and the practicability of the device is improved.

The invention discloses a method for industrially preparing gambiered canton gauze, and solves the problems that the traditional manual dyeing process for producing gambiered canton gauze has strong dependence on natural environmental factors, low mechanization degree and high product cost, and river mud has bacteria and heavy metal pollution hidden dangers. Comprising the following reaction processes: 1) hydrolyzing tannin slurry on the silk fabric to generate gallic acid; 2) reacting the calcium carbonate slurry with gallic acid to generate calcium gallate, water and carbon dioxide, and gradually remaining the calcium gallate in a fiber amorphous region and between fibers to form calcification deposition through hydrogen bonds and Van der Waals force effects between molecules and between the calcium gallate and silk protein fibers; (3) carrying out color development crosslinking on trace iron ions in the color development paste and calcium gallate and fully reacting; and 3) performing esterification cross-linking reaction on residual carboxyl and phenolic hydroxyl in the reaction system in the step 3) in a heating and drying environment to generate low-shrinkage tannin ester and water, and finally forming a calcium gallate and real silk fiber integrated polymolecular cross-linked polymer, namely the gambiered canton gauze.

The embodiment of the invention provides a skin care composition as well as a preparation method and application thereof, the skin care composition comprises alkyl gallate, tryptophan and mannitol, and the concentration of the alkyl gallate is 0.1 mu mol / L-4 mmol / L. The skin care composition can be prepared into skin care compositions in various dosage forms, is used for skin care and repair, has the effects of sunscreen, anti-inflammation, wrinkle removal and the like, and is simple and convenient to prepare, safe, high in yield and suitable for industrial production.

The invention discloses application of hempseed (-)-epicatechin-3-O-gallate, and belongs to the technical field of biology. According to the invention, the EPI (-)-epicatechin-3-O-gallate extracted from the EPI is applied to the diabetic kidney diseases, so that the EPI can significantly reduce blood sugar and blood fat levels, improve pathological changes of the kidney of diabetic mice, delay senescence and fibrosis of renal tubular epithelial cells of the diabetic mice, improve the drug efficacy of DKD (Dikyl Ketene Dimer), and can be used for treating the diabetic kidney diseases. And reliable treatment targets and theoretical basis are provided for treating DKD by natural medicine monomer components.