83 results about "Dermal patch" patented technology

A dermal patch having comprising at least two layers wherein at least one layer is a polymer matrix system having an active agent admixed therein. At least one of the layers includes a water-dispersible or water-dissipatable polymer. The dermal patch has an elongation factor of at least 50%.

A catheter and patch electrode system is provided for use with an apparatus, such as an ablation generator, having a 4-wire interface for improved impedance measurement. The 4-wire interface includes a pair of source connectors across which an excitation signal is produced and a pair of sense connector wires across which the impedance is measured. The RF ablation generator may also produce an ablation signal across a source wire and an indifferent return patch electrode. The system further includes a cable that connects the generator to a catheter. The catheter includes a shaft having a proximal end and a distal end, with an ablation tip electrode disposed at the distal end. A source lead is electrically coupled to the tip electrode and extends through the shaft to the proximal end where it is terminated. An optional sense lead is also electrically coupled to the tip electrode and extends through the shaft to the proximal end. The system further includes a source return (e.g., skin patch) and a sense return (e.g., skin patch), either or none of which may be combined with the indifferent return, and if used may be placed on opposite sides of the patient for improved performance. The impedance sensor circuit produces an excitation signal across the source connectors, which is then carried to the catheter by the cable, then to the tip electrode, travels through the complex load (tissue volume), and returns to the generator via a patch electrode. The impedance is measured by observing the voltage drop across the sense connectors caused by the excitation signal.

The invention relates generally to intradermal, transdermal, and/or transmembrane delivery of biologically active substances in the epidermis and/or through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The biologically active substances may have a molecular weight no less than about 5.8 kDa to about 2,500 kDa, such as Hyaluronic Acid (HA). The biologically active substances may be deposited in a dermal patch containing a red algae polysaccharide-based matrix, wherein the red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch. The invention provides systems and methods for enhanced intradermal, transdermal, and/or transmembrane delivery of such biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.

The invention relates to systems for securing a tube (e.g. feeding tube) and/or a patient interface or a dermal patch to a user. One embodiment comprises a holder, an interface side of the holder attachable to the patient interface or the dermal patch for securing a feeding tube to the patient interface or the patch, the holder comprising at least a first channel or recess for receiving the feeding tube to couple the feeding tube to the patient interface. Another embodiment comprises a patient interface itself comprising a backing for positioning on a patient's face, a dermal patch having a patient side and an interface side, the patient side of the patch attachable to the user, the patch comprising at least a first flap portion attachable to the tube for affixing the tube to the patch, a two-part releasable connection arrangement for releasably securing the patient interface to the patch.

The present invention relates to dermal patches comprising natural polysaccharides without the need for any pressure sensitive synthetic polymers. Particularly, the present invention relates to patches comprising a bioadhesive composition comprising a polysaccharide exudate and an essential oil useful for transdermal delivery of therapeutic or cosmetic agents.

Receiver apparatus for use with an analyte sensor, and methods of operation and manufacturing. In one embodiment, the analyte sensor is an implanted/implantable blood glucose sensor, including oxygen-based detector elements. The receiver apparatus is a wireless-enabled small form-factor device with limited functionality that can be easily worn or kept with the user on a continual basis, thereby obviating the need for a more fully featured receiver or smartphone for extended periods of time (e.g., one week). The exemplary oxygen based analyte sensor, with high degree of stability over time, enables the user to divorce themselves from the more fully functioned receiver or smartphone, since no external calibration of the sensor is required during the extended period. In one variant, the device is a lightweight wristband. Other variants include e.g., pendants, finger-worn rings, arm or head bands, skin patches, and even dental, subcutaneous, or prosthetic implants.

A method and system of Continual Temperature Monitoring of a patient pre-surgical, intra-surgical, and post-surgical by multiple, wireless, temperature sensors that transmit low-power radio frequencies to a monitor capable of receiving signals of temperature data, wherein the monitor interfaces with conventional PC platforms having specifically designed software, and the multiple wireless sensors are of two types: 1.) a capsule shaped sensor which can be ingested or inserted rectally which transmits core body temperature (CBT); 2.) a dermal patch which transmits external body temperature, and the PC software allows the user to set upper and lower limits for each sensor transmitter placed in or on a patient which will activate a notification method selected by the user if these limits are exceeded or subceeded, and the PC software has file transfer protocol (FTP) allowing the user with an internet connection from any location worldwide to access a secure, password protected intranet or internet website and monitor, in real-time, the temperature data of a patient.

The invention relates to a pharmaceutical composition and in particular a dermal patch or wound dressing comprising an acid-hydrolyzing oligomer and/or polymer and an acid-activated prodrug such that the active principle in the pharmaceutical composition or in the dermal patch or wound dressing is formed A from the prodrug under the effect of acid. The invention further relates to a corresponding method for releasing active principles from a pharmaceutical composition.

An adhesive composition for dermal patches, comprising (A) a (meth)acrylic acid-base polymer having repeating units represented by formulae (1) and (2): (wherein R¹ and R² each independently represents a hydrogen atom or a methyl group and M represents NH₄⁺ or an alkali metal) with the ratio of (1)/(2) being in a range of 100/0 to 90/10 (by mol), (B) water, (C) a polyhydric alcohol and (D) an aluminum compound, with the content of (B) water being from 5 to 30 mass %; and a production process thereof. The adhesive composition for dermal patch of the present invention can contain a large amount of polyhydric alcohol between skeletons of the adhesive layer and forms a stable between skeletons of the adhesive layer and forms a stable base material free from syneresis of the polyhydric alcohol. Furthermore, the dermal patch using the adhesive composition for dermal patch of the present invention is excellent in the release property and adherence and has high safety.

The present invention provides an adhesive for a dermal patch comprising an acrylate-base polymer in which the repetitive unit is represented by the formulae (1), (2) and (3):

wherein M represents NH₄⁺ or an alkali metal, and X represents an unsaturated monomer unit other than the formulae (1) and (2), containing 5 mol % or more of acrylic acid (salt) represented by the formula (1) as a monomer unit, in which the content of β-hydroxypropionic acid (salt) is 5,000 ppm or less per solid content of the polymer and having a stable shape retainability, adhesion and percutaneous absorptivity of medicines; an production process thereof; and an adhesive composition for a dermal patch containing the adhesive for a dermal patch, an aluminum compound and water.

The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided. The system includes a dermal patch having a first side configured to deliver an active ingredient to a skin or mucosal surface, wherein the first side also includes a dermal adhesive. The system also includes an adhesive-coated device. The adhesive-coated surface of the device can be configured to adhere to the first side, wherein upon use of the dermal patch followed by contacting the adhesive-coated surface with the first side, residual active ingredient is rendered substantially inaccessible.

The invention provides a monitoring device of blood parameters. The monitoring device comprises a dermal patch, a blood parameter sensor, a processor, a time recorder and an alarm device, wherein the dermal patch can be worn on the skin of an organism; the blood parameter sensor is arranged on the dermal patch and is used for detecting the blood parameters of the organism; the processor is used for sending out abnormal indication signals when the detected blood parameters exceed the preset range and sending out normal indication signals when the detected blood parameters are within the preset range; the time recorder is used for starting to record time when receiving the abnormal indication signals, stopping recording time when receiving the normal indication signals, and sending out alarm signals when the recorded time is longer than or equal to the preset time; the alarm device is connected with the time recorder and is used for emitting alarms when receiving the alarm signals and/or triggering a preset mobile communication terminal to send alarm signals to preset phone numbers after receiving the alarm signals. The monitoring device disclosed by the invention can send out alarm signals when the detection results show that the blood parameters of the organism are in the abnormal state for a long time, so that the crisis of a life is avoided.

Devices, systems and methods are described for providing muscle contraction stimulation therapy to treat myriad diseases, including heart failure, Type 2 diabetes, and peripheral vascular disease using a skin patch or implantable stimulator that includes a multiplicity of electrodes, a processor, a stimulation circuit, one or more sensors and programming for a patient interface unit, wherein the processor is programmed to control selection of a subset of the multiplicity of electrodes and of operation of the stimulation circuit responsive to an indication of an adverse physiologic response. The indication of patient discomfort may be determined by monitoring a physiologic parameter of the subject using the one or more sensors, by direct input from the subject via the patient interface unit programming, or a combination thereof. The devices, systems and methods also provide for automatically optimizing the stimulation parameters applied by the stimulation circuit responsive to feedback from the one or more sensors and/or by using direct input from the subject.

The invention relates to a delivery system for biologically active oligopeptides. The delivery system comprises an electrochemical cell and a skin-beneficial amount of one or more oligopeptides. In a preferred embodiment the electrochemical cell and the peptide are contained in a dermal patch. The invention also relates to a topically acceptable hydrogel that comprises a hydrophilic polymer, an aqueous or aqueous alcoholic carrier, at least one skin-beneficial oligopeptide, and a salt, wherein at least a portion of the carrier is a structured water.

The present invention provides a dermal patch for selectively retaining one or more analyte(s) from a body of a subject comprising: a membrane layer (101) for retaining one or more analyte(s) from a body of a subject, with a first and a second side, wherein the first side is adapted to be in fluid communication with the skin of the subject; optionally holding means for securing the membrane layer in place; an adhesive layer (104); and a backing layer; wherein between the backing layer and the membrane layer (101) there is an expandable layer (103) for applying pressure to the membrane layer.

An apparatus is disclosed that allows for the delivery of medications and or chemicals for treatment of tissue through permeable dermal patch positioned inside a vessel for use in treating of any particular disease or aliment. The vessel self-adheres through activation of a chemical heater which may be activated by a pull tab exterior of the vessel. Initiation of the chemical reaction generates heat sufficient to raise the air temperature inside the vessel to allow the vessel to auto-generate a vacuum for wound treatment and to aid in sterilization of the wound site. The heated air expands and is evacuates through a one-way valve exterior of the vessel. Cooling of the interior air generates a vacuum inside the vessel to create a suction that holds the vessel in place. Increases blood flow to the treated tissue area, stimulated by the vacuum, facilitates improved delivery of the medication or pharmacological composition to the user. Application of vacuum to the treated tissue disinfects the tissue while providing a bacterial infiltration barrier.

The present invention is of an electrode comprising an electrode substrate, wherein the electrode substrate has an electrode side and a back side; a conductive material layer disposed on the back side of the electrode substrate; and an insoluble electroactive material disposed on the electrode side of the electrode substrate. The electrode substrate can be a conductive substrate or a non-conductive substrate. In an embodiment wherein the substrate is a non-conductive substrate, the electrode can include vias which extend from the electrode substrate backside to the electrode side of the substrate. In some embodiments, the electroactive material is zinc and the conductive material is silver. The present invention provides an electrode with improved current distribution and high capacity, which can provide higher current and/or higher voltage. In addition, the present invention provides a dermal patch, which includes a higher powered, high capacity electrode with uniform current distribution. Still further the present invention provides methods of making the electrode and of attaching the electrode to a power source.