Treatment of peanut allergy

Modified peanut protein extracts, reduced and alkylated, and complexed with aluminum hydroxide, offer a safer and more effective immunotherapy for peanut allergy by minimizing allergic reactions and enhancing immune response, addressing the limitations of current treatments.

WO2026027059A1 Publication Date: 2026-02-05HAL ALLERGY BV
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Patent Information

Application Number
PCT/EP2024/071986
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-08-02
Publication Date
2026-02-05

AI Technical Summary

Technical Problem

Current immunotherapy treatments for peanut allergy, such as subcutaneous, oral, and sublingual immunotherapy, face challenges with high systemic reactions, poor compliance, and safety issues, particularly in children and adolescents, necessitating a safer and more effective immunotherapy protocol.

Method used

The use of modified peanut protein extracts, reduced and alkylated, and complexed with aluminum hydroxide, administered in controlled doses starting from less than 0.1 μg and increasing up to 750 μg, provides a safer and more effective immunotherapy by reducing allergenicity while maintaining immunogenicity.

Benefits of technology

The modified peanut protein extracts demonstrate a significantly improved safety profile with reduced anaphylactic potential and effective immune response induction, as shown in animal models, without loss of therapeutic efficacy.

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Abstract

The present invention relates to modified peanut protein extracts for use in the prevention, reduction, or treatment of peanut allergy in a human wherein said use comprises exposing said human to an initial dose of said peanut protein extract of less than 0.1 µg followed by multiple increasing dosages up to 750 µg peanut protein extract, and wherein said peanut protein extract protein extract preferably a reduced and subsequently alkylated peanut protein extract. The present modified peanut protein extracts can be formulated as a pharmaceutical composition, a beverage, a food product, a toothpaste, a skin patch, a band aid, a mouth wash, a candy, a skin crème, a tablet, a lozenge, a food supplement, a foodstuff or combinations thereof.
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