400 results about "Scars" patented technology

The present disclosure provides a method and system for analyzing unipolar electrophysiological (EP) signals acquired by a multi-electrode catheter placed in a ventricle of a patient's heart. The method includes receiving unipolar EP signals, extracting unipolar far-field signals from the unipolar EP signals, and analyzing the extracted unipolar far-field signals to estimate the distribution of scar regions across a thickness of wall tissue of the ventricle. Using the estimated distribution, a unipolar far-field EP map showing the scar regions is generated. The method further includes displaying the unipolar far-field EP map including the scar regions to a user. The system comprises a display device and a processor configured to perform the steps of the method.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses application of a cell surface adhesion molecule CD22 as a target spot in preparation of drugs for treating spinal cord injury related diseases. The change of gene expression in the glial scar formation process is represented by space transcriptome sequencing, and the specific expression of CD22 in the glial scar region is up-regulated. According to single cell sequencing, in-situ hybridization and immunohistochemistry, specific high expression CD22 of part of microglial cells in a glial scar area is found. CD22 is knocked out through a genetic means, and it is found that formation of glial scars after spinal cord injury is remarkably reduced through inhibition of CD22. Behavioral detection finds that the error rate of irregular horizontal ladders is remarkably reduced by inhibiting CD22, and fine movement recovery of hind limbs of mice after spinal cord injury is promoted. The siRNA specifically targeting CD22 is injected into the sheath, so that the expression of microglial cells CD22 is inhibited, the error rate of irregular horizontal ladders of hind limbs can be reduced, and the recovery of the fine movement function of the hind limbs of the mouse after spinal cord injury is promoted. The invention provides a new possibility for development of drugs for spinal cord injury and treatment of spinal cord injury.

Disclosed in the present disclosure are an inhibitor against CTGF RNA, MITF RNA and SRD5A2 RNA and the use of the inhibitor. The inhibitor is a gene editing system. The gene editing system of the present disclosure is capable of knocking down CTGF RNA, MITF RNA and SRD5A2 RNA, and can be used for repairing scars, whitening skin, reducing or eliminating chloasma, preventing or treating melanoma, and / or preventing or treating androgenetic alopecia.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of radix notoginseng, 8-15 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma chuanxiong, 8-15 parts of rhizoma curcumae longae, 15-35 parts of radix angelicae sinensis, 3-8 parts of sandalwood, 3-8 parts of fructus aurantii immaturus, 40-60 parts of ramulus cinnamomi, 8-15 parts of rhizoma corydalis, 8-15 parts of rhizoma curcumae, 2-5 parts of flos carthami, 5-12 parts of radix puerariae, 8-15 parts of radix rehmanniae, 3-8 parts of pericarpium citri reticulatae and 8-15 parts of spica prunellae. The traditional Chinese medicine composition is prepared from 3-8 parts of radix trichosanthis, 15-35 parts of tribulus terrestris, 15-35 parts of cicada slough, 5-12 parts of stiff silkworm and 8-15 parts of rhizoma drynariae. According to a multi-target collaborative mechanism, network pharmacology proves that 12 pathological pathways such as IL-17A and the like can be regulated and controlled, and the TNF-alpha inhibition rate is 89% and the barrier repair speed is increased by 2.3 times through key component combination. According to a transdermal synergistic technology, the specific surface area of the medicine reaches 8.5 m < 2 > / g through superfine grinding, a Franz test shows that the penetration amount of tanshinone is increased by 3.7 times, and the onset time is shortened to 8.3 minutes. Dual scar regulation and control: the thickness of scars in 12 weeks is reduced by half through TGF-beta3 up-regulation and alpha-SMA inhibition, and the collagen order degree is improved by 3.2 times.

The invention provides a method for three-dimensional visualization of heart scars, a control device and a storage medium, and belongs to the technical field of three-dimensional heart modeling and visual display. The method comprises the following steps: matching a heart structure obtained by segmenting a pre-trained nnU-Net and a binary tag graph corresponding to a scar tissue with a myocardial shape shown by the binary tag graph of the heart structure by using a standard myocardial grid model as a template; and fitting deformation parameters of a standard myocardial grid model by using a deep learning regression model, and applying the deformation parameters to a standard grid to complete grid deformation so as to fit individual myocardial morphology. The heart shape prior is effectively utilized based on the template deformation method, so that the reconstructed three-dimensional model has higher anatomical consistency and fineness. And superposing the fitted three-dimensional myocardial grid model and the reconstructed scar tissue grid under the same coordinate for registration and superposition to realize image three-dimensional transparent myocardial scar visualization so as to accurately restore a continuous three-dimensional scar surface.

The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

A system for capturing, identifying, and processing images and soft biometrics includes an image capture device, a pan and tilt device, a speaker for audio feedback, and a microphone for voice capture, all controlled by a computing device. Image capture is enhanced by detecting image focus, facial recognition matching, detecting the number of subjects and unwanted objects, and checking the cropped image by detecting whether eyes and mouth are open or closed, detecting redeye, detecting background color, detecting lighting conditions, and detecting subject location, pose and expression. Soft biometrics including scars, marks, and tattoos are also identified, cropped and classified.

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The invention discloses an anti-infection ointment for promoting healing of burns and scalds and other wound surfaces and a preparation method thereof, the anti-infection ointment comprises active components and auxiliary materials, the active components comprise 0.2-3 parts by weight of ganoderma lucidum chitosan, 0.2-5 parts by weight of recombinant III type collagen, 0.1-2 parts by weight of zinc and 0.5-8 parts by weight of a Cur-Mg compound; the Cur-Mg compound is a compound of Cur-Mg (at) PP hydrogel, antibacterial polyphenol and boric acid ester bond hydrogel. Compared with the prior art, the ointment disclosed by the invention has the advantages of good antibacterial property, high wound healing promoting speed, reduction of scar formation and the like through a synergistic effect of multiple components, and realizes slow release of active components and good wound microenvironment regulation through a hydrogel system.

The invention discloses a quick classification method and system for human scars through visual calculation, and relates to the technical field of artificial intelligence, and the method comprises the following steps: S1, scar image collection and preprocessing: obtaining a human scar region image and shooting parameters, and carrying out the noise removal, illumination correction and scar region segmentation of an original image; s2, multi-modal scar feature extraction: based on the segmented scar region, extracting color features, texture features, morphological features and depth features; s3, feature fusion and dimension reduction; s4, constructing and training a lightweight scar classification model; s5, outputting a classification result and dynamically optimizing the model; according to the rapid classification method and system for the human body scars through visual calculation, through multi-modal feature fusion and improvement of a lightweight model, the classification accuracy is better than that of a traditional manual classification and single feature machine learning method, subjective differences of doctors are eliminated, and the classification objectivity is guaranteed.

The invention provides a nerve growth factor functionalized exosome as well as a preparation method and application thereof. The functionalized exosome can activate a Wnt / beta-catenin signal channel to maintain dryness of corneal limbal stem cells (LSCs) so as to promote corneal epithelium repair, can activate a cAMP signal channel to relieve inflammatory response and promote corneal nerve regeneration, and can be used for treating or relieving corneal chemical burns, including relieving inflammatory response, reducing stromal scar formation and inhibiting corneal neovascularization. Corneal epithelium repair and nerve regeneration are promoted.

The present invention relates to a skin suture device, and relates to the technical field of skin suture devices, which includes a fixing member and a tightening member; the fixing member includes a fixing strip, a movable block, and an adhesive strip, the fixing strip bottom is fixedly connected to the adhesive strip, the fixing strip top is raised to form a guide rail, the guide rail is slidably connected to the movable block, and the movable block top is fixedly connected to the fixed block, the fixing block is provided with a first through hole, the inner wall of the first through hole is fixedly connected to one end of a spring sheet; the tightening member is composed of a plurality of clips connected in sequence, the clips are provided with a ratchet groove, the ratchet groove engages and connects the other end of the spring sheet. Two fixing strips with the same structure are fixed to both sides of the skin by the adhesive strip, the fixing strips are made of flexible material, and the fixing strips can be bent and adjusted according to the shape of the wound. If the wound is arc-shaped, the fixing strip can be bent into an arc accordingly, so that the fixing strip fits the wound, thereby preventing the skin on both sides of the wound from being uneven or unable to be sutured, resulting in scars.

The invention belongs to the technical field of medicines, and discloses application of protein nano-selenium gel in preparation of a medicine for repairing wounds and preventing and treating scars. Compared with the nano-selenium gel prepared by the traditional method, the protein nano-selenium gel disclosed by the invention is better in stability and stronger in antioxidant, antibacterial and anti-inflammatory effects, has better functions in the aspects of repairing wound surfaces and diabetic wound surfaces and inhibiting scar formation, and can be well applied to preparation of medicines for repairing wound surfaces and preventing and treating scars.

The present invention discloses a polypeptide combination wound healing preparation with high permeability, specifically relating to a polypeptide combination of tripeptide-1, hexapeptide-9, and palmitoyl-modified peptide, and a new use for treating skin diseases such as wounds, ulcers, burns, scars, and keloids. While the polypeptide combination plays a significant synergistic effect in wound healing, it can effectively prevent and inhibit scar hyperplasia. In addition, the polypeptide combination wound healing preparation of the present invention utilizes the wound healing promoting activity of the composite polypeptide, and is compounded with specific penetration enhancers and antioxidants to be prepared into a gel with functions of moisturizing, promoting healing, reducing infection, and relieving pain, greatly increasing skin penetration, significantly enhancing the skin retention dose, and having significant antibacterial, anti-inflammatory, eschar-removing and muscle-generating, astringent healing, and scar hyperplasia inhibiting effects, being particularly suitable for wound healing and reducing scar residue.

To provide a laminate excellent in tearing property while reducing environmental load.SOLUTION: A laminate comprises a substrate film, a primer layer, an adhesive layer, and a sealant film in this order, and includes a printed surface of an electrostatic ink composition adhered to the adhesive layer. The adhesive layer contains a solvent-free adhesive composition including a polyol component and a polyisocyanate component, its cured product, or a mixture thereof, and the adhesive strength of the adhesive layer is 1.0 N / 15 mm width or more. The laminate has a group of scratches, each consisting of multiple scratches that include through-holes.SELECTED DRAWING: Figure 1

The invention discloses a fusion polypeptide TGNL and application of neural stem cells modified by the fusion polypeptide TGNL in spinal cord injury repair. The fusion polypeptide TGNL is composed of a TAT penetrating domain, a GSTP targeting domain, an NICDi inhibition domain, an MMP-2 activation domain and a flexible Linker connecting the three domains, and the full-length amino acid sequence is as shown in SEQ ID NO. 1. The invention also provides a preparation method of the polypeptide, a neural stem cell (hNSCs-TGNL) for expressing the polypeptide and a construction method of the neural stem cell (hNSCs-TGNL). Experiments show that the fusion polypeptide TGNL can efficiently penetrate nerve cells, specifically target glial scars, is selectively activated by MMP-2, and promotes neural stem cells to differentiate into neurons by inhibiting Notch signals; the hNSCs-TGNL has high survival rate and strong penetrability in an in-vitro glial scar model, and can significantly promote motor function recovery, reduce injury volume, increase axon density and reduce glial scars in a rat spinal cord contusion model. The invention provides a novel candidate drug and a cell treatment strategy for clinical treatment of spinal cord injury, and has remarkable clinical application value.

The invention relates to the technical field of biological medicines, and provides functional hydrogel for promoting hair follicle regeneration as well as a preparation method and application of the functional hydrogel. The functional hydrogel comprises a hydrogel matrix and an SHP2 inhibitor SHP099 carried on the hydrogel matrix. The invention further provides a corresponding preparation method and application in preparation of dressing for treating scar wound surfaces. The functional hydrogel constructed by the invention is used as a powerful tool for researching the formation of a dermis shell, not only plays a huge role in the fundamental research of the formation of skin appendages in the future, but also has a wide market application prospect in the aspects of wound healing promotion and hair follicle regeneration promotion dressings.

A system for capturing, identifying, and processing images and soft biometrics includes an image capture device, a pan and tilt device, a speaker for audio feedback, and a microphone for voice capture, all controlled by a computing device. Image capture is enhanced by detecting image focus, facial recognition matching, detecting the number of subjects and unwanted objects, and checking the cropped image by detecting whether eyes and mouth are open or closed, detecting redeye, detecting background color, detecting lighting conditions, and detecting subject location, pose and expression. Soft biometrics including scars, marks, and tattoos are also identified, cropped and classified.

The utility model discloses a scar treatment laser beauty instrument, which relates to the field of scar treatment, and comprises a main body and a connecting line fixedly connected to the top of the main body, the other end of the connecting line is fixedly connected to a handle part, a fixing component is fixedly installed on the outside of the handle part, a disinfection chamber is opened on the left side of the main body, a placement component is movably installed inside the disinfection chamber, and a scanning head is movably installed inside the fixing component and the placement component. The utility model is provided with a fixing component located outside the handle part, and the scanning head is inserted into the fixing component from the bottom, and the scanning head is fixed from the side through the fixing component, so as to install the scanning head. When the scanning head needs to be replaced, the scanning head is separated from the inside of the fixing component by operating and pressing the fixing component, so as to facilitate the replacement of the scanning head and avoid infection caused by contamination of the scanning head.

The invention discloses an abdominal operation postoperative scar nursing bellyband, and relates to the technical field of postoperative nursing, the abdominal operation postoperative scar nursing bellyband comprises an elastic band, the outer wall of the elastic band is provided with a detachable adjusting mechanism convenient for dismounting a gasket, through the structural arrangement, the abdominal operation postoperative scar nursing bellyband can realize the purpose that the gasket can be conveniently dismounted without dismounting a bellyband body; only the positions of the cloth and the wound are adjusted, so that the working difficulty of medical staff is simplified, wound tearing or secondary infection caused by re-winding of the bellyband on the wound of a patient is reduced, and the cloth can be independently detached so as to be directly replaced or applied with liquid medicine. And the recovery state of the wound can be observed through the detachable adjusting mechanism, so that the medical staff can conveniently adjust subsequent medication.

The invention discloses a compound scar ointment and a preparation method thereof, the ointment is prepared by decocting and concentrating Chinese herbal medicines such as salvia miltiorrhiza, cassia twig, radix paeoniae alba, rheum officinale, radix sophorae flavescentis, pepper, folium artemisiae argyi, lycopodium clavatum, garden balsam stem, pawpaw and borneol as raw materials and adding a matrix. The ointment has the effects of promoting blood circulation to remove blood stasis, relaxing tendons, activating collaterals, clearing heat and eliminating dampness, can effectively inhibit scar hyperplasia and promote scar softening and dissipation, and is suitable for treating various scars and acne marks. The ointment is simple in preparation process, green and environment-friendly, safe and non-irritant to use, good in clinical effect and wide in application prospect.

A superconducting array ion instrument, the invention relates to the technical field of ion generators; a treatment head inner cover is embedded inside the treatment head body, a sapphire lens and a conductive head are embedded in the treatment head inner cover from left to right in sequence, the right end of the conductive head is inserted and fixed in a fixing plate, the fixing plate is embedded and fixed in the right side of the treatment head inner cover, the left end of the conductive needle is inserted in the fixing plate and is contacted with the right side wall of the conductive head, the right end of the conductive needle is inserted in the fixing plate and is arranged in contact with the right side wall of the conductive head, the right end of the conductive needle is inserted in a circuit board, a treatment head cover is arranged on the right side of the circuit board, and the positioning column on the left side of the lower part of the treatment head cover passes through the arc groove at the bottom of the circuit board, and is plugged and fixed with the positioning sleeve at the bottom of the treatment head inner cover. Diseases are treated directly through the photoelectric effect, and the effect of beauty and skin care can be achieved after reasonable discharge treatment; it is effective for acne treatment, skin sterilization, scar inhibition and wound healing.

This invention discloses a multimodal imaging and multidimensional index evaluation software and hardware system for scars, involving an infrared, RGB, and stereoscopic three-modal imaging hardware system, and an intelligent calculation and monitoring software system for more than twenty scar evaluation indicators. The intelligent evaluation system for scars includes indicators such as perimeter, length, width, thickness, area, volume, color, roughness, consistency, elasticity, blood flow density, risk of continued scar growth, and color difference. This forms an objective, multidimensional, precise, and intelligent evaluation system for the scar diagnosis and treatment process, thereby assisting in diagnosis and treatment, as well as monitoring and tracking the entire life cycle of scars. This contributes to the visualization, objectification, and accuracy of the scar diagnosis and treatment process, providing doctors and patients with comprehensive diagnostic and treatment evidence and enabling tracking and tracing.

The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel. The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

According to the application of the arcangelisia loureiri extract in preparing the burn and scald wound healing medicine, the arcangelisia loureiri crude extract is obtained through extraction and concentration with a decoction method, and wound healing can be promoted by reducing the area of a rat skin wound, shortening the healing time of the rat skin wound, reducing the hyperplasia speed of the skin corium layer and promoting healing of the wound; the effects of remarkably promoting wound healing of burns and scalds and reducing scars are achieved.

The present invention comprises: a high-frequency oscillator that transmits high-frequency energy and includes a control unit; a high-frequency connecting line connected to the high-frequency oscillator; and a high-frequency transmission pad connected to the other end of the high-frequency connecting line and attached to the curve of facial skin in close contact with it, wherein the high-frequency transmission pad is configured such that an adhesive pad and a bipolar pad are integrated or separate. This invention relates to a non-invasive automatic facial lifting device using high-frequency energy that adheres closely to the curves of the face to be treated, thereby enabling uniform delivery of high-frequency energy to the skin, allowing for effective treatment without separate operation, minimizing the risk of excessive thermal damage to specific areas of the skin, resolving issues such as pain, scarring, and infection associated with existing invasive technologies, enhancing user convenience and safety through an automated control system and customized settings, and providing uniform treatment effects and reducing treatment time and fatigue by monitoring skin temperature in real time and delivering high-frequency energy according to set output, time, and patterns.

This item is primarily intended for use as nursing clothing for four-legged pets such as cats. The back opening, closed with a hook-and-loop fastener, is opened to the left and right sides of the back, the front and back legs are passed through the holes, and the garment is then closed to cover the neck and torso. The neck is covered by the cylindrical part at the bottom right of the front, top, and right side views. When the garment is worn, the abdominal opening, closed with a hook-and-eye fastener, can be opened to the left and right sides of the abdomen to allow for nursing care such as changing gauze applied to abdominal surgical scars.

The invention relates to the technical field of cosmetics, and particularly discloses an all-directional anti-acne repairing composition as well as a preparation method and application thereof. The comprehensive anti-acne repairing composition is prepared from the following components in parts by weight: 0.01 to 2 parts of flexible salicylic acid, 0.001 to 2 parts of rhodomyrtus tomentosa fruit extract, 0.001 to 0.5 part of quaternary ammonium salt, 0.01 to 5 parts of nicotinamide, 0.001 to 3 parts of herba centellae extract, 0.01 to 3 parts of phellinus linteus extract, 0.0001 to 2 parts of phaeodactylum tricornutum extract and 0.001 to 2 parts of bio-saccharide gum-1. The comprehensive anti-acne repairing composition provided by the invention can resist acnes comprehensively, achieves the effects of removing aged cutin, controlling oil, sterilizing, resisting inflammation, relieving and fading marks and moisturizing, and has a comprehensive repairing effect on various skin injuries including acne skin.