715 results about "Scars" patented technology

The present disclosure provides a method and system for analyzing unipolar electrophysiological (EP) signals acquired by a multi-electrode catheter placed in a ventricle of a patient's heart. The method includes receiving unipolar EP signals, extracting unipolar far-field signals from the unipolar EP signals, and analyzing the extracted unipolar far-field signals to estimate the distribution of scar regions across a thickness of wall tissue of the ventricle. Using the estimated distribution, a unipolar far-field EP map showing the scar regions is generated. The method further includes displaying the unipolar far-field EP map including the scar regions to a user. The system comprises a display device and a processor configured to perform the steps of the method.

In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface. Improving the appearance of the skin surface can be at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and / or preventing acne, reducing a blemish, reducing an appearance of spider veins and / or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses application of a cell surface adhesion molecule CD22 as a target spot in preparation of drugs for treating spinal cord injury related diseases. The change of gene expression in the glial scar formation process is represented by space transcriptome sequencing, and the specific expression of CD22 in the glial scar region is up-regulated. According to single cell sequencing, in-situ hybridization and immunohistochemistry, specific high expression CD22 of part of microglial cells in a glial scar area is found. CD22 is knocked out through a genetic means, and it is found that formation of glial scars after spinal cord injury is remarkably reduced through inhibition of CD22. Behavioral detection finds that the error rate of irregular horizontal ladders is remarkably reduced by inhibiting CD22, and fine movement recovery of hind limbs of mice after spinal cord injury is promoted. The siRNA specifically targeting CD22 is injected into the sheath, so that the expression of microglial cells CD22 is inhibited, the error rate of irregular horizontal ladders of hind limbs can be reduced, and the recovery of the fine movement function of the hind limbs of the mouse after spinal cord injury is promoted. The invention provides a new possibility for development of drugs for spinal cord injury and treatment of spinal cord injury.

A composition capable of resisting inflammation and promoting skin repair, includes platelet-rich plasma(PRP) and further includes β-nicotinamide mononucleotide(NMN) and sialic acid(NANA). The composition can significantly accelerate wound healing. Compared with separate use of the platelet-rich plasma, the NMN or the sialic acid,the composition promotes faster wound healing. Moreover, after wound scar repair, the resulting scar appears lighter in color.

The invention discloses a registration method based on a three-dimensional retina OCT (Optical Coherence Tomography) image, which relates to the technical field of OCT image registration, and comprises the following steps of: in the registration process of the OCT image, firstly, carrying out preliminary registration by taking anatomical feature points of the retina as key references of basic alignment, and eliminating global mismatching errors; after the preliminary registration is completed, the OCT image is divided into a plurality of sub-regions in an equal area, and each sub-region is used as an independent analysis unit, thereby facilitating the subsequent precise analysis of the local optical characteristics of each analysis unit. According to the method, global errors are eliminated through initial registration of retina anatomical feature points, image division and abnormal signal extraction are combined, healthy and scar tissue areas are intelligently recognized through a machine learning model, weights are dynamically adjusted to preferentially depend on the healthy areas, interference of scars on registration is reduced, registration reliability is improved, clinical misjudgment is reduced, and the accuracy of registration is improved. And technical support is provided for accurate diagnosis and treatment of retinopathy.

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel dressing for inhibiting wound scar formation and a preparation method and application thereof. The invention firstly provides a composition for preparing the anti-scar hydrogel dressing, wherein the composition is prepared from arsenic trioxide and auxiliary materials; the auxiliary materials comprise chitosan and sodium alginate. The preparation method of the hydrogel dressing is provided based on the composition, and comprises the following steps: mixing a chitosan solution and a sodium alginate solution to obtain CS / SA pre-gel; the preparation method comprises the following steps: dispersing arsenic trioxide into a sodium alginate solution, and adding chitosan to obtain an ATO-coated CS / SA pregel solution; and respectively soaking the CS / SA pre-gel and the ATO coated CS / SA pre-gel solution in a CaCl2 solution to obtain the ATO coated CS / SA hydrogel. The ATO coated CS / SA hydrogel can effectively inhibit formation of wound scars, overcomes the toxicity problem of ATO, and has great clinical application value.

Disclosed in the present disclosure are an inhibitor against CTGF RNA, MITF RNA and SRD5A2 RNA and the use of the inhibitor. The inhibitor is a gene editing system. The gene editing system of the present disclosure is capable of knocking down CTGF RNA, MITF RNA and SRD5A2 RNA, and can be used for repairing scars, whitening skin, reducing or eliminating chloasma, preventing or treating melanoma, and / or preventing or treating androgenetic alopecia.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of radix notoginseng, 8-15 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma chuanxiong, 8-15 parts of rhizoma curcumae longae, 15-35 parts of radix angelicae sinensis, 3-8 parts of sandalwood, 3-8 parts of fructus aurantii immaturus, 40-60 parts of ramulus cinnamomi, 8-15 parts of rhizoma corydalis, 8-15 parts of rhizoma curcumae, 2-5 parts of flos carthami, 5-12 parts of radix puerariae, 8-15 parts of radix rehmanniae, 3-8 parts of pericarpium citri reticulatae and 8-15 parts of spica prunellae. The traditional Chinese medicine composition is prepared from 3-8 parts of radix trichosanthis, 15-35 parts of tribulus terrestris, 15-35 parts of cicada slough, 5-12 parts of stiff silkworm and 8-15 parts of rhizoma drynariae. According to a multi-target collaborative mechanism, network pharmacology proves that 12 pathological pathways such as IL-17A and the like can be regulated and controlled, and the TNF-alpha inhibition rate is 89% and the barrier repair speed is increased by 2.3 times through key component combination. According to a transdermal synergistic technology, the specific surface area of the medicine reaches 8.5 m < 2 > / g through superfine grinding, a Franz test shows that the penetration amount of tanshinone is increased by 3.7 times, and the onset time is shortened to 8.3 minutes. Dual scar regulation and control: the thickness of scars in 12 weeks is reduced by half through TGF-beta3 up-regulation and alpha-SMA inhibition, and the collagen order degree is improved by 3.2 times.

The invention provides a method for three-dimensional visualization of heart scars, a control device and a storage medium, and belongs to the technical field of three-dimensional heart modeling and visual display. The method comprises the following steps: matching a heart structure obtained by segmenting a pre-trained nnU-Net and a binary tag graph corresponding to a scar tissue with a myocardial shape shown by the binary tag graph of the heart structure by using a standard myocardial grid model as a template; and fitting deformation parameters of a standard myocardial grid model by using a deep learning regression model, and applying the deformation parameters to a standard grid to complete grid deformation so as to fit individual myocardial morphology. The heart shape prior is effectively utilized based on the template deformation method, so that the reconstructed three-dimensional model has higher anatomical consistency and fineness. And superposing the fitted three-dimensional myocardial grid model and the reconstructed scar tissue grid under the same coordinate for registration and superposition to realize image three-dimensional transparent myocardial scar visualization so as to accurately restore a continuous three-dimensional scar surface.

The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

The invention relates to a preparation method of a sodium alginate composite hydrogel microneedle for treating pathological scars, and belongs to the technical field of hydrogel microneedles, the microneedle takes sodium alginate as a main material, the sodium alginate is methylated to obtain methylacryloylated sodium alginate AlgMA, hollow manganese dioxide nanoparticles loaded with matrix metalloproteinase are added, and the microneedle is prepared by a hydrothermal method. A hydrogel microneedle filling solution is obtained; the preparation method comprises the following steps: transferring the hydrogel microneedle into a PDMS microneedle mold, carrying out negative pressure vacuum bubble removal, drying and concentrating twice in a drying oven, carrying out photopolymerization crosslinking, forming a solid hydrogel microneedle tip, adding a 20% PVA solution, and drying in the drying oven to form the microneedle substrate, and the preparation method is simple, convenient and efficient, has industrial application potential, and is suitable for the scenes of drug delivery, skin care and the like; according to the application of the sodium alginate composite hydrogel microneedle in pathological scar drug delivery, the sodium alginate composite hydrogel microneedle has excellent mechanical strength and biocompatibility, and painless and noninvasive drug delivery can be carried out on the surface of scar skin.

The invention discloses a python oil compound for treating skin burns, scalds and cuts and a preparation method thereof, and relates to the technical field of traditional Chinese medicine. The python oil compound formula is composed of python oil extract, aloe, borneol, jade square gold tablets, psoralea corylifolia, scutellaria baicalensis, rosmarinus officinalis, sophora flavescens extract, cnidium monnieri and glycerol. Appropriate raw materials are weighed in parts by weight, and the python oil compound is obtained through screening, crushing, boiling and cooling. The python oil compound for treating skin burns, scalds and cuts provided by the invention has a reasonable ratio of Chinese medicinal materials, has strong permeability, can promote blood circulation, has obvious analgesic effect, can repair damaged cells, is not easy to leave scars after healing, and has the advantages of simple preparation process and convenient product use.

A system for capturing, identifying, and processing images and soft biometrics includes an image capture device, a pan and tilt device, a speaker for audio feedback, and a microphone for voice capture, all controlled by a computing device. Image capture is enhanced by detecting image focus, facial recognition matching, detecting the number of subjects and unwanted objects, and checking the cropped image by detecting whether eyes and mouth are open or closed, detecting redeye, detecting background color, detecting lighting conditions, and detecting subject location, pose and expression. Soft biometrics including scars, marks, and tattoos are also identified, cropped and classified.

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The invention discloses an anti-infection ointment for promoting healing of burns and scalds and other wound surfaces and a preparation method thereof, the anti-infection ointment comprises active components and auxiliary materials, the active components comprise 0.2-3 parts by weight of ganoderma lucidum chitosan, 0.2-5 parts by weight of recombinant III type collagen, 0.1-2 parts by weight of zinc and 0.5-8 parts by weight of a Cur-Mg compound; the Cur-Mg compound is a compound of Cur-Mg (at) PP hydrogel, antibacterial polyphenol and boric acid ester bond hydrogel. Compared with the prior art, the ointment disclosed by the invention has the advantages of good antibacterial property, high wound healing promoting speed, reduction of scar formation and the like through a synergistic effect of multiple components, and realizes slow release of active components and good wound microenvironment regulation through a hydrogel system.

The invention discloses a quick classification method and system for human scars through visual calculation, and relates to the technical field of artificial intelligence, and the method comprises the following steps: S1, scar image collection and preprocessing: obtaining a human scar region image and shooting parameters, and carrying out the noise removal, illumination correction and scar region segmentation of an original image; s2, multi-modal scar feature extraction: based on the segmented scar region, extracting color features, texture features, morphological features and depth features; s3, feature fusion and dimension reduction; s4, constructing and training a lightweight scar classification model; s5, outputting a classification result and dynamically optimizing the model; according to the rapid classification method and system for the human body scars through visual calculation, through multi-modal feature fusion and improvement of a lightweight model, the classification accuracy is better than that of a traditional manual classification and single feature machine learning method, subjective differences of doctors are eliminated, and the classification objectivity is guaranteed.

The invention provides a nerve growth factor functionalized exosome as well as a preparation method and application thereof. The functionalized exosome can activate a Wnt / beta-catenin signal channel to maintain dryness of corneal limbal stem cells (LSCs) so as to promote corneal epithelium repair, can activate a cAMP signal channel to relieve inflammatory response and promote corneal nerve regeneration, and can be used for treating or relieving corneal chemical burns, including relieving inflammatory response, reducing stromal scar formation and inhibiting corneal neovascularization. Corneal epithelium repair and nerve regeneration are promoted.

The present invention relates to a skin suture device, and relates to the technical field of skin suture devices, which includes a fixing member and a tightening member; the fixing member includes a fixing strip, a movable block, and an adhesive strip, the fixing strip bottom is fixedly connected to the adhesive strip, the fixing strip top is raised to form a guide rail, the guide rail is slidably connected to the movable block, and the movable block top is fixedly connected to the fixed block, the fixing block is provided with a first through hole, the inner wall of the first through hole is fixedly connected to one end of a spring sheet; the tightening member is composed of a plurality of clips connected in sequence, the clips are provided with a ratchet groove, the ratchet groove engages and connects the other end of the spring sheet. Two fixing strips with the same structure are fixed to both sides of the skin by the adhesive strip, the fixing strips are made of flexible material, and the fixing strips can be bent and adjusted according to the shape of the wound. If the wound is arc-shaped, the fixing strip can be bent into an arc accordingly, so that the fixing strip fits the wound, thereby preventing the skin on both sides of the wound from being uneven or unable to be sutured, resulting in scars.

According to the multifunctional conductive injection hydrogel OQG provided by the invention, through dynamic Schiff base crosslinking between oxidized dextran (Dextran) and quaternary ammonium salt chitosan (QCS), enhancement by using polydopamine modified reduced graphene oxide (rGO (at) PDA) and loading of polydopamine encapsulated asiaticoside (AC (at) PDA), the obtained hydrogel has injectability, is suitable for irregular wounds, can be quickly self-healed, and has the advantages of good biocompatibility and good biocompatibility. And the wound adhesive force is relatively good. In addition, the composite hydrogel also has antioxidant and antibacterial activity, and can relieve inflammation and prevent infection. The incorporation of conductive reduced graphene oxide further promotes the delivery of endogenous electrical signals, stimulates cell migration and tissue regeneration, while also maintaining the release of AC to modulate collagen deposition and angiogenesis. In-vitro evaluation proves that the hydrogel disclosed by the invention has cell compatibility for promoting cell migration. Rat wound assessment results show that the multifunctional hydrogel can accelerate wound healing, reduce inflammation and reduce scars.

The invention discloses a fibroblast exosome for repairing scars and a preparation method and application thereof, and relates to the technical field of biology, and the preparation method comprises the following steps: S1, taking fibroblasts, and carrying out adaptive culture on the fibroblasts in a complete culture medium for 24-30 hours; s2, after the adaptive culture is completed, replacing a new culture medium, culturing in a complete culture medium containing 10% of fetal calf serum until the fusion degree is 80%, carrying out digestion treatment by adopting 0.25% of pancreatin, centrifuging, collecting supernate, and carrying out ultracentrifugation extraction on the supernate to obtain a primary product of the fibroblast exosome; s3, carrying out transfection treatment on the primary product of the fibroblast exosome to obtain the fibroblast exosome for repairing scars; the prepared fiber-forming exosome can also influence the movement of epidermal and dermal cells by regulating the expression of related factors in a TGF-beta / Smad signal channel, and the regulating effect is mainly to promote scar-free healing of the skin, so that the generation of scars is reduced from the source.

The invention belongs to the technical field of medicines, and discloses application of protein nano-selenium gel in preparation of a medicine for repairing wounds and preventing and treating scars. Compared with the nano-selenium gel prepared by the traditional method, the protein nano-selenium gel disclosed by the invention is better in stability and stronger in antioxidant, antibacterial and anti-inflammatory effects, has better functions in the aspects of repairing wound surfaces and diabetic wound surfaces and inhibiting scar formation, and can be well applied to preparation of medicines for repairing wound surfaces and preventing and treating scars.

The present invention discloses a polypeptide combination wound healing preparation with high permeability, specifically relating to a polypeptide combination of tripeptide-1, hexapeptide-9, and palmitoyl-modified peptide, and a new use for treating skin diseases such as wounds, ulcers, burns, scars, and keloids. While the polypeptide combination plays a significant synergistic effect in wound healing, it can effectively prevent and inhibit scar hyperplasia. In addition, the polypeptide combination wound healing preparation of the present invention utilizes the wound healing promoting activity of the composite polypeptide, and is compounded with specific penetration enhancers and antioxidants to be prepared into a gel with functions of moisturizing, promoting healing, reducing infection, and relieving pain, greatly increasing skin penetration, significantly enhancing the skin retention dose, and having significant antibacterial, anti-inflammatory, eschar-removing and muscle-generating, astringent healing, and scar hyperplasia inhibiting effects, being particularly suitable for wound healing and reducing scar residue.

Disclosed examples include technology for the detection and treatment of neotissue formation proximate an implantable stimulator. Neotissue formation can include ossification, scar tissue, soft tissue fibrosis, and other tissue growth. The neotissue formation can be detected by analyzing (e.g., using a machine-learning framework) stimulation data relating to the implantable stimulator. Neotissue formation characteristics can be analyzed to determine appropriate treatment actions for ameliorating the effects of neotissue formation.

To provide a laminate excellent in tearing property while reducing environmental load.SOLUTION: A laminate comprises a substrate film, a primer layer, an adhesive layer, and a sealant film in this order, and includes a printed surface of an electrostatic ink composition adhered to the adhesive layer. The adhesive layer contains a solvent-free adhesive composition including a polyol component and a polyisocyanate component, its cured product, or a mixture thereof, and the adhesive strength of the adhesive layer is 1.0 N / 15 mm width or more. The laminate has a group of scratches, each consisting of multiple scratches that include through-holes.SELECTED DRAWING: Figure 1

The present invention belongs to the field of medical technology, and in particular to a hydrogel dressing for promoting wound healing and a preparation method thereof. The hydrogel dressing includes the following raw materials in parts by weight: 10-18 parts of gel matrix, 1-5 parts of silk fibroin, 0.3-0.8 parts of scutellariae, 0.1-0.5 parts of diphenylethylene glycosides, 0.4-0.8 parts of modified soybean lecithin, 0.5-1 parts of trehalose, and 80-100 parts of deionized water. The hydroxyl groups in the modified soybean lecithin and the amino groups of the components such as chitosan in the gel matrix form hydrogen bonds, thereby improving the mechanical properties of the hydrogel dressing. In addition, the modified soybean lecithin can also increase the water content of the stratum corneum of the skin, which is beneficial to the repair of scars after wound healing. And the results of wound healing experiments show that the use of scutellariae and diphenylethylene glycosides can effectively promote wound healing.

The invention discloses a fusion polypeptide TGNL and application of neural stem cells modified by the fusion polypeptide TGNL in spinal cord injury repair. The fusion polypeptide TGNL is composed of a TAT penetrating domain, a GSTP targeting domain, an NICDi inhibition domain, an MMP-2 activation domain and a flexible Linker connecting the three domains, and the full-length amino acid sequence is as shown in SEQ ID NO. 1. The invention also provides a preparation method of the polypeptide, a neural stem cell (hNSCs-TGNL) for expressing the polypeptide and a construction method of the neural stem cell (hNSCs-TGNL). Experiments show that the fusion polypeptide TGNL can efficiently penetrate nerve cells, specifically target glial scars, is selectively activated by MMP-2, and promotes neural stem cells to differentiate into neurons by inhibiting Notch signals; the hNSCs-TGNL has high survival rate and strong penetrability in an in-vitro glial scar model, and can significantly promote motor function recovery, reduce injury volume, increase axon density and reduce glial scars in a rat spinal cord contusion model. The invention provides a novel candidate drug and a cell treatment strategy for clinical treatment of spinal cord injury, and has remarkable clinical application value.

The invention belongs to the field of medical cosmetology, and particularly relates to a method for washing tattoo to prevent scars and application of the method. The method mainly comprises the steps that the skin temperature is reduced, then dot matrix air holes are reserved in the tattooing position through program-controlled CO2 dot matrix laser, then the tattooing is cleaned through program-controlled Q-switched laser, meanwhile, the skin surface needs to be physically cooled after a certain period of time till all the tattooing positions are cleaned, and finally traditional Chinese medicine liquid for clearing heat, detoxifying and resisting bacteria is sprayed to the skin surface. Parameters of laser power, pulse time, light spot moving speed, dot matrix interval and the like are debugged systematically, a proper parameter range is adjusted, and the risk of scars can be reduced more regularly and effectively. The method has important application value in the field of medical cosmetology.

The invention relates to the technical field of biological medicines, and provides functional hydrogel for promoting hair follicle regeneration as well as a preparation method and application of the functional hydrogel. The functional hydrogel comprises a hydrogel matrix and an SHP2 inhibitor SHP099 carried on the hydrogel matrix. The invention further provides a corresponding preparation method and application in preparation of dressing for treating scar wound surfaces. The functional hydrogel constructed by the invention is used as a powerful tool for researching the formation of a dermis shell, not only plays a huge role in the fundamental research of the formation of skin appendages in the future, but also has a wide market application prospect in the aspects of wound healing promotion and hair follicle regeneration promotion dressings.