14 results about "Scar tissues" patented technology

This disclosure relates to electro-anatomical mappings of cardiac tissue at different depths using a multi-electrode catheter. A multi-electrode catheter within a heart of a patient has a first plurality of electrodes on a first side and a second plurality of electrodes on a second side, wherein the first side is proximate to cardiac tissue at a first location and the second side is facing away from the cardiac tissue. Electrical activity is received from at least one electrode on the first side and the at least one electrode on the second side, and a signal analysis is performed thereon based at least in part on distances between electrodes on different sides of the multi-electrode catheter. The process is repeated for further locations of cardiac tissue in the heart, and an electro-anatomical map of the heart depicting electrical activity or scar tissue is generated based on the signal analysis.

This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help prevent or reduce scar tissue growth in cardiovascular system and restore heart function. According to certain embodiments, a fluid-induced, pathological shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for preventing or reducing scar tissue growth in cardiovascular system. Therefore, compositions comprising the exosomes derived from stem cells and methods of preventing and / or treating scar tissue growth in cardiovascular system by administering the exosomes isolated from stem cells are also provided.

The application discloses a nerve electrode modified by an atomic dispersion metal catalytic material under super-temperature and a preparation method thereof, and the preparation method is as follows: roughening treatment is performed on the surface of a metal wire, cleaning, drying, and a nerve electrode base is obtained; polyimide solution is used to coat the other parts of the nerve electrode base except electrode recording sites; an electrochemical three-electrode system constant current mode is used to prepare the interface of the nerve electrode modified by the atomic dispersion metal catalytic material under super-temperature; the electrode can not only increase the effective contact area of the electrode interface and enhance the electron transport capacity, but also can play the high efficient biological catalytic activity of the atomic dispersion metal catalytic material, reduce the inflammatory reaction of the electrode-tissue interface, reduce the formation of scar tissue, greatly improve the biocompatibility of the nerve electrode, and improve the signal quality and detection sensitivity of long-term recording.

The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and / or mobility, or alter normal cell growth and / or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.

To provide a system and method for generating, visualizing, and displaying cardiac signal information present at different depths in cardiac tissue. [Solution] This disclosure relates to electroanatomical mapping of cardiac tissue at different depths using a multi-electrode catheter. The multi-electrode catheter in the patient's heart has a first plurality of electrodes on a first side and a second plurality of electrodes on a second side, with the first side facing close to cardiac tissue at a first position and the second side facing away from cardiac tissue. Electrical activity is received from at least one electrode on the first side and at least one electrode on the second side, and signal analysis is performed thereon, at least partially based on the distance between the electrodes on the different sides of the multi-electrode catheter. This process is repeated for further locations of cardiac tissue in the heart, and an electroanatomical map of the heart showing electrical activity or scar tissue is generated based on the signal analysis.

The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and / or mobility, or alter normal cell growth and / or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

Apparatuses, systems, and methods are disclosed for providing controlled delivery of electrolysis products and cellular permeabilization treatment to a site in tissue. A minimally invasive regenerative surgery of subjecting a target area in living tissue to an electric input composed of a combination of electric fields of a magnitude that permeabilizes the cell membrane and to an electrolytic reaction that generates products of electrolysis of a magnitude that, by themselves, do not cause damage to cells or the extracellular matrix, but induces cell death in combination with electric field of the magnitude that permeabilizes the cell membrane. It is shown that the apparatuses, systems, and methods generate a region of tissue in which complete regeneration of the ablated tissue occurs without massive inflammation, ulceration, coagulative necrosis, fibrotic tissue, or scar tissue.

This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help prevent or reduce scar tissue growth in cardiovascular system and restore heart function. According to certain embodiments, a fluid-induced, pathological shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for preventing or reducing scar tissue growth in cardiovascular system. Therefore, compositions comprising the exosomes derived from stem cells and methods of preventing and / or treating scar tissue growth in cardiovascular system by administering the exosomes isolated from stem cells are also provided.

The present invention discloses a registration method based on three-dimensional retinal OCT images, which relates to the technical field of OCT image registration, and includes the following steps: in the registration process of OCT images, firstly, the anatomical feature points of the retina are used as the key reference for basic alignment to perform preliminary registration to eliminate global mismatch errors; after the preliminary registration is completed, the OCT image is divided into a number of sub-areas with equal areas, so that each sub-area is used as an independent analysis unit, which is convenient for subsequent accurate analysis of the local optical characteristics of each analysis unit. The present invention eliminates global errors through preliminary registration of retinal anatomical feature points, combines image segmentation with abnormal signal extraction, uses a machine learning model to intelligently identify healthy and scar tissue areas, and dynamically adjusts the weight to prioritize healthy areas, thereby reducing the interference of scars on registration, improving registration reliability, and reducing clinical misjudgments, providing technical support for accurate diagnosis and treatment of retinal diseases.

A method for characterizing aspects of the musculoskeletal system of a subject includes accessing medical images of the subject, which include a plurality of voxels. The method includes segmenting the images to generate a 3D model that identifies at least two groups of the voxels that belong to at least two of a muscle, a tendon, a bone, scar tissue, edema, or fat. Generating a report that characterizes aspects of the musculoskeletal system, including at least two of a dimension of the muscle, a dimension of the tendon, a dimension of the bone, a dimension of the scar tissue, a dimension of the edema, a dimension of the fat, fat infiltration in the muscle, an extent of intra-muscular scar tissue, an extent of intra-muscular edema, an extent of free tendon, a surface area of a junction of the muscle and the tendon, or a density of the bone.

A composition for enhancing scar tissue healing and / or reducing pain and inflammation is disclosed. The composition comprises a first active ingredient including salicylic acid in an anti-microbial topical mixture, and a second active ingredient comprising an admixture of at least two vitamins. The composition is formulated such that the combined action of the topical and vitamin components is effective to promote scar tissue healing and mitigate pain and inflammation.

A method is provided. The method is implemented by a mapping engine. The method includes receiving biometric data of at least a portion of an anatomical structure from at least a catheter and analyzing the biometric data based on an automatic tagging operation, a time weighted local activation time assignment operation, or a discrimination operation. The method also includes determining scar tissue of the portion of the anatomical structure based on the analyzing of the biometric data.