14 results about "Scarring tissue" patented technology

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

Some embodiments are directed to a skin treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat a dermatologic condition such as an epidermal or dermal tissue structure irregularity, cellulite, a stretch mark, a scar, scar-tissue, a hypertrophic scar, an acne scar, etc.

The application provides an engineered exosome loaded with a CD63 transmembrane domain-matrix metalloproteinase fusion protein and a preparation method and application thereof. The engineered exosome is secreted by a genetically engineered mesenchymal stem cell, has a CD63 derived transmembrane domain anchored on the membrane, and has a matrix metalloproteinase (MMP) loaded on the inner side of the membrane. The fusion protein comprises, from N-terminus to C-terminus, a fourth transmembrane domain and a C-terminal cytoplasmic tail of a human CD63 protein, a flexible linker peptide, and a human MMP without a natural signal peptide. The application realizes efficient and directional loading of MMPs by using a natural biological generation path of the exosome, shields the inhibition of MMPs by metalloproteinase tissue inhibitors in a scar tissue by using the membrane of the exosome, realizes specific activation of MMPs in a target cell, degrades abnormally deposited collagen, adjusts the ratio of type I and type III collagens, and plays an anti-fibrosis and anti-scar formation role. The application also provides a preparation method of the engineered exosome and application thereof in preparation of a medicine for preventing or treating pathological scars.

The invention discloses an anti-infection scar-free healing promoting tissue repair material as well as a preparation method and application thereof. The tissue repair material can recover endogenous potential of a wound to the maximum extent, a suitable microenvironment is provided for cell migration and epithelial regeneration, in-vitro experiments verify that a micro electric field generated by the tissue repair material effectively kills bacteria and promotes reprogramming of macrophages, and the tissue repair material shows excellent antibacterial performance and immune regulation performance. In addition, various infectious skin wound animal models all show that the traditional Chinese medicine composition can effectively promote scar-free wound healing through the ways of resisting bacteria, relieving inflammation, promoting collagen regeneration and angiogenesis and the like.

The application discloses a scar softening liquid and a preparation method thereof, and raw materials of the scar softening liquid include the following components in parts by weight: cassia twig 18-36 parts, white peony root 18-36 parts, rhubarb 18-36 parts, sophora flavescens 36-72 parts, zanthoxylum 36-72 parts, wormwood leaf 36-72 parts, cortex meliae 12-24 parts and fried tribulus terrestris 12-24 parts. The scar softening liquid is prepared by using Chinese herbal medicines as raw materials, can be used by external application, and can improve the scar hyperplasia by using the external treatment method of traditional Chinese medicine; when used by external application, the Chinese herbal medicines can penetrate into scar tissues to inhibit the scar hyperplasia, and then promote the scar softening and dispersion, and efficiently treat and inhibit the occurrence and development of the scar. The scar softening liquid is non-toxic, non-irritating, mild to the skin, brown, has moderate viscosity, and has no residue after wiping.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The application discloses a kind of gallium phytate-tranilast-PLGA nano suspension and preparation method thereof.It includes the following steps: under stirring condition, organic phase is added dropwise into aqueous phase, ultrasonic mixing, solvent removal;Organic phase is the mixed solution containing tranilast and PLGA;The concentration of tranilast in organic phase is 0.5g / L-2.5g / L, and the concentration of PLGA is 5g / L-25g / L;Aqueous phase is the mixed solution containing gallium phytate and polyvinyl alcohol;The volume ratio of organic phase and aqueous phase is 1:2-1:6.The gallium phytate-tranilast-PLGA nano suspension of the application, nanoparticle morphology is uniform, and has high encapsulation efficiency, high drug loading, good stability;In vitro sustained-release effect is good, and the gallium phytate loaded can effectively play antibacterial role, and tranilast can inhibit scar tissue proliferation, and lay important key foundation for subsequent development of stent surface functional coating.

The application belongs to the technical field of biological medicine, and discloses soluble microneedles for treating hyperplastic scars, and a preparation method and application thereof. The hyaluronic acid is modified to obtain sulfonated hyaluronic acid, which is blended with natural penetration enhancer dextro-borneol having anti-inflammatory activity, rotary evaporated and freeze-dried to obtain a sulfonated hyaluronic acid-dextro-borneol solid dispersion, and then the solid dispersion is loaded into the microneedles to obtain the soluble microneedles having the function of treating hyperplastic scars. The method improves the bioavailability and biocompatibility of dextro-borneol, and the dextro-borneol is loaded into the microneedles, so that the anti-inflammatory and migration inhibition of fibroblasts of the solid dispersion can be maximized, and the microneedles and dextro-borneol can penetrate the dense scar tissue to achieve the purpose of deep drug delivery under the double penetration of the microneedles and dextro-borneol. The application provides a safe and efficient novel transdermal drug delivery system for treating hyperplastic scars, and has a wide clinical application prospect and market value.

The invention relates to a self-constriction scar patch and a preparation method thereof, and belongs to the technical field of medical materials. The self-constriction scar patch comprises a base material layer, and a bonding layer, a silicone gel layer and an isolating layer which are sequentially arranged on the base material layer, the base material layer is prepared from a self-shrinking polymer through 3D printing, and the bonding layer is formed by a bonding material coated on the base material layer; and the silicone gel layer is formed by silicone gel coated on the bonding layer. Through the shape memory function of the self-constriction polymer of the base material layer, the self-constriction scar paste contracts under body temperature stimulation, mechanical stimulation is applied to scar tissue, effective compression on scars is kept, remodeling of the scar tissue is promoted, and the width and thickness of the scars are reduced; meanwhile, silicone gel is combined, good moisturizing and air permeability are provided, and the treatment effect is better; the base material layer is prepared through 3D printing, personalized customization can be achieved, the fitting degree of the scar patch and the irregular-shaped part is met, and the treatment effect is improved.

The invention discloses application of hydrogel in preparation of an anti-infection and anti-scar repair external preparation for treating and chemotherapy skin wounds, and belongs to the field of biomedical materials. The hydrogel comprises sodium alginate and a copper ion solution, the mass fraction of the copper ion solution is 0.01%-0.05%, and 0.1%-1% of sodium alginate is added into every 100 mL of the copper ion solution according to the mass fraction; the external preparation realizes skin wound infection resistance and scar inhibition after chemotherapy by regulating and controlling the expression of collagen and basement membrane protein in wound tissues. According to the application, bacterial contamination can be effectively inhibited, up-regulation of collagen III and Laminin beta1 is promoted, abnormal hyperplasia of collagen I and collagen VII is inhibited, a soft and regular reticular collagen structure is formed on a wound surface, and HE dyeing shows that dermal fibers are uniform and ordered in direction, and scar tissues are obviously reduced.

Disclosed is a production method of a product that is developed for treatment of hair loss, alopecia areata (pelade or ringworm), androgenetic alopecia (AGA), hair follicle nourishment, scalp nourishment and scar, scar tissue, eczema, acne treatments, for neurodegenerative, inflammatory diseases and for immune modulation purposes (regulation of the immunological response against inflammation of human tissues and fluids, for regeneration purposes). In particular, the disclosed is a method for the production of a chemical-free product with amniotic fluid content, which has been standardized by pooling and then freeze-dried and gamma irradiated (pooled / cocktail and gamma irradiated amnion-OTIA 1.0), that has been developed to be used in the treatment of ailments such as hair loss, alopecia areata (pelade), androgenetic alopecia (AGA), hair follicle nutrition, scalp nourishment, scar, scar tissue, eczema and acne.

The invention relates to the technical field of terahertz biological application, in particular to a method for acting, adjusting and dredging skin capillaries based on a terahertz technology. According to the technical scheme, the method comprises the following steps that low-energy terahertz waves are utilized to periodically irradiate the skin at the scar position, so that the terahertz waves penetrate through the epidermal layer to reach the corium layer and act on water molecules in blood capillaries to accelerate movement, and the blood capillaries are dredged and thickened. According to the invention, scar tissue is irradiated by low-power terahertz waves, dredging and expansion of capillary vessels of a corium layer are promoted, local microcirculation is improved, the action process can be visually monitored through a skin redness reaction, and the action process is sequentially subjected to a gradual stage from local improvement, peripheral integration to scar body fading; and finally, ordered synthesis of collagen and scar repair are realized, and the device has the advantages of non-invasion, no pain and capability of being operated at home.

The application belongs to the technical field of medicine, and particularly relates to an antibacterial hydrogel microneedle based on exosomes and a preparation method and application thereof. The antibacterial hydrogel microneedle comprises a base part and a needle tip part arranged in an array on the base, and the needle tip part comprises the following components by weight: 10-20 parts of methacrylated gelatin, 10-20 parts of polyethylene glycol dipolyacrylate, 0.1-0.5 parts of a photoinitiator, 0.5-1 part of a steviol, 1-3 parts of a mannose erythritol lipid, 0.3-0.5 parts of exosome freeze-dried powder, 0.1-0.5 parts of nano-silver, and 80-90 parts of water. The antibacterial hydrogel microneedle can effectively shorten the wound healing period and significantly inhibit the excessive proliferation of scar tissue.

The application discloses a functional polypeptide for promoting endometrial stem cells to repair clitoral sensitive nerves and application, and belongs to the technical field of stem cell repair. The functional polypeptide is used for modifying endometrial stem cells, Schwann cells and local slow-release gel delivery to realize clitoral sensitive nerve repair. The functional polypeptide can activate Laminin expression and control ECM degradation balance, so as to reduce collagen deposition in scar tissue. The functional polypeptide can also effectively inhibit HOXA1 expression, enhance axon extension capacity and strengthen axon microtubule protein polymerization capacity at a nerve injury site, and significantly improves nerve repair efficiency and functional recovery quality.