47 results about "Scarring tissue" patented technology

Force modulating tissue bridges, and associated applicators, kits and methods are provided. A force modulating tissue bridge can be a medical article for at least partially covering a wound and / or scar tissue. The medical article can include an elastic arch extending over an area, and a medial strut connected to the arch and extending into the area over which the central section extends.

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The invention discloses a functional polypeptide for promoting repair of endometrial stem cells to clitoris sensitive nerves and application, and belongs to the technical field of stem cell repair, the functional polypeptide is used for modifying the endometrial stem cells and Schwann cells through the functional polypeptide, and the clitoris sensitive nerves are repaired in a local slow-release gel delivery mode. The functional polypeptide can activate Laminin expression and regulate and control ECM degradation balance, so that collagen deposition in scar tissues is reduced; in addition, the functional polypeptide can effectively inhibit HOXA1 expression, enhance the axon extension capacity and strengthen the axon microtubulin polymerization capacity of the nerve injury part, and the nerve repair efficiency and the function recovery quality are remarkably improved.

The invention discloses a preparation method and application of a porous GelMA microneedle for delivering AIE molecules based on HSF derived exosome. The preparation method comprises the following steps: S1, preparing TTMN molecules; s2, dispersing DPPC and Chol in chloroform, performing water bath evaporation at 50 DEG C to form a thin film, hydrating the thin film in PBS, incubating to enable DPPC and Chol to form a liposome structure again, and uniformly dispersing TTMN molecules in the liposome structure to obtain TL; s3, extracting an exosome from the HSF cells; s4, loading the TL into the exosome by utilizing an electroporation technology, so as to obtain TE; s5, preparing the GelMA; and S6, mixing the GelMA with the TE, so that the TE is uniformly dispersed in the GelMA to obtain a mixed solution, injecting the mixed solution into a microneedle mold, and irradiating with 405nm laser to obtain the porous GelMA microneedle. According to the invention, high-efficiency treatment of hypertrophic scars is realized, and the system has a remarkable drug delivery effect, an innovative photodynamic therapy, a high-efficiency scar tissue remodeling effect and good biological safety and stability, and has important clinical application value and market prospect.

Some embodiments are directed to a skin treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat a dermatologic condition such as an epidermal or dermal tissue structure irregularity, cellulite, a stretch mark, a scar, scar-tissue, a hypertrophic scar, an acne scar, etc.

Force modulating tissue bridges, and associated applicators, kits and methods are provided. A force modulating tissue bridge can be a medical article for at least partially covering a wound and / or scar tissue. The medical article can include an elastic arch extending over an area, and a medial strut connected to the arch and extending into the area over which the central section extends.

The invention belongs to the technical field of biomedicine, and discloses a soluble microneedle for treating hyperplastic scars as well as a preparation method and application of the soluble microneedle. The preparation method comprises the following steps: modifying hyaluronic acid to obtain sulfonated hyaluronic acid, blending the sulfonated hyaluronic acid with a natural penetration enhancer d-borneol with anti-inflammatory activity, carrying out rotary evaporation and freeze-drying to obtain a sulfonated hyaluronic acid-d-borneol solid dispersion, and loading the solid dispersion into a microneedle to obtain the soluble microneedle with the hyperplastic scar treatment function. The preparation method is simple and easy to operate, and large-scale production can be realized. According to the preparation method, the sulfonated hyaluronic acid and the d-borneol are effectively combined, the bioavailability and biocompatibility of the d-borneol are improved, and the d-borneol is loaded into the microneedle, so that the anti-inflammatory and fibroblast migration inhibition capability of the solid dispersion is maximized, and meanwhile, the anti-inflammatory and fibroblast migration inhibition capability of the solid dispersion can be further improved under the dual permeation promotion of the microneedle and the d-borneol. And the aim of deeply delivering the medicine is fulfilled by penetrating dense scar tissues. The problems that in a traditional scar treatment method, medicine permeability is poor, and the treatment effect is limited are solved, a safe and efficient novel transdermal drug delivery system is provided for treating hyperplastic scars, and wide clinical application prospects and market value are achieved.

Compositions including metformin and their use for inhibiting or treating soft tissue musculoskeletal injuries, such as tendinopathy, and / or treating or inhibiting scar tissue are disclosed.

The application provides an engineered exosome loaded with a CD63 transmembrane domain-matrix metalloproteinase fusion protein and a preparation method and application thereof. The engineered exosome is secreted by a genetically engineered mesenchymal stem cell, has a CD63 derived transmembrane domain anchored on the membrane, and has a matrix metalloproteinase (MMP) loaded on the inner side of the membrane. The fusion protein comprises, from N-terminus to C-terminus, a fourth transmembrane domain and a C-terminal cytoplasmic tail of a human CD63 protein, a flexible linker peptide, and a human MMP without a natural signal peptide. The application realizes efficient and directional loading of MMPs by using a natural biological generation path of the exosome, shields the inhibition of MMPs by metalloproteinase tissue inhibitors in a scar tissue by using the membrane of the exosome, realizes specific activation of MMPs in a target cell, degrades abnormally deposited collagen, adjusts the ratio of type I and type III collagens, and plays an anti-fibrosis and anti-scar formation role. The application also provides a preparation method of the engineered exosome and application thereof in preparation of a medicine for preventing or treating pathological scars.

The invention provides a nanofiber composite membrane as well as a preparation method and application thereof. The nanofiber composite membrane comprises an oriented fiber membrane, a non-woven supporting membrane and a non-woven fiber membrane which are sequentially stacked. The nanofiber composite membrane provided by the invention can realize step-by-step and slow degradation matched with a nerve repair process through different degradation speeds and performances of different materials, and the nanofiber composite membrane presents different micro-pore structures at different time stages; the requirements on tissues and nutrient substances in each stage of nerve repair can be met, and scar tissues cannot be formed at the nerve anastomosis broken end during use.

The invention discloses an anti-infection scar-free healing promoting tissue repair material as well as a preparation method and application thereof. The tissue repair material can recover endogenous potential of a wound to the maximum extent, a suitable microenvironment is provided for cell migration and epithelial regeneration, in-vitro experiments verify that a micro electric field generated by the tissue repair material effectively kills bacteria and promotes reprogramming of macrophages, and the tissue repair material shows excellent antibacterial performance and immune regulation performance. In addition, various infectious skin wound animal models all show that the traditional Chinese medicine composition can effectively promote scar-free wound healing through the ways of resisting bacteria, relieving inflammation, promoting collagen regeneration and angiogenesis and the like.

The invention discloses a hydrogel material as well as a preparation method and application thereof, and belongs to the field of preparation of tissue engineering scaffolds. According to the technical scheme, the preparation method comprises the following steps: putting alginate hydrogel into a dopamine solution to prepare PDA-SA hydrogel, and putting the PDA-SA hydrogel into an expanded graphene dispersion to prepare the GR-PDA-SA hydrogel. The preparation method is applied to the aspect of conductive heart patches, and has the characteristics that the photothermal effect and the conductivity are achieved, the shape of the stent can be changed from a flat structure to an arch structure under near-infrared irradiation, and the adhesion of the stent on heart scar tissues can be well promoted.

The application discloses a scar softening liquid and a preparation method thereof, and raw materials of the scar softening liquid include the following components in parts by weight: cassia twig 18-36 parts, white peony root 18-36 parts, rhubarb 18-36 parts, sophora flavescens 36-72 parts, zanthoxylum 36-72 parts, wormwood leaf 36-72 parts, cortex meliae 12-24 parts and fried tribulus terrestris 12-24 parts. The scar softening liquid is prepared by using Chinese herbal medicines as raw materials, can be used by external application, and can improve the scar hyperplasia by using the external treatment method of traditional Chinese medicine; when used by external application, the Chinese herbal medicines can penetrate into scar tissues to inhibit the scar hyperplasia, and then promote the scar softening and dispersion, and efficiently treat and inhibit the occurrence and development of the scar. The scar softening liquid is non-toxic, non-irritating, mild to the skin, brown, has moderate viscosity, and has no residue after wiping.

The invention provides a drainage disc with a shape memory surface pattern, a preparation method and a drainage valve, and relates to the technical field of medical devices for eyes, the drainage disc is made of shape memory polymer, the drainage disc has an initial shape and a temporary shape, the initial shape comprises a groove structure facing the direction of the eyes, and the temporary shape comprises a groove structure facing the direction of the eyes. The temporary shape comprises a flat structure, the temporary shape is configured to be converted into the initial shape from the flat structure under temperature stimulation, and the cell surface morphology of the eye is restrained through the groove structure. The drainage disc is made of the shape memory polymer material, the drainage disc made of the shape memory polymer material recovers to the initial shape under temperature stimulation, the drainage disc with the groove structure is formed, the groove structure generates surface appearance constraint on eye cells, formation of scar tissue is reduced, and therefore the eye cells can be effectively protected. And the operation success rate of implanting the glaucoma drainage device is improved.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The present invention relates to a composition based on ethanolic extract of Brassica olearacea var. capitata leaves, anhydrous lanolin and castor oil, for the treatment of burns and their complications, such as infections. Emulsions made from ethanolic extract of Brassica olearacea var. capitata leaves, anhydrous lanolin and castor oil in semi-solid formulations such as creams and ointments, with 10% and 20% w / v of Brassica extract, can be used as healing agents, accelerating closure of the skin area damaged by up to 3rd degree burns, inducing the production of protective enzymes as well as the proliferation of cells and blood vessels, modulating the production of matrix components and stimulating the formation of strong scar tissue, while having no side effects due to their lack of toxicity.

The invention relates to an ALG-RGD-CS hydrogel dressing and a preparation method thereof, and the ALG-RGD-CS hydrogel dressing is a three-dimensional space active composite hydrogel dressing constructed by taking chitosan-sodium alginate as a basic skeleton and crosslinking RGD peptide into the basic skeleton under the action of a cross-linking agent genipin. Through the synergistic effect of the genipin cross-linking agent, the RGD peptide, the chitosan and the sodium alginate, the composite hydrogel dressing which is excellent in mechanical strength, excellent in healing effect and extremely stable in space structure is constructed, and the composite hydrogel dressing is particularly suitable for treatment of skin superficial layer wounds and can effectively promote wound healing and reduce formation of regenerated scar tissues.

Compositions including metformin and their use for inhibiting or treating soft tissue musculoskeletal injuries, such as tendinopathy, and / or treating or inhibiting scar tissue are disclosed.

The invention discloses an external Tibetan medicine ointment formula for treating burns, a preparation method and application, and belongs to the technical field of burn medicine preparation, the external Tibetan medicine ointment formula comprises the following raw materials by weight: 16.7-20.8 parts of lithospermum, 2.1-2.5 parts of saffron crocus, 5.5-7.6 parts of artificial bear gall powder, 1.5-3.0 parts of artificial musk, and 48-62 parts of a medicine carrier. The external Tibetan medicine ointment prepared by the invention can promote cell regeneration and promote wound healing. After treatment, the VSS score and the VAS score are low, formation of scar tissue can be effectively reduced, and the traditional Chinese medicine composition has good antibacterial and anti-inflammatory effects and can effectively relieve itching. Meanwhile, after treatment, the levels of IL-6 and IL-8 are low, and the level of inflammatory factors can be effectively reduced. The untoward effect occurrence rate of the external Tibetan medicine ointment prepared by the invention is not greatly different from that of commercially available medicines, and the safety risk is low.

The application discloses a kind of gallium phytate-tranilast-PLGA nano suspension and preparation method thereof.It includes the following steps: under stirring condition, organic phase is added dropwise into aqueous phase, ultrasonic mixing, solvent removal;Organic phase is the mixed solution containing tranilast and PLGA;The concentration of tranilast in organic phase is 0.5g / L-2.5g / L, and the concentration of PLGA is 5g / L-25g / L;Aqueous phase is the mixed solution containing gallium phytate and polyvinyl alcohol;The volume ratio of organic phase and aqueous phase is 1:2-1:6.The gallium phytate-tranilast-PLGA nano suspension of the application, nanoparticle morphology is uniform, and has high encapsulation efficiency, high drug loading, good stability;In vitro sustained-release effect is good, and the gallium phytate loaded can effectively play antibacterial role, and tranilast can inhibit scar tissue proliferation, and lay important key foundation for subsequent development of stent surface functional coating.

The application belongs to the technical field of biological medicine, and discloses soluble microneedles for treating hyperplastic scars, and a preparation method and application thereof. The hyaluronic acid is modified to obtain sulfonated hyaluronic acid, which is blended with natural penetration enhancer dextro-borneol having anti-inflammatory activity, rotary evaporated and freeze-dried to obtain a sulfonated hyaluronic acid-dextro-borneol solid dispersion, and then the solid dispersion is loaded into the microneedles to obtain the soluble microneedles having the function of treating hyperplastic scars. The method improves the bioavailability and biocompatibility of dextro-borneol, and the dextro-borneol is loaded into the microneedles, so that the anti-inflammatory and migration inhibition of fibroblasts of the solid dispersion can be maximized, and the microneedles and dextro-borneol can penetrate the dense scar tissue to achieve the purpose of deep drug delivery under the double penetration of the microneedles and dextro-borneol. The application provides a safe and efficient novel transdermal drug delivery system for treating hyperplastic scars, and has a wide clinical application prospect and market value.

The invention relates to a self-constriction scar patch and a preparation method thereof, and belongs to the technical field of medical materials. The self-constriction scar patch comprises a base material layer, and a bonding layer, a silicone gel layer and an isolating layer which are sequentially arranged on the base material layer, the base material layer is prepared from a self-shrinking polymer through 3D printing, and the bonding layer is formed by a bonding material coated on the base material layer; and the silicone gel layer is formed by silicone gel coated on the bonding layer. Through the shape memory function of the self-constriction polymer of the base material layer, the self-constriction scar paste contracts under body temperature stimulation, mechanical stimulation is applied to scar tissue, effective compression on scars is kept, remodeling of the scar tissue is promoted, and the width and thickness of the scars are reduced; meanwhile, silicone gel is combined, good moisturizing and air permeability are provided, and the treatment effect is better; the base material layer is prepared through 3D printing, personalized customization can be achieved, the fitting degree of the scar patch and the irregular-shaped part is met, and the treatment effect is improved.

The invention provides a nuclide microneedle patch for treating scars and a preparation method of the nuclide microneedle patch. A needle body part of the microneedle patch comprises metal nuclides and DOTA molecules with photo-crosslinking activity, the DOTA molecules with photo-crosslinking activity are chelated with the metal nuclides and then can be prepared into the nuclide microneedle patch through ultraviolet light crosslinking curing, and the metal nuclides are uniformly distributed in the needle body. The nuclide microneedle patch can be directly adhered to a body surface scar part, metal nuclide is delivered into scar tissue cells for radiotherapy, the penetrating power of the metal nuclide to scars is improved, and the metal nuclide cannot be left in scar tissues after radiotherapy is finished. The nuclide microneedle patch provided by the invention is high in universality and good in stability, a new direction is provided for treating scars, and meanwhile, the uptake probability of normal tissues and organs to the metal nuclide is extremely low or almost no uptake.

The invention discloses application of hydrogel in preparation of an anti-infection and anti-scar repair external preparation for treating and chemotherapy skin wounds, and belongs to the field of biomedical materials. The hydrogel comprises sodium alginate and a copper ion solution, the mass fraction of the copper ion solution is 0.01%-0.05%, and 0.1%-1% of sodium alginate is added into every 100 mL of the copper ion solution according to the mass fraction; the external preparation realizes skin wound infection resistance and scar inhibition after chemotherapy by regulating and controlling the expression of collagen and basement membrane protein in wound tissues. According to the application, bacterial contamination can be effectively inhibited, up-regulation of collagen III and Laminin beta1 is promoted, abnormal hyperplasia of collagen I and collagen VII is inhibited, a soft and regular reticular collagen structure is formed on a wound surface, and HE dyeing shows that dermal fibers are uniform and ordered in direction, and scar tissues are obviously reduced.

The present invention proposes a scar auxiliary inspection tool based on multivariate fusion analysis of collagen fibers, which is used to fuse and analyze the multivariate structural characteristics of scar tissue collagen fibers, establish a multi-parameter scar auxiliary inspection model to automatically perform scar detection and analysis. The tool can perform multivariate fusion analysis on scar tissue collagen fiber images to obtain multivariate structural parameters such as fiber orientation, fiber curvature, fiber direction variance, and fiber local density. Based on these parameters, a scar detection model is established, which can automatically perform scar detection and analysis. This method can process and analyze collagen fiber images obtained by various optical microscopy techniques, providing multidimensional and mutually complementary collagen fiber structural information, and can more comprehensively analyze the morphological characteristics of collagen fibers and scar tissue. It has the advantages of being fast, highly precise, non-invasive, simple, and highly applicable.

A traditional Chinese medicine composition for treating burns and scalds, prepared from radix seu herba cirsii chlorolepis and radix ampelopsis delavayanae according to a certain combination. Said composition has the following effects: pain relieving: within fifteen minutes, relieving pain or even making pain disappeared; astringing: stopping exudation of tissue fluid within two hours; bacteriostasis: for newly generated burns and scalds or wounds having been festered for several months, enabling all the wound surfaces to be gradually healed and necrotic tissue to scab and fall off following the using of the composition; and tissue regeneration: avoiding skin grafting for patients with burns and scalds, and avoiding the generation of scar tissue, thus greatly reducing the disability rate of patients.

Disclosed is a production method of a product that is developed for treatment of hair loss, alopecia areata (pelade or ringworm), androgenetic alopecia (AGA), hair follicle nourishment, scalp nourishment and scar, scar tissue, eczema, acne treatments, for neurodegenerative, inflammatory diseases and for immune modulation purposes (regulation of the immunological response against inflammation of human tissues and fluids, for regeneration purposes). In particular, the disclosed is a method for the production of a chemical-free product with amniotic fluid content, which has been standardized by pooling and then freeze-dried and gamma irradiated (pooled / cocktail and gamma irradiated amnion-OTIA 1.0), that has been developed to be used in the treatment of ailments such as hair loss, alopecia areata (pelade), androgenetic alopecia (AGA), hair follicle nutrition, scalp nourishment, scar, scar tissue, eczema and acne.

Compounds, compositions, combined preparations, and multiple-dose formulations, for use in the treatment of tissue damage or injury, in particular, for example, spinal cord injury and tendon injury, a

The invention relates to the technical field of terahertz biological application, in particular to a method for acting, adjusting and dredging skin capillaries based on a terahertz technology. According to the technical scheme, the method comprises the following steps that low-energy terahertz waves are utilized to periodically irradiate the skin at the scar position, so that the terahertz waves penetrate through the epidermal layer to reach the corium layer and act on water molecules in blood capillaries to accelerate movement, and the blood capillaries are dredged and thickened. According to the invention, scar tissue is irradiated by low-power terahertz waves, dredging and expansion of capillary vessels of a corium layer are promoted, local microcirculation is improved, the action process can be visually monitored through a skin redness reaction, and the action process is sequentially subjected to a gradual stage from local improvement, peripheral integration to scar body fading; and finally, ordered synthesis of collagen and scar repair are realized, and the device has the advantages of non-invasion, no pain and capability of being operated at home.

The invention belongs to the technical field of biological medicines, and particularly relates to application of divalent metal lactate in a product for promoting tissue regeneration, growth, healing and damage repair. Preferably, the divalent metal lactate comprises one or a combination of more of calcium lactate, magnesium lactate, zinc lactate and ferrous lactate. The invention provides a new treatment mode for tissue injury and repair, and prevention and treatment of tissue fibrosis and / or scar tissue generation, and has wide application prospects in the aspects of injury treatment and repair of tissues such as skin, connective tissues, tendons, fascia and the like.