24 results about "Scarring tissue" patented technology

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The invention discloses a functional polypeptide for promoting repair of endometrial stem cells to clitoris sensitive nerves and application, and belongs to the technical field of stem cell repair, the functional polypeptide is used for modifying the endometrial stem cells and Schwann cells through the functional polypeptide, and the clitoris sensitive nerves are repaired in a local slow-release gel delivery mode. The functional polypeptide can activate Laminin expression and regulate and control ECM degradation balance, so that collagen deposition in scar tissues is reduced; in addition, the functional polypeptide can effectively inhibit HOXA1 expression, enhance the axon extension capacity and strengthen the axon microtubulin polymerization capacity of the nerve injury part, and the nerve repair efficiency and the function recovery quality are remarkably improved.

Some embodiments are directed to a skin treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat a dermatologic condition such as an epidermal or dermal tissue structure irregularity, cellulite, a stretch mark, a scar, scar-tissue, a hypertrophic scar, an acne scar, etc.

The application provides an engineered exosome loaded with a CD63 transmembrane domain-matrix metalloproteinase fusion protein and a preparation method and application thereof. The engineered exosome is secreted by a genetically engineered mesenchymal stem cell, has a CD63 derived transmembrane domain anchored on the membrane, and has a matrix metalloproteinase (MMP) loaded on the inner side of the membrane. The fusion protein comprises, from N-terminus to C-terminus, a fourth transmembrane domain and a C-terminal cytoplasmic tail of a human CD63 protein, a flexible linker peptide, and a human MMP without a natural signal peptide. The application realizes efficient and directional loading of MMPs by using a natural biological generation path of the exosome, shields the inhibition of MMPs by metalloproteinase tissue inhibitors in a scar tissue by using the membrane of the exosome, realizes specific activation of MMPs in a target cell, degrades abnormally deposited collagen, adjusts the ratio of type I and type III collagens, and plays an anti-fibrosis and anti-scar formation role. The application also provides a preparation method of the engineered exosome and application thereof in preparation of a medicine for preventing or treating pathological scars.

The invention discloses an anti-infection scar-free healing promoting tissue repair material as well as a preparation method and application thereof. The tissue repair material can recover endogenous potential of a wound to the maximum extent, a suitable microenvironment is provided for cell migration and epithelial regeneration, in-vitro experiments verify that a micro electric field generated by the tissue repair material effectively kills bacteria and promotes reprogramming of macrophages, and the tissue repair material shows excellent antibacterial performance and immune regulation performance. In addition, various infectious skin wound animal models all show that the traditional Chinese medicine composition can effectively promote scar-free wound healing through the ways of resisting bacteria, relieving inflammation, promoting collagen regeneration and angiogenesis and the like.

The application discloses a scar softening liquid and a preparation method thereof, and raw materials of the scar softening liquid include the following components in parts by weight: cassia twig 18-36 parts, white peony root 18-36 parts, rhubarb 18-36 parts, sophora flavescens 36-72 parts, zanthoxylum 36-72 parts, wormwood leaf 36-72 parts, cortex meliae 12-24 parts and fried tribulus terrestris 12-24 parts. The scar softening liquid is prepared by using Chinese herbal medicines as raw materials, can be used by external application, and can improve the scar hyperplasia by using the external treatment method of traditional Chinese medicine; when used by external application, the Chinese herbal medicines can penetrate into scar tissues to inhibit the scar hyperplasia, and then promote the scar softening and dispersion, and efficiently treat and inhibit the occurrence and development of the scar. The scar softening liquid is non-toxic, non-irritating, mild to the skin, brown, has moderate viscosity, and has no residue after wiping.

The invention relates to the field of medical implant materials, and particularly discloses an absorbable patch for uterine muscular layer repair and a preparation method of the absorbable patch. The invention discloses an absorbable patch for repairing a uterine muscular layer. The absorbable patch is prepared by mixing 2-9.5 parts of poly (L-lactide-caprolactone) and 0.5-8 parts of a biomedical material, the molecular weight of the poly (L-lactide-caprolactone) is 5 to 30 thousand; the preparation method comprises the following steps: mixing a biomedical material stock solution with a poly (L-lactide-caprolactone) stock solution, performing electrostatic spinning, freeze drying or tape casting treatment, and drying to remove an organic solvent, thereby obtaining the absorbable patch for uterine muscular layer repair. The absorbable patch disclosed by the invention not only can be completely degraded in vivo, but also has a similar extracellular matrix structure, can provide muscle cell repair for an injured part of a uterine muscular layer, avoids scar tissues formed by fibrosis, and reduces the risk caused by a secondary operation required by a uterine scar diverticulum.

The application discloses a kind of gallium phytate-tranilast-PLGA nano suspension and preparation method thereof.It includes the following steps: under stirring condition, organic phase is added dropwise into aqueous phase, ultrasonic mixing, solvent removal;Organic phase is the mixed solution containing tranilast and PLGA;The concentration of tranilast in organic phase is 0.5g / L-2.5g / L, and the concentration of PLGA is 5g / L-25g / L;Aqueous phase is the mixed solution containing gallium phytate and polyvinyl alcohol;The volume ratio of organic phase and aqueous phase is 1:2-1:6.The gallium phytate-tranilast-PLGA nano suspension of the application, nanoparticle morphology is uniform, and has high encapsulation efficiency, high drug loading, good stability;In vitro sustained-release effect is good, and the gallium phytate loaded can effectively play antibacterial role, and tranilast can inhibit scar tissue proliferation, and lay important key foundation for subsequent development of stent surface functional coating.

The application belongs to the technical field of biological medicine, and discloses soluble microneedles for treating hyperplastic scars, and a preparation method and application thereof. The hyaluronic acid is modified to obtain sulfonated hyaluronic acid, which is blended with natural penetration enhancer dextro-borneol having anti-inflammatory activity, rotary evaporated and freeze-dried to obtain a sulfonated hyaluronic acid-dextro-borneol solid dispersion, and then the solid dispersion is loaded into the microneedles to obtain the soluble microneedles having the function of treating hyperplastic scars. The method improves the bioavailability and biocompatibility of dextro-borneol, and the dextro-borneol is loaded into the microneedles, so that the anti-inflammatory and migration inhibition of fibroblasts of the solid dispersion can be maximized, and the microneedles and dextro-borneol can penetrate the dense scar tissue to achieve the purpose of deep drug delivery under the double penetration of the microneedles and dextro-borneol. The application provides a safe and efficient novel transdermal drug delivery system for treating hyperplastic scars, and has a wide clinical application prospect and market value.

The invention relates to a self-constriction scar patch and a preparation method thereof, and belongs to the technical field of medical materials. The self-constriction scar patch comprises a base material layer, and a bonding layer, a silicone gel layer and an isolating layer which are sequentially arranged on the base material layer, the base material layer is prepared from a self-shrinking polymer through 3D printing, and the bonding layer is formed by a bonding material coated on the base material layer; and the silicone gel layer is formed by silicone gel coated on the bonding layer. Through the shape memory function of the self-constriction polymer of the base material layer, the self-constriction scar paste contracts under body temperature stimulation, mechanical stimulation is applied to scar tissue, effective compression on scars is kept, remodeling of the scar tissue is promoted, and the width and thickness of the scars are reduced; meanwhile, silicone gel is combined, good moisturizing and air permeability are provided, and the treatment effect is better; the base material layer is prepared through 3D printing, personalized customization can be achieved, the fitting degree of the scar patch and the irregular-shaped part is met, and the treatment effect is improved.

The invention provides a nuclide microneedle patch for treating scars and a preparation method of the nuclide microneedle patch. A needle body part of the microneedle patch comprises metal nuclides and DOTA molecules with photo-crosslinking activity, the DOTA molecules with photo-crosslinking activity are chelated with the metal nuclides and then can be prepared into the nuclide microneedle patch through ultraviolet light crosslinking curing, and the metal nuclides are uniformly distributed in the needle body. The nuclide microneedle patch can be directly adhered to a body surface scar part, metal nuclide is delivered into scar tissue cells for radiotherapy, the penetrating power of the metal nuclide to scars is improved, and the metal nuclide cannot be left in scar tissues after radiotherapy is finished. The nuclide microneedle patch provided by the invention is high in universality and good in stability, a new direction is provided for treating scars, and meanwhile, the uptake probability of normal tissues and organs to the metal nuclide is extremely low or almost no uptake.

The invention discloses application of hydrogel in preparation of an anti-infection and anti-scar repair external preparation for treating and chemotherapy skin wounds, and belongs to the field of biomedical materials. The hydrogel comprises sodium alginate and a copper ion solution, the mass fraction of the copper ion solution is 0.01%-0.05%, and 0.1%-1% of sodium alginate is added into every 100 mL of the copper ion solution according to the mass fraction; the external preparation realizes skin wound infection resistance and scar inhibition after chemotherapy by regulating and controlling the expression of collagen and basement membrane protein in wound tissues. According to the application, bacterial contamination can be effectively inhibited, up-regulation of collagen III and Laminin beta1 is promoted, abnormal hyperplasia of collagen I and collagen VII is inhibited, a soft and regular reticular collagen structure is formed on a wound surface, and HE dyeing shows that dermal fibers are uniform and ordered in direction, and scar tissues are obviously reduced.

Disclosed is a production method of a product that is developed for treatment of hair loss, alopecia areata (pelade or ringworm), androgenetic alopecia (AGA), hair follicle nourishment, scalp nourishment and scar, scar tissue, eczema, acne treatments, for neurodegenerative, inflammatory diseases and for immune modulation purposes (regulation of the immunological response against inflammation of human tissues and fluids, for regeneration purposes). In particular, the disclosed is a method for the production of a chemical-free product with amniotic fluid content, which has been standardized by pooling and then freeze-dried and gamma irradiated (pooled / cocktail and gamma irradiated amnion-OTIA 1.0), that has been developed to be used in the treatment of ailments such as hair loss, alopecia areata (pelade), androgenetic alopecia (AGA), hair follicle nutrition, scalp nourishment, scar, scar tissue, eczema and acne.

Compounds, compositions, combined preparations, and multiple-dose formulations, for use in the treatment of tissue damage or injury, in particular, for example, spinal cord injury and tendon injury, a

The invention relates to the technical field of terahertz biological application, in particular to a method for acting, adjusting and dredging skin capillaries based on a terahertz technology. According to the technical scheme, the method comprises the following steps that low-energy terahertz waves are utilized to periodically irradiate the skin at the scar position, so that the terahertz waves penetrate through the epidermal layer to reach the corium layer and act on water molecules in blood capillaries to accelerate movement, and the blood capillaries are dredged and thickened. According to the invention, scar tissue is irradiated by low-power terahertz waves, dredging and expansion of capillary vessels of a corium layer are promoted, local microcirculation is improved, the action process can be visually monitored through a skin redness reaction, and the action process is sequentially subjected to a gradual stage from local improvement, peripheral integration to scar body fading; and finally, ordered synthesis of collagen and scar repair are realized, and the device has the advantages of non-invasion, no pain and capability of being operated at home.

The invention belongs to the technical field of biological medicines, and particularly relates to application of divalent metal lactate in a product for promoting tissue regeneration, growth, healing and damage repair. Preferably, the divalent metal lactate comprises one or a combination of more of calcium lactate, magnesium lactate, zinc lactate and ferrous lactate. The invention provides a new treatment mode for tissue injury and repair, and prevention and treatment of tissue fibrosis and / or scar tissue generation, and has wide application prospects in the aspects of injury treatment and repair of tissues such as skin, connective tissues, tendons, fascia and the like.

The application belongs to the technical field of medicine, and particularly relates to an antibacterial hydrogel microneedle based on exosomes and a preparation method and application thereof. The antibacterial hydrogel microneedle comprises a base part and a needle tip part arranged in an array on the base, and the needle tip part comprises the following components by weight: 10-20 parts of methacrylated gelatin, 10-20 parts of polyethylene glycol dipolyacrylate, 0.1-0.5 parts of a photoinitiator, 0.5-1 part of a steviol, 1-3 parts of a mannose erythritol lipid, 0.3-0.5 parts of exosome freeze-dried powder, 0.1-0.5 parts of nano-silver, and 80-90 parts of water. The antibacterial hydrogel microneedle can effectively shorten the wound healing period and significantly inhibit the excessive proliferation of scar tissue.

The present invention belongs to the field of biomedicine and specifically relates to the use of divalent metal lactates in products that promote tissue regeneration, growth, healing, and injury repair. Preferably, the divalent metal lactate comprises a combination of one or more of calcium lactate, magnesium lactate, zinc lactate, and ferrous lactate. The present invention provides a new treatment for tissue injury and repair, as well as for the prevention and treatment of tissue fibrosis and / or scar tissue formation. It has broad application prospects in the treatment and repair of injuries to tissues such as skin, connective tissue, tendons, and fascia.

The application discloses a traditional Chinese medicine for treating scars, which comprises the following components in terms of weight: white chrysanthemum 10-15 parts, canty caterpillar fungus 8-12 parts, clove 20-30 parts, peach kernel 4-8 parts, soapberry 3-5 parts, dandelion 20-40 parts, schizonepeta 6-8 parts, salvia miltiorrhiza 8-12 parts, rhubarb 3-5 parts and licorice 6-10 parts. The application can obviously improve superficial scars and hypertrophic scars within one month, soften scar tissues, promote epithelialization of scar tissues and normalization of skin gland tissue secretion, disperse local melanocyte aggregation, and increase skin gloss and skin elasticity.

A prosthetic liner having a cylindrical or conical body with an open proximal end, a closed distal end, a posterior face, an anterior face, an internal thermoplastic elastomeric layer, and an external fabric layer, with a support material attached to the anterior face and a plurality of interior surface modifications on the internal thermoplastic elastomeric layer with the option of including at least one channel for wicking. The liner may be a locking or cushion liner. Also, the support material may be attached to the distal end of the liner inside of an enclosed pocket or inside of an open pocket attached to the exterior fabric layer. The support material is preferably a foam the foam selected from the group consisting of ethyl vinyl acetate, polyethylene, neoprene, ethylene propylene diene terpolymer, vinyl, silicone, and urethane. These liners allow for a bulbous formation at the distal end of a residual limb to give comfort to a user who may have a traumatic injury, scar tissue buildup, or simply seeking further comfort.

An embodiment includes therapeutic compositions that include a hydrogel medium and a plurality of tissue segments dispersed within the medium. The hydrogel medium preserves and stores the tissue through processing, transport, and storage. The embodiment addresses an identified problem of preserving a tissue, whether such tissue is fresh, cryopreserved, or sterile. The therapeutic compositions may be placed on or within the body to cover and protect wounds, provide a scaffold for reconstruction, repair, or replacement, and reduce surgical complications as a result of inflammation and scar tissue formation. Other embodiments are described herein.

Methods of using inhibitors of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) for treating heart disease are provided. In addition, methods are provided for screening candidate agents for inhibition of CTLA-4 and effectiveness of candidate inhibitors of CTLA-4 in improving cardiac function, decreasing or preventing damage to the heart, including reducing chamber dilatation, ventricular remodeling, and / or amount of fibrotic scar tissue, and increasing survival.

The application discloses a functional polypeptide for promoting endometrial stem cells to repair clitoral sensitive nerves and application, and belongs to the technical field of stem cell repair. The functional polypeptide is used for modifying endometrial stem cells, Schwann cells and local slow-release gel delivery to realize clitoral sensitive nerve repair. The functional polypeptide can activate Laminin expression and control ECM degradation balance, so as to reduce collagen deposition in scar tissue. The functional polypeptide can also effectively inhibit HOXA1 expression, enhance axon extension capacity and strengthen axon microtubule protein polymerization capacity at a nerve injury site, and significantly improves nerve repair efficiency and functional recovery quality.

Medical applications for the devices disclosed in this patent include reducing wrinkles, acne, scar tissue, warts, and brown spots, as well as cauterizing wounds, promoting wound healing and relieving chronic joint pain in knees, shoulders, elbow, and hands. The devices disclosed in this patent all use the same semiconductor device where the device is packaged to create low cost, compact, portable and handheld medical devices for the applications described herein.