705results about "Radioactive preparation forms" patented technology

The invention provides a radionuclide-labeled PDL1 targeting small protein as well as a preparation method and application thereof. Specifically, the invention provides a radionuclide-labeled PD-L1 targeted small protein probe and a preparation method thereof, and the radionuclide-labeled PD-L1 targeted small protein probe is used for diagnosis of malignant tumors, accurate positioning of focuses, curative effect monitoring and radioimmunotherapy. The small protein conjugate provided by the invention can be prepared by labeling in a temperature range from room temperature to 60 DEG C, and compared with other nuclides or linkers, the coupling efficiency is higher, and the finished product is more stable.

The present disclosure generally relates to materials, processes, generators, and / or systems, for generating radioisotope. The present disclosure also generally relates to ceramic materials comprising radioisotope suitable for use in a radioisotope generator. The present disclosure also generally relates to processes, generators and / or systems, for producing and capturing radioisotope. The present disclosure also generally relates to the preparation of radioisotope solutions for use in radiopharmacy and / or other clinical applications.

The present invention discloses a medical microsphere and its preparation method and application. The medical microsphere includes phenolic resin microspheres and radioactive metal elements loaded on the phenolic resin microspheres; the average particle size of the phenolic resin microspheres is 1 to 150 μm. The medical microsphere in the present invention can not only achieve local cell killing in the blood vessels of a specific part, but also effectively avoid the occurrence of fragmentation; further, the medical microsphere has a good loading rate and an extremely low exudation loss rate, which can meet the loading and safety requirements of radioactive elements; in addition, the preparation method of the medical microsphere is simple.

The invention discloses a metal polyphenol network modified drug-loaded radioactive microsphere as well as a preparation method and application thereof, radionuclides are labeled on different microspheres by a precipitation method or an adsorption method, and the metal polyphenol network is modified on the surface of the radioactive microsphere to improve the nuclide labeling stability and the synchronous drug loading capability of the radioactive microsphere. Subsequently, medicine molecules can be adsorbed to the modified radioactive microspheres to obtain the metal polyphenol network modified medicine-carrying radioactive microspheres. The metal polyphenol network modified drug-loaded radioactive microspheres prepared by the invention can solve the problems of radionuclide non-target shedding and DNA damage repair caused by nuclear drugs, avoid secondary drug administration, ensure that drugs directly and accurately reach tumor targets, and improve the drug delivery efficiency. And the selective internal irradiation therapy based on radioactive microsphere mediation is further promoted to play a more effective tumor treatment effect.

The invention discloses a lung deep targeted delivery method and a micro-robot cluster, and the method comprises the following steps: preparing microgel particles containing magnetic particles, developing particles and cargos, and combining the prepared microgel particles to obtain the micro-robot cluster; the micro-robot cluster is controlled to move, climb and reconstruct in a non-fluid environment, so that the micro-robot cluster moves in a pipeline environment with holes; controlling the micro-robot cluster to move in the lung sample under the guidance of X-rays, and delivering the micro-robot cluster to a target bronchus of the lung sample; or the micro-robot cluster is controlled to be delivered in the target lung under the guidance of computed tomography imaging, and the wrapped goods are released in the target bronchus; the micro robot cluster provided by the invention can realize targeted delivery in a lung environment full of air, a lung environment with a mucus layer and a lung deep target bronchus.

The invention discloses a radionuclide-labeled polymer as well as a preparation method and application thereof. Specifically, the invention provides a radionuclide labeled polymer which has the following structure: G-L1-L2-P, wherein G is a radionuclide-containing group and comprises a chelating group and a radionuclide, the chelating group is chelated with the radionuclide, and L1 and L2 are independently chemical bonds or linking groups; p is a temperature-sensitive structural unit. The radionuclide-labeled polymer can be used as a tracer of hydrogel, can be combined with the hydrogel under the condition that the property of the hydrogel is not changed, has good compatibility and stability, and further can be used for tracing implanted hydrogel and continuously tracking the position and state of the implanted hydrogel in real time.

The invention discloses a preparation method of a 32P-loaded ultrathin flaky chitosan hydrogel applicator. The preparation method comprises the following steps: (1) preparing a chitosan aqueous solution; (2) dropwise adding methacrylic anhydride into the chitosan aqueous solution for reaction to obtain methylacryloylated chitosan; (3) preparing a methylacryloyl chitosan aqueous solution; (4) adding 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone into the methylacryloylated chitosan aqueous solution to obtain a chitosan hydrogel precursor solution, and (5) coating the inner wall of a mold made of a polytetrafluoroethylene material with a super-hydrophilic coating; (6) adding the Na2H32PO4 aqueous solution and the chitosan hydrogel precursor solution into a mold, stirring, and carrying out illumination curing; and (7) taking out the cured hydrogel and packaging the hydrogel between two layers of transparent adhesive tapes. According to the application, the ultrathin hydrogel applicator can be prepared, so that the blocking of the hydrogel material to rays is reduced, and the curative effect of the applicator is enhanced.

Methods and compositions for inducing long-term tolerance by hybrid nanoparticles are provided. Compositions and formulations comprising hybrid nanoparticles with inherent affinity for innate immune cells are provided.

The invention provides a preparation method of Al18F tracer integrated freeze-dried powder, a kit and application thereof, and the preparation method comprises the following steps: dissolving 1-10 mg of a precursor by using deionized water, adding a pH buffer solution with the concentration of 0.2-0.5 M and an AlCl3 solution with the concentration of 10 mM, with the ratio of the amount of substance of AlCl3 to the amount of substance of the precursor being 0.8-1.0, then continuously adding a stabilizer solution with the concentration of 0.5 M and 1-4 mg of an excipient, and uniformly stirring to obtain the Al18F tracer integrated freeze-dried powder. And finally, adding deionized water to enable the concentration of the precursor to be 0.5-1.0 mM, uniformly mixing the solution, sub-packaging the solution into 1.5 mL cryopreservation tubes or 2 mL penicillin bottles according to a certain volume, and then putting the cryopreservation tubes or the penicillin bottles into a vacuum freeze dryer to remove water at a low temperature to obtain powder or freeze-dried cakes, and the container is a freeze-dried powder / cake storage container and is used for storing the freeze-dried powder / cakes. Meanwhile, the reaction container is also used during radioactive labeling.

Disclosed herein are methods and systems for the use of extraction chromatography resins to concentrate Ac from dilute solutions that may contain Th isotopes and / or other isotopes, such as Ra. As disclosed herein, at least some extraction chromatography resins strongly retain trivalent actinides between 4 and 6 M HNO3 that can be recovered in good yields with small volumes of dilute acids. These small volumes of acid eluents result in significant concentration of the solution of the trivalent / certain tetravalent ions, such that they can be further processed without requiring lengthy evaporation steps that are utilized in standard Ac concentration methods.

The invention belongs to the field of tumor drugs, and discloses a radioactive hydrogel based on crosslinking of sodium alginate and metal ions and a preparation method and application thereof.The preparation method of the radioactive hydrogel comprises the following steps that lutetium chloride and metal ions are mixed, and a metal ion mixed solution is obtained; doping 177Lu radioactive isotope into the obtained metal ion mixed solution to obtain a metal ion cross-linking agent; and injecting a metal ion cross-linking agent into the sodium alginate solution under a vortex condition, centrifuging, and discarding the supernatant to obtain the radioactive hydrogel. The radioactive hydrogel (177Lu-RH) provided by the invention has good in-tumor colonization capability, can be directly injected into a tumor to realize local radiotherapy, has good radioactive stability, and can be stably retained at a tumor part for more than 120 hours, so that the stability of radioactive labeling in a treatment process is ensured.

The invention provides a multifunctional microsphere for tumor chemoradiotherapy embolism treatment and imaging and a preparation method and application thereof.According to the multifunctional microsphere, a polylactic acid-glycolic acid copolymer serves as a framework material, a small molecule medicine is entrapped in the multifunctional microsphere, and surface modification and radionuclide labeling are conducted at the same time; the small molecular medicine is prepared from one or more of icaritin, icariin, lecimod, imiquimod, motod, visamod and tilamod, and preferably, the icaritin and the lecimod are selected; the surface modification is performed by adopting tyramine or tyrosine polypeptide; the radionuclides include 123I, 125I, and 131 I, preferably 131 I. The preparation process and equipment of the multifunctional microsphere are simple, the cost is low, chemotherapy drugs and immunologic adjuvants are entrapped at the same time, radionuclides are marked, hepatic artery embolism treatment, 131I long-term local nuclide treatment and combined treatment of local chemotherapy and immunoregulation are achieved, and meanwhile the SPECT / CT imaging in-vivo tracing function of the multifunctional microsphere is achieved.

The present invention relates to polymeric radiotherapeutic particles, compositions and methods for producing same, wherein the radionuclide is an alpha and / or beta-emitting radionuclide. The invention also relates to the use of said particle and compositions, in the treatment of cancer and their use in locoregional radiotherapy, brachytherapy and transarterial radioembolization.

A radioactive thermogel suspension, including a thermogel and a plurality of insoluble radioactive isotope phosphate particles, such as yttrium phosphate, suspended in the thermogel. The thermogel is PLGA-g-PEG. The thermogel contains less than 65 ppm stannous octanoate. The plurality of radioactive yttrium phosphate particles are between 0.03 μm and 10 μm in diameter. The plurality of radioactive yttrium phosphate particles are generally spherical. The YPO4 particle concentration is in the range of 3 mg / ml to 100 mg / ml.

The invention relates to the technical field of radiopharmaceutical preparations, in particular to yttrium [90Y] microsphere injection as well as a preparation method and application thereof. The preparation method of the yttrium [90Y] microsphere injection comprises the following steps: S1, uniformly mixing a radioactive stock solution and an yttrium sulfate solution, stirring and mixing with resin microspheres, and washing to obtain yttrium [90Y] microspheres; s2, stirring and mixing a sodium phosphate solution and the yttrium [90Y] microspheres, taking out 1 / 3 volume of clear liquid, carrying out suction filtration on the residual clear liquid, and mixing the taken clear liquid with the yttrium [90Y] microspheres to obtain mixed liquid; and S3, stirring and mixing the sodium dihydrogen phosphate solution and the mixed liquid, taking out 4 / 10 volume of clear liquid, carrying out suction filtration on the residual clear liquid, mixing the taken clear liquid with yttrium [90Y] microspheres, washing, filling and sealing, and sterilizing to obtain the yttrium [90Y] microsphere injection. The labeling rate of yttrium [90Y] in the produced yttrium [90Y] microsphere injection is high.

The invention relates to preparation and application of a tumor radiotherapy embolism microsphere preparation capable of achieving CT imaging tracing. The microsphere is prepared by taking a polyvinyl alcohol derivative as a framework material, polymerizing, cross-linking and curing the polyvinyl alcohol derivative and an N-(aminoalkyl) methacrylamide hydrochloride monomer, and further covalently connecting a metal chelating agent and a CT imaging agent 2, 3, 5-triiodobenzaldehyde. The microsphere can mark radionuclides 111ln, 68Ga, Al18F, 64Cu, 177Lu and 90Y, embolism treatment and radionuclide internal irradiation treatment are combined, meanwhile, the microsphere CT tracing function is beneficial to monitoring the distribution condition of the microsphere in real time, and ectopic embolism is reduced.

A method of generating an emulsion for treating a patient. The method includes generating a water-based solution carrying an agent which turns into a hydrogel by addition of calcium ions. Radium radionuclides are added to the water-based solution in a concentration sufficient for radiotherapy. After adding the radium to the water-based solution, the water-based solution is mixed with an emulsifier and an oil.

The present application relates to the technical field of radiopharmaceutical preparation, specifically relates to an yttrium [90Y] microsphere and preparation method therefor and use thereof. The yttrium [90Y] microsphere comprises a polystyrene sulfonic acid type resin microsphere and yttrium-90 adsorbed within the polystyrene sulfonic acid type resin microsphere. The use of polystyrene sulfonic acid type resin microsphere to adsorb yttrium-90 has significantly improved adsorption strength, significantly improved safety during preparation and use, and has a good killing effect on tumor cells.

The present invention relates to an isolated cellular targeted delivery system comprising a CD45+ leukocyte cell comprising within said cell a complex of one or more iron binding proteins and / or a label as well as methods for producing such isolated cellular targeted delivery system and uses of such system for therapy diagnosis and in particular for diagnosis of cancer, particularly metastatic cancer, in particular for therapy of cancer.

The present disclosure relates to enriched and stable radiopharmaceutical compositions comprising [225Ac]Ac-DOTA-TATE.

The present disclosure relates to stable compositions comprising a radiolabeled compound, and related pharmaceutical compositions and methods of manufacture. Such compositions are useful in both the diagnostic imaging of and the treatment of diseases (e.g., cancer).

Systems and methods are disclosed for determining the spatial distributions of radionuclides in tissue samples via mass spectrometry imaging. After administration of a radiopharmaceutical that contains a radionuclide, a mass spectrometry imaging system, such as an imaging mass cytometer or a multiplexed ion beam imaging system, is employed to interrogate a tissue sample to obtain a dataset. The radiopharmaceutical includes, or generates via radioactive decay of the radionuclide, a metal isotope detectable by the mass spectrometry imaging system. The dataset is processed to determine a spatial distribution of the metal isotope within the tissue sample, thereby characterizing the spatial distribution of the radionuclide delivered within the tissue sample. The tissue sample may be stained with a biomarker reagent that includes an additional metal isotope attached to a biomarker ligand, enabling the spatially multiplexed and co-registered analysis. The present methods can be adapted to infer and assess localization of non-radioactive pharmaceuticals.

The present disclosure relates to pharmaceutical compositions comprising [61Cu]Cu-NODAGA-LM3 or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of imaging subjects suspected of having or diagnosed with a somatostatin receptor subtype 2 (SST2)-expressing tumor by administering the pharmaceutical compositions described herein and generating one or more radiographic images of the subject.

The present disclosure generally relates to materials, processes, generators, and / or systems, for generating radioisotope. The present disclosure also generally relates to ceramic materials comprising radioisotope suitable for use in a radioisotope generator. The present disclosure also generally relates to processes, generators and / or systems, for producing and capturing radioisotope. The present disclosure also generally relates to the preparation of radioisotope solutions for use in radiopharmacy and / or other clinical applications.

The application provides a radionuclide nanohydrogel microneedle and a preparation method and application thereof, and belongs to the field of nanobiomedicine. 32 P-labeled calcium phosphate, which is formed by a biomimetic reaction of Ag2S@Ca 32 P nanoparticles, and a base layer which is a base matrix and comprises hyaluronic acid 32 P nanohydrogel microneedle can release Ag2S nanoparticles in response to a weakly acidic tumor environment, and under the irradiation of near-infrared light, the photothermal conversion efficiency can effectively kill bacteria, effectively improve the tumor hypoxic environment, enhance the treatment effect of radionuclides, play an antibacterial and wound healing promoting role in melanoma defect repair, and maximize the inhibition of tumor growth and tumor recurrence.

Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and / or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

The present invention relates to MOFs for radiotherapy. More specifically, the present invention provides: a particle comprising an MOF, optionally at least one targeting moiety, and at least one beta-emitting radionuclide; a composition comprising the particles; said particles or composition for use as a medicament; said particles or compositions for use in a method of treating a proliferative disease; and a kit comprising a particle comprising an MOF, optionally a targeting moiety, and a beta-emitting radionuclide.

The invention belongs to the technical field of hydrogel, and provides photo-crosslinking hydrogel, a preparation method and application thereof, a radionuclide preparation and an application. The photo-crosslinking hydrogel with the adhesion comprises a crosslinking network structure formed by dopamine modified methacrylic acid gelatin and o-nitrobenzyl sulfide light trigger modified hyaluronic acid, has injectability, can be gelatinized after being triggered by light, is high in adhesion, and can be used for preparing the hydrogel while improving the mechanical property of the hydrogel. And the hydrogel can bear larger deformation and maintain better elasticity, so that physical-chemical synergistic enhanced adhesion is realized, and instant and firm adhesion with biological tissues can be realized. Furthermore, the photo-crosslinked hydrogel can be used as a carrier, for example, a radionuclide-loaded preparation, or a patch containing radionuclide is prepared, or the photo-crosslinked hydrogel can also be used as a hemostatic material.

Liposomes encapsulating a radioisotope can be used in the treatment of cancers including, but not limited to, leptomeningeal metastases. In an embodiment, liposome encapsulating a radioisotope comprising (186Re) obisbemeda can be administered to a patient through an Ommaya reservoir. The therapies can include imaging the liposome encapsulating a radioisotopе concomitant or subsequent to administration. Longitudinal analysis of the presence of tumor cells and biomarkers can be used to inform treatment strategy.

The present disclosure generally relates to materials, processes, generators, and / or systems, for generating radioisotope. The present disclosure also generally relates to ceramic materials comprising radioisotope suitable for use in a radioisotope generator. The present disclosure also generally relates to processes, generators and / or systems, for producing and capturing radioisotope. The present disclosure also generally relates to the preparation of radioisotope solutions for use in radiopharmacy and / or other clinical applications.