127 results about "Osteoarthritis" patented technology

The invention discloses a photoacoustic spectrum-confocal Raman spectrum multi-view-field high-dimensional imaging method and a photoacoustic spectrum-confocal Raman spectrum multi-view-field high-dimensional imaging device. Nanosecond pulse laser with adjustable wavelength is generated through a continuous spectrum nanosecond pulser and a narrow-band spectrum tuning module and cooperates with a microscopic detection module, a depth imaging module, a galvanometer system and an electric displacement table to obtain spatial three-dimensional data, a photoacoustic spectrum and a Raman spectrum under multiple view fields; shallow photoacoustic spectrum-Raman spectrum tomography and deep three-dimensional photoacoustic imaging are realized; correcting a photoacoustic spectrum quantitative error by using a spectrum decoupling algorithm, and fusing the multi-view-field data to generate multi-view-field high-dimensional photoacoustic spectrum-Raman spectrum data; high-dimensional data features are extracted based on a 3D convolution instance segmentation network, and quantitative analysis and spatial distribution visualization of blood oxygen, inflammatory factors and the like are achieved. According to the method, the limitation that substances are difficult to analyze in photoacoustic imaging is overcome, the contradiction between the imaging resolution and the penetration depth is solved, and an accurate analysis means is provided for diagnosis of diseases such as knee osteoarthritis and sepsis.

The invention discloses a bone repair material based on pH controlled release and a preparation method thereof. The bone repair material comprises the following raw materials: polycaprolactone, nano hydroxyapatite and nano magnesium oxide. The composite bone repair scaffold has the beneficial effects that the composite bone repair scaffold with excellent biocompatibility, excellent osteogenesis performance, excellent degradation performance and pH controlled release of magnesium ions is prepared by printing the bone repair material through a 3D printing technology, a temporary three-dimensional structure can be provided for cells, cell adhesion, proliferation and differentiation are promoted, growth factors are released at the same time, and the growth rate of the cells is increased. The formation of new bone tissues is guided; the composite bone repair scaffold can continuously and quantitatively release magnesium ions through pH value control, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the magnesium ion release speed of the composite bone repair scaffold is increased, the anti-inflammatory effect is achieved, and the magnesium ions which are continuously released can promote bone tissue repair.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition for relieving knee osteoarthritis and a preparation method of an external patch thereof, the composition comprises a Zhuang medicine component and sweet tea liquid, the Zhuang medicine component comprises a main medicine, a male medicine and an auxiliary medicine, and the main medicine comprises dendropanax dentiger, pseudo-ginseng and radix clematidis; the male medicine is prepared from litsea cubeba, tea pepper, cortex cinnamomi and prostrate centipede; the upper medicine comprises polygonum cuspidatum, philippine flemingia root, bark of himalayan coralbean, radix zanthoxyli and fructus liquidambaris. Compared with the prior art, Zhuang medicine components of a main common helper are configured on the basis of KOA Zhuang medicine pathogenesis and Zhuang medicine pathology, and all the medicines are combined for use, so that the purposes of dispelling wind, eliminating dampness, regulating and smoothing a dragon road and a fire road, promoting blood circulation to arrest pain, tonifying deficiency and strengthening muscles and bones are achieved, and the purpose of treating knee osteoarthritis is achieved; meanwhile, animal experiments and clinical experiments verify the efficacy of the external application agent, and the external application agent has the effect of relieving knee osteoarthritis.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

Provided herein are compositions and methods for ablating intracellular signaling through specific cell surface receptors as means of treatment for various conditions of a pro-inflammatory character. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint. In some aspects, the compositions and method are for treating or preventing localized nociception, inflammation, degeneration, or morphological changes associated with back or spine conditions or disorders.

The present invention discloses chondrocytes for treating osteoarthritis, and a preparation method and application thereof, which relate to the field of biomedical technology, and include the following process: taking mesenchymal stem cells and collagen microspheres for mixing, inoculating them in a culture device for culture, adding induction culture medium for induction culture, harvesting, and obtaining chondrocytes. The present invention mixes mesenchymal stem cells with collagen microspheres so that the mesenchymal stem cells are adsorbed / inoculated on the collagen microspheres, the cells are amplified, and cultured induction is performed. The mesenchymal stem cells are induced to form chondrocytes to obtain chondrocytes, and the product is collected, resuspended in 0.9% physiological saline, and injected locally into the bone and joints. It can be used for the treatment of osteoarthritis, reducing the adverse reactions caused by the use of traditional drugs and the damage caused by surgical methods. Chondrocytes fundamentally solve the cause of osteoarthritis by repairing cartilage through cells, and have a significant therapeutic effect.

The invention relates to the technical field of computer-aided teaching and medical image recognition, and particularly discloses an intelligent knee osteoarthritis image analysis teaching system based on computer vision. The system comprises an image data management module, a student interaction and behavior acquisition module, a multi-dimensional skill quantitative analysis module, a personalized knowledge graph construction and gap analysis module, a self-adaptive teaching path planning module and a teaching feedback and report generation module. By collecting and quantitatively analyzing operation behaviors and sight tracks of students, a personal knowledge graph is constructed to accurately position skill defects, and a personalized teaching path is planned according to the skill defects, so that refined evaluation and adaptive teaching guidance of image analysis practical skills are realized.

The invention provides a traditional Chinese medicine composition with anti-inflammatory and analgesic effects as well as a preparation method, application and a medicine thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 30-55 parts of pseudo-ginseng, 26-40 parts of notopterygium root, 15-35 parts of safflower, 15-35 parts of berba aristolochiae mollissimae, 20-40 parts of liquorice, 10-20 parts of acanthopanax and 10-30 parts of dandelion. Performing reflux extraction on the pseudo-ginseng, the notopterygium root, the safflower and the dandelion by using an ethanol solution to obtain an ethanol extracting solution and medicine residues; mixing the medicine residues, berba aristolochiae mollissimae, liquorice and acanthopanax, decocting with water, and then carrying out microwave treatment to obtain a water extracting solution; combining the ethanol extracting solution and the water extracting solution, and drying to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has synergistic effects of diminishing inflammation, easing pain and diminishing swelling; when the compound is applied to medicine preparation, the obtained medicine can remarkably reduce the pain degree and the osteoarthritis index and improve the joint motion range.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention belongs to the technical field of organic-inorganic compounding, and aims to solve the problem of treatment of temporomandibular joint osteoarthritis (TMJOA). Magnesium-gallic acid metal organic framework (Mg-GA MOF) particles are synthesized through a hydrothermal method, hyaluronic acid is subjected to hydroformylation and double-bond modification to obtain OHAMA, and the magnesium-gallic acid metal organic framework (Mg-GA MOF) particles and the OHAMA particles are compounded to prepare the MOF-Gel composite hydrogel. The hydrogel is injectable and high in tissue retention rate, has dual effects of inhibiting pyroptosis and promoting regeneration on condylar cartilage cells, can effectively promote cartilage repair, shows a good effect in TMJOA treatment, and has a wide application prospect.

The invention discloses a knee joint force line adjusting system and method based on intelligent feedback control, and relates to the technical field of medical rehabilitation instruments. The system comprises an overall control and man-machine interaction end, a correction device sensor end and a correction device hardware platform end. The hardware platform end comprises a joint force applying module and a thigh and shank multi-degree-of-freedom motion module; the sensor end is used for detecting joint pressure and lower limb force line state in real time. On the basis of traditional three-point type orthopedics, the applied force is adjusted through the control module according to real-time feedback, and the shank is matched for synchronous stretching and rotating movement, so that the knee joint force line is dynamically adjusted. In addition, the system combines multi-modal data, constructs a closed-loop decision model by using deep learning and large model reasoning technologies, and outputs correction effect evaluation and next training parameter recommendation. The digital and intelligent knee joint correction system realizes digitization and intelligentization of knee joint correction, can effectively enlarge joint gaps, improves stress distribution, and provides a personalized and safe rehabilitation treatment scheme for middle-aged and elderly osteoarthritis patients.

Provided are a chondrogenic stem cell for promoting joint repair and use thereof. Specifically, disclosed is a cell preparation used for alleviating or treating osteoarthritis, comprising a Procr-positive pluripotent stem cell. The Procr-positive chondrogenic stem cell can differentiate and generate downstream chondrocytes in vivo and promote cartilage repair in osteoarthritis damage, which will be a more effective cell treatment method. In addition, Procr proteins can be used as a new target of a drug for treating osteoarthritis.

The present invention relates to a special internal fixation device for proximal tibial combined osteotomy, including a support plate and a plurality of locking screws. The support plate is composed of a proximal head, an intermediate connecting part and a distal tail which are sequentially connected and integrally formed. Locking screw holes are respectively provided on the proximal head and the distal tail. A locking / pressurizing combination hole is also provided on the intermediate connecting part. The locking screws are respectively and correspondingly inserted into the locking screw holes and the locking / pressurizing combination holes. The locking screw holes on the proximal head include a first screw hole, a second screw hole and a third screw hole which are arranged horizontally, and an additional screw hole located at the lower corner position of the proximal head. The installation angle of the additional screw hole satisfies that the direction of the locking screw inserted into the additional screw hole is perpendicular to the osteotomy surface at the intercondylar eminence of the tibia. The present invention can provide a more stable knee joint biomechanical environment for the treatment of varus knee osteoarthritis by proximal tibial combined osteotomy, and is more firm and reliable than the existing plate internal fixation.

The invention discloses a manufacturing method and application of a bone repair material based on photo-thermal controlled release and a bone repair scaffold. The bone repair material comprises polycaprolactone and nano-hydroxyapatite. The bone repair scaffold has the beneficial effects that the bone repair scaffold is printed by a 3D printing technology and prepared by a polydopamine surface modification method, so that the bone repair scaffold is excellent in mechanical property, biocompatibility, osteogenesis performance and degradation performance; the bone repair scaffold can provide a temporary three-dimensional structure for cells, promote cell adhesion, proliferation and differentiation, release growth factors and guide formation of new bone tissues; the bone repair scaffold is controlled by near-infrared light to continuously and quantitatively release magnesium ions, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the release speed of the magnesium ions and calcium ions can be increased through the near-infrared light, the dual effects of resisting inflammation and promoting osteogenesis are achieved, and the bone repair scaffold has the advantages of being simple in structure and convenient to use. And the continuously released calcium and magnesium ions can promote bone tissue repair.

The utility model discloses an osteoarthritis middle-symptom joint fixator which comprises an upper support, a lower support and a connecting mechanism connected between the upper support and the lower support. The upper support comprises an upper support arm corresponding to the side face of the leg, an upper surrounding part connected to the upper support arm and extending towards the front side of the thigh in an arc mode, and a first upper connecting belt matched with the upper surrounding part to bind the upper support to the leg, and the first upper connecting belt is detachably assembled with the upper surrounding part and / or the upper support arm through a quick snap fastener. The lower support comprises lower support arms corresponding to the side faces of the legs, lower enclosures connected to the lower support arms and extending towards the rear sides of the shanks in an arc mode, and first lower connecting belts matched with the lower enclosures to bind the lower support to the legs, and the first lower connecting belts are detachably assembled with the lower enclosures and / or the lower support arms through quick snap fasteners. The joint fixator for osteoarthritis can be stably worn on the legs of a user and prevented from loosening, and the joint fixator for osteoarthritis can be quickly worn through quick disassembly and assembly of the quick snap fasteners.

The present invention discloses the use of CircSS18 in a drug for the treatment of osteoarthritis and a method for its preparation. Local intra-articular injection of a nano-controlled-release hydrogel composite overexpressing circSS18 has significant potential clinical value in the targeted treatment of osteoarthritis: 1. Compared with current clinical local intra-articular injections of sodium hyaluronate and platelet-rich plasma (PRP), this method has a clear target and mechanism of action, making the treatment more targeted and effective, and a curative approach. 2. Compared with current clinical oral symptomatic treatments such as NSAIDs and glucosamine, this method can fundamentally inhibit the progression of osteoarthritis. 3. Compared with surgical procedures such as arthroscopy and joint replacement, this method is less invasive, less expensive, more feasible, and more practical, making it more acceptable to patients.

Disclosed are a hyaluronic acid-based zwitterionic polymer brush, a preparation method thereof, and the use thereof. The structure of the zwitterionic polymer brush is represented by formula (I), wherein n is an integer from 60-150, x is an integer from 589-686, and y is an integer from 125-230. The above-mentioned zwitterionic polymer brush can delay the pathological progress of osteoarthritis, promote cartilage regeneration, and even treat osteoarthritis and improve conditions such as the generation of abraded fragments of implants such as joints and related diseases triggered thereby, and can be combined with cartilage repairing materials to improve the frictional mechanical properties thereof for achieving better repair results. Moreover, the above-mentioned zwitterionic polymer brush can selectively bind to proteins in cartilage and has an excellent lubricating effect. The present invention has the advantages of simple method, convenient operation, easy purification, high yield, and the like.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for treating osteoarthritis and a preparation method thereof. The composition for treating osteoarthritis is prepared from the following raw materials in parts by weight: 1 to 3 parts of non-denatured type II collagen, 0.3 to 0.5 part of cowherb seed cyclic peptide A and 0.4 to 0.7 part of balanosine. According to the composition, through the synergistic effect of multiple active ingredients, the osteoarthritis symptom is jointly relieved, and joint tissue repair is promoted.

The application discloses a kind of food relieving bone joint damage evaluation method, it is related to food efficacy evaluation technical field, for solving the problem of single dimension of existing evaluation method, unstable model leads to poor reliability of conclusion.The application builds composite modeling and multi-modal analysis mechanism, first, a stable animal model is established by using chemical injury combined with forced exercise training, a two-stage increasing dosing regimen is set, and behavior dynamic trend data and histology, imaging multi-modal results are collected synchronously.Then, based on the weight assigned to osteoarthritis stage, a weighted composite score is generated, and a perturbation sensitivity index is calculated, a multi-index collaborative influence map is constructed, a key evaluation node is located, a graded evaluation conclusion is generated based on the food action characteristics and efficacy determination threshold, and false positives caused by single index fluctuations are avoided.Finally, a full-cycle closed-loop evaluation process is formed, which improves the scientificity, reproducibility and self-adaptive ability of efficacy determination in complex biological systems.

The invention provides a micron self-assembly material with joint retention, lubrication and anti-inflammatory functions as well as a preparation method and application of the micron self-assembly material. The micron self-assembly material is formed by self-assembly of avidin modified mesoporous polydopamine nanoparticles and biotinylated XII type collagen targeted lubricating peptide modified mesoporous polydopamine nanoparticles, and the mesoporous polydopamine nanoparticles and the biotinylated XII type collagen targeted lubricating peptide are combined to form the micron self-assembly material. In the avidin modified mesoporous polydopamine nanoparticles, avidin and the mesoporous polydopamine nanoparticles are connected through a covalent bond; in the biotinylated XII type collagen targeted lubricating peptide modified mesoporous polydopamine nanoparticle, the N end of the XII type collagen targeted lubricating peptide is connected with biotin through a covalent bond, and the C end of the XII type collagen targeted lubricating peptide is connected with the mesoporous polydopamine nanoparticle through an amino acid and a covalent bond. The micron self-assembly material can be specifically combined with a cartilage focus area, the retention time in joints is prolonged, good lubrication and excellent anti-inflammatory activity are shown, and the pathological progress of osteoarthritis can be effectively inhibited.

The invention provides a knee joint bionic lower limb exoskeleton for osteoarthritis rehabilitation, and relates to the technical field of exoskeleton robots, the exoskeleton robot comprises a waist mechanism, a hip joint mechanism, a knee joint bionic mechanism and a leg mechanism; the waist mechanism is adaptive to different body types through an adjustable waistline adjuster and an adjustable waist height adjuster; the hip joint mechanism transmits power to the front of the thigh protector through a motor driving connecting rod; the knee joint bionic mechanism adopts a sliding square block and damping coupling design to simulate a migration track of an instantaneous rotation center of the knee joint of a human body; the leg mechanism is of an orthotropic chain structure and is combined with a flexible protection pad to achieve rigid force transmission in the vertical direction and flexible adaptation in the horizontal direction. The problem that a traditional exoskeleton is insufficient in bionic property and has binding defects is effectively solved, and the exoskeleton is suitable for rehabilitation training of knee osteoarthritis patients.

The invention discloses compounds of Formula (I), wherein the compounds are used as anti-inflammatory agents, for treatment or prevention of a number of diseases or conditions such as atherosclerosis, auto-immune diseases, psoriasis, multiple sclerosis, transplant rejection, asthma, bacterial infection, rhinovirus infection, brain ischemia, ischemia-reperfusion injury, limb ischemia, acute kidney injury, diabetic nephropathy, sepsis, acute respiratory distress syndrome (ARDS), cancer, osteoarthritis, sepsis-induced kidney injury, liver disease, and septic and cardiogenic shock.

The application provides a temporomandibular joint distraction soft tissue traction device, which comprises an X-axis connecting mechanism and a Y-axis adjusting mechanism, the X-axis connecting mechanism further comprises an arch strip, an abutment structure and an arc-shaped abutment distraction mechanism for hooking the patient's jaw bone, the arch strip is vertically connected with the Y-axis adjusting mechanism, the abutment structure comprises two independent ladder blocks arranged above the arch strip, the upper surfaces of the two independent ladder blocks are sequentially provided with a U-shaped support for clamping sliding, a sliding rod, a clamping buckle and a limiting hole, wherein the U-shaped supports are respectively installed at the upper ends of the two independent ladder blocks, and the arch strip and the abutment structure are adopted to promote the middle-aged and old patients suffering from temporomandibular joint osteoarthritis to seek medical treatment, and an operable space is established during the open surgery of the temporomandibular joint (similar to the state of the bag opening being adapted), and the load bearing rod, the clamping buckle, the sliding rod and the specific sliding structure state can be used for the distraction of the temporomandibular joint region.

The application relates to a hyaluronic acid-based quercetin conjugate micelle and a preparation method and application thereof, and comprises the following steps: adding a coupling agent into a hyaluronic acid solution to carry out an activation reaction, then adding a phenylboronic acid solution to carry out a grafting reaction, and carrying out purification treatment to obtain HA-PBA; mixing HA-PBA and quercetin in an organic solvent, carrying out grafting reaction and purification treatment on the obtained mixed solution to obtain the hyaluronic acid-based quercetin conjugate micelle (HPQ). The hyaluronic acid-based quercetin conjugate micelle and KGN can also be used to prepare the hyaluronic acid-based quercetin conjugate micelle loaded with KGN (HPQ@K) through a loading reaction; the prepared HPQ and HPQ@K have a spherical structure, can make the interosseous joints reach a super-lubrication state, and can improve the solubility of quercetin and KGN, and improve the treatment and repair effect of osteoarthritis.

The invention relates to a preparation method and application of vitronectin, stromal cell-derived factor-1 or fusion protein hydrogel thereof, vitronectin and stromal cell-derived factor-1 are connected through a flexible joint composed of a plurality of amino acids to form a fusion protein, and the fusion protein can carry a purification label or does not carry a purification label; the fusion protein is finally designed into hydrogel in a self-assembly or biochemical or bio-physicochemical cross-linking mode. The hydrogel disclosed by the invention has good biocompatibility, has a remarkable effect on recruiting stem cells, can realize dryness maintenance of in-situ stem cells, can be applied to the fields of skin tissue wound healing, cartilage repair, osteoarthritis clinical treatment, bone defect repair and the like, and has important significance on wound healing and body injury repair and regeneration.

The invention discloses a compound gel preparation for treating osteoarthritis as well as a preparation method and application thereof, relates to the field of biological medicines, and aims to solve the problems of low number of anti-inflammatory and repairing factors, few types and non-lasting effect in the existing multi-factor product for treating osteoarthritis. The compound gel preparation comprises a platelet-derived anti-inflammatory repair factor and a vesicle lysate. The method comprises the following steps: 1, adding schisandrin B into blood to prepare platelet-rich plasma, and performing freeze thawing treatment to prepare platelet-derived anti-inflammatory repair factors; 2, inducing the bone marrow mesenchymal stem cells by using an induction solution added with 18 beta-glycyrrhetinic acid; separating to obtain extracellular vesicles, and carrying out ultrasonic lysis to obtain a vesicle lysis solution; 3, mixing the platelet-derived anti-inflammatory repair factor with the vesicle lysis buffer to obtain a joint repair factor; and 4, mixing the joint repair factor with the chitosan-poloxamer temperature-sensitive gel to obtain the compound gel preparation. The compound gel preparation is used for treating osteoarthritis.

Disclosed herein are methods of administering resiniferatoxin (RTX) for treatment of osteoarthritis (OA) pain, and compositions for use in such methods.

The invention belongs to the technical field of drug-loaded gel, and particularly discloses near-infrared laser excited injectable photo-thermal composite gel and a preparation method thereof, and the preparation method comprises the following steps: preparing a carboxymethyl chitosan solution and an oxidized hyaluronic acid solution; the preparation method comprises the following steps: loading a medicine for treating temporomandibular joint osteoarthritis on near-infrared laser excited photo-thermal nanoparticles; dispersing the photo-thermal nano-particles loaded with the medicine in a carboxymethyl chitosan solution to obtain a first solution; and mixing the first solution with the oxidized hyaluronic acid solution to obtain the near-infrared laser excited injectable photo-thermal composite gel. Drug is loaded on photo-thermal nano-particles, carboxymethyl chitosan modified oxidized hyaluronic acid gel is used for wrapping to form injectable composite gel, the problems that drug water solubility is poor and bioavailability is low are solved, meanwhile, photo-thermal nano-particles with high photo-thermal conversion efficiency are used as a photo-response material, and the injectable composite gel is prepared. And the synergistic treatment of the temporomandibular joint osteoarthritis by combining medicines with photo-thermal is possible.

The present invention relates to a food composition, in particular in powder form, characterized in that it contains, by weight, per 100g, at least 50g of proteins, at least 35µg of vitamin D3, at least 140mg of choline, vitamin K1 and at least 0.400g of leucine. The composition can be used, in particular, to restore mobility and treat osteoarthritis in elderly dogs.