84 results about "Osteoarthritis" patented technology

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition for relieving knee osteoarthritis and a preparation method of an external patch thereof, the composition comprises a Zhuang medicine component and sweet tea liquid, the Zhuang medicine component comprises a main medicine, a male medicine and an auxiliary medicine, and the main medicine comprises dendropanax dentiger, pseudo-ginseng and radix clematidis; the male medicine is prepared from litsea cubeba, tea pepper, cortex cinnamomi and prostrate centipede; the upper medicine comprises polygonum cuspidatum, philippine flemingia root, bark of himalayan coralbean, radix zanthoxyli and fructus liquidambaris. Compared with the prior art, Zhuang medicine components of a main common helper are configured on the basis of KOA Zhuang medicine pathogenesis and Zhuang medicine pathology, and all the medicines are combined for use, so that the purposes of dispelling wind, eliminating dampness, regulating and smoothing a dragon road and a fire road, promoting blood circulation to arrest pain, tonifying deficiency and strengthening muscles and bones are achieved, and the purpose of treating knee osteoarthritis is achieved; meanwhile, animal experiments and clinical experiments verify the efficacy of the external application agent, and the external application agent has the effect of relieving knee osteoarthritis.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

The invention relates to the technical field of computer-aided teaching and medical image recognition, and particularly discloses an intelligent knee osteoarthritis image analysis teaching system based on computer vision. The system comprises an image data management module, a student interaction and behavior acquisition module, a multi-dimensional skill quantitative analysis module, a personalized knowledge graph construction and gap analysis module, a self-adaptive teaching path planning module and a teaching feedback and report generation module. By collecting and quantitatively analyzing operation behaviors and sight tracks of students, a personal knowledge graph is constructed to accurately position skill defects, and a personalized teaching path is planned according to the skill defects, so that refined evaluation and adaptive teaching guidance of image analysis practical skills are realized.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention belongs to the technical field of organic-inorganic compounding, and aims to solve the problem of treatment of temporomandibular joint osteoarthritis (TMJOA). Magnesium-gallic acid metal organic framework (Mg-GA MOF) particles are synthesized through a hydrothermal method, hyaluronic acid is subjected to hydroformylation and double-bond modification to obtain OHAMA, and the magnesium-gallic acid metal organic framework (Mg-GA MOF) particles and the OHAMA particles are compounded to prepare the MOF-Gel composite hydrogel. The hydrogel is injectable and high in tissue retention rate, has dual effects of inhibiting pyroptosis and promoting regeneration on condylar cartilage cells, can effectively promote cartilage repair, shows a good effect in TMJOA treatment, and has a wide application prospect.

The invention discloses a knee joint force line adjusting system and method based on intelligent feedback control, and relates to the technical field of medical rehabilitation instruments. The system comprises an overall control and man-machine interaction end, a correction device sensor end and a correction device hardware platform end. The hardware platform end comprises a joint force applying module and a thigh and shank multi-degree-of-freedom motion module; the sensor end is used for detecting joint pressure and lower limb force line state in real time. On the basis of traditional three-point type orthopedics, the applied force is adjusted through the control module according to real-time feedback, and the shank is matched for synchronous stretching and rotating movement, so that the knee joint force line is dynamically adjusted. In addition, the system combines multi-modal data, constructs a closed-loop decision model by using deep learning and large model reasoning technologies, and outputs correction effect evaluation and next training parameter recommendation. The digital and intelligent knee joint correction system realizes digitization and intelligentization of knee joint correction, can effectively enlarge joint gaps, improves stress distribution, and provides a personalized and safe rehabilitation treatment scheme for middle-aged and elderly osteoarthritis patients.

Provided are a chondrogenic stem cell for promoting joint repair and use thereof. Specifically, disclosed is a cell preparation used for alleviating or treating osteoarthritis, comprising a Procr-positive pluripotent stem cell. The Procr-positive chondrogenic stem cell can differentiate and generate downstream chondrocytes in vivo and promote cartilage repair in osteoarthritis damage, which will be a more effective cell treatment method. In addition, Procr proteins can be used as a new target of a drug for treating osteoarthritis.

The invention discloses a manufacturing method and application of a bone repair material based on photo-thermal controlled release and a bone repair scaffold. The bone repair material comprises polycaprolactone and nano-hydroxyapatite. The bone repair scaffold has the beneficial effects that the bone repair scaffold is printed by a 3D printing technology and prepared by a polydopamine surface modification method, so that the bone repair scaffold is excellent in mechanical property, biocompatibility, osteogenesis performance and degradation performance; the bone repair scaffold can provide a temporary three-dimensional structure for cells, promote cell adhesion, proliferation and differentiation, release growth factors and guide formation of new bone tissues; the bone repair scaffold is controlled by near-infrared light to continuously and quantitatively release magnesium ions, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the release speed of the magnesium ions and calcium ions can be increased through the near-infrared light, the dual effects of resisting inflammation and promoting osteogenesis are achieved, and the bone repair scaffold has the advantages of being simple in structure and convenient to use. And the continuously released calcium and magnesium ions can promote bone tissue repair.

The utility model discloses an osteoarthritis middle-symptom joint fixator which comprises an upper support, a lower support and a connecting mechanism connected between the upper support and the lower support. The upper support comprises an upper support arm corresponding to the side face of the leg, an upper surrounding part connected to the upper support arm and extending towards the front side of the thigh in an arc mode, and a first upper connecting belt matched with the upper surrounding part to bind the upper support to the leg, and the first upper connecting belt is detachably assembled with the upper surrounding part and / or the upper support arm through a quick snap fastener. The lower support comprises lower support arms corresponding to the side faces of the legs, lower enclosures connected to the lower support arms and extending towards the rear sides of the shanks in an arc mode, and first lower connecting belts matched with the lower enclosures to bind the lower support to the legs, and the first lower connecting belts are detachably assembled with the lower enclosures and / or the lower support arms through quick snap fasteners. The joint fixator for osteoarthritis can be stably worn on the legs of a user and prevented from loosening, and the joint fixator for osteoarthritis can be quickly worn through quick disassembly and assembly of the quick snap fasteners.

The present invention discloses the use of CircSS18 in a drug for the treatment of osteoarthritis and a method for its preparation. Local intra-articular injection of a nano-controlled-release hydrogel composite overexpressing circSS18 has significant potential clinical value in the targeted treatment of osteoarthritis: 1. Compared with current clinical local intra-articular injections of sodium hyaluronate and platelet-rich plasma (PRP), this method has a clear target and mechanism of action, making the treatment more targeted and effective, and a curative approach. 2. Compared with current clinical oral symptomatic treatments such as NSAIDs and glucosamine, this method can fundamentally inhibit the progression of osteoarthritis. 3. Compared with surgical procedures such as arthroscopy and joint replacement, this method is less invasive, less expensive, more feasible, and more practical, making it more acceptable to patients.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for treating osteoarthritis and a preparation method thereof. The composition for treating osteoarthritis is prepared from the following raw materials in parts by weight: 1 to 3 parts of non-denatured type II collagen, 0.3 to 0.5 part of cowherb seed cyclic peptide A and 0.4 to 0.7 part of balanosine. According to the composition, through the synergistic effect of multiple active ingredients, the osteoarthritis symptom is jointly relieved, and joint tissue repair is promoted.

The application discloses a kind of food relieving bone joint damage evaluation method, it is related to food efficacy evaluation technical field, for solving the problem of single dimension of existing evaluation method, unstable model leads to poor reliability of conclusion.The application builds composite modeling and multi-modal analysis mechanism, first, a stable animal model is established by using chemical injury combined with forced exercise training, a two-stage increasing dosing regimen is set, and behavior dynamic trend data and histology, imaging multi-modal results are collected synchronously.Then, based on the weight assigned to osteoarthritis stage, a weighted composite score is generated, and a perturbation sensitivity index is calculated, a multi-index collaborative influence map is constructed, a key evaluation node is located, a graded evaluation conclusion is generated based on the food action characteristics and efficacy determination threshold, and false positives caused by single index fluctuations are avoided.Finally, a full-cycle closed-loop evaluation process is formed, which improves the scientificity, reproducibility and self-adaptive ability of efficacy determination in complex biological systems.

The invention provides a knee joint bionic lower limb exoskeleton for osteoarthritis rehabilitation, and relates to the technical field of exoskeleton robots, the exoskeleton robot comprises a waist mechanism, a hip joint mechanism, a knee joint bionic mechanism and a leg mechanism; the waist mechanism is adaptive to different body types through an adjustable waistline adjuster and an adjustable waist height adjuster; the hip joint mechanism transmits power to the front of the thigh protector through a motor driving connecting rod; the knee joint bionic mechanism adopts a sliding square block and damping coupling design to simulate a migration track of an instantaneous rotation center of the knee joint of a human body; the leg mechanism is of an orthotropic chain structure and is combined with a flexible protection pad to achieve rigid force transmission in the vertical direction and flexible adaptation in the horizontal direction. The problem that a traditional exoskeleton is insufficient in bionic property and has binding defects is effectively solved, and the exoskeleton is suitable for rehabilitation training of knee osteoarthritis patients.

The invention discloses compounds of Formula (I), wherein the compounds are used as anti-inflammatory agents, for treatment or prevention of a number of diseases or conditions such as atherosclerosis, auto-immune diseases, psoriasis, multiple sclerosis, transplant rejection, asthma, bacterial infection, rhinovirus infection, brain ischemia, ischemia-reperfusion injury, limb ischemia, acute kidney injury, diabetic nephropathy, sepsis, acute respiratory distress syndrome (ARDS), cancer, osteoarthritis, sepsis-induced kidney injury, liver disease, and septic and cardiogenic shock.

The application provides a temporomandibular joint distraction soft tissue traction device, which comprises an X-axis connecting mechanism and a Y-axis adjusting mechanism, the X-axis connecting mechanism further comprises an arch strip, an abutment structure and an arc-shaped abutment distraction mechanism for hooking the patient's jaw bone, the arch strip is vertically connected with the Y-axis adjusting mechanism, the abutment structure comprises two independent ladder blocks arranged above the arch strip, the upper surfaces of the two independent ladder blocks are sequentially provided with a U-shaped support for clamping sliding, a sliding rod, a clamping buckle and a limiting hole, wherein the U-shaped supports are respectively installed at the upper ends of the two independent ladder blocks, and the arch strip and the abutment structure are adopted to promote the middle-aged and old patients suffering from temporomandibular joint osteoarthritis to seek medical treatment, and an operable space is established during the open surgery of the temporomandibular joint (similar to the state of the bag opening being adapted), and the load bearing rod, the clamping buckle, the sliding rod and the specific sliding structure state can be used for the distraction of the temporomandibular joint region.

The application relates to a hyaluronic acid-based quercetin conjugate micelle and a preparation method and application thereof, and comprises the following steps: adding a coupling agent into a hyaluronic acid solution to carry out an activation reaction, then adding a phenylboronic acid solution to carry out a grafting reaction, and carrying out purification treatment to obtain HA-PBA; mixing HA-PBA and quercetin in an organic solvent, carrying out grafting reaction and purification treatment on the obtained mixed solution to obtain the hyaluronic acid-based quercetin conjugate micelle (HPQ). The hyaluronic acid-based quercetin conjugate micelle and KGN can also be used to prepare the hyaluronic acid-based quercetin conjugate micelle loaded with KGN (HPQ@K) through a loading reaction; the prepared HPQ and HPQ@K have a spherical structure, can make the interosseous joints reach a super-lubrication state, and can improve the solubility of quercetin and KGN, and improve the treatment and repair effect of osteoarthritis.

The invention relates to a preparation method and application of vitronectin, stromal cell-derived factor-1 or fusion protein hydrogel thereof, vitronectin and stromal cell-derived factor-1 are connected through a flexible joint composed of a plurality of amino acids to form a fusion protein, and the fusion protein can carry a purification label or does not carry a purification label; the fusion protein is finally designed into hydrogel in a self-assembly or biochemical or bio-physicochemical cross-linking mode. The hydrogel disclosed by the invention has good biocompatibility, has a remarkable effect on recruiting stem cells, can realize dryness maintenance of in-situ stem cells, can be applied to the fields of skin tissue wound healing, cartilage repair, osteoarthritis clinical treatment, bone defect repair and the like, and has important significance on wound healing and body injury repair and regeneration.

The invention discloses a compound gel preparation for treating osteoarthritis as well as a preparation method and application thereof, relates to the field of biological medicines, and aims to solve the problems of low number of anti-inflammatory and repairing factors, few types and non-lasting effect in the existing multi-factor product for treating osteoarthritis. The compound gel preparation comprises a platelet-derived anti-inflammatory repair factor and a vesicle lysate. The method comprises the following steps: 1, adding schisandrin B into blood to prepare platelet-rich plasma, and performing freeze thawing treatment to prepare platelet-derived anti-inflammatory repair factors; 2, inducing the bone marrow mesenchymal stem cells by using an induction solution added with 18 beta-glycyrrhetinic acid; separating to obtain extracellular vesicles, and carrying out ultrasonic lysis to obtain a vesicle lysis solution; 3, mixing the platelet-derived anti-inflammatory repair factor with the vesicle lysis buffer to obtain a joint repair factor; and 4, mixing the joint repair factor with the chitosan-poloxamer temperature-sensitive gel to obtain the compound gel preparation. The compound gel preparation is used for treating osteoarthritis.

Composition for improving inflammation in osteoarthritis, characterized in that the composition comprises the following components, measured in parts by weight: 1 to 5 parts by weight of N-acetylglucosamine and 0.1 to 2 parts by weight of calcium element in a calcium source.

The application discloses a knee osteoarthritis image prediction method and system based on a diffusion model. The method comprises the following steps: acquiring multi-modal data of a patient in a baseline period, wherein the multi-modal data comprises X-ray images, MRI sequences and clinical features; adopting a latent diffusion model as a basic prediction network architecture; adding a multi-modal fusion module and a cross-attention mask regulation in a U-Net structure of the latent diffusion model; selecting an AdamW optimizer; performing end-to-end training on the model; inputting the multi-modal data into the trained latent diffusion model; completing feature fusion through adaptive gating; and performing inverse diffusion denoising under the constraint of an inflation joint gap key point mask, and finally decoding and outputting a predicted knee X-ray image. The application can improve the accuracy of joint image prediction.

The invention discloses a multivalent triangular DNA origami delivery system as well as a preparation method and application thereof, which can be used as a novel method for treating osteoarthritis, and is particularly suitable for patients with cartilage degeneration and joint inflammation caused by age, obesity, joint reuse, sport injury or genetic factors and the like. Specific siRNAs (small interfering RNAs) are delivered by the use of multivalent triangular DNA origami. According to the scheme, the expression of inflammation and degeneration related genes, such as Stat3, MMP3 and MMP13, in cartilage cells in joints can be specifically inhibited, so that the inflammatory response is relieved, cartilage decomposition is inhibited, and repair and regeneration of cartilage tissues are promoted. The invention provides a method for treating osteoarthritis, which has the advantages of strong targeting property, small side effect and obvious curative effect, is suitable for clinical treatment and basic medical research, and has wide application prospect.

The application belongs to the technical field of biotechnology, and discloses application of a new sialyloligosaccharide and astaxanthin composition in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the application comprises new sialyloligosaccharide, astaxanthin, carbomer and alginate with a mass ratio of (1-10):(1-10):(0.01-0.5):(0.1-1). The composition can realize efficient enrichment of the new sialyloligosaccharide and astaxanthin in the joint cavity through a diffusion pathway of skin penetration, deep tissue diffusion, joint capsule penetration and joint cavity enrichment of the substance, and the new sialyloligosaccharide and astaxanthin have excellent synergistic effects, can efficiently relieve acute inflammatory symptoms of gouty osteoarthritis, block the disease progression and repair the joint tissue pathological changes, and have excellent application prospects in preparation of the transdermal drug for treating osteoarthritis.

The invention discloses a medical composite material for synergistically regulating cholesterol and oxidative stress. The material comprises a Fe2-N6 / NC carrier, cholesterol oxidase loaded on the Fe2-N6 / NC carrier and a hyaluronic acid targeting layer modified on the surface, the carrier is a nitrogen-doped carbon material loaded with iron double-atom active sites, the distance between adjacent iron atoms is 0.311 + / -0.009 nm, and the iron content is 0.393 wt%; the average particle size of the composite material is 242.5 nm, and the Zeta potential of the composite material is-23.71 mV; the preparation method comprises the following steps: synthesizing Fe2-N6 / NC through mechanochemical-assisted in-situ MOF packaging, ultrasonically loading cholesterol oxidase and modifying with hyaluronic acid. The material has cholesterol degradation activity (the degradation rate is 33.94%) and active oxygen scavenging activity (the scavenging rate is 78.8%), and can be used for preparing an implant material for joint repair or a medical material for articular cavity injection so as to realize coordinated regulation of osteoarthritis cholesterol metabolism disorder and oxidative stress.

Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.

Devices, systems, and methods for surgical treatment of mid-foot disorders such as osteoarthritis, spacing disorders, or alignment disorders, including mid-foot arthroplasty devices and systems for the 2nd and 3rd tarsometatarsal (TMT) joint, implants for post-osteotomy spacing and realignment, arthroplasty articular implants, dowel grafts for TMT arthrodesis or fusion, dowel grafts for navicular cuneiform (NC) arthrodesis, dowel grafts for intercuneiform arthrodesis, and / or locking dowels for joint fusion.

The invention provides a nanoparticle composition based on perinatal tissue as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The nanoparticle composition disclosed by the invention is obtained by decellularizing and purifying perinatal tissues. The nano-particle composition obtained by the invention contains rich cell factors and growth factors and more diverse miRNA (micro Ribonucleic Acid) components, and is applied to related joints. Clinical tests carried out in the sports and joint medicine department of the tenth people hospital in Shanghai and a rat model are passed, after the nano-particle composition is injected into the rat model, the pain and function of osteoarthritis can be effectively improved, and no adverse event is generated. The invention provides a novel safe and effective treatment way for promoting tissue repair and regeneration.

This invention proposes a method for constructing an animal model for the prevention of temporomandibular joint osteoarthritis (TMJ) by knocking out the FAM20C gene, belonging to the field of pharmaceutical technology. It solves the problem of providing effective treatment and prevention methods for TTMJ osteoarthritis. It includes the application of the FAM20C gene in the preparation of drugs for the prevention or treatment of TTMJ osteoarthritis. It is mainly used for the prevention or treatment of TTMJ osteoarthritis.

A chitosan thermosensitive glue composition for treating osteoarthritis and a preparation method thereof. The composition comprises 0.5-5% chitosan thermosensitive glue and 10 6 -10 7 / mL stem cells. After mixing mesenchymal stem cells with chitosan thermosensitive glue, the mixture is injected into the joint cavity, which can not only play the effect of chitosan gel in lubricating the joint, but also inhibit inflammatory factors secreted by mesenchymal stem cells, and at the same time, mesenchymal stem cells can promote the regeneration of chondrocytes, effectively treating osteoarthritis.

The invention relates to the technical field of biomedicine, in particular to a preparation method and application of wrinkled Nb2CTx-SeNPs based on a physical-chemical cooperative signal. The core of the preparation method disclosed by the invention is to realize the synergism of physical and chemical signals, and the nanoscale fold topological structure constructed by a special process can provide unique physical stimulation for the macrophage and guide the functional phenotype of the macrophage. Meanwhile, the anti-inflammatory potential of the substrate material Nb2CTx and the biological activity of the loaded SeNPs for removing active oxygen and relieving oxidative stress jointly form a composite chemical signal. The simultaneous delivery and synergistic effect of physical and chemical dual signals endow the nano-platform with the ability of efficiently remodeling the functional homeostasis of macrophages, and the nano-platform can be used for treating osteoarthritis.

The invention belongs to the technical field of joint rehabilitation training, and discloses intelligent feedback type knee joint rehabilitation training equipment based on traditional Chinese medicine. Comprising a structure body, a gait acquisition, storage and analysis feedback system, a thigh component, a shank component, a binding component, a damping knee joint, a microcontroller MCU, an inertial sensor IMU, a display screen SD card recorder, a voice playing module, a pluggable lithium battery, a surface myoelectricity sensor and a graphene heating sheet. The device is light in weight, small in size, high in skin friendliness, convenient to wear and more suitable for patients with knee osteoarthritis in all stages, and the illness state of the patients is effectively relieved through active monitoring of various physiological indexes, intelligent sensing and intelligent traditional Chinese medicine rehabilitation physiotherapy in the wearing process. The device adopts the NIC thermistor, has the characteristics of small size, small resistance value and temperature characteristic fluctuation, quick temperature change response and the like, and can perform high-sensitivity and high-precision detection.