3results about How to "Cause death" patented technology

The application discloses a method and application of knocking down ubiquitin-specific peptidase 7 protein, and belongs to the field of biological medicine. The method for knocking down the USP7 protein comprises: specifically inhibiting the expression of USP7 in endothelial cells through gene intervention, and the gene intervention means comprises shRNA, siRNA or recombinant virus carrier-mediated USP7 expression down-regulation. Further provided is a USP7 knockdown reagent for preparing a drug for treating endothelial cell inflammation or a cardiovascular disease, in particular, the USP7 knockdown reagent is a USP7 knockdown virus carrier containing a Cdh5 promoter; the cardiovascular disease comprises heart failure, myocardial infarction or ischemic cardiomyopathy. The application specifically knocks down the expression of USP7 in endothelial cells through gene intervention, significantly improves the migration, tube formation capacity and reduces the apoptosis of the endothelial cells, repairs endothelial dysfunction, the USP7 knockdown virus carrier is used for preparing a drug for treating a cardiovascular disease, and has important clinical value.

This invention relates to the field of dampening solution technology and discloses a rinse-free, alcohol-free dampening solution and its preparation method. The invention utilizes the phenolic hydroxyl groups in cashew nut shells to react with cyanuric chloride to obtain intermediate 1. Then, the chlorine atoms in intermediate 1 are used to substitute the amino groups in 5-amino-4-hydroxy-1,3-benzenedisulfonic acid to obtain cashew nut shells containing sodium tetrasulfonate. Butyl acrylate, hexyl methacrylate, and cashew nut shells containing sodium tetrasulfonate are copolymerized under the initiation of azobisisobutyronitrile to obtain a modified acrylate polymeric surfactant. Finally, citric acid, sodium citrate, a polymeric film-forming agent, 1,2-propanediol, and the modified acrylate polymeric surfactant are mixed and stirred evenly to obtain the rinse-free, alcohol-free dampening solution. The acrylate polymeric surfactant prepared by this invention, when applied to the dampening solution, can improve the antibacterial and wetting effects of the dampening solution.

The utility model relates to seedling raising equipment technical field discloses a seedling raising tray's open air seedling raising equipment, including base: the top of base is fixed with mounting panel, the both ends of mounting panel both sides all install a plurality of L type rest rack, L type rest rack is longitudinal arrangement, the length of L type rest rack is increasing gradually from top to bottom, the both sides of mounting panel all are provided with a plurality of rest tray that uses in coordination with L type rest rack, rest tray is misaligned from top to bottom. The middle part of mounting panel both sides all are fixed with a plurality of first supporting plate that uses in coordination with the placing groove. The seedling raising tray's open air seedling raising equipment, through the misaligned of rest tray, on the basis of using longitudinal space, can greatly reduce the upper layer to the lower layer sunshade, make seedling be able to receive sufficient illumination, to guarantee the efficiency of photosynthesis, improve the overall seedling raising quality and consistency.