66results about How to "Improve inflammation" patented technology

The invention provides recombinant IV-type collagen as well as a preparation method and application thereof, and relates to the technical field of biochemical engineering. The preparation method of the recombinant IV-type collagen comprises the following steps: obtaining a codon from amino acid of the recombinant IV-type collagen, further obtaining a target gene, and synthesizing the target gene onto an expression vector to obtain a plasmid; transferring the plasmid into an expression host, and screening a positive transformant to obtain an expression strain; and culturing the expression strain, and expressing the target protein to obtain the crude recombinant IV-type collagen. The high-purity recombinant IV-type collagen is prepared through a genetic engineering technology, and the recombinant IV-type collagen can significantly down-regulate inflammatory factors and reduce inflammation; heat injury can be reduced by up-regulating heat shock protein; after heat injury, the recombinant IV-type collagen can obviously lower metal matrix protease of heat injury cells, and also can obviously promote gene expression of type I collagen and type III collagen, improve skin elasticity and moisture content and delay skin aging.

The invention discloses plant lactobacillus WH021 and application thereof in preventing and / or relieving neuroinflammation, and belongs to the technical field of microorganisms. The plant lactobacillus WH021 is separated and purified from excrement of healthy babies, is a probiotic with the function of relieving neuroinflammation, and has good application potential in development of food, health care products and drugs for preventing brain inflammation related diseases caused by chronic inflammation of bodies of middle-aged and elderly people.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

The invention discloses a preparation method of a squalene and tocopherol composition microcapsule, and relates to the technical field of microcapsule preparation, and the preparation method is characterized by comprising the following steps: squalene, tocopherol and an emulsifier form a core material emulsion, Arabic gum, modified corn starch and maltodextrin are compounded to obtain a wall material emulsion, and the wall material emulsion is prepared into the squalene and tocopherol composition microcapsule. Uniformly mixing the core material emulsion and the wall material emulsion, and performing a spray drying process to obtain the squalene and tocopherol composition microcapsule. The obtained microcapsule has good thermal stability and antioxidant activity, and can well protect active components.

The invention relates to the field of daily cosmetics, health care product raw materials and biology, and discloses lactobacillus rhamnosus JMB235 with the preservation number of CCTCC (China Center for Type Culture Collection) No.M 20232530. The fermentation product of lactobacillus rhamnosus has multiple effects, and can control grease secretion, prevent alopecia, inhibit acne, promote hair growth, inhibit eczema, inhibit inflammation, maintain skin barrier, promote epidermal cell proliferation and differentiation, block sun, repair damaged skin or improve insomnia. The compound can be used for preparing skin external preparations, health-care products, beautifying oral preparations, foods or food additives. And the fermentation product has good stability, is storable and has a wide application prospect.

The composition for repairing the meniscus comprises a growth differentiation factor and emodin, and is used for improving inflammation and oxidative stress in a microenvironment and promoting a cell chondrogenic differentiation process. Through verification, according to the core-shell co-delivery nano-carrier provided by the invention, two bioactive compounds, namely emodin and a growth differentiation factor, are wrapped by mesoporous silicon dioxide nano-particles, and the two bioactive compounds are used for promoting fibrocartilage differentiation. The double-drug nano delivery system provides continuous release of emodin and GDF, synergistically regulates severe inflammation and oxidation environments, and promotes in-vitro and in-vivo fibrous cartilage regeneration. Benefited from this, according to the invention, a three-dimensionally printed meniscus-shaped PCL framework is combined with the composition by using cartilage-specific matrix hydrogel, a stability-enhanced meniscus replacement model is constructed, a cartilage immune microenvironment is synergistically adjusted, and successful repair of animal (rabbit) full meniscus replacement is realized.

The invention belongs to the technical field of oral health care, and particularly discloses a toothpaste composition for inhibiting dental plaque and improving gingival inflammation, finished toothpaste and a preparation method thereof. The toothpaste composition is prepared from 0.5 to 10 parts of zinc carbonate hydroxide, 0.01 to 0.2 part of pearl powder, 0.01 to 0.2 part of amber powder, 0.5 to 5 parts of lactobacillus / soybean milk fermentation product filtrate, 0.05 to 1 part of borneol and 0.01 to 0.2 part of clove oil. The toothpaste composition provided by the invention inherits a classic formula, is simple in components and high in safety, and has good effects of inhibiting dental plaque and improving gingival inflammation; and the provided preparation process is simple and easy for large-scale production.

The invention relates to the technical field of polypeptide drugs, in particular to a nanoscale mitochondrial DNA scavenger and application thereof. The polypeptide targeting myocardial cells in the nanoscale mitochondrial DNA scavenger provided by the invention can target the myocardial cells, so that the STING inhibitor is enriched in the myocardial cells; the mtDNA probe can be combined with mtDNA in a targeted manner to form an NS-mtDNA compound; the self-assembly peptide is a convertible self-assembly unit, forms a nano structure, can transport an NS-mtDNA compound to lysosome to promote degradation, can prolong the retention time and stability of the nano-scale mitochondrial DNA scavenger and continuously release an STING inhibitor, the released STING inhibitor can inhibit an STING pathway, and the self-assembly peptide can be used for inhibiting the activity of the nano-scale mitochondrial DNA scavenger, so that the activity of the nano-scale mitochondrial DNA scavenger can be improved, and the activity of the nano-scale mitochondrial DNA scavenger is improved. Therefore, myocarditis or inflammations related to myocarditis are improved, and a new technical support is provided for treatment of myocarditis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating uterine incision diverticulum. The traditional Chinese medicine composition comprises an oral medicine, an enema and a ginger treatment bag, wherein the oral medicine is prepared from the following raw materials in parts by weight: 8-12 parts of lycopodium clavatum, 12-18 parts of radix paeoniae alba, 8-15 parts of radix bupleuri, 12-18 parts of fructus liquidambaris, 12-18 parts of caulis spatholobi, 12-18 parts of codonopsis pilosula, 12-18 parts of roasted rhizoma atractylodis macrocephalae, 12-18 parts of astragalus membranaceus, 12-18 parts of radices trichosanthis, 8-12 parts of rumex nepalensis, 8-12 parts of platycodon grandiflorum, 12-18 parts of honeysuckle stem, 1-5 parts of dragon's blood, 8-12 parts of cassia twig and 8-12 parts of fenugreek; the traditional Chinese medicine composition for treating the uterine incision diverticulosis has the effects of dispelling pathogenic qi, promoting blood circulation to remove blood stasis, clearing away heat and toxic materials and regulating qi and blood, and has a better effect of treating infection and inflammation; the traditional Chinese medicine composition has multi-dimensional synergistic effects on focuses through oral administration, ginger treatment and enema, is used for treating menstrual period shortening of uterine incision diverticulosis, and is good in pain relieving effect and quick in effect.

The invention relates to the field of biological medicine, in particular to application of demethyleneberberine in preparation of medicine for preventing or treating gout. In-vitro experiments show that the demethyleneberberine hydrochloride can inhibit RAW264.7 cell inflammation caused by monosodium urate crystals; in-vitro experiments show that the traditional Chinese medicine composition can relieve rat gout-like symptoms induced by MSU and relieve hyperuricemia induced by oteracil potassium combined with hypoxanthine. The result shows that the demethyleneberberine hydrochloride (DMB) can inhibit gout induced by monosodium urate crystals in the aspects of resisting inflammation and regulating uric acid metabolism, and the application range of the demethyleneberberine hydrochloride is widened.

The present invention discloses an application of FN-1501 and its pharmaceutical composition in the preparation of drugs for preventing and / or treating liver injury, specifically including drugs for preventing and treating autoimmune hepatitis, viral hepatitis or drug-induced liver injury, especially drugs for preventing and treating autoimmune hepatitis. It can achieve multiple pharmacological effects of improving liver tissue structure damage, liver inflammation, reducing serum transaminase, serum lactate dehydrogenase and mRNA levels of inflammatory factors, and can play a therapeutic role at the gene level, molecular level and tissue level. There are no toxic side effects in the body, and the preparation form used is wide. The appropriate drug dosage form can be selected according to the clinical application scenario, which provides a new development strategy for targeted drugs for the prevention and treatment of liver injury.

The invention provides application of rhizoma atractylodis macrocephalae polysaccharide in preparation of a medicine for treating diabetes mellitus complicated with steatohepatitis, and belongs to the field of traditional Chinese medicines. The atractylodes macrocephala polysaccharide (APMs) composed of glucose, arabinose, galactose, galacturonic acid and glucuronic acid is prepared through a water extraction and alcohol precipitation method, can be used for treating diabetes mellitus complicated with steatohepatitis, and has a remarkable treatment effect on diabetes mellitus complicated with steatohepatitis; insulin resistance, lipid metabolism disorder, liver inflammation, liver injury and liver fibrosis caused by diabetes mellitus complicated with steatohepatitis can be improved.

The invention discloses a hair blackening traditional Chinese medicine formula which comprises the following components: cacumen biotae, radix polygoni multiflori, herba ecliptae, cortex eucommiae, semen sesami nigrum, radix rehmanniae preparata, fructus ligustri lucidi, indigo naturalis and rhizoma bletillae. Meanwhile, the invention discloses a hair blackening traditional Chinese medicine ointment smearing device which comprises an ointment bottle, a bottle opening transition tool, a hair blackening ointment suction and heating suite and anti-curl comb teeth, the bottle opening transition tool is detachably fixed to the ointment bottle, the suction pipe is inserted into the ointment bottle, the hair blackening ointment suction and heating suite is connected to the bottle opening transition tool in an inserted mode, and the anti-curl comb teeth are arranged on the bottle opening transition tool. The hair blackening paste sucking and heating suite is connected with the suction tube, and the hair curling prevention comb teeth are inserted into a paste conveying connector of the hair blackening paste sucking and heating suite. The hair blackening formula disclosed by the invention can be used for blackening hair and nursing scalp, so that the scalp environment is improved, and the problems of scalp inflammation and the like are solved at the same time; and the hair blackening ointment can be heated, so that the painful experience of a user due to the fact that the ice-cold hair blackening ointment is directly smeared on the scalp is prevented.

The present invention provides a probiotic for preventing, treating or assisting in the treatment of colorectal cancer and its application, and relates to the technical field of microorganisms. Lactobacillus plantarum , specifically Lactobacillus plantarum KSFY202401, which is deposited in the General Microbiology Center of China Microorganism Culture Collection Administration Committee, and the deposit number is CGMCC NO.30984. The Lactobacillus plantarum KSFY202401 provided by the present invention has a significant effect in intervening in the occurrence and development of colorectal cancer, and it slows down the development of colorectal cancer by improving intestinal inflammation and promoting intestinal tumor cell apoptosis. It provides scientific evidence for the healthy functionality of Lactobacillus plantarum KSFY202401 on the intestine, and provides more scientific basis for the prevention and auxiliary treatment of colorectal cancer from the dietary aspect.

The application discloses a method and application of knocking down ubiquitin-specific peptidase 7 protein, and belongs to the field of biological medicine. The method for knocking down the USP7 protein comprises: specifically inhibiting the expression of USP7 in endothelial cells through gene intervention, and the gene intervention means comprises shRNA, siRNA or recombinant virus carrier-mediated USP7 expression down-regulation. Further provided is a USP7 knockdown reagent for preparing a drug for treating endothelial cell inflammation or a cardiovascular disease, in particular, the USP7 knockdown reagent is a USP7 knockdown virus carrier containing a Cdh5 promoter; the cardiovascular disease comprises heart failure, myocardial infarction or ischemic cardiomyopathy. The application specifically knocks down the expression of USP7 in endothelial cells through gene intervention, significantly improves the migration, tube formation capacity and reduces the apoptosis of the endothelial cells, repairs endothelial dysfunction, the USP7 knockdown virus carrier is used for preparing a drug for treating a cardiovascular disease, and has important clinical value.

The invention relates to the technical field of medicines, and discloses a preparation method and application of an alcohol extract of root tuber of pilose asiabell. The preparation method comprises the following steps: crushing dried tuberous roots of cayenne pepper, sieving, weighing cayenne pepper powder, adding 95% ethanol, soaking and extracting at room temperature for 2 days, stirring once within 2 hours, once stirring for 30 minutes, performing suction filtration after soaking to obtain ethanol leaching liquor, soaking and extracting filter residues for 2 times, merging the ethanol leaching liquor, transferring into a rotary vacuum concentrator, and concentrating to obtain the cayenne pepper pure extract. Concentrating and drying to obtain a maozhou root tuber alcohol extract; experimental verification shows that the prepared pure extract of the sauced head has the effect of relieving the fatty liver, so that the pure extract of the sauced head can be used for preparing the medicine for relieving the fatty liver.

The present invention provides the use of macrophage PHGDH in the preparation of TAK1 inhibitors, and belongs to the field of biomedicine technology. The present invention finds that knocking down PHGDH in macrophages can promote PA-induced inflammation. In addition, macrophage-specific PHGDH binds to TAK1, inhibiting its interaction with TAB1, thereby inhibiting the activation of TAK1 and downstream NF-κB and MAPK signaling. Inhibiting TAK1 activation can slow the development of metabolic dysfunction-related fatty hepatitis MASH caused by myeloid PHGDH knockout. Importantly, adeno-associated virus-mediated overexpression of PHGDH in liver macrophages alleviates MAFLD. The present invention finds that macrophage PHGDH is a promising drug for the treatment of MAFLD.

The invention provides application of resolvin E1 in preparation of a medicine for relieving pulpitis and / or promoting repair of dental pulp tissue damage. According to the application, pulpitis can be effectively improved, the pulp retention rate is increased, and a new thought is provided for development, screening and preparation of drugs for relieving pulpitis and / or promoting damage repair of dental pulp tissues.

The present application provides an edible plant enzyme composition that synergistically improves skin moisture and inflammation. The composition comprises edible plant enzymes and Sophora japonica, and the weight ratio of edible plant enzymes to Sophora japonica is 7:2-29:2. The composition is used in the field of food or health food, and the main dosage forms used are oral liquid, beverage, and soft candy, mainly through direct oral administration. The composition of the present invention can synergistically improve skin moisture and inflammation.

The invention relates to the technical field of cosmetics, in particular to soothing and sunscreen spray as well as a preparation method and application thereof. The spray is prepared from the following raw materials: cyclopentasiloxane, octyl polymethylsiloxane, polydimethylsiloxane, butanediol, polymethylsilsesquioxane, ethylhexyl salicylate, diethylaminohydroxybenzoyl hexyl benzoate, octocrylene, lauryl polyethylene glycol (PEG)-10 tri (trimethylsiloxy) silyl ethyl polydimethylsiloxane, ethylhexyl triazinone, an organic solvent, an organic solvent and a solvent. The composition is prepared from herba centellae extract, radix gentianae extract and water. The spray prepared by the invention has excellent effects of soothing the skin, blocking the sun and preventing the skin from dullness.

The invention discloses a composition for improving male and female dysfunction and climacteric syndrome, the composition is prepared from the following raw materials in parts by weight: 5-20 parts of royal jelly freeze-dried powder and 5-20 parts of bee pollen, and the composition is prepared by the following preparation method: step 1, sequentially putting the royal jelly freeze-dried powder and the bee pollen into a container according to the proportion, and uniformly stirring; uniformly stirring through a stirring rod to obtain mixed powder; step 2, placing the mixed powder obtained in the step 1 in an environment of minus 40 DEG C for freeze drying to obtain a mixed composition; and step 3, pressing the mixed composition obtained in the step 2 into tablets in an environment of 15 DEG C through a tablet press. The composition disclosed by the invention is scientific and reasonable in formula, can directly act on affected parts, can be used for treating male and female dysfunction, prostate symptoms and climacteric syndromes, improves the activeness of male sperms, improves the survival rate of female ova, enhances the immunity, and improves female vaginal dryness, inflammation and endocrine disorder.

The present invention relates to the field of microorganisms, and specifically to providing a new functional lactic acid bacteria expressing ETEC antigens, and a preparation method and application thereof. The recombinant Lactobacillus plantarum expressing ETEC antigens uses Lactobacillus plantarum NC8 as a host bacterium and a pPG612.1 expression vector, wherein the pPG612.1 expression vector contains the FaeC gene or LngC gene of ETEC. The present invention innovatively integrates the FaeC and LngC genes of ETEC into Lactobacillus plantarum NC8 for expression, and can activate the intestinal mucosal immune response by oral administration, which can not only directly counteract the intestinal damage caused by ETEC and protect the intestinal villus structure, but also can regulate the intestinal microenvironment, stimulate the body to produce a systemic immune response, improve the body's ability to resist ETEC infection, reduce the morbidity and mortality of ETEC infection, and thus improve the economic benefits of the pig farming industry.

The invention relates to the field of microorganisms, in particular to novel functional lactic acid bacteria for expressing an ETEC antigen as well as a preparation method and application of the novel functional lactic acid bacteria. According to the recombinant lactobacillus plantarum for expressing the ETEC antigen, lactobacillus plantarum NC8 is used as host bacteria, a pPG612.1 expression vector is used, and the pPG612.1 expression vector contains a FaeC gene or an LngC gene of ETEC. According to the invention, FaeC and LngC genes of ETEC are creatively integrated into lactobacillus plantarum NC8 for expression, and the immune response of intestinal mucosa can be activated in an oral administration mode, so that intestinal injury caused by ETEC can be directly resisted, the villus structure of the intestinal tract can be protected, the whole-body immune response can be generated by regulating the microenvironment of the intestinal tract and stimulating the organism, and the immune response of the intestinal tract can be inhibited. The ETEC infection resistance of the body is improved, and the morbidity and mortality of ETEC infection are reduced, so that the economic benefits of the pig industry are improved.

The invention belongs to the technical field of biomedicine, and particularly relates to nano albumin paclitaxel particles as well as a preparation method and application thereof. According to the invention, DCC and NHS are used as condensing agents, so that the conjugate HSA-RA with relatively high in-vivo stability can be obtained; hSA-RA and PTX are self-assembled according to a specific ratio, so that the effect of synergistically inhibiting cancer cells by PTX and RA can be improved, and the effective release rate of the medicine can also be improved. The nano albumin paclitaxel particle provided by the invention not only enhances the killing effect of paclitaxel on living tumor cells, but also has an obvious improvement effect on cervical cancer cell inflammation and oxidative damage, so that by inhibiting the expression of CYP3A4 and CYP2C8, the nano albumin paclitaxel particle has obvious and positive effects on treatment and prognosis of cervical cancer.

The invention provides a composite active dressing for neural restoration and a preparation method and application thereof, and relates to the technical field of medical materials. The composite active dressing comprises a transdermal inner layer and a small extracellular vesicle slow-release outer layer, the transdermal inner layer is of a membrane-shaped structure and comprises a composite active component and a hydrogel matrix material, and the composite active component is selected from one or more of an anti-inflammatory component, a microcirculation improving component, an antioxidant component and a neurotrophic component; the small extracellular vesicle sustained-release outer layer is of a three-dimensional network structure and comprises small extracellular vesicles and a hydrogel matrix material. According to the invention, stable loading and layered deep delivery and release of the small extracellular vesicles are realized, the inflammatory response and microcirculation state of an injured part are improved, proliferation migration and remyelination of Schwann cells can be promoted, and axon regeneration and effective repair of nerve injury can also be promoted.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

The invention provides a method for treating arthritis by using mesenchymal stem cells subjected to limited induction in vitro. Osteoarthritis is a common joint degenerative disease and is mainly characterized by cartilage injury and inflammatory response. The traditional treatment method is difficult to realize cartilage regeneration, but mesenchymal stem cells (MSC) show a prospect in joint repair due to multidirectional differentiation potential and immunomodulatory effect. According to the invention, bergenin (KGN) is utilized in vitro to induce MSC to differentiate into chondrocytes, so that the chondrogenic ability of the cells is enhanced. The inducible MSC is injected into a rat gonitis model, cartilage repair is remarkably promoted, and inflammation is reduced. Experimental results show that the method can effectively relieve arthrocele, improve the motion function and reduce the pain sensitivity. The invention not only improves the treatment effect of MSC, but also provides a safe and effective new approach for treating arthritis, and has important clinical application value.

The invention belongs to the technical field of cosmetics, and particularly relates to anti-wrinkle essence water and a preparation method thereof.The anti-wrinkle essence water is mainly capable of achieving the anti-wrinkle and skin care effects due to combination of multiple anti-wrinkle components in the anti-wrinkle essence water, the anti-wrinkle essence water has the effects of promoting skin metabolism, resisting oxidation and reducing inflammation due to matching of the different components in the anti-wrinkle essence water, and the anti-wrinkle essence water is free of side effects. The composition promotes synthesis of collagen by enhancing metabolism and promoting cell regeneration so as to improve skin laxity and wrinkles, improve skin compactness and achieve an anti-aging effect, reduces formation of fine wrinkles and wrinkles by resisting oxidation and neutralizing free radicals, reduces skin inflammation, regulates skin micro-ecology and slows down skin aging by resisting inflammation, and has a good anti-aging effect. In addition, the anti-wrinkle essence water also contains a plurality of moisturizing and soothing components, and the anti-wrinkle, moisturizing and soothing effects are mutually combined and mutually promoted.

The invention provides probiotics for preventing, treating or adjunctively treating colorectal cancer and application of the probiotics, and relates to the technical field of microorganisms. The invention provides lactobacillus plantarum, in particular to lactobacillus plantarum KSFY202401, which is preserved in the General Microbiological Center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CGMCC NO.30984. The lactobacillus plantarum has the advantages that the lactobacillus plantarum is prepared from lactobacillus plantarum, lactobacillus plantarum KSFY202401 and lactobacillus plantarum KSFY202401; the lactobacillus plantarum KSFY202401 provided by the invention plays a remarkable role in interfering the occurrence and development of colorectal cancer, and plays a role in slowing down the development of colorectal cancer by improving intestinal inflammation and promoting the apoptosis of intestinal tumor cells. The lactobacillus plantarum KSFY202401 provides scientific evidence for the healthy function of the lactobacillus plantarum KSFY202401 on intestinal tracts, and provides more scientific basis for prevention and adjuvant therapy of colorectal cancer from the diet aspect.

The invention discloses an application of cordyceps guangdongensis sporocarp polysaccharide in preparation of a product for treating and improving diabetic nephropathy. Experimental results show that the cordyceps guangdongensis sporocarp polysaccharide can treat and improve the diabetic nephropathy, improve the renal function, reduce the levels of serum urea nitrogen and serum creatinine, and reduce the level of uremia toxin indolesulfuric acid phenol in the plasma of diabetic mice; kidney inflammation is improved, and mRNA expression of IL-6, TNF-alpha, IL-1beta and MCP-1 in the kidney is reduced; the oxidative stress and fibrosis of the kidney are inhibited, and the mRNA expression of Rac1, keap1, Ncf2 and Nsf11c of the kidney is reduced; the abundance of pathogenic bacteria in intestinal tracts and kidneys is reduced, and the pathogenic bacteria are mainly Escherichia.