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A nanomaterial for relieving tendinopathy inflammation and pain and its preparation method

ActiveCN121731346Brelieve inflammationrelief the painAntipyreticAnalgesicsLocal immunityTendinopathy
This invention provides a nanomaterial for relieving inflammation and pain in tendinopathy and its preparation method, relating to the field of biomedical technology. The nanomaterial comprises decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. The aforementioned nanomaterial for relieving inflammation and pain in tendinopathy includes decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. Combining these two components yields DTM-MSM, which regulates the proliferation and differentiation of tendon stem cells, modulates the local immune microenvironment, and relieves pain. It can improve inflammation and pain in tendinopathy and accelerate the repair of damaged tendons. In other words, DTM-MSM can not only alleviate the pathophysiological changes in tendinopathy but also rapidly improve the main clinical symptoms of tendinopathy, such as pain, swelling, and functional limitation, thus overcoming the current shortcomings of tendinopathy treatments, including slow onset of action, poor compliance, significant side effects, and unclear efficacy.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

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