87results about How to "Control secretion" patented technology

A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having at least one collecting well and at least one collecting flow channel, wherein, the culture plate is placed between the orifice plate and the bottom plate. The collecting flow channel connects to all regulating orifices in the culture wells and guides the fluid from the culture wells, then receives the fluid in the collecting well. The fluid flows into the orifice plate from the inlet port of the top plate, and then diversifies into the culture plate, then arrives at each culture well by way of the injection ports, and finally collects in the collecting well of the bottom plate.

The invention relates to a processing method of organic white tea and belongs to the technical field of tea leaf processing. The processing method of the organic white tea comprises the following steps: pick up tea leaves, spreading green leaves, withering, kneading gently, drying and packaging. The processing method provided by the invention is simple in processing working procedure, is high in production efficiency, is low in production cost, does not damage the activity of enzyme, cannot promote the oxidization effect in the production process, and moreover can reveals pekoe flavor and ensure fresh soup flavor; tea leaves processed by the method are high in nutritional value; in addition, the tea leaves used in the invention are tea leaves from organic plantation gardens; chicken manure is used as an organic fertilizer for tea leaves so that the tea leaves are not polluted by chemical fertilizers, pesticides and the like; therefore, the tea product is good in mouthfeel and is healthy.

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; ring B represents aryl or heteroaryl; RB represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E1 and E2 represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO2—Y, —O— (alkylene)-Y, —O-Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.

The invention discloses an externally used composition and a skin cleansing mask with blackhead removing and pore shrinking effects, and aims at providing an externally used composition with the advantages of mildness, no irritation, effective softening and dissolving of debris and grease in pores, removal of blackheads in the skins, promotion of no obstruction of the skins, pore shrinkage and supplementation of water to the skins, and a skin cleansing mask containing the composition. The externally used composition mainly comprises, by weight, 20-45 parts of a plant composition , 20-30 parts of floral water, 5-20 parts of polyol and 5-15 parts of deionized water; and the cleansing mask contains 5-20 wt% of the externally used composition blackhead removing and pore shrinking effects. The externally used composition and the skin cleansing mask belong to the technical field of cosmetics.

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like ; ring B represents aryl or heteroaryl; RB represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E1 and E2 represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO2—Y, —O—(alkylene)—Y, —O—Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.

Disclosed is a hair-nourishing agent comprising the following constituents (by weight ratio): prepared fleece-flower root 10-25, ligustrum japonicum 10-25, sesame seed 10-25, doddor seed 10-25, mulberry seed 10-25, black soyabean 10-25, Chinese prickly ash 15-20, ginger 15-20, chrysanthemum flower 15-20, chastetree fruit 15-20, Chinese dittany bark 15-20, pine leaves 15-20, arborvitae tops 10-20, Chinese parasol tree leaves 10-20, eclipta 10-20, safflower 10-20, 60-75 deg white spirit with a total weight of 3-8 times of each herbs. The preparing process comprises the steps of disintegrating, immersing and filtering.

The invention discloses a cosmetic composition with anti-acne efficacy, and a mud-like mask with anti-acne efficacy. The cosmetic composition comprises 2-9 parts of white water lily lotus extract, 2-6 parts of lotus extract, 1-5 parts of Moringa Pterygosperma seed extract, and 3-7 parts of Laminaria Saccharina extract. The cosmetic composition is a multi-efficacy cosmetic composition formed through compounding the white water lily lotus extract, the lotus extract, the Moringa Pterygosperma seed extract and the Laminaria Saccharina extract according to specific proportions, and effective ingredients contained in all above efficacy components complement and cooperate to reasonably and efficiently use the components in order to well inhibit formation of bacteria and control grease secretion, so the anti-acne efficacy is reached. The cosmetic composition and the mud-like mask have the advantages of safety, no irritation, and no dependence in the long-term use process, and can be used by sensitive people.

The invention relates to a scalp care solution. The scalp care solution comprises, by weight, 1-2% of salicylic acid, 5-10% of a slow-release dispersant, 1-3.5% of a sebum conditioner, 0.5-2% of a repairing agent, 1% of a plant extract and the balance water; preferably, a suitable quantity of a cooling agent such as menthol can be added. The scalp care solution does not contain an alcohol reagent,reduces scalp stimulation and further repairs the skin barrier; by proportioning the content of the components, a synergistic effect of the components is fully exerted, a patient feels comfortable during use and has no stimulation and adverse reactions, and the clinical curative effect is good.

The invention provides a formula of Chinese herbal medicine for lipsotrichia stopping and hair growth and a preparation method thereof, belonging to the technical field of the Chinese herbal medicines. The formula comprises a medicine for oral administration and a medicine for external application. The medicine for oral administration is a clear solution which is prepared by the following steps of: weighing 13 kinds of Chinese herbal medicines such as ginseng, Chinese caterpillar fungus, herba cistanche, tuber fleeceflower root and the like according to the weight ratio, mixing and crushing the Chinese herbal medicines, adding water according to a proportion of 1:5, decocting and standing still for 48 hours. The medicine for external application is a clear solution which is prepared by the following steps of: weighing 14 kinds of Chinese herbal medicines such as asarum, tall gastrodia tuber, simpleleaf shrub chastetree fruit, feverfew and the like according to the weight ratio, mixing and crushing the Chinese herbal medicines, adding water according to a proportion of 1:10, decocting and standing still for 48 hours. The medicine for external application takes an effect in stopping lipsotrichia within 3 to 5 days on various lipsotrichia symptoms including seborrheic alopecia when used alone. The combination use of the medicine for oral administration and the medicine for external application can achieve very good hair growth effect on the various lipsotrichia symptoms including the seborrheic alopecia; and the grown hair is healthy and robust and does not fall off. The formula is a natural Chinese herbal medicinal solution and has the advantages of no simulation and no toxic or side effects.

The present invention discloses a hair loss preventing and growth promoting lotion and a method of preparing the same. The hair loss preventing and growth promoting lotion comprises, by weight percent, 35% to 45% of ethanol, 25% to 35% of water, 5% to 10% of ligustrum, 4% to 8% of prepared fleeceflower root, 3% to 8% of astragalus membranaceus, 2% to 5% of ginseng, 2% to 5% of safflower, 2% to 5% of arborvitae and 1% to 3% of liquorice root. The method comprises the following steps of immersing, decocting and filtering the above solid ingredients with ethanol and water to extract extracting solutions; mixing the extracting solutions with ethanol and water according to a formula ratio; and obtaining the hair loss preventing and growth promoting lotion after filtering and packaging. The hair loss preventing and growth promoting lotion provided in the invention has the effects of preventing hair falling out and promoting hair metabolism.

A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having at least one collecting well and at least one collecting flow channel, wherein, the culture plate is placed between the orifice plate and the bottom plate. The collecting flow channel connects to all regulating orifices in the culture wells and guides the fluid from the culture wells, then receives the fluid in the collecting well. The fluid flows into the orifice plate from the inlet port of the top plate, and then diversifies into the culture plate, then arrives at each culture well by way of the injection ports, and finally collects in the collecting well of the bottom plate.

A topical composition comprising: (a) conjugated linoleic acid and / or derivatives thereof; (b) a retinoic acid, retinol, retinyl ester and / or an LRAT / ARAT inhibitor; and (c) a dermatologically acceptable vehicle. Such skin care compositions are useful for treating and / or preventing normal, but undesirable, skin conditions selected from the group consisting of wrinkling, sagging, photodamaged skin, dry skin and age spots and soothing sensitive skin.

The invention belongs to the technical field of cosmetics, and discloses a plant acne-removing compound as well as a preparation method and applications of the plant acne-removing compound. The plant acne-removing compound is prepared from the following components in parts by weight: 40-80 parts of shallot extracting solution, 10-20 parts of wild chrysanthemum flower extracting solution, 10-20 parts of lotus leaf extracting solution, and 2-10 parts of betaine salicylate. The shallot extracting solution can effectively inhibit the breeding of propionibacterium acnes and kill bacteria; the lotus leaf extracting solution can effectively control the secretion of skin sebum; the wild chrysanthemum flower extracting solution has the effects of clearing away heat and toxic materials, and diminishing inflammation; betaine salicylate can accelerate the falling of the human epidermal keratinocytes; through the synergistic effect of the four components, the plant acne-removing compound achieves the effect of inhibiting propionibacterium acnes from the formation mechanism of acnes.

The invention discloses a compound traditional Chinese medicine extract with an acne removing function and application thereof in cosmetics. The compound traditional Chinese medicine extract disclosed by the invention contains the following traditional Chinese medicine ingredients in percentage by weight: 1-25% of honeysuckle flowers, 1-20% of loquat leaves, 1-25% of forsythia fruit, 1-15% of radix scutellariae, 1-20% of Chinese holly, 1-25% of herba andrographitis, 1-20% of tribulus terrestris and 1-25% of mulberry barks. The compound traditional Chinese medicine extract disclosed by the invention has good effects of controlling the secretion of oils and fats, dredging sweat pores, carrying out bacteriostasis and disinfection and removing acnes. The composition does not contain chemically-synthesized substances, is free from toxic or side effects, is low in skin irritation and stable in nature, and is safe and reliable.

The invention discloses a composition containing a radix sophorae flavescentis extract and a cortex magnoliae officinalis extract and cosmetics applying the composition. The composition mainly comprises the radix sophorae flavescentis extract, the cortex magnoliae officinalis extract, a herba artemisiae annuae extract, an extract of seeds of calyx-shaped carrierea and dichlorobenzyl alcohol. By the composition, multi-way mite inhibition is realized through three ways of controlling oil and preventing mites, protecting skin through bacteriostasis and inhibiting mites. In addition, due to the fact that the content of a compound mite killing agent in the composition is small, in combination with plant type mite killing components, the product is mild and free of irritation, and meanwhile, themite killing effect is excellent. According to the technical scheme, the invention belongs to the technical field of cosmetics.

Provided is a compound useful as a preventive or therapeutic agent for sexual-hormone-dependent diseases, etc. It is a fused heterocyclic derivative represented by the following general formula (I). In the formula (I), ring A is a five-membered cyclic unsaturated hydrocarbon or five-membered heteroaryl; R is halogeno, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; ring B is aryl or heteroaryl; R is halogeno, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; E<1> and E<2> each is oxygen, etc.; U is a single bond or alkylene; and X is, e.g., a group represented by Y, -SO2-Y, -O-(alkylene)-Y-, or -O-Z (wherein Y is Z, amino, etc. and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.).

Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.

The invention discloses essential oil handmade soap with effects of cooling, moisturizing and cleaning skin. The essential oil handmade soap comprises, by weight, 35-45 parts of sodium cocoyl glutamate, 10-15 parts of flower and plant essential oil, 5-8 parts of tea polyphenol, 3-6 parts of lycium barbarum polysaccharide, 1-3 parts of lotus leaf extract, 1-3 parts of radix scrophulariae extract, 12-15 parts of trehalose, 7-10 parts of glutathione, 3-5 parts of vitamins, 30-35 parts of grape seed oil, 15-20 parts of palm kernel oil, 7-10 parts of castor oil, 1-2 parts of olive oil, 1.5-2.5 parts of sodium hydroxide, 5-8 parts of phosphatidylcholine bilayer, 1-2 parts of superoxide dismutase, 0.5-1 part of a placenta growth factor, 2-3 parts of royal jelly, 1-2 parts of 1, 2-propylene glycol, 2-3 parts of hydroxyethyl urea, 1-2 parts of carbomer and 2-3 parts of sodium lactate. The essential oil handmade soap has effects of deep cleaning skin, softening skin, reducing skin pruritus, balancing skin pH, supplying water, fading wrinkles, promoting shrinkage of enlarged pores of skin and keeping water-oil balance.

The invention provides an oil control composition. The oil control composition is prepared from the following raw material in parts by weight: 0.01 to 5 parts of ectoin, 1 to 10 parts of spiraea ulmoides extract and 0.01 to 10 parts of 10-hydroxydecanoic acid. The oil control composition can be applied to an external oil control product, and the addition amount of the oil control composition in the external oil control product is 1-20%. The type of the external oil control product can be toning lotion, essence, cream or lotion cosmetics. According to the oil control composition disclosed by the invention, the problem of system instability caused by the spiraea ulmoides extract is reduced. When being used in a functional skin care product, the oil control composition has an excellent effectof controlling grease secretion and can quickly eliminate glossy and greasy feeling and bring refreshing feeling to skin; and meanwhile, water and oil composition of the skin can be gradually balanced after the oil control composition is used for a long time, the skin barrier can be repaired, and a continuous oil control effect can be showed after stopping using the oil control composition. In addition, the combination of the three components also has a better improvement effect on the redness of the face.

The invention relates to a processing method of organic white tea and belongs to the technical field of tea processing. The method includes steps of picking, spreading, withering, slightly rolling, drying and packaging. The method is simple in processing steps, high in production efficiency and low in production cost. The method does not destroy enzyme activity or promote oxidation in production processes. The method maintains obvious pekoe and fragrance and ensures a fresh soup flavor. The tea processed through the method is high in nutrition value. Tea leaves used in the method are tea leaves in an organic plantation, adopt chicken manure as an organic fertilizer, are free of pollutions caused by fertilizers, pesticides, and the like, and are good in taste and healthy.

The invention relates to an oil-control cosmetic composition and application thereof. The oil-control cosmetic composition is prepared from, by weight, 20-30% of peony root extract, 20-50% of fructusforsythiae extract and 20-60% of rhizoma anemarrhenae extract. The oil-control cosmetic composition has the excellent functions of oil control, enlarged pore shrinkage, skin secretion adjustment and others, is good in durability, low in stimulation and irritability and capable of reducing excessive grease secretion of human skin and skin texture roughness after being added into cosmetics, and keeps the skin young and energetic.

The invention provides application of polypeptide RK12 in preparation of a medicine for treating acne. The new application of the polypeptide RK12 is used for preparing the medicine for treating the acne, the polypeptide RK12 has a remarkable inhibition effect on propionibacterium acnes and clindamycin-resistant propionibacterium acnes, and compared with antibiotics, the polypeptide RK12 is low in drug resistance, has concentration and time dependence, and has a good application prospect in preparation of medicines for treating the acne and the clindamycin-resistant propionibacterium acnes. The research result of an in-vitro antibacterial spectrum experiment also proves that the composition can rapidly inhibit the growth of propionibacterium acnes and clindamycin-resistant propionibacterium acnes, the research result of an in-vitro anti-inflammatory experiment also proves that the composition has an obvious anti-inflammatory effect, and the composition is not easy to generate drug-resistant bacteria due to an antibacterial mechanism different from that of antibiotics. According to the new strategy and thought for treating acne provided by the invention, the antibacterial action mechanism is helpful for clinically limiting the influence of antibiotic resistance.

The invention discloses face cleaning and acne removing handmade soap. The face cleaning and acne removing handmade soap comprises the following components in parts by weight: 20-40 parts of kakorot powder, 15-30 parts of tea tree powder, 3-5 parts of Echinacea powder, 5-10 parts of purple flower lucerne powder, 0.2-0.5 part of jasmine essential oil, 0.2-0.5 part of chamomile essential oil, 150-200 parts of rice bran oil, 90-100 parts of palm kernel oil, 15-20 parts of honey, 60-80 parts of sodium hydroxide and 200-250 parts of lemon juice. The invention also discloses a preparation method of the face cleaning and acne removing handmade soap. The prepared face cleaning and acne removing handmade soap can effectively control secretion of lipid on face and has the effects of moisturizing, activating skin and promoting regeneration of skin, the skin can be deeply cleaned, the problem of coarse pores is solved, the preparation method is simple and easy, and the face cleaning and acne removing handmade soap can be made at home when conditions permit.

The invention belongs to the technical field of tea processing and relates to a long leaf pekoe white tea processing technology. The technology comprises (1) picking: picking white jade-color fresh leaves of long leaf pekoe with one leaf and one bud, (2) withering: removing stems, slices, wax leaves, red leaves and dark leaves and then carrying out withering under sunlight, (3) de-enzyming: putting the withered white tea into a dryer until the moisture content is 20 to 30%, then spreading the tea and carrying out micro-fermentation for 12 to 14 hours, (4) drying: carrying out primary baking through a baking machine at a baking machine temperature of 100 to 120 DEG C, carrying out spreading cooling for 20 minutes and carrying out re-baking at a temperature of 70 to 80 DEG C, and (5) packaging. The technology can effectively prevent the loss of nutrients of the white tea and keeps complete appearance of the white tea. The cultured long leaf pekoe white tea has fluff covering the whole white tea leaf and can produce the tea soup with a fresh fragrance and a mellow taste. The technology has simple processes, is easy to produce in a large scale, removes the bitter taste and realizes a mellow tea fragrance.

The invention discloses a preparation method of olive oil essence, which comprises the steps of collecting an olive kernel, performing low-temperature drying on the olive kernel, adding sodium bicarbonate, performing water soaking, performing ultrasonic treatment, soaking the olive kernel in a green tea concentrated solution, performing filtering, performing the low-temperature drying on the olive kernel, performing high-pressure treatment on the olive kernel in a high-pressure kettle, performing cold pressing by a hydraulic press after the pressure is instantly reduced to the normal pressure to obtain coarse olive oil, performing carbon dioxide supercritical extraction to obtain olive oil, and mixing the olive oil, glycerol, snail slime, hyaluronic acid, collagen powder and hyaluronic acid to obtain the olive oil essence. According to the method, moisture in an olive kernel cell is effectively removed to achieve oil-water separation, and the green tea concentrated solution contains a rich antioxidant substance and can effectively protect a nutrient substance in the olive kernel, so that a nutrient component in the olive kernel can be effectively extracted as a main component of the olive oil essence.

The invention discloses a wristband watchband with a conductive function, relates to the technical field of smart wristbands, and aims to solve the problem that the watchband is only used for fixing awristband on a wrist and has fewer functions. Key points of the technical scheme are as follows, the watchband comprises a buckle end silica gel watchband and a tongue end silica gel watchband. A buckle is arranged on the buckle end silica gel watchband; a plurality of lock holes are formed in the tongue end silica gel watchband, an electrical stimulation module is arranged in the buckle end silica gel watchband, the electrical stimulation module comprises a signal strip arranged in the length direction of the buckle end silica gel watchband, a circuit board connected with the signal strip and an electrode connected with the circuit board, and the electrode is located at the end, away from the dial plate, of the buckle end silica gel watchband. The signal strip is placed in the buckle endsilica gel watchband, the characteristics of conductivity, waterproofness, stability and the like are achieved, the functionality of the watchband is improved, an electrode is installed at a port ofthe buckle end silica gel watchband, the space of a wristband host is saved, the signal strip embedded in the buckle end silica gel watchband is laid in a snake shape, and the bendable characteristicof the buckle end silica gel watchband is achieved.

The invention discloses cleansing milk for pox-skin care and a preparation method of the milk. The cleansing milk for pox-skin care is prepared from, by mass, 22-26 parts of aloe, 18-22 parts of honeysuckle flowers, 16-20 parts of herba portulacae, 8-10 parts of glycerinum, 2-6 parts of propylene glycol, 4-6 parts of myristic acid, 1-3 parts of stearic acid, 2-6 parts of sodium lauroyl glutamate,3-7 parts of potassium hydroxide, 2-4 parts of palmatic acid, 1-3 parts of ceteareth-25, 2-4 parts of glycol distearate, 1-5 parts of lauric acid, 3-5 parts of methylparaben, 4-6 parts of propyl hydroxybenzoate, 20-30 parts of deionized water, 15-25 parts of an amino acid surfactant, 10-14 parts of a thickener and 6-10 parts of inorganic salt. The cleansing milk has the advantages that redundant fat of the skin can be washed out, the face dirt and fat are effectively and deeply removed, and the cleansing milk has the functions of pore blocking prevention, pox prevention, nourishing and herbalcare.

The invention discloses a pre-makeup lotion capable of improving darkness of base makeup, and relates to the technical field of cosmetics. The pre-makeup lotion is prepared from the following raw materials in percentage by mass: 0.3%-30% of water-holding grease; 0.4%-12% of oil absorption powder; 0.2%-12% of a filling component; 0.3%-6% of a lipophilic film forming agent; 0.3%-9% of a hydrophilic film-forming agent; 1.0%-10% of an emulsifier; 0.1%-5% of a thickening agent; 0.1%-10% of an auxiliary component, and the balance of solvent. The filling component is prepared from a filling agent and a brightening agent. The water-holding grease, the oil-absorbing powder, the lipophilic film-forming agent, the hydrophilic film-forming agent and the filling component are compounded, so that the makeup pre-emulsion can act jointly from four aspects of controlling sebum secretion, absorbing redundant sebum, reducing contact between the sebum and foundation make-up and improving the gloss of the foundation make-up, and has the effect of synergistically enhancing the anti-darkness effect of the foundation make-up.