Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes

一种衍生物、稠环的技术，应用在含氮的稠环衍生物领域
CN101663302AInactive Publication Date: 2010-03-03KISSEI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KISSEI PHARMA
Publication Date
2010-03-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

To provide a compound useful as a prophylactic or therapeutic agent for a sex hormone-dependent disease or the like. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a nitrogenated fused ring derivative represented by the general formula (I), or a prodrug, salt or the like thereof, which has a GnRH antagonistic activity; a pharmaceutical composition comprising the derivative or the prodrug, salt or the like thereof; use of the the derivative or the prodrug, salt or the like thereof for medical purposes; and others. In the general formula (I), the rings A and B independently represent an aryl or a heteroaryl; R and R independently represent a halogen, a cyano, an alkyl, an alkylsulfonyl, -OW<1>, -SW<1>, -COW<2>, -NW<3>W<4>, -SO2NW<3>W<4>, an aryl or the like; R<C> represents H or an alkyl; Erepresents an oxygen atom or the like; U represetns a single bond or an alkylene; and X represents Y, -CO-Y, -SO2-Y, -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y or the like [wherein Y represents Z, an amino or the like; and Z represents a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl or the like].
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Description

technical field

[0001] The present invention relates to nitrogen-containing fused ring derivatives.

[0002] More specifically, the present invention relates to the following nitrogen-containing fused ring derivatives or their prodrugs or pharmaceutically acceptable salts thereof and the nitrogen-containing fused ring derivatives or their prodrugs or pharmaceutically acceptable salts thereof, etc. The pharmaceutical composition of said nitrogen-containing fused ring derivative has antagonistic activity against gonadotropin-releasing hormone and can be used for the prevention or treatment of sex hormone-dependent diseases, such as benign prostatic hypertrophy, uterine fibroids, endometriosis, Uterine fibroids, precocious puberty, amenorrhea, premenstrual syndrome, dysmenorrhea, etc. Background technique

[0003] Gonadotropin-releasing hormone (GnRH, or luteinizing hormone-releasing hormone LHRH, hereinafter referred to as "GnRH") is a peptide including 10 amino acids: pGlu-H...

Claims

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