201 results about "Sexual hormones" patented technology

The invention belongs to the field of biological medicines, and particularly relates to application of FeTMPyP in preparation of a medicine for relieving ovarian toxicity. FeTMPyP is selected as an intervention agent aiming at the fact that MC-LR and NaNON combined exposure can remarkably induce mouse ovary nitration stress, mouse follicle barrier damage and ovarian reproductive endocrine dysfunction; the FeTMPyP can be used for effectively relieving nitration stress induced by combined exposure of MC-LR and NaNO2 in mouse ovaries, improving sex hormone disorder, disordered estrus cycle and follicular atresia phenomena caused by combined exposure of the two poisons, and recovering the fertility of the mouse, so that the intervention of the FeTMPyP can be used for relieving the mouse ovarian toxicity induced by combined exposure of MC-LR and NaNO2, and can be used for treating the ovarian toxicity of the mouse caused by combined exposure of the MC-LR and NaNO2. The compound can be used for preparing medicines for preventing and treating related diseases such as mouse ovarian toxicity caused by environmental toxin exposure, and a new way is provided for early recognition and targeted intervention of ovarian related diseases.

Provided herein are oral abiraterone prodrug formulations, related methods and kits, for example, for oral administration to a subject having a sex hormone-dependent benign or malignant disorder such as prostate cancer, an androgen receptor driven cancer, a syndrome due to androgen excess, and / or a syndrome due to glucocorticoid excess such as hypercortisolemia.

The invention relates to the technical field of microorganisms, and provides Witzia ciliaris KY009 (preservation number is CGMCC (China General Microbiological Culture Collection Center) NO. 33480) and Clostridium butyricum KY002 (preservation number is CGMCC NO. 33478), and the two strains are separated from an excrement sample. Experiments prove that the two strains can obviously improve the sperm quality and quantity, regulate the sex hormone level, improve the intestinal inflammation symptom and regulate the expression of related inflammatory factors. The invention also provides a composition containing the two strains, wherein the composition comprises a food composition, a pharmaceutical composition, a health-care product composition, a functional microbial agent and the like. The compositions are useful for improving reproductive health, modulating sex hormone levels, treating intestinal inflammation and promoting mucosal repair, and alleviating metabolic and immune related diseases. The strain and the composition provided by the invention have wide application prospects in the fields of medicines, foods and health-care products.

Use of a mulberry extract in the preparation of a product for treating and / or improving polycystic ovarian syndrome. It is demonstrated in the experiment that the mulberry twig alkaloids can reduce the ovarian weight of rats with polycystic ovarian syndrome and improve the ovarian pathology, regulate the estrous cycle of rats with polycystic ovarian syndrome in the intervention process, and can remarkably adjust the secretion level of sex hormones in rats with polycystic ovarian syndrome.

The present invention relates to a gonadotropin-releasing hormone antagonist, which has an antagonistic activity against gonadotropin-releasing hormone and can be used for the prevention or treatment of a sex hormone-dependent disease, such as benign prostatic hypertrophy, hysteromyoma, endometriosis, metrofibroma, precocious puberty, amenorrhea, premenstrual syndrome, or dysmenorrhea, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, and a pharmaceutical composition comprising the same.

The invention discloses a method for constructing a polycystic ovarian syndrome (PCOS) rat model with reduced sex hormone binding globulin (SHBG) on the basis of ruminococcus aureus with the preservation number of ATCC29149, and belongs to the technical field of animal models. According to the present invention, the bacterial strain is subjected to anaerobic culture to prepare the bacterial liquid, the dosage is 0.2-1 mL / 100 g, the intragastric administration frequency is one time per day to two times per week, and the time lasts for 4-8 weeks, such that the SHBG synthesis of the rat liver is induced to decrease, and the PCOS pathological characteristics such as testosterone level increase, estrus cycle disorder, ovarian polycystic change, insulin resistance and the like are initiated; the problem that a traditional hormone induction method does not conform to the physiological status is solved, the modeling period of a high-fat diet induction method is shortened, and an efficient experimental tool is provided for PCOS mechanism research and drug development.

Disclosed are devices and methods for providing local administration of a sex hormone composition in a mammalian body to promote bone remodeling. The device includes an implantable structure configured for placement at a target intraosseous and / or periosteal site in the mammalian body and an effective amount of a sex hormone composition associated with the implantable structure. The sex hormone composition comprises both an estrogen and an androgen.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a new application of a Homai black-bone chicken Baifeng pill in preparation of a medicine for treating premature ovarian failure. According to the invention, a chemotherapy-induced premature ovarian failure rat model is established by intraperitoneal injection of cis-platinum, an immune premature ovarian failure mouse model is established by subcutaneous multi-point injection of mouse zona pellucida polypeptide 3 (pZP3), and the influence of Jianjing black-bone chicken Baifeng pills on animal estrus cycles, visceral organ coefficients, serum sex hormone levels and ovarian histopathologic changes of the two models is observed. The treatment effect of the Hoojing black-bone chicken Baifeng pill on the premature ovarian failure is verified and defined, the new clinical application of the medicine is expanded, and a new treatment medicine and means are provided for treating the premature ovarian failure, so that a technical support is provided for clinical precise medication.

The present invention relates to methods of treating pleasant sensation loss in a human subject by administering a SIRT6 activator. The invention also provides methods of treating a pleasant sensation loss in a human female subject by administering a SIRT6 activator, wherein the female subject can be recognized by, for example, the presence of two X chromosomes or circulating a female hormone.

The embodiment of the invention relates to the field of microorganisms, in particular to lactobacillus pentosus A2 used for preventing or improving polycystic ovarian syndrome, a microbial agent, a dairy product and application of the lactobacillus pentosus A2, the microbial agent and the dairy product. The preservation number of the lactobacillus pentosus A2 is CGMCC (China General Microbiological Culture Collection Center) NO.27253. The lactobacillus pentosus A2 disclosed by the invention can correct irregular estrus cycles, improve ovarian polycystic lesions, sex hormone disorder and abnormal blood fat and blood sugar metabolism, can effectively reduce the LPS level in serum and oxidative stress injury of ovarian tissues, is a product capable of repairing ovarian functions and improving sex hormone secretion, and can be used for preventing, relieving or treating PCOS.

The invention discloses an intelligent ovulation detection system and method, and the method comprises the steps: taking a picture of immune layer test paper with to-be-detected urine dropped on an immune layer of a patient, and obtaining the picture of the immune layer test paper with the to-be-detected urine dropped; receiving and processing the picture of the immune layer test paper dripped with the urine to be detected to obtain the LH concentration value of the test paper of the patient; storing test paper LH concentration values, calculated according to the immune layer test paper pictures dropped with the urine to be detected and received for multiple days continuously, of the patient for multiple days continuously; according to the change trend of the LH concentration value of the test paper of the patient for multiple consecutive days, estimating that ovulation of the patient is about to occur according to the time when the LH concentration value of the test paper is close to the peak; when it is estimated that ovulation of the patient is about to occur, the patient is prompted to conduct sex hormone examination and B-ultrasonic examination, and then it is finally confirmed that ovulation is about to occur according to the sex hormone examination result and the B-ultrasonic examination result of the patient.

Provided are methods for administering to a disease or condition afflicted with sex hormone dependence or androgen receptor actuation, sustained release abiraterone prodrug formulations, methods, and kits for parenteral administration in human subjects, such as sex hormone dependent benign or malignant conditions such as prostate cancer, androgen receptor driven cancer, and / or syndromes caused by hyperandrogen.

The invention discloses plant lactobacillus La10 and application thereof in regulating estrogen secretion stability and enhancing ovarian function, and belongs to the technical field of microorganisms. The plant lactobacillus La10 provided by the invention can effectively promote the conversion of free isoflavone (daidzein and genistein), so that the absorption and utilization of intestinal tracts are promoted; the composition has the advantages that the ovarian index and sex hormone estradiol E2 secretion level reduction caused by premature ovarian failure of rats can be obviously improved, and meanwhile, the estrogen secretion level and ovarian index up-regulation caused by mouse hysteromyoma can be improved; the irregular menstruation phenomenon of women is improved, so that the estrogen secretion disorder is regulated. The plant lactobacillus La10 disclosed by the invention has a very wide application range in preparation of functional foods and health-care foods for promoting estrogen balance and protecting female health, and is healthy and safe.

The invention relates to a construction method and application of a retinal artery occlusion disease risk assessment model. Specifically, according to the retinal artery occlusion disease risk assessment model, a retinal artery occlusion disease risk assessment result of a subject is obtained based on the RAO protein marker level of a biological sample of the subject; wherein the RAO protein marker is a combination of integrin subunit alpha M, sex hormone binding globulin, S100 calcium binding protein A7, immune globulin heavy chain delta and synaptic-like protein 1. The prediction accuracy of the retinal artery occlusion disease risk prediction model can reach 88%, the area (AUC) under the working characteristic curve of a subject reaches 0.944, and extremely high distinguishing efficiency and clinical application value are shown.

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating ovarian dysfunction, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 8-10 parts of American ginseng, 2-4 parts of pseudo-ginseng, 55-65 parts of kudzuvine root, 42-48 parts of coptis chinensis, 42-48 parts of scutellaria baicalensis, 14-16 parts of stiff silkworm, 14-16 parts of rhizoma zingiberis, 42-48 parts of bitter gourd and 55-65 parts of rhizoma anemarrhenae. The traditional Chinese medicine composition has the effects of increasing the number of follicles and corpus luteum, restoring the duration of an estrus cycle and restoring the levels of serum hormones and sex hormone receptors. The traditional Chinese medicine composition provided by the invention provides a new means for preventing and treating ovarian dysfunction.

Sustained-release abiraterone prodrug formulations, methods, and kits for parenteral administration to a human subject having a sex hormone-dependent or androgen receptor driven disease or disorder, such as a sex hormone-dependent benign or malignant disorder such as prostate cancer, an androgen receptor driven cancer, and / or a syndrome due to androgen excess.

The present disclosure relates to methods of treating PTEN-deficient metastatic hormone- sensitive prostate cancer (mHSPC) in patients in need thereof, the methods comprising administering to the patients a combination comprising capivasertib or a pharmaceutically acceptable salt thereof; and abiraterone or an ester prodrug thereof, or a pharmaceutically acceptable salt thereof.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to Kunxinning and a preparation method and application thereof. The effective components of the Kunxingning disclosed by the invention are artemisinin and artemisinin. Animal experiments prove that kunxingning can improve the early-onset ovarian insufficiency toxicity state of SD rats caused by tripterygium glycosides, reduce ovarian granular cell apoptosis, improve the ovarian pathological state, promote follicular development, restore the serum sex hormone level to be normal to a certain extent, improve the state of proportion imbalance of Th17 / Treg immune cells, and improve the early-onset ovarian insufficiency toxicity of the SD rats. And the mood cycle of the rats is recovered to a certain extent. Meanwhile, the physiological activity of the tripterygium glycosides composition obtained by compounding the kunxingning and the TG is equivalent to that of the TG.

The present invention relates to the field of medical technology, and discloses the use of MAS receptor agonists in the preparation of drugs for preventing or treating polycystic ovary syndrome. Through experiments, it is proved for the first time that MAS receptors affect the occurrence and development of polycystic ovary syndrome. The MAS receptor agonist AVE0991 is used to intervene in PCOS group mice, so that the estrous cycle of mice tends to be normal; fasting blood sugar is reduced, and body weight is significantly reduced; the expression of ovarian sex hormone-related genes is reduced; in addition, the expression of genes related to liver, brown fat and subcutaneous fat metabolism in PCOS group mice intervened by AVE0991 is significantly improved; and AVE0991 significantly improves the fertility of PCOS group mice.

This invention relates to a novel use of propargylcysteine ​​in the preparation of anti-mastopathy drugs. The invention discovers that S-propargylcysteine ​​can improve E2 / P imbalance by regulating HPO axis function and inhibiting abnormal activation of the GnRH-sex hormone axis; it also reduces the inflammatory microenvironment by inhibiting the release of inflammatory factors; ultimately, it downregulates ER / PR-mediated proliferation signals and inhibits PCNA expression locally in the breast. Through multi-target regulation of neuroendocrine, inflammatory responses, and proliferation-related signaling pathways, it effectively alleviates breast hyperplasia and its associated chronic stress-induced depressive-like behaviors, thus exerting anti-mastopathy and therapeutic effects on breast hyperplasia complicated with depression.

The application provides a protein composition for predicting the prognosis effect of metastatic hormone-sensitive prostate cancer and application thereof, and belongs to the technical field of prognosis evaluation.The protein composition for predicting the prognosis effect of metastatic hormone-sensitive prostate cancer comprises protein molecules for evaluating drug resistance of a patient and protein molecules for evaluating sensitivity of the patient; the protein molecules for evaluating drug resistance of the patient comprise MCM4, NT5E, LTBP4, IAH1, HP, DOCK2 and EEF1A2; and the protein molecules for evaluating sensitivity of the patient comprise TFF3, FABP5 and LAMP2.The application constructs a molecular typing of mHSPC based on the above protein composition, evaluates the sensitivity of a mHSPC patient to ADT treatment in advance, and thus realizes precise treatment.

The invention discloses a preparation for improving male erectile function and sperm quality. The health-care food is characterized by being prepared from the following raw materials in parts by weight: 30-50 parts of herba epimedii extract, 20-40 parts of herba cistanche extract, 15-30 parts of fructus lycii extract, 18-35 parts of semen cuscutae extract, 10-25 parts of herba cynomorii extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine and 0.3-1 part of vitamin B family (vitamin B1, vitamin B2, vitamin B6 and vitamin B12 are mixed according to the mass ratio of 1: 1: 2: 0.5). The herba epimedii extract is selected as a main component, the content of icariin is regulated to be not lower than 60%, the high-content icariin can more effectively promote sex hormone secretion, enhance sexual desire and improve erectile function, the total content of echinacoside and verbascoside in the herba cistanche extract is not lower than 45%, and the herba epimedii extract and the herba cistanche extract have the effect of promoting sex hormone secretion, enhancing sexual desire and improving erectile function. The two components have the effects of tonifying kidney yang and benefiting essence and blood, and can enhance kidney functions.

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and / or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and / or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

The invention discloses a non-invasive prediction method for acne risk of puberty women and a kit, and belongs to the technical field of biological detection. According to the present invention, the non-invasive advantage of the saliva sample is adopted, and the cycle specificity of saliva crystallization and the pathological correlation of the sex hormone ratio are combined to achieve the early accurate early warning of the acne risk, such that the problems of strong invasion and difficult promotion in the teenager group of the traditional serum detection are solved, and the characteristics of convenient operation, low cost and repeatable monitoring are provided; and a new technical means is provided for prevention and early intervention of acne of puberty women.

The invention provides application of rosa roxburghii tratt fruit extract in preparation of drugs or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. The invention belongs to the technical field of biological medicines, and provides application of a roxburgh rose extract in preparation of medicines or health care products for preventing and treating male lower urinary tract symptoms / prostatic fibrosis. Animal experiments prove that the rosa roxburghii tratt extract can effectively improve mouse prostate fibrosis and bladder urinary retention caused by high fat diet and relieve lower urinary tract symptoms by regulating lipid metabolism, resisting inflammation, resisting oxidative stress, regulating sex hormone level and inhibiting a TGF-beta / Smad signal channel.

The application of the autologous dendritic cell in preparation of the medicine for treating the nerve injury erectile dysfunction can well promote recovery of the erectile function, perform staged reinfusion, induce immune regulation, repair nerve and blood vessel functions and improve a sex hormone regulation pathway. And the autologous dendritic cells are derived from a user, and have the advantages of safety, effectiveness and convenience in use. The combined immune cell therapy is obviously superior to a single treatment path in efficacy, is also more suitable for chronic, non-structural, subclinical and other ED people which are difficult to intervene by traditional methods, and has stronger individual adaptation ability and long-term controllability at the same time. Compared with a traditional scheme, the cell therapy targeting is better, and the treatment effect is faster.

The present invention provides a production method of modified forest frog oil, including the steps of purifying water for spawning, treating fertilized eggs, freeze drying, separating oil and eggs, etc., and the obtained forest frog oil is the modified forest frog oil. The method of the present invention is based on the characteristics of forest frog embryonic development, and extracts pure forest frog oil without impurities without excessive external intervention. The obtained forest frog oil no longer has the characteristics of the morphology, component content, and medicinal properties of traditional forest frog oil, but the water absorption expansion rate and odor are similar to those of traditional forest frog oil, the protein content is inversely proportional to the time before the embryonic development is completed, and the content of polypeptides, oligopeptides, and amino acids is proportional to the time before the embryonic development is completed. The method of the present invention does not harm the health of forest frogs, and the eggs are laid and survived normally, and the utilization cycle of forest frogs is extended. It is upgraded from the traditional method of killing frogs to obtain oil to raising frogs to obtain "oil", which is of great significance to the protection of the precious germplasm resources of Chinese forest frogs, orderly development, rational utilization, and benefit to society.

The invention discloses a traditional Chinese medicine composition for treating hypoovarian reserve function. The traditional Chinese medicine composition comprises the following raw material medicines: 10-30 parts of vinegar tortoise shell, 10-15 parts of prepared rehmannia root, 6-20 parts of salt-processed semen cuscutae, 9-15 parts of wine-processed rhizoma polygonati, 10-30 parts of radix puerariae, 9-15 parts of polygonum cuspidatum, 6-20 parts of acanthopanax, 5-15 parts of salvia miltiorrhiza, 6-10 parts of roasted herba epimedii and 3-10 parts of pericarpium citri reticulatae. The invention further discloses application of the traditional Chinese medicine composition in preparation of a medicine for treating ovarian reserve hypofunction. The traditional Chinese medicine composition has the effects of improving the ovarian function and the sex hormone level, increasing the AFC quantity, adjusting the ovarian blood flow state, improving the menstrual condition, the traditional Chinese medicine syndrome and the anxiety level of a patient and improving the clinical pregnancy rate, and is safe and reliable.