169 results about "Sexual hormones" patented technology

This invention relates to a pernasally administrable preparation for the controlled release of sexual hormones to the systemic circulation, in particular to a formulation which enables its active ingredient to be absorbed in a sustained manner providing a better bioavailability at very low doses and longer duration of action.

The present invention provides a protein capable of binding to a female sex hormone, which protein is supplemented with useful properties for measuring, quantifying and concentrating female sex hormones, such as high sensitivity, low cross-reactivity, unlikelihood of being influenced by interfering substances, and unlikelihood of being influenced by solvents. Specifically, the present invention provides a recombinant protein prepared by obtaining various genes for various antibodies against female sex hormones, and modifying, by gene recombination technology, various properties of the original antibody, such as affinity, avidity, cross-reactivity, resistance for interfering substance on antigen-antibody reaction, resistance for interfering substance on enzymatic color developing reaction, resistance for solvent and the like.

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; R^A represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; ring B represents aryl or heteroaryl; R^B represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E¹ and E² represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO₂—Y, —O— (alkylene)-Y, —O-Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.

The present invention relates to a compound medicine for preventing and curing angiocardiopathy and cerebrovascular disease, belonging to the field of chemical medicine. It is characterized by that said compound medicine includes sexual hormones medicine, lipid-reducing medicine, hypotenser, hypoglycemic medicine and anticoagulant medicine. Said compound medicine can be made into various dosage forms. Besides, said compound medicine also can be used for curing the diseases of climacteric syndrome, osteoporosis, endometrial carcinoma, diabetes and metabolic syndrome, etc.

Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

The medicine for preventing and treating osteoporosis is prepared with the natural plants drynaria rhizome, desert cistanche, malaytea scurfpea fruit, epimedium, American ginseng, etc. and through drying, crushing, decoction and solvent extraction, mixing, disinfection and other steps of prepare medicine powder or table. The said preparation process can maintain the biological activity of the medicine components, and the medicine can raise the sexual hormone level of the body, stimulate the osteoplast to secret collagenase, release grorth factor and cell factor, raise the activity of the osteoplast to promote the production of bone matrix, speed the bone formation process, inhibit the dynamic balance of osteoclast and thus prevent and treating osteoporosis radically.

A compound medicine for preventing and treating the cardiovascular and cerebrovascular diseases of climacteric woman and adult man, climacteric syndrome, osteoporosis, endometrial carcinoma, senile dementia, diabetes and metabolism syndrome contains sexual hormones, hypolipemic component, antihypertensive component and anticoagulating component. It features that the ratio of its components is adjustable according to actual disease.

The invention relates to a Chinese medicinal composition for a kidney-yang deficiency and phlegm-retention type polycystic ovary syndrome. The Chinese medicinal composition comprises the following medicinal materials of epimedium, caladium, semen psoraleae, sliced deerhorn, sea horse, tortoise plastron and the like, does not contain rhubarb and Chinese angelica. The Chinese medicinal composition can reduce the level of androgens and androgen receptors of polycystic ovanian syndrome (PCOS) patients, improve the level of sex hormone binding globulin, reduce the level of free testosterone, improve the level of in-vivo estrogens, improve the growth and development of follicles and improve the ovulation rate and pregnancy rate of patients.

A method of birth control and hormone regulation comprises utilizing a vaginal ring worn continuously during each menstrual cycle. A vaginal ring delivers predetermined doses of progesterone and beta-estradiol. Beta-estradiol does not cause an increase in sex hormone binding globulin and thereby does not decrease a woman's levels of free testosterone and libido.

The invention relates to the field of immunology, endocrinology and oncology and, in particular, the generation of a combined immune response to determined growth factors and hormones. A synergic effect, outlined herein, between growth regulating factors (EGF, TGF and VEGF) and hormones involved in the sexual hormones release cascade or reproduction (GnRH, LH, FSH) stimulates the anti-tumor response which is expressed as a reduction in the tumor mass and an increase in the survival time.

The invention discloses a polypeptide carrier used for improving targeting ability and transfection efficiency of a medicine/gene. The polypeptide carrier has a structure represented by a formula (I): TATp-Cys-LHRHp (I), wherein TATp is a TAT fragment of HIV, Cys is Cysteine, LHRHp is an analogue of luteinizing hormone releasing hormone LHRH. The polypeptide carrier provided by the invention carries a large amount of positive charges. The polypeptide carrier has good water-solubility and high targeting ability aiming at sexual hormone dependent tumor and liver cancer. The carrier can directlycarry negatively charged nucleic acid or medicine, and mediate the nucleic acid or medicine into cells. Also, the carrier can be used for modifying other gene or medicine carriers, such that tumor targeting abilities and transfection efficiency of the gene or medicine carriers can be improved. Therefore, a novel carrier is provided for gene/medicine delivering.

The life prolonging Chinese medicine wine is prepared through soaking palls pit viper, cobra and 11 kinds of Chinese medicinal materials including glossy ganoderma, fleeceflower root, wolfberry fruit, desert cistanche, pilose antler, etc. in Kaoliang wine of 50% alcohol content. It has the functions of prolonging life, nourishing Yin, strengthening Yang, preventing and treating cancer, promoting sexual organ growth and raising sexual hormone secreting level, etc.

The invention relates to decapeptide derivative which has LHRH receptor antagonism activity, an effect of inhibiting pituitary to excrete gonadotrophic hormone, an effect of inhibiting the gonad to excrete steroid hormone and has a lower histamine releasing effect, its producing method, the drug combination and its drug applications for treating the sex hormone correlated disease such as prostatecancer and the disease correlated to the anti-histamine or reducing histamine release.

Applications of cyanidin-3-O-glucoside in preparation of medicines treating and/or preventing diseases caused by 3-chloropropane-1,2-diol are provided. The cyanidin-3-O-glucoside (C3G) can improve rat ingestion decrease and growth retardation which are caused by 3-MCPD poisoning, can effectively resist rat antioxidant system damage caused by 3-MCPD poisoning, and can activate and adjust BTB structural functions of sustentacular cells through inhibiting an MAPK signaling pathway, thus relieving seminiferous epithelium injuries caused by the 3-MCPD, maintaining stability of a spermatogenic microenvironment, regulating spermatogenic cell proliferation and differentiation, and improving dyszoospermia. In addition, the C3G can improve sperm activity through adjusting sperm energy metabolism related enzymes. The C3G can regulate rat sex hormone secretion disorders caused by 3-MCPD poisoning and can maintain normal levels of sex hormone in serum and androgen in testis inner environments. The applications provide theoretical foundations for 3-MCPD reproduction toxicity nutritional intervention utilizing anthocyanin.

Provided is a compound useful as a preventive or therapeutic agent for sexual-hormone-dependent diseases, etc. It is a fused heterocyclic derivative represented by the following general formula (I). In the formula (I), ring A is a five-membered cyclic unsaturated hydrocarbon or five-membered heteroaryl; R is halogeno, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; ring B is aryl or heteroaryl; R is halogeno, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; E<1> and E<2> each is oxygen, etc.; U is a single bond or alkylene; and X is, e.g., a group represented by Y, -SO2-Y, -O-(alkylene)-Y-, or -O-Z (wherein Y is Z, amino, etc. and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.).

The invention discloses a Chinese medicine preparation for treating primary dysmenorrheal, a preparation method and an application. The Chinese medicine preparation is composed of medicines of angelica, flos rosae rugosae, fennel fruits, ligusticum wallichii, red paenoy roots and the like. On the basis of traditional Chinese medicine syndrome differentiation and treatment theory, the Chinese medicine preparation for treating primary dysmenorrheal is prepared by combining years of clinical experience. The Chinese medicine preparation for treating primary dysmenorrheal is characterized in that according to characteristics of hormonal level change at each stage of a sexual cycle, medicine intervention is performed at the luteal regression stage, two hormone peaks in the whole sexual cycle process can be avoided, relative excited signal molecues at the local position of uterus tissue can be directly confronted, interference for feedback effect on thalamus-hypophysis-ovarian axis sex hormone is weakened, and thereby the effect of treating the primary dysmenorrheal can be exerted. The Chinese medicine preparation for treating the primary dysmenorrheal has special good effects on the diseases of dysmenorrheal and abnormal menstruation and the like caused by kidney energy loss, qi stagnation and blood stasis, congealing cold blood stasis, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach and damp and hot accumulation, the Chinese medicine preparation for treating the primary dysmenorrheal is widely applied to clinic and relieves pains of patients, and the effective rate can reach to 96%.