11 results about "Sexual hormones" patented technology

The present disclosure relates to methods of treating PTEN-deficient metastatic hormone- sensitive prostate cancer (mHSPC) in patients in need thereof, the methods comprising administering to the patients a combination comprising capivasertib or a pharmaceutically acceptable salt thereof; and abiraterone or an ester prodrug thereof, or a pharmaceutically acceptable salt thereof.

This invention belongs to the field of biomedicine, and specifically relates to the application of FeTMPyP in the preparation of drugs to alleviate ovarian toxicity. This application addresses the issue that combined exposure to MC-LR and NaNO₂ significantly induces nitrification stress in mouse ovaries, leading to follicular barrier disruption and ovarian reproductive endocrine dysfunction. FeTMPyP was selected as an intervention agent, which effectively alleviated nitrification stress induced by combined exposure to MC-LR and NaNO₂ in mouse ovaries, and improved sex hormone disorders, estrous cycle irregularities, and follicular atresia caused by the combined exposure to these two toxins. Simultaneously, it restored the fertility of mice, indicating that FeTMPyP intervention can alleviate ovarian toxicity induced by combined exposure to MC-LR and NaNO₂ in mice. This invention can be used to prepare drugs to prevent and treat diseases related to ovarian toxicity caused by environmental toxin exposure in mice, providing a new approach for the early identification and targeted intervention of ovarian-related diseases.

The application discloses application of a compound in preparation of a medicine for treating androgen alopecia, and relates to the technical field of biological medicines. The foreskin mesenchymal stem cell extracellular small vesicle has water-soluble and fat-soluble double-soluble characteristics, can be absorbed through the skin, and is administered in a manner of intravenous administration / mist administration and the like. The foreskin mesenchymal stem cell extracellular small vesicle is used as a carrier to load curcumin, so that the absorption of the curcumin can be effectively improved, the pharmacological effect of the curcumin can be improved, and the targeting and anti-inflammatory efficiency can be improved. Moreover, the compound obtained by loading the foreskin mesenchymal stem cell extracellular small vesicle with curcumin can easily penetrate into the skin, directly acts on the hair follicles damaged by androgen, has a good effect of treating androgen alopecia, and can significantly promote hair regeneration.

The present application relates to a kind of compound with anti-androgen receptor activity and its use, the present application provides the compound shown in formula I, its racemate, stereoisomer, tautomer, solvate, polymorph or their pharmaceutically acceptable salt.The compound has good prostate tumor cell proliferation inhibitory activity and anti-AR activity.The compound has good in vivo metabolic properties, AUC and C max Both are higher, and the drug has good property, can be used for preventing and / or treating male hormone related disorder disease.The compound of the present application also has good hair production promoting effect, can effectively increase the number of hair follicle and the length of hair growth.

The present invention relates to a composition for preventing or treating asthma, comprising a resistin inhibitor as an active ingredient. Obesity-associated asthma exhibits different patterns from general asthma as a result of structural changes in the lungs caused by fat deposition in the airways, systemic inflammatory responses, changes in sex-related hormonal mechanisms, etc. Accordingly, obesity-associated asthma has recently been newly defined as a phenotype on the basis of the onset of asthma or the presence or absence of sensitization to allergens. Therefore, there is a need for a therapeutic agent or treatment method specific to obesity-associated asthma as distinct from general asthma, but research thereon still remains insufficient. The resistin inhibitor provided in the present invention exhibits a remarkable therapeutic effect on asthma, especially asthma caused by obesity, and thus is expected to be actively used in the medical and health fields.

This invention relates to the field of biotechnology, specifically to a hippocampal exosome-like vesicle, its preparation method, and its applications. This invention discloses for the first time a hippocampal exosome-like vesicle, which is a nanoscale membrane vesicle exhibiting a typical saucer-like morphology with an average particle size of less than 150 nm. It can be effectively taken up by mouse testicular interstitial cells, promoting testicular interstitial cell proliferation and sex hormone secretion. It can be used as a beneficial dietary supplement to improve male reproductive health and enhance reproductive function.

The application discloses a subcutaneous implantable continuous hormone monitoring device for an IVF (In Vitro Fertilization) stimulation cycle, which comprises a shell, a tissue fluid flow channel, a plurality of monitoring components and a control system; the shell is provided with a liquid inlet hole and a containing cavity; the tissue fluid flow channel is arranged in the containing cavity and comprises a tissue fluid inflow channel and at least four detection cavities; the liquid inlet hole, the containing cavity, the tissue fluid inflow channel and the at least four detection cavities are sequentially communicated; each monitoring component is one-to-one correspondingly arranged in each detection cavity; the monitoring component comprises a first electrochemical sensor and a specific recognition element; a working electrode of the first electrochemical sensor is arranged in the detection cavity; the specific recognition element is arranged on the working electrode and is used for being specifically combined with a target hormone; the specific recognition elements belonging to different monitoring components are specifically combined with different target hormones; and the plurality of first electrochemical sensors are electrically connected with the control system. The application aims at improving the accuracy of monitoring data.

The application provides application of animal Bifidobacterium lactis BGI-L99 in prevention and treatment of hormone imbalance and aging related diseases, and belongs to the technical field of biotechnology. The aforementioned animal Bifidobacterium lactis BGI-L99 is preserved in Guangdong Microbial Culture Collection Center (GDMCC) on March 31, 2026, and the preservation number is GDMCC No. 68017. Products prepared from the animal Bifidobacterium lactis BGI-L99 in the examples of the application can effectively prevent and treat sex hormone imbalance related diseases and delay aging related degenerative diseases, including relieving polycystic ovary syndrome and osteoporosis, specifically including improving ovarian function, endocrine disorder, depression, metabolic disorder, inflammatory reaction, abnormal intestinal metabolic product, bone microstructure degradation, imbalance between bone formation and bone resorption and the like.

The application provides a construction method and application of a polycystic ovary syndrome animal model; through a way of intragastric administration, the mouse intestinal tract is transplanted with fusobacterium nucleatum, and through a certain frequency, the fusobacterium nucleatum can be stably planted, and a stable polycystic ovary syndrome symptom is successfully generated; the sex hormone level of the mouse is significantly different from the PCOS characteristic, is shown as the increase of the LH level, the LH / FSH ratio and the T level, and multiple vesicle structures are seen in the ovary, and no mature follicle and corpus luteum are seen, so that the typical symptom of the polycystic ovary syndrome is met, and a new model selection is provided for screening of a treatment drug or experimental research of the polycystic ovary syndrome.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and preparation and application thereof. The composition provided by the present application comprises Ramulus cinnamomi, Poria cocos, Cortex moutan, Semen persicae, Radix paeoniae alba, Radix rubiae, Cornus officinalis, and Rhizoma sparganii. The composition can obviously reduce the prostate index and prostate epithelial thickness of a benign prostatic hyperplasia model rat, and relieve interstitial edema. The experimental results show that the composition can obviously reduce the content of dihydrotestosterone, estradiol, testosterone, gonadotropin-releasing hormone, and rat luteinizing hormone in the prostate serum of a model mouse, and increase the content of follicle-stimulating hormone. The above results show that the traditional Chinese medicine composition can inhibit sex hormone disorder, and has the effect of treating prostatic hyperplasia.

The present application relates to the technical field of livestock breeding regulation, and discloses a natural inducer for promoting the estrus synchronization of cows, a preparation method and application, comprising the following steps: first, collecting natural musk of adult male forest musk deer and uniformly mixing the same to obtain musk raw materials; then, adding the musk raw materials into a solvent to obtain a solid-liquid mixture; then, placing the solid-liquid mixture in an ultrasonic device for ultrasonic extraction, so that the active ingredients in the musk raw materials are dissolved; finally, removing the precipitate and collecting the supernatant to obtain the natural inducer. The chemical signal is transmitted to the hypothalamus through the olfactory pathway, avoiding the pain stress and the risk of inflammation at the injection site caused by muscle injection; at the same time, the reproductive cycle is regulated by activating the neuroendocrine system of the cow itself, rather than directly supplementing exogenous hormones, thereby fundamentally eliminating the hidden danger of exogenous hormone residues in cow's milk or beef, meeting the requirements of modern livestock farming for green and healthy breeding.