1062 results about "Skin barrier" patented technology

A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and / or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.

A method for acquiring cardiac information from a patient having a pacer for pacing a heart rhythm, an abnormal EKG, or an abnormal heartbeat is disclosed. The method includes: placing a signal injection device proximate the pacer of the patient and injecting a signal across a skin barrier of the patient toward the pacer; in response to the signal received at the pacer, pacing the patient's heart in a fixed asynchronous pacing mode; and, acquiring cardiac information relating to the patient's fixed asynchronously paced heart.

A skin barrier lotion for protection against contact with irritants comprises: about 5 to 15 percent by weight of a long-chain fatty acid; about 1 to 5 percent by weight of a long-chain fatty alcohol; about 1 to 10 percent by weight of a hydrocarbon oil; about 1 to 30 percent by weight of a silicone skin protectant; about 0.5 to about 5 percent by weight of an alkanolamine; about 0.5 to about 5 percent by weight of a humectant; about 0.5 to about 10 percent by weight of an inorganic skin protectant; about 0.5 to 15 weight percent of a preservative; and about 50 to 90 percent by weight water. Optionally, the lotion will also contain up to about 5 percent by weight of a fragrance, odor neutralizer or a mixture thereof.

A self-contained, conveniently disposable percutaneous absorptive patch of the present invention utilizes, in a novel ways, the existing percutaneous absorptive principles to delivering topical medications quickly, painlessly, and effectively through the skin barrier. The absorptive principles include the epidermal microcuts / micro-needles, permeation enhancers, and micro-current iontophoresis. Most importantly, the transdermal absorptive patch of the present invention introduces a novel incorporation of self-producing micro-electrical currents and micro-electrodes into the existing conventional iontophoretic principle.

An ostomy faceplate and its method of application are disclosed in which the faceplate comprises an annular adhesive wafer of soft, moisture-absorbent, memory-free, essentially non-elastic and finger-moldable adhesive skin barrier material, the wafer's distal surface having an outer zone terminating at the outer periphery of the wafer and an inner zone extending inwardly from the inner limits of the outer zone to a stoma-receiving opening at the inner periphery of the wafer. The faceplate also includes a flexible backing layer covering the outer zone and a removable cover member having a smooth surface releasably covering the proximal bodyside surface of the wafer. The distal surface of the inner zone has undulations defined by a plurality of concentric ridges and valleys with the ridges progressively diminishing in thickness, when measured by the distance between the distal and proximal surfaces at each ridge, as the series progresses inwardly from the maximum thickness of the wafer towards the stoma-receiving opening. The method of application includes both a preliminary molding step and a secondary molding step.

A faceplate for an ostomy appliance is disclosed in which a unitary release sheet covers both the bodyside (rear) surface of an adhesive skin barrier layer and the surrounding adhesive surface of an outwardly-projecting porous covering layer. The barrier layer is beveled to a feathered outer edge and the release sheet contacts the adhesive surface of the covering layer immediately adjacent the outer edge of said barrier layer. A continuous in-line method for making such faceplates is disclosed.

A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and / or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.

The present invention relates to novel methods and compositions comprising a combination of ingredients for treating aged, mature, nutritionally-compromised, or environmentally-damaged skin. These methods and compositions provide improvements in the skin's visual appearance, physiological functions, clinical properties, and biophysical properties. The compositions of the present invention can include, for example, a compound that stimulates microcirculation through the skin, a compound that stimulates the immune system, a compound that reduces ultraviolet light or sun exposure damage, a compound that evens out the pigmentation of the skin, and / or a compound that improves the barrier properties of the skin.

The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical damage on skin. Sufficient electric pulses applied to a region of skin surface temporarily create new pathways through the lipid skin barrier, thereby delivering an L-ascorbic acid-containing composition through the lipid skin barrier and enhancing production of collagen in the region of the skin so treated. A handheld electrical pulser apparatus, optionally table-top adaptable, and methods of use for cosmetic treatment of degenerative skin conditions are provided by the invention.

The invention discloses a soothing repair serum containing a bifida ferment lysate. The soothing repair serum is prepared from, by weight, 1-10 parts of polyhydric alcohol, 1-10 parts of a moisturizing agent, 0.5-10 parts of a skin moisturizing agent, 0.5-5 parts of an emulsifying agent, 0.1-2 parts of a thickening agent, 0.1-2 parts of a pH adjusting agent, 0.1-5 parts of an anti-allergy soothingagent, 0.1-10 parts of a skin conditioning agent, 0.1-1 part of a preservative, 0.01-0.05 pat of essence and the balance deionized water, wherein the sum of the weight parts of all the components is100. The soothing repair serum can obviously reduce wrinkles, reduce the content of pigment, improve the glossiness of skin, brighten the skin color, improve the skin elasticity, repair the skin barrier and reduce moisture loss; the soothing repair serum is free of irritation to the skin, has the functions of preventing skin aging and perpetually moisturizing the skin and makes the skin in a healthy natural bright white status.

The invention is a cosmetic or dermatological preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes a method of strengthening the skin barrier comprising applying to the skin a preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes methods of moisturizing the skin, improving the microtopography of the skin, improving the elasticity of the skin, treating or preventing functional disorders of skin appendages, treating or preventing the symptoms of skin ageing, and treating or preventing the harmful effects of ultraviolet radiation on the skin comprising applying the preparation.

A metallic microneedle array chip for allowing the medicinal moleculae to penetrate the corneal layer of skin and come in human body without pain and irritation features that said metallic microneedles with the length just to penetrate the corneal layer are made up of metal material by microelectromechanical system (MEMS) and electrolytical polishing technique.

The invention belongs to the technical field of cosmetics, and particularly discloses a matrix with skin barrier repairing and anti-aging effects. The matrix is prepared from, by mass, 3-4% of 1,2-pentanediol, 10-15% of methyl propanediol, 1-2% of sodium hyaluronate, 3-5% of myrothamnus flabellifolia leaf / stem extracts, 10-15% of hydrolysis elastic protein, 10-20% of an anti-aging agent containing 100-200 ppm palmitoyl oligopeptide, 5-10% of tea extracts, 0.2-0.5% of a cell growth factor stock solution, 3-5% of an anti-aging agent containing 45-55 ppm neurotransmitter inhibition signal peptides, 5-10% of algae extracts and the balance water. According to the skin protection matrix, the skin barrier repairing and anti-aging effects are remarkable, the effect can be seen in a short period, and the skin barrier can be repaired when a user uses the matrix for a long time, so that wrinkles are reduced.

The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.

The invention relates to a moisturizing composition, and a preparation method and application thereof, which belong to the field of cosmetics. The moisturizing composition is prepared from the following components in parts by weight: 1.0 to 5.0 parts of sodium hyaluronate, 2.0 to 10.0 parts of carboxymethyl deacetyl chitosan, 30.0 to 60.0 parts of dendrobium officinale extract, and 25.0 to 67.0 parts of deionized water. The moisturizing composition can well form a netted natural biomimetic membrane with skin, the sodium hyaluronate performs the water supplementation and moisturizing in the biomimetic membrane, the carboxymethyl deacetyl chitosan forms a biomimetic sterile membrane, so that natural moisturizing factors such as the sodium hyaluronate can be effectively locked, the water loss rate is decreased; and the dendrobium officinale polysaccharide is combined with the natural biomimetic sterile membrane, so that the moisturizing lasting property after long-term use can be further improved, the restoration effect is improved, and the dryness and allergy problems of the skin can be fundamentally solved. The moisturizing composition has multidimensional efficacy such as moisturizing function, restoration function and skin barrier increasing function.

The invention belongs to the technical field of daily care products and discloses a facial mask with the functions of improving skin barrier and delaying senescence and a preparation method thereof. The facial mask comprises the following components in percentage by weight: 0.05-4 percent of macromolecule hyaluronic acid, 0.1-3 percent of middle molecule hyaluronic acid, 0.1-5 percent of micromolecule hyaluronic acid, 0.05-3 percent of oligomeric hyaluronic acid, 0.5-6 percent of grape seed extract, 0.5-6 percent of purslane extract, 2-12 percent of hydroxyethyl urea, 1-6 percent of sodium pyrrolidonecarboxylate, 0.1-1 percent of allantoin, 2-12 percent of butanediol, 0.05-0.3 percent of thickening agent and the balance of deionized water. According to the facial mask disclosed by the invention, by reasonably combining natural compounds with plant extracts, the synergistic effect is realized, and the functions of better improving the skin barrier and delaying the senescence are achieved.

The invention discloses a skin barrier repairing preparation. The preparation is prepared from the following components: deionized water, sucrose stearate, phytosteryl isostearate, vitamin E, glycerinum, butylene glycol, 1,2-pentylene glycol, octyldodecanol, polydimethylsiloxane, hydrogenated polyisobutene, oleic acid, linoleic acid, ceramide 2, ceramide 3, ceramide 6II, sodium hyaluronate, xanthan gum, disodium EDTA, acrylates C10-30 alkyl acrylate crosslinked polymer, allantoin and sorbitan caprylate. The invention further provides a method for preparing the skin barrier repairing preparation. According to the preparation method, the problem of dissolving compound ceramide can be solved, the impact of ceramide crystallization on stability under a low-temperature condition can be reduced, the stability of the preparation can be improved, and other skin repairing components can be added and compounded with the compound ceramide. The skin barrier repairing preparation has an excellent product formula stability and a multiple repairing effect on the skin barrier.

The invention discloses a probiotic composition for skin moisturizing and barrier protection and application of the probiotic composition in cosmetics. The probiotic composition for skin moisturizingand barrier protection is prepared from the following components in parts by weight: 1-40 parts of saccharomycetes / a rice fermentation product, 1-30 parts of lactic acid bacterium lysate, 1-30 parts of bilobate saccharomycetes ferment extract lysate, and 1-30 parts of a thermus thermophilus ferment extract. The probiotic composition has strong effects of moisturizing and repairing skin barrier, can effectively inhibit the survival of harmful bacteria, prevent skin infection, can further quickly alleviate skin problems, and cooperate the body self-healing immunity to restore health.

Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to environmental elements and / or in a pathological condition. In general, divalent cations such as calcium ions and / or magnesium ions are included in a physiologically acceptable medium. In some embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin condition, and preventing or treating dermatological diseases and skin disorders.

The invention discloses a Prinsepia utilis Royle oil-containing functional skin care product and a preparation method thereof. The Prinsepia utilis Royle oil-containing functional skin care product is prepared from the following raw materials in part by weight: 1 to 2 parts of Prinsepia utilis Royle oil, 10 to 25 parts of purslane extracting solution, 5 parts of glycerol, 2 to 3 parts of 1,2-pentanediol, 5 to 7 parts of caprylic / caprictriglycerides, 2 parts of synthetic squalane, 1 to 5 parts of tocopheryl acetate, 1 to 3 parts of cetearyl alcohol, 0.1 to 0.2 part of allantoin, 0.6 to 0.9 part of coconut oil-base glucoside, 0.5 to 1 part of coconut oil alcohol, 0.5 to 2 parts of glyceryl stearate, 0.1 to 1 part of sodium hyaluronate and the balance of water. The functional skin care product has mild property and high safety without toxic or side reaction and anaphylactic reaction, can repair the destructed skin barrier, resists inflammation and skin ageing, and has a good effect and high safety of assisting in treating skin diseases related with skin barrier destruction, such as facial dermatitis (hormone dependence dermatitis, allergic dermatitis and acne), atopic dermatitis and the like.

The invention is a functional skin care product containing purslane extractive. Raw materials of the functional skin care product include, by weight, 10 parts of purslane extractive, 1-2 parts of Prinsepia utilis rogle oil, 2-5 parts of glycerol, 0.3-0.5 parts of crylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, 2-3 parts of 1,2-pentanediol, 1-5 parts of synthesized squalane, 1-2 parts of tocopheryl acetate, 2-3 parts of cetostearyl alcohol, 0.1-0.2 part of allantoin, 0.3-0.8 part of sodium hyaluronate, 3-5 parts of Butyrospermum parkii butter, and 100 parts of deionized water. Or the Prinsepia utilis rogle oil and the Butyrospermum parkii butter are not added. By the aid of animal experiments, namely, mouse auricle swelling models due to dimethlbenzene, the functional skin care product containing purslane extractive is fine in anti-inflammation and anti-allergy effects, mild in nature and fine in safety, and is free of toxic reaction and anaphylaxis. The functional skin care product has an adjuvant therapy function to skin barrier recovery of common discosmetic dermatosis such as hormone dependent dermatitis and acne, and is fine in curative effect and safety.

The invention discloses a human-derived cell-factor germinal preparation and the preparation method, relating to the technical filed of the healthcare product. The invention contains lecithin which is the lipid membrane-forming material, cholesterin and active component germinal cell factor, with the proportion by weight between them being 2-6:1-4:1-5; the lecithin is selected from egg yolk lecithin or soybean lecithin; the germinal cell factor is selected from the albumen freeze-dry powder of the culture supernatant of human fibroblasts, placental cells, cuticle cells or dermal papilla cells, with abundant cell factors for the hair growth in the culture supernatant; the germinal cell factors are enveloped in the lipid membrane. The rotary evaporating method is adopted in the process to make the product the lipidosome medicament form which can easily permeate the skin barrier. In addition, the product is frozen and dried into the more stable powder, which needs only to be dissolved by the distilled water containing 2% penetrating enhancer azone while in use. The invention is of easy penetration, high skin retention and good curative effect and free of side effect.

The invention belongs to the field of cosmetics, and particularly relates to a composition containing bifida ferment lysate and a preparation method and application of the composition to the cosmetics. The composition includes a bifida ferment lysate composition, a peptide composition and a rice extract, and the composition is prepared from the following components in parts by mass: 1-40 parts ofthe bifida ferment lysate, 1-20 parts of the peptide composition, and 1-20 parts of the rice extract, and the composition further includes 1-20 parts of a moisturizing composition, and the bifida ferment lysate composition includes bifida freeze-dried powder, and a bifida freeze-dried powder lyase solution. The composition containing the bifida ferment lysate has the beneficial effects that a formula is reasonably set, functions are various, wrinkles can be significantly reduced, the pigment content is reduced, skin glossiness is increased, the skin color is brightened, skin elasticity is increased, the skin barrier is repaired, the water loss is reduced, the composition has no stimulation to the skin, and at the same time, the composition has the functions of preventing skin aging and keeping moisture for a long time, and makes the skin obtain a healthy and natural bright white state.

A low-profile faceplate assembly for a two-piece ostomy appliance, and a method for manufacturing it, are disclosed. The faceplate includes a wafer of an adhesive skin barrier material and a flexible plastic coupling ring (for detachably coupling the faceplate to an ostomy pouch having a mating ring), and is distinguished by the mounting flange of the coupling ring being embedded within the faceplate. The faceplate is made by a convergence of in-line processes taking place simultaneously with an injection / compression molding operation for the skin barrier wafer as disclosed in U.S. Pat. No. 5,716,475, thereby eliminating or greatly reducing the assembly labor for the various process steps plus the handling, storing and transferring steps commonly associated with the manufacture of ostomy faceplate assemblies.

The invention discloses a moisturizing essence emulsion and a preparation method thereof. The moisturizing essence emulsion is prepared from components in parts by weight as follows: 4-12 parts of a polyhydric alcohol moisturizer, 0.1-1.8 parts of a thickening agent, 5-18 parts of a moisturizing emollient, 0.5-4.5 parts of an emulsifier, 0.1-0.8 parts of a neutralizer and the balance of other basematerials. The moisturizing essence emulsion has good skin feeling in use and is thin and not greasy in texture, the skin is fresh and moist after use, and the moisturizing essence emulsion is mild,non-irritating and not sticky basically. No preservatives are added to the moisturizing essence emulsion, and stimulation to skin and damage to skin barriers by traditional preservatives are avoided;the preparation process is simple to operate, low in economic cost, green and safe and has bright industrial application prospects.

The invention provides a moisturizing repair composition containing camellia seed oil and an application of the moisturizing repair composition. The moisturizing composition consists of the following components in percentage by mass: 45-65% of camellia seed oil, 15-35% of wheat germ oil, 5-10% of a wheat bran extract, 5-15% of a fucus vesiculosus extract, 5-20% of a calendula officinalis flower extract and 5-10% of a galangal root extract. The moisturizing composition has the following beneficial effects: the moisturizing composition is capable of improving a synergistic effect among active ingredients; the moisturizing composition, which is free from organically synthesized chemical moisturizing raw materials, cannot absorb moisture from skin; the moisturizing composition, which is easily permeable, can be easily absorbed by the skin; the moisturizing composition, on the basis of moisturizing, can repair a skin barrier, so as to retain moisture in the skin; and the moisturizing composition can relieve a series of problems caused by skin inflammation. The moisturizing composition containing the camellia seed oil can be used for preparing cosmetics.

The invention relates to an anti-sensitive relieving skin-care product composition and a preparation method thereof. The skin-care product composition comprises the following raw materials by weight percent: 1-5% of an anti-irritating component, 1-3% of plant extract, 0.5-1% of a skin barrier repair agent, 0.5-1% of a wetting agent, 0.1-5% of a functional auxiliary agent and the balance of water, wherein the anti-irritating component is alpha-bisabolol, ginger root extract and hydroxymethyl chitosan oligosaccharide; and the plant extract is prepared from one or more of centella, fructus perillae, divaricate saposhnikovia root, flos magnolia and scutellaria baicalensis as raw materials. The skin-care product composition can effectively alleviate symptoms such as fever, rubedo and pruritus of skin with allergic symptoms and avoid edema, bleeding, fester and the like as the skin is scratched.