633 results about "Skin barrier" patented technology

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

The invention provides an in-vitro skin blood vessel immune model as well as a preparation method and application thereof. THP-1 human monocyte leukemia cells are induced to be differentiated into M0 type macrophages, and then the M0 type macrophages are respectively induced into M1 type macrophages and / or M2 type macrophages; then co-culturing the M1 type and / or M2 type macrophages and vascular endothelial cells to form a vascular immune model; finally, the 3D skin model is placed on the blood vessel immune model, external stimulation is conducted, and the in-vitro skin blood vessel immune model is constructed. The in-vitro skin blood vessel immune model can be used for repairing skin barriers, inflammation pathways, blood vessel metabolism, the expression level of genes or proteins related to extracellular matrixes, vascular endothelial cells, the proliferation and migration ability of activated macrophages and the like. The seven feature dimensions of the physiological structure feature of the skin model are used for screening the to-be-tested sample and exploring the action mechanism, and the method has the characteristics of rapidness, multiple screening dimensions, high accuracy, low construction difficulty, low cost and high universality.

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

This invention belongs to the field of cosmetic technology, specifically relating to a composition for skin barrier repair and anti-inflammation after non-surgical cosmetic procedures and its application. The composition comprises Xinjiang comfrey peptide and Xinjiang comfrey naphthoquinone, with a mass ratio of 50-200:1. This composition synergistically inhibits the release of LPS-induced inflammatory factors, alleviating acute inflammatory reactions such as redness and burning after cosmetic procedures, achieving a dual effect of anti-inflammation and repair. The composition significantly reduces postoperative inflammatory redness and improves discomfort symptoms such as dryness and stinging. Through a multi-target mechanism, this invention solves the technical problems of existing repair products having single functions and slow onset of action, providing a highly efficient and comprehensive repair solution for skin after cosmetic procedures.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to shea butter fermentation liquor as well as a preparation method and application thereof. Lactobacillus plantarum, lactobacillus fermentum and lactobacillus gasseri in a specific proportion are adopted to construct a composite fermentation system, acid-resistant aspergillus niger lipase is combined, and shea butter is treated through a one-step fermentation process. By means of the synergistic effect of the three strains and the synergistic effect of the enzyme and the strains, efficient fermentation can be achieved, the content of active ingredients such as polysaccharide, amino acid and polypeptide in fermentation liquor is remarkably increased, meanwhile, the technological process is simple and stable, and the infectious microbe pollution risk is avoided. According to the fermentation liquor prepared by the process, on the basis of enhancing the original moisturizing and soothing effects of the shea butter, the problems of greasy skin feeling and poor permeation and absorption of the shea butter are effectively solved, the shea butter is further endowed with new functions of repairing skin barriers and balancing skin micro-ecology, and the application values of the shea butter and the fermentation liquor are greatly improved.

The invention discloses a method for promoting skin repair by assisting exosome transdermal delivery through a sponge spicule. The method comprises the following steps: pretreating skin by using a composition containing the sponge spicule; mixing the exosome vesicle freeze-dried powder with a redissolving medium at 5-40 DEG C, and then applying the mixture to the skin; the exosome vesicle freeze-dried powder is obtained by performing membrane fusion on exosome and liposome to obtain exosome vesicles and then performing freeze drying. According to the invention, the skin is pretreated by using the composition containing the sponge bone needle, the skin barrier resistance is reduced, the skin repair response is stimulated, and then the exosome vesicles are re-dissolved and then applied to the skin surface, so that the transdermal utilization rate of exosome contents is promoted. The exosome vesicle provided by the invention has good in-vitro storage stability, and after the exosome vesicle is stored at 0-5 DEG C for 180 days, the activity retention rate after redissolution is 80% or above.

The invention relates to a recombinant elastin and a preparation method thereof as well as a recombinant elastin raw material and application thereof, and belongs to the technical field of recombinant proteins. The amino acid sequence of the recombinant elastin is an amino acid sequence as shown in SEQ ID No.1 or a derivative amino acid sequence of which the sequence identity with the SEQ ID No.1 is more than 90%. The protein is high in expression level, high in purity and relatively high in biological activity, and has the effects of supplementing skin collagen, resisting aging and repairing skin barriers.

The application discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application thereof, and belongs to the technical field of cosmetics and skin care products. The composition contains the following active ingredients in percentage by mass: 0.01%-20% of recombinant humanized type I collagen, 0.01%-20% of recombinant humanized type III collagen, 0.01%-10% of recombinant humanized type XVII collagen, and 0.01%-20% of space-bred desert algae extract. The three kinds of recombinant humanized collagens and the space-bred desert algae extract form a complex system, and when the total mass ratio is in a specific interval of 1.3:1-4:1, the three kinds of recombinant humanized collagens and the space-bred desert algae extract can synergistically improve the skin barrier function. Based on the synergistic mechanism of the complex system, the composition disclosed by the application can effectively promote the skin moisture retention and anti-wrinkle ability, repair the skin barrier, and is suitable for the development and application of skin care products for anti-wrinkle, skin tightening and skin aging delay.

The invention discloses a hyaluronic acid moisturizing and repairing composition and a preparation method thereof, belongs to the field of cosmetics, and specially meets the requirement of dry skin. The composition consists of a core moisturizing component, an auxiliary functional component and the balance of purified water, the core moisturizing component comprises hyaluronic acid components with oligomeric, low, medium and high molecular weights and sodium hyaluronate cross-linked polymer microbeads with gradient particle sizes; the auxiliary functional components comprise bionic liposome, a nonionic emulsifier, polyol, a natural penetration enhancer, a retardant and a preservative. The gradient microbeads and HA with different molecular weights achieve all-around water replenishing and locking from the surface layer to the deep layer of the skin, the bionic lipidosome promotes component permeation and repairs the skin barrier, the composition is good in stability, mild and free of irritation, the problems that the deep layer of the dry skin is dry, water is continuously deficient, and the barrier is fragile can be effectively solved, and the composition has wide cosmetic application prospects.

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a soothing anti-inflammatory composition as well as a preparation method and application thereof. The preparation method of the soothing anti-inflammatory composition comprises the following steps: step 1) mixing saffron crocus, radix sophorae flavescentis, houttuynia cordata, moringa seeds and astragalus membranaceus to obtain a composite raw material; the invention discloses a soothing and anti-inflammatory composition and a preparation method thereof.The soothing and anti-inflammatory composition and the preparation method thereof.The soothing and anti-inflammatory composition has the advantages that soothing, anti-inflammatory and skin barrier repairing effects are further improved.

The invention relates to the technical field of wet tissues, in particular to an antibacterial sanitary wet tissue and a preparation method thereof. The antibacterial sanitary wet tissue comprises a fiber substrate and antibacterial liquid. The wet tissue is free of alcohol and quaternary ammonium salt, safe to use and suitable for nursing people with sensitive skin and infants. Glycerin, butanediol, panthenol, allantoin and sodium hyaluronate have a synergistic effect, and moisturizing and skin barrier repairing are provided. The wet tissue is prepared by adopting a conventional spraying process and a low-temperature condition and can be directly applied to an existing wet tissue production line without additional equipment. The product still keeps the antibacterial effect under high-temperature and high-humidity storage conditions, and is suitable for commercial circulation and long-term storage.

The invention relates to traditional Chinese medicine fermentation liquor, in particular to a preparation method and application of the traditional Chinese medicine fermentation liquor. Through the double-bacterium symbiotic fermentation technology, traditional Chinese medicine macromolecules are decomposed into micromolecules through fermentation, efficient absorption of the skin can be promoted, and by combining with the thuja old ointment, the antibacterial rate is increased, the skin barrier repairing function is achieved, and the thuja old ointment can be used for daily chemical products such as handmade soap, hand sanitizer, shower gel, shampoo and facial cleanser. Therefore, a multi-effect synergistic effect of cleaning, fixing hair, preventing hair loss and nourishing skin is realized.

Use of an active peptide in the manufacture of a product to improve the skin barrier and promote collagen expression and / or increase skin elasticity and suppleness and / or reduce wrinkles, characterized in that the active peptide has the structural formula HA-OH, wherein A comprises at least two amino acid residues, and the amino acid residues comprise at least one from Hyp, Gly, Pro and Ala.

The invention provides a mild and moisturizing base makeup product and a preparation method thereof. The base makeup product is prepared from the following raw materials in parts by weight: 0.5 to 2.0 parts of camellia japonica extract, 0.5 to 2.0 parts of black spore block extract, 0.2 to 1.0 part of crithmum maritimum extract, 3.0 to 8.0 parts of four-dimensional hyaluronic acid slurry, 1.0 to 4.0 parts of film-forming agent, 5.0 to 20.0 parts of toner, 2.0 to 6.0 parts of styrene / butadiene copolymer, 8.0 to 15.0 parts of bionic lipid, 40 to 90 parts of purified water, 0.2 to 0.5 part of pH (Potential of Hydrogen) regulator, 1.5 to 3.0 parts of emulsifier and 0.8 to 1.5 parts of preservative. According to the base makeup product disclosed by the invention, a dynamic moisturizing system is constructed through multiple mechanisms. Wherein the four-dimensional hyaluronic acid slurry is used as a core, and all-around and three-dimensional moisturizing from epidermis water locking, stratum corneum permeation water replenishing to surface water storage is realized through the cooperation of hyaluronic acids with different molecular weights. The bionic lipid simulates a human body sebum film to form a skin-friendly moisturizing barrier, so that water loss is effectively prevented. Meanwhile, the crithmum maritimum extract and the lactobacillus fermentation product can actively repair the skin barrier, and the moisturizing capacity of the skin is further enhanced.

The invention relates to preparation and application of a desoxyribonucleic acid and desoxyribonucleic acid derivative transdermal delivery system, and belongs to the technical field of biological medicine and skin care products. Desoxyribonucleic acid and derivatives thereof have the effects of resisting aging, repairing and the like, but are difficult to penetrate through a skin barrier due to large molecular weight and strong polarity. According to the invention, hydroxyethyl chitosan, desoxyribonucleic acid and derivatives thereof are combined through electrostatic interaction to form the nano-composite. The compound is small in particle size and can promote transdermal absorption through hair follicle or cuticle gaps. The preparation method is simple, does not need an auxiliary reagent, and comprises the step of mixing a hydroxyethyl chitosan solution and a deoxyribonucleic acid derivative solution. Experiments show that the compound significantly enhances the transdermal efficiency, and has the effects of promoting cell repair and proliferation and resisting inflammation. The composition can be used for skin care products, and is high in safety and wide in application prospect.

The invention discloses a percutaneous barrier function evaluation method and system based on precise temperature and humidity control. The method comprises the steps that S1, an individualized skin barrier baseline model containing daytime fluctuation characteristics and temperature and humidity sensitivity parameters and a baseline database are constructed; s2, executing an environment adaptability evaluation scheme through dynamic temperature and humidity spectrum scanning; s3, multi-dimensional skin physiological parameters are collected, a static parameter set and a dynamic parameter set are distinguished, and data standardization is achieved through dynamic baseline subtraction and cross-parameter interference compensation by adopting a physiological constraint type data correction algorithm based on a skin physiological relevance matrix; s4, integrating the standardized parameters to calculate a comprehensive barrier function index; and S5, predicting a barrier function trend. The system comprises a precise environment control module, a multi-parameter acquisition module, an intelligent analysis module, a data storage and interaction module and a central processing module, the accuracy and comprehensiveness of percutaneous barrier function evaluation can be improved, and technical support is provided for skin health management, skin disease diagnosis and treatment and the like.

The invention discloses an antioxidant repairing composite composition containing a picea norvegensis leaf extract and a preparation method thereof, and relates to the field of skincare products, the picea norvegensis leaf extract, leontopodium alpinum and citrus fruit extract are used as main materials, and the picea norvegensis leaf extract and leontopodium alpinum can play a role in the whole pathway of Nrf2 and NF-kappa B, so that the antioxidant repairing composite composition has the advantages that the antioxidant repairing composite composition is free of toxic and side effects; and the citrus fruit extract can inhibit the activation of TRPV1 and relieve the discomfort of the sensitive skin, so that the composition not only can improve the skin barrier of the sensitive skin, but also can inhibit the activity of the TRPV1, and the TRPV1 can be activated only by breaking the barrier and damaging the barrier under the two actions, so that the skin barrier can be well repaired. And the vicious circle of barrier injury can be aggravated by the excessive activation of the TRPV1, so that the stabilization and repair of the skin are realized, and the emulsion provided by the invention has a relatively good DPPH clearance rate and relatively good oxidation resistance.

The invention belongs to the technical field of daily chemicals, and particularly relates to high-temperature and neutral alkyl glycoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the invention is obtained by utilizing hydroxyl activity on a glucoside sugar unit to perform chemical modification, and specifically, 1, 3-dichloro-2-propanol is firstly adopted to perform intramolecular crosslinking on alkyl glucoside, and then 3-chloro-2-hydroxy sodium propanesulfonate is adopted to perform anionic modification. The prepared alkyl glycoside sulfonate has the advantages of being mild, low in irritation, high in hard water resistance, good in foaming performance, low in permeation amount on skin and small in residual amount, and can effectively overcome the defects that alkyl glucoside is high in permeability, high in deproteinization and degreasing capacity, large in damage to skin barriers, weak in thickening effect and the like in personal cleaning products; the method is very suitable for being widely used and popularized in daily chemicals.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with an acne removing effect, a preparation method of the sialic acid composition and cosmetics. The composition is prepared from 8%-20% of sialic acid, 10%-25% of ectoine, 5%-15% of a humectant, 0.1%-1% of a thickening agent, 0.05%-0.5% of a pH regulator and the balance of water. Cubilose acid can promote collagen synthesis, repair damaged skin barrier and reduce inflammatory response caused by external stimulation, and acne generation is inhibited from acne inducement; meanwhile, the sialic acid can inhibit release of proinflammatory factors such as TNF-alpha and IL-6 by adjusting a TLR receptor signal channel, red and swollen pox is relieved, and the generated pox is inhibited from the aspect of inhibiting inflammation; the sialic acid is non-irritant, and can slightly promote cutin renewal under high concentration, so that the problems of skin desquamation, sensitivity and the like caused by barrier injury can be effectively avoided. Ectoin is compounded, so that the Ectoin and sialic acid can generate a synergistic interaction effect.

The invention relates to repairing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The repairing essence disclosed by the invention contains a repairing composition, wherein the repairing composition is prepared from oligopeptide-215, Ectoine, a codium tomentosum extract, a liquorice root extract and a purple coneflower extract; the purple coneflower extract is prepared by taking purple coneflower as a raw material, performing mixed fermentation through bacillus amyloliquefaciens and lactobacillus plantarum and then performing ultrasonic extraction, and the obtained purple coneflower extract has an improved anti-inflammatory effect. The five components in the repair composition can synergistically promote expression of skin barrier repair related proteins, and the repair essence containing the repair composition can significantly improve the skin TEWL value and the skin moisture content of a subject and improve the redness condition, and has significant moisturizing, soothing and barrier repair capabilities.

The invention belongs to the technical field of cosmetics, and discloses a preparation process of a composition with an anti-wrinkle effect and application of the composition in cosmetics, the composition comprises a mixing tank, and the top of the mixing tank is provided with a tank cover; the discharging pipe is connected to the bottom of the mixing tank; the first driving part is connected to the top of the tank cover, the output end of the first driving part is connected with a rotating shaft, and a first cleaning assembly is arranged in the bottom end of the rotating shaft; the stirring rod is connected to the outer side of the rotating shaft, and stirring assemblies are arranged on the outer side of the stirring rod and the bottom of the rotating shaft. Through natural plant extracts and bioactive components, skin barriers are repaired while deep moisturizing and skin color brightening are achieved, the problem of dry skin is solved, the elasticity and compactness of the skin are improved, fine lines and wrinkles are reduced, skin aging is delayed, the antioxidant capacity is high, and compared with other anti-wrinkle products, chemical additives harmful to the skin are not contained; and the formula is low in cost and suitable for large-scale production.

This invention provides an antimicrobial peptide spray, its preparation method, and its application in the prevention and treatment of peristomal skin infections. The spray comprises, by weight percentage, 0.05%-0.5% of a complex antimicrobial peptide, 0.1%-5% of a moisturizing and repairing film-forming matrix, 0.05%-0.2% of a buffer, 0.8%-1.2% of an isotonic regulator, 0.01%-0.5% of a stabilizer, and 0.005%-0.05% of a metal ion chelating agent, with the balance being water for injection. The complex antimicrobial peptide is composed of bovine lactoferrin antimicrobial peptide, sericin oligopeptide, and buckwheat-derived anti-inflammatory active peptide in a weight ratio of (3-5):(2-3):1. This spray possesses four core functions: broad-spectrum antibacterial activity, inhibition of bacterial biofilm, anti-inflammatory and soothing effects, and skin barrier repair. It is less likely to induce bacterial resistance, does not irritate damaged skin around the stoma, and can effectively prevent and treat peristomal skin infections.

The present specification relates to arrangements for modifying a skin barrier provide transdermal pathways into the skin Such pathways can be used to improve ease of delivery of a wide variety of actives into the skin. In one aspect there is an arrangement for modifying a skin barrier, the arrangement comprising: - a substrate and a first skin modifier comprising a first and second electrode supported by the substrate, each of the first and second electrodes electrically isolated from one another; and - a second skin modifier, the second skin modifier different to the first skin modifier.

The application belongs to the technical field of medicine or cosmetics, and particularly relates to a composition for treating atopic dermatitis and application thereof. The composition is composed of polysaccharide of Arnebia euchroma and naphthoquinone of Arnebia euchroma, and the mass ratio of the polysaccharide of Arnebia euchroma to the naphthoquinone of Arnebia euchroma is 250-500:1. The polysaccharide of Arnebia euchroma and the naphthoquinone of Arnebia euchroma are compounded according to a specific ratio, and the two components have a synergistic effect, can significantly inhibit secretion of inflammatory factors, and promote expression of key proteins of a skin barrier, so that atopic dermatitis is treated from two paths of 'anti-inflammation' and 'barrier repair', and the effect is significantly better than that of a single component. The composition of the application is derived from natural plant ingredients, has high safety, can be prepared into various dosage forms, is used for auxiliary treatment or daily care of atopic dermatitis, and has a good application prospect.

The invention discloses a pawpaw moisturizing and soothing mask and a preparation method thereof, relates to the technical field of cosmetics, and aims to solve the problems that a pawpaw mask is relatively poor in water locking property, has a moisturizing effect, but is relatively short in lasting time and still needs to be improved in moisturizing and moisturizing effects. The pawpaw moisturizing and soothing mask is prepared from a first mixture, a second mixture and a third mixture, the pawpaw moisturizing and soothing mask contains plant extract essence, has the effects of softening and moistening skin, improving skin dryness, carefully caring and moisturizing skin and soothing skin, has the effects of moisturizing, soothing and moistening, has a deep moisturizing effect, provides extra moisture and nutritional value for the skin, helps the skin to deeply moisturize, makes the skin more elastic and glossy, and has a good moisturizing effect. The mask can fade darkness and flaws, make the skin brighter and shiny, extract natural plant essence, enhance the skin immunity, protect the skin from being damaged by the external environment, and play a role in repairing the skin barrier.

The invention discloses a plant cell extract-containing traditional Chinese medicine aromatic penetration enhancer and a preparation method thereof, and the penetration enhancer comprises the following components in parts by mass: 8-15 parts of storax nano-vesicles, 3-8 parts of agilawood nano-vesicles, 1-5 parts of refined turpentine, 0.5-3 parts of panax notoginseng saponins, 0.5-3 parts of rhododendron dauricum oil and 20-35 parts of grape seed oil, the storax nano-vesicles and the agilawood nano-vesicles are exosome-like nano-vesicles extracted from plant secretion, and the particle size of the vesicles is 50-200 nm. Skin interstices are opened, skin meridians and blood are dredged, and accordingly relieving, inflammation resisting, redness improving and skin barrier repairing are achieved.

The invention relates to the technical field of skin medicines, in particular to a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The invention discloses a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The composition comprises active ingredients of astacin and derivatives thereof, p-toluene sulfonamide and derivatives thereof, and pharmaceutically or cosmetically acceptable excipients. Through the synergistic effect of the two active components, the composition can effectively inhibit skin inflammatory response, relieve pruritus and erythema and promote skin barrier repair and wound healing. The composition can be prepared into multiple external dosage forms such as cream, gel and spray, is suitable for preventing or treating multiple inflammatory skin diseases such as atopic dermatitis, eczema and psoriasis, and can also be used for repairing and nursing skin wounds. The external formula provided by the invention has both curative effect and safety, and provides a new choice for the treatment of inflammatory dermatosis.