Application and synthesis method of cyclic peptide

By using the linear peptide cyclization method to prepare cyclic peptides, the problems of high synthesis cost and loss of active sites in the prior art are solved, and the preparation of cyclic peptides with high safety and significant biological activity are achieved. They are suitable for cosmetics and skin care products, and the product efficacy is improved.

CN119818387APending Publication Date: 2025-04-15SHANGHAI ZHONGYI DAILY CHEM CO LTD +1
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Patent Information

Application Number
CN202510023792.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-07
Publication Date
2025-04-15

AI Technical Summary

Technical Problem

In the prior art, the synthesis of cyclic peptides is high and inefficient, and the cyclic peptides formed by cyclization may lose certain key active sites, resulting in a weakening or loss of the biological activity of the original linear polypeptide.

Method used

The cyclic peptide is prepared by cyclization of single or multiple linear peptides, and the linear peptide is prepared by amino acid dehydration and condensation reaction, and the cyclic peptide is synthesized by cyclization such as head-tail connection. The synthesis steps are simple and cost-effective.

Benefits of technology

It has achieved high safety and significant biological activity in the preparation of cyclic peptides, with anti-inflammatory, moisturizing, barrier repair and soothing effects. It is suitable for cosmetics and skin care products, improving product efficacy.

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Abstract

The invention relates to the technical field of cosmetics, in particular to application and a synthesis method of cyclic peptide. The inhibition objects of the cyclic peptide comprise IL-1beta, IL-6 and TNF-alpha (Tumor Necrosis Factor-alpha); when the concentration is less than or equal to 10ppm, the inhibition rate on IL-1beta is greater than or equal to 40%, the inhibition rate on IL-6 is greater than or equal to 50%, and the inhibition rate on TNF-alpha is greater than or equal to 40%. The cyclopeptide has a barrier repairing effect and can improve FLG expression; meanwhile, the moisturizing effect is achieved, and percutaneous moisture loss of the skin can be reduced. The invention provides a group of cyclic peptides, which has excellent anti-inflammatory, moisturizing, barrier repairing and soothing effects, and compared with the existing straight-chain peptides in the market, the group of cyclic peptides has more obvious anti-inflammatory and soothing effects, and has a certain skin barrier repairing effect. The group of cyclic peptides can be applied to the fields of cosmetics and skin care products, and the product efficacy is improved; and the synthetic method of the cyclic peptide is easy to implement and wide in application prospect.
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