274 results about "Carnosine" patented technology

The invention belongs to the technical field of biochemical engineering, and provides a method for increasing L-carnosine yield of escherichia coli by increasing PRPP supply, and the yield and yield of L-carnosine are remarkably increased by up-regulating expression of a prs gene, increasing PRPP content in cells and promoting synthesis of L-histidine. Experiments show that the yield of the L-carnosine in different recombinant strains is increased by 55.56%-140%, and L-histidine and beta-alanine do not need to be added in the production process.

The invention belongs to the technical field of cosmetics, and particularly relates to essence with anti-wrinkle, repairing and skin-brightening effects as well as a preparation method and application of the essence. The essence is prepared from the following components in parts by weight: 10 to 70 parts of herba centellae extract, 0.0015 to 0.04 part of crocus sativus extract, 0.5 to 2.5 parts of spirulina maxima extract, 0.015 to 0.2 part of radix gentianae extract, 0.1 to 1.5 parts of panthenol, 0.25 to 1.5 parts of leuconostoc / radish root fermentation product filtrate, 0.1 to 1.5 parts of carnosine and 0.21 to 5.3 parts of anti-wrinkle components. According to the essence, various effective components such as the centella asiatica extract, the spirulina maxima extract and the radix gentianae extract are matched for use, a unique composite formula is formed, all the components promote one another, the anti-wrinkle, repairing and skin brightening effects of the essence can be remarkably enhanced, and therefore all-around skin care is provided for consumers, and the essence has a good market prospect. The overall quality of the skin can be effectively improved.

The invention relates to a composition containing ceramide and collagen tripeptide and a preparation method thereof, and belongs to the technical field of health care products. The invention discloses a composition containing ceramide and collagen tripeptide. The composition is prepared from the following raw materials: collagen tripeptide, rice bran oil powder, a herba houttuyniae extract, pineapple powder, konjaku flour, a grape seed extract, olive fruit powder, carnosine, pomegranate concentrated powder and a whey fermentation product. The grape seed extract, the olive fruit powder, the carnosine and the pomegranate concentrated powder inhibit the Maillard reaction of the collagen peptide and improve the utilization rate of collagen tripeptide; ceramide rich in the rice bran oil powder is a natural skin moisturizing factor, and is matched with the pineapple powder and the konjaku flour which have a keratin metabolism effect to maintain the health of cuticles; the herba houttuyniae extract and the whey fermentation product are matched to have an excellent anti-inflammatory effect, so that the components enhance the skin barrier in multiple dimensions through collagen synthesis, cuticle maintenance, anti-inflammatory and anti-oxidation.

The invention relates to the technical field of microorganisms, and particularly discloses a recombinant microorganism and application thereof in fermentation production of decarboxylated carnosine. Compared with an original strain, the recombinant microorganism disclosed by the invention has the advantages that the expression of the mdtK gene is enhanced; the starting strain is escherichia coli capable of producing decarboxylated carnosine. When the recombinant microorganism is used for fermentation production, the yield of the decarboxylated carnosine can be increased, L-histidine, histamine or beta-alanine and other precursors do not need to be added in the production process, and an effective novel method is provided for industrial production of the decarboxylated carnosine.

The invention provides a preparation method and application of a camellia polypeptide composition with anti-wrinkle, repairing and brightening effects. The camellia polypeptide composition comprises a component A and a component B, wherein the component A comprises a wrapping solubilizer and polyhydric alcohol; component B: a plurality of polypeptides; the component C comprises carnosine, camellia polypeptide and water. The camellia polypeptide disclosed by the invention is prepared by the following steps: performing supercritical deoiling on camellia seeds, performing alkali extraction, acid precipitation and enzymolysis to prepare polypeptide, performing membrane filtration, taking micromolecule polypeptide as a main component, promoting synthesis of type I, type III and type V collagen, promoting cell migration and scavenging free radicals, and has the effects of resisting wrinkles, repairing and resisting oxidation; according to the invention, the problem of water solubility of palmitoyl peptide and acetyl peptide is solved, so that palmitoyl peptide and acetyl peptide can form a stable composition together with water-soluble polypeptide. The anti-wrinkle, repairing and whitening effects are achieved in multiple ways and multiple directions, the effects of improving wrinkles, repairing the skin, brightening the skin color and delaying senescence can be better achieved, and the anti-wrinkle, repairing and whitening composition can be widely applied to various types of cosmetics.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The present invention relates to the fields of medicine and cosmetology, and discloses a cell active peptide composition that promotes the regeneration of multi-type collagen structural proteins, its preparation method, and its application in medicine and cosmetology. The composition uses raw materials such as tripeptide-10 citrulline, hexapeptide-9, hydrolyzed sodium hyaluronate, γ-aminobutyric acid, decarboxylated carnosine hydrochloride, acetyl tetrapeptide-3, acetyl tetrapeptide-11, palmitoyl dipeptide-7, and palmitoyl pentapeptide-4. The composition can promote the coordinated expression of skin type I, type III, type IV, type VII, type XVII collagen, fibronectin, elastin, and glycosaminoglycans; prevent collagen cross-linking, maintain triple helix structure, and inhibit collagen degradation. Applied to dermatology and cosmetology, it can accelerate the regeneration of structural proteins such as skin collagen, repair skin damage, reduce wrinkles such as crow's feet, tear groove lines, nasolabial folds, and under-eye lines, solve the skin aging problem caused by the loss of structural proteins such as collagen, and improve skin elasticity and firmness.

The invention discloses an active exosome stent coating based on traditional Chinese medicine enhanced secretion promotion and a preparation method and application thereof, and belongs to the technical field of biological medicine and interventional instruments. The stent coating comprises exosomes, wherein the exosomes comprise myocardial cell active exosomes and human mesenchymal stem cell active exosomes which are intensified and secreted by traditional Chinese medicines; wherein the traditional Chinese medicines comprise placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, lycium ruthenicum peptide, cnidium lactone, curculigo orchioides extract and morinda officinalis extract; the intervention concentration of each component added into cells is 2-50 [mu] g / mL; the light-cured gel matrix is prepared from methacrylated gelatin, a photoinitiator and polyether 127; tacrolimus; the final concentration of the exosome is 1 * 10 < 9 >-12 * 10 < 9 > particles / mL, and the final concentration of the tacrolimus is 5-25 mu g / mL. The coating can be coated on the surface of the poly-L-lactic acid degradable stent to prepare the degradable stent, and has obvious vascular repair promoting capability.

The invention relates to the technical field of cosmetics, and particularly discloses emulsion type foaming cleaning scrub cream with a skin care effect and a preparation method of the emulsion type foaming cleaning scrub cream. The scrub cream is prepared from the following raw material components in percentage by mass: 8 to 15 percent of glycerol, 0.2 to 0.9 percent of sodium hydroxide, 0.3 to 0.8 percent of citric acid, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.5 to 1.5 percent of an auxiliary agent, 1.5 to 3.0 percent of a thickening agent A, 1.5 to 3.0 percent of a thickening agent B, 5.86 to 1457 percent of an emollient, 12 to 22 percent of a surface active foaming agent, 0.8 to 3.0 percent of an emulsifying agent, 2.5 to 13 percent of a cutin stripping agent, 0.7 to 1.3 percent of a preservative, 0.32 to 0.92 percent of a skin conditioning agent and the balance of water, the skin conditioner is a mixture prepared from sodium hyaluronate, tocopherol, papain, nicotinamide, carnosine, panthenol and phytosterol oleate.

The invention relates to an anti-wrinkle and anti-aging composition and application thereof. The anti-wrinkle and anti-aging composition is prepared from hydrolyzed rice protein, a bifidus yeast fermentation product lysate, dipeptide diaminobutyryl benzyl amide diacetate, adenosine, hydroxydecyl ubiquinone, ceramide NP, palmitoyl tripeptide-5, carnosine and acetyl hexapeptide-8. According to the present invention, the components achieve the synergistic effect, such that the fibroblast proliferation can be promoted, the cell metabolism can be improved, the generation of collagen, elastin and the like can be promoted, the excellent oxidation resistance can be provided, and the effects of expression line inhibition, existing wrinkle fading and long-term aging resistance can be combined.

The invention discloses a gelatin-hyaluronic acid injectable hydrogel drug-carrying nanoparticle composite material as well as a preparation method and application thereof, relates to the technical field of biomedicine, and solves the problems that in the prior art, existing drugs for treating cartilage related diseases are difficult to deliver; the chronic inflammatory response in the articular cavity cannot be effectively controlled and cartilage cells cannot be protected at the same time, so that the application effect of the medicine is limited. The preparation method disclosed by the invention comprises the following steps: S1, obtaining a carnosine modified hyaluronic acid derivative Car-HA; s2, preparing nano particles (FNPs) loaded with fenofibrate; and S3, mixing the gelatin solution containing the FNPs with a Car-HA solution, adding transglutaminase into the mixed system, and carrying out an enzymatic cross-linking reaction to form the hydrogel FNPs-GelHA with a stable network structure. The CarHA and FNPs synergistic hydrogel strategy provided by the invention has good structural adjustability and drug adaptability, is suitable for delivery of various anti-inflammatory, anti-oxidation and cartilage repair drugs, and can be widely applied to local precise treatment of cartilage related diseases.

The invention belongs to the field of cosmetics, and particularly discloses an ormosia henryi bark extract-containing composition capable of nourishing, repairing and brightening skin as well as a preparation method and application of the composition. The composition comprises an active component, a solubilizer, polyol, phospholipid and water, wherein the active ingredients comprise an ormosia henryi bark extract, acetylchitosamine, decarboxylated carnosine or salt thereof and a coast pine bark extract. Active ingredients in the composition are good in solubility in the composition, the composition is good in stability, good in skin permeability and good in AGEs inhibition effect, the four active ingredients including the ormosia henryi bark extract, the acetylchitosamine, the decarboxylated carnosine and the coast pine bark extract are in mutual synergistic interaction, and an excellent unexpected technical effect is achieved.

The invention relates to the technical field of microorganisms, and particularly discloses a PhPepD mutant and application of the PhPepD mutant in fermentation production of L-carnosine. According to the invention, a new PhPepD mutant is screened by means of construction of a mutation library from PepD of different sources and error-prone PCR, site-directed saturation mutation and the like, the amino acid sequence of the PhPepD mutant is shown as SEQ ID NO: 18, and compared with wild type PhPepD protein, the PhPepD mutant has N158D / I176F / E393Q mutation. By using the mutant, a microorganism with increased L-carnosine yield can be obtained, and in recombinant microorganisms capable of producing carnosine without adding beta-alanine, the mutant also shows an effect of increasing the L-carnosine yield, and a new effective method is provided for industrial large-scale production of L-carnosine.

The invention relates to the technical field of skin care products. The invention aims to provide a split storage type novel skin-brightening skin-care product combined by oligopeptide freeze-dried powder and essence. The split storage type novel skin-brightening skin-care product comprises multiple oligopeptide freeze-dried powder and solvent essence, the multi-oligopeptide freeze-dried powder is prepared from the following raw materials in parts by weight: 90 to 95 parts of water, 1 to 2 parts of glutathione, 1 to 2 parts of mannitol, 1 to 2 parts of carnosine, 0.5 to 1 part of ergothioneine, 0.5 to 1 part of vitamin C and 0.0005 to 0.001 part of a multi-peptide-zinc chelate. The multi-peptide-zinc chelate is prepared from the following raw materials in parts by weight: 1-2 parts of hexapeptide-2, 1-2 parts of nonapeptide-1, 1-2 parts of dipeptide-2, 1-2 parts of tripeptide-10 and 2-3 parts of zinc oxide. According to the invention, various peptides with small molecular weights are chelated with zinc, the characteristics of good permeability and strong skin affinity of the small molecular peptides are fully played, the effects of zinc and other components are effectively played, and the overall use effect is greatly improved. Through compounding of multiple components, the moisturizing and brightening mask has multiple effects of moisturizing, good permeability, whitening, brightening and the like.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The present invention relates to the field of microbial technology, and specifically discloses a recombinant microorganism and its application in the fermentation production of decarboxylated carnosine. The recombinant microorganism of the present invention has enhanced mdtK The starting strain is Escherichia coli capable of producing decarboxylated carnosine. Fermentation production using the recombinant microorganism of the present invention can increase the yield of decarboxylated carnosine without adding precursors such as L-histidine, histamine, or β-alanine during the production process, thereby providing an effective new method for the industrial production of decarboxylated carnosine.

The invention relates to the technical field of whitening and freckle removing, in particular to light-sensitive whitening and freckle removing essence and a preparation method and application thereof.The light-sensitive whitening and freckle removing essence is prepared from, by mass, 72.07% of water, 6% of butanediol, 3%-5% of X-resveratrol, 3% of tranexamic acid, 2.5% of nicotinamide, 2% of a red removing factor, 1% of panthenol, 1% of an anti-inflammatory agent, 0.5% of an anti-allergy agent, 0.5% of carnosine, 0.5% of p-hydroxyacetophenone, 1% of 1, 2-propylene glycol and the balance 1, 2-propylene glycol. The mask comprises the following components in percentage by weight: 0.5% of 1, 2-hexanediol, 0.2% of carbomer, 0.18% of arginine, 0.05% of sodium hyaluronate, 0.1%-1% of a light stabilizer and 5% of bis-ethylhexyloxyphenol sulfonate. According to the invention, the resveratrol is esterified by methyl propiolate, so that the molecular structure of the resveratrol is optimized, the performance of the resveratrol in the aspect of light stability is enhanced, and the degradation under the illumination condition is reduced; the esterified resveratrol can effectively inhibit tyrosinase activity, regulate melanocyte signal transduction and realize whitening and spot fading effects.

The invention discloses an application of an mRNA combination in predicting the curative effect of myocardial peptide in treating myocardial ischemia-reperfusion injury, and belongs to the technical field of biology. The mRNA combination comprises Asb10 (Asb10) and Egr2 (Egr2); the nucleotide sequence of the Asb10 is as shown in SEQ ID NO. 1, and the nucleotide sequence of the Egr2 is as shown in SEQ ID NO. 2. Experiments prove that compared with a normal mouse, the expression of Asb10 in a model group is remarkably reduced, the expression of Egr2 is remarkably improved, and compared with the model group and a cardiomyopeptide group, the level of Asb10 is remarkably improved, and the level of Egr2 is remarkably reduced. The ROC curves of Asb10 and Egr2 after myocardial peptide treatment are constructed, and the AUC of Asb10 and Egr2 is 0.816 and 0.762 respectively. The invention provides a more effective monitoring means and a new thought for more stably predicting the curative effect of myocardial peptide on myocardial ischemia-reperfusion injury at low cost.

The present application relates to polypeptides having carnosine synthase activity; a polynucleotide encoding the polypeptide; a microorganism comprising any one or more of the polypeptide, the polynucleotide, and a vector comprising the polynucleotide; variant polypeptides having carnosine synthase activity; a polynucleotide encoding the variant polypeptide; a microorganism comprising any one or more of the variant polypeptide, the polynucleotide, and a vector comprising the polynucleotide; a composition for producing carnosine, the composition comprising any one or more of a polypeptide having carnosine synthase activity, the variant polypeptide, the microorganism, and a culture product of the microorganism; a method for producing carnosine using any one or more of a polypeptide having carnosine synthase activity, the variant polypeptide, and the microorganism; and polypeptides having carnosine synthase activity, the use of the variant polypeptides and the microorganisms for the production of carnosine.

The invention relates to the technical field of food processing safety and environmental pollution control, in particular to a natural compound preparation with a synergistic formaldehyde removal function and a preparation method and application thereof. The natural compound preparation is prepared from the following raw materials in percentage by mass: 5%-10% of carnosine, 0.5%-2% of epigallocatechin gallate, 0.05%-0.2% of edible essence, 10%-20% of a surfactant and the balance of a solvent, and the total percentage is 100%. The invention aims to reduce the exposure risk of specific groups such as chefs and guarantee the health level of the specific groups, the main component carnosine is dipeptide which can be used as a food additive and has good antioxidant activity, and amino in the structure of the carnosine can be subjected to Michael addition reaction with carbonyl of aldehydes. The epigallocatechin gallate is a common polyphenol substance, and phenolic hydroxyl groups in the epigallocatechin gallate can be reacted with aldehydes to capture and remove the aldehydes.

The invention provides an external composition for improving the sub-health state of people in a high-glucose lifestyle and application of the external composition, and belongs to the technical field of biological agents. The composition provided by the invention is prepared from the following components: caffeine silanol C, a radix sophorae flavescentis extract, a lotus leaf extract, a corn poppy extract, a bitter gourd extract, soy isoflavone, beta-glucan, a tea leaf extract, an apple extract, resveratrol, a pueraria mirifica extract, a propolis extract, an angelica sinensis root extract, a radix ophiopogonis extract and a rhizoma anemarrhenae root extract. The composition is prepared from a fructus gardeniae extract, a Thermus thermophilus fermentation product, oligopeptide-1 and carnosine. The composition provided by the invention can be prepared into an external preparation, is suitable for people in the high-glucose lifestyle, has the technical effects of improving the sub-health states of the people in the high-glucose lifestyle, such as weakness, skin itch, dark skin color, thirst, frequent urination and the like, and improves the life quality of the people in the high-glucose lifestyle.

The invention provides an anti-aging and skin-tightening composition and a preparation method thereof, and belongs to the technical field of anti-aging and skincare, and the composition comprises a hovenia acerba infructescence extract, an okra seed extract, tetrapeptide-4, acetyl octapeptide-1, a hill-pit snail extract, paeonol and a carnosine-zinc gluconate chelate. And carrying out aerobic fermentation on the raisin tree infructescence powder through aspergillus oryzae, and purifying the centrifuged supernatant through a composite filler resin column to obtain the raisin tree infructescence extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on okra seeds by virtue of compound enzyme, ficin and subtilisin, adding absolute ethyl alcohol for extraction, centrifuging supernate, and purifying by virtue of an LH-20 sephadex column, so as to obtain the okra seed extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on the mountain snail meat through trypsin and lumbrukinase, centrifuging the enzymatic hydrolysate, and carrying out ultrafiltration on the supernate to obtain the mountain snail extract with the molecular weight of less than 3kDa. The components are matched for use, so that the balance of high-efficiency anti-aging and low-irritation can be realized through synergism of three major pathways of inhibiting collagen degradation, promoting collagen synthesis and resisting sugar and relieving.

The invention relates to the field of functional additives for daily chemicals, and particularly discloses hydrolyzed procyanidine freeze-dried powder and a preparation method thereof. The hydrolyzed procyanidine freeze-dried powder is prepared by freeze-drying and comprises the following raw materials in parts by weight: 0.1-0.2 part of hydrolyzed procyanidine, 25-35 parts of carnosine, 10-20 parts of a stabilizer, 0.1-0.3 part of acetyl hexapeptide-8 and 45-55 parts of water. The stabilizer is selected from at least one of mannan, trehalose, mannitol, cane sugar, betaine, whey protein, PVP (Polyvinyl Pyrrolidone), PEG (Polyethylene Glycol), glycine, histidine, leucine, sodium alginate, beta-cyclodextrin, maltodextrin and chitosan. The hydrolyzed procyanidine freeze-dried powder has good storage stability, can keep activity for a long time, is still stable after being dissolved in water for a long time, and has less activity loss.

The invention discloses a firming and anti-aging composition containing a Campania acuta bark extract and application of the firming and anti-aging composition, and belongs to the technical field of cosmetics. The firming and anti-aging composition containing the Campanumoea maculata bark extract comprises the following components: the Campanumoea maculata bark extract, a Flos Magnoliae Officinalis extract, a Tremella aurantialba extract and a composite polypeptide, and the composite polypeptide is composed of carnosine, acetyl tetrapeptide-5 and tripeptide-10 citrulline in a mass ratio of 1: (0.4-0.6): (0.2-0.6). Through the synergistic effect of the four components, the firming and anti-aging composition has a good effect of inhibiting the activity of elastase and collagenase.

The invention relates to the technical field of cosmetics, in particular to a skin repairing composition for whitening and resisting light damage and a preparation method. The composition comprises polypeptides such as acetyl tetrapeptide-11, glutathione, decarboxylated carnosine, tripeptide-1 and the like, the effects of whitening and brightening the skin, resisting light aging and repairing the skin are achieved through multi-way, multi-azimuth and multi-target combined action and mutual cooperation, and the effects of improving the skin quality and repairing the skin can be better achieved. The composition disclosed by the invention can be widely applied to various cosmetics.

The invention provides a method for extracting goose carnosine and / or carnosine. The method comprises the steps of low-salt water extraction and high-salt water extraction under alkaline and heating conditions. The extraction method of the goose carnosine and / or carnosine provided by the invention is simple to operate, low in cost and easy for large-scale industrial use.

The invention discloses a collagen peptide composition with a skin saccharification resisting effect and a preparation method of the collagen peptide composition, and belongs to the technical field of health care products. The composition is prepared from the following raw materials in parts by mass: 50-60 parts of collagen peptide, 9-15 parts of decarboxylated carnosine, 5-8 parts of peony peptide, 2-4 parts of fucoxanthol, 5-8 parts of tricholoma lobayense heim polysaccharide, 1-2 parts of sesamin and 3-7 parts of cyclodextrin. The collagen peptide composition is prepared through a reasonable material compounding agent inclusion technology, the anti-saccharification activity of the collagen peptide composition is remarkably improved, and a better scheme is provided for resisting skin saccharification.

The invention provides a method for producing L-carnosine, a genetic engineering strain as well as a preparation method and application of the genetic engineering strain, and belongs to the field of genetic engineering. According to the genetic engineering strain provided by the invention, by knocking out a glucose-6-phosphate isomerase coding gene pgi, knocking out an L-threonine / L-homoserine transporter coding gene rhtA or knocking out a dipeptide transfer protein coding gene dppABCD, the yield of extracellular L-carnosine is increased, the shake flask yield of the finally constructed strain reaches 9.1 g / L, the 5L fermentation tank yield reaches 65 g / L, and the yield of the extracellular L-carnosine reaches 9.1 g / L; and the method has a good application prospect in L-carnosine biosynthesis.

The present invention discloses an active exosome scaffold coating based on traditional Chinese medicine enhanced secretion, its preparation method and application, belonging to the technical field of biomedicine and interventional devices. The scaffold coating of the present invention includes: exosomes, including cardiomyocyte active exosomes and human mesenchymal stem cell active exosomes enhanced by traditional Chinese medicine; wherein, the traditional Chinese medicine includes: placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, black wolfberry peptide, osthole, curculigo rhizome extract, and morinda officinalis extract; the intervention concentration of each component added to the cells is 2-50 μg / mL; a photocurable gel matrix, including methacrylated gelatin, a photoinitiator, and polyether 127; tacrolimus; the final concentration of exosomes is 1×10 9 ~12×10 9 particles / mL, and the final concentration of tacrolimus is 5-25 μg / mL. This coating can be coated on the surface of a poly-L-lactic acid degradable stent to prepare a degradable stent, which has obvious ability to promote blood vessel repair.

The invention discloses snowflake cream with pearly luster and a preparation process of the snowflake cream. The snowflake cream comprises the following raw material components: a phase A: water; butanediol; glycerol; methyl glucitol polyether-20; a polyacrylate cross-linked polymer-6; sodium hyaluronate; potassium hydroxide (90%); 4-hydroxyacetophenone; xanthan gum; phase B: caprylic / capric triglyceride; cetostearyl alcohol; stearic acid; a polydimethylsiloxane; squalane; simmondsia chinensis seed oil; mineral oil; and polyethylene glycol (PEG)-100 stearate. Glyceryl stearate; tocopheryl acetate; isononyl isononanoate; a phase C: 1, 2-hexanediol; carnosine; a centella asiatica extract; collagen; the snowflake cream has the advantages of uniform pearly luster texture and the advantages of traditional snowflake cream.