341 results about "Green chemistry" patented technology

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The present invention relates to the technical field of polymer preparation. Disclosed are a covalent organic framework material, and a preparation method therefor and a use thereof. The preparation method for the covalent organic framework material comprises the following step: subjecting an organic aldehyde and an organic amine to a condensation reaction in a deep eutectic solvent to obtain the covalent organic framework material, wherein the deep eutectic solvent is a two-component eutectic liquid composed of menthol and acetic acid. The temperature for the reaction is 25-120ºC, and the time for the reaction is 1-72 hours. The deep eutectic solvent composed of menthol and acetic acid used in the present invention has good dissolution properties for organic matters, and can also efficiently catalyze the condensation reaction between the organic amine and the organic aldehyde. The prepared covalent organic framework material exhibits high crystallinity and has good applications in the fields of adsorptive separation, heterogeneous catalysis, energy storage, etc. The present method has mild reaction conditions, simple operation, and good universality, is conducive to industrial large-scale production, and conforms to the concept of green chemistry.

The invention provides a two-dimensional layered kaolinite nanofiltration membrane, and a preparation method and application thereof, and the preparation method comprises the following steps: mixing kaolinite powder and an intercalator according to a first solid-to-liquid ratio, heating, stirring, carrying out intercalation reaction completely, and carrying out solid-liquid separation to obtain a solid kaolinite intercalation compound; mixing the kaolinite intercalation compound with water according to a second solid-to-liquid ratio, adjusting the pH value of the mixed solution to 9-13, and carrying out dispersion treatment to obtain a kaolinite nanosheet dispersion liquid; enabling the kaolinite nanosheet dispersion liquid to penetrate through the porous basement membrane, and depositing kaolinite nanosheets in the kaolinite nanosheet dispersion liquid on the porous basement membrane to obtain the two-dimensional layered kaolinite nanofiltration membrane; the operation steps are simple, no complex equipment or a large amount of organic solvent is used, and the method conforms to the concept of green chemistry. The prepared two-dimensional layered kaolinite nanofiltration membrane can be used in various fields of water treatment, organic solvent separation and the like, and has a wide application prospect.

The invention discloses an environment-friendly waterborne polyurethane glove and a preparation method thereof. The environment-friendly waterborne polyurethane glove comprises a glove core and an environment-friendly waterborne polyurethane layer wrapping the surface layer of the glove core. The environment-friendly waterborne polyurethane layer is prepared from the following raw materials in parts by mass: 20 to 35 parts of isocyanate, 40 to 60 parts of bio-based polyol, 3 to 8 parts of a fluorine-containing chain extender, 0.5 to 3 parts of nano cellulose, 1 to 5 parts of an environment-friendly cross-linking agent, 0.3 to 1.5 parts of a nonionic emulsifier, 2 to 6 parts of an environment-friendly plasticizer, 0.1 to 0.5 part of a low-toxicity preservative and 15 to 30 parts of deionized water. The preparation method has the advantages that no organic solvent is contained, no VOCs are discharged in the production process, the green chemistry principle is met, and the overall strength and performance are higher.

The invention belongs to the technical field of antibacterial materials, and particularly relates to a sericin / tannic acid-silver antibacterial-anti-biofilm nanocomposite as well as a preparation method and application thereof. According to the method, the TA-Ag nano material is prepared by adopting a simple water bath method; and then, dispersing SS in a TA-Ag aqueous solution to realize hydrogen bond combination of SS and TA so as to obtain the SS / TA-Ag nanocomposite with a stable structure. In the preparation process, plant polyphenol tannic acid is taken as a carrier, silver ions and tannic acid are combined by adopting a water bath method, and the antibacterial property of tannic acid is effectively improved; and the sericin is further modified through hydrogen bond crosslinking, so that the obtained composite material not only has antibacterial and anti-biofilm dual functions, but also is simple in preparation process and mild in reaction condition, and conforms to green chemistry and environment-friendly concepts.

The application provides a method for synthesizing an eplerenone intermediate N-1 by one-pot method, and belongs to the technical field of organic synthesis. The method is characterized in that: the eplerenone intermediate N-4 is dissolved in dichloromethane, a potassium carbonate aqueous solution and dibromohydantoin are added to perform an opening ring reaction; after the reaction is completed, hydrochloric acid is directly added to perform a rearrangement reaction; then water is separated and methanol is added in the organic layer to perform an ozonation reaction; then sodium sulfite is added to perform a reduction reaction; then hydrochloric acid is added to perform a methyl esterification reaction, so as to obtain the eplerenone intermediate N-1 crude product, and finally the eplerenone intermediate N-1 fine product is obtained through refining. The method realizes the one-pot synthesis of the eplerenone intermediate N-1 from the eplerenone intermediate N-4 through the continuous reactions of opening ring, rearrangement, ozonation, reduction and methyl esterification, and can avoid column chromatography purification, so that the method becomes a green chemical process route with greatly reduced organic solvent consumption and wastewater.

This invention relates to the field of organic synthesis technology and discloses a method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester, comprising the steps of: S1, providing raw material: 3-cyclohexenecarboxylic acid-3′-cyclohexene methyl ester; S2, epoxidation reaction: mixing the raw material with hydrogen peroxide, a composite catalyst, and a buffer to obtain a reaction solution containing the target product; S3, separation and purification: allowing the reaction solution to stand and separate into layers, separating the organic phase, washing with water, drying, and vacuum distilling to obtain 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester. This method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester uses hydrogen peroxide as the oxygen source, resulting in no heavy metal pollution, low wastewater volume, and conforming to the trend of green chemistry. The composite catalyst requires a small amount, has high activity and good selectivity, can be recycled ≥5 times, reducing costs, requiring less equipment, and is highly safe. The product is colorless and transparent, with a high epoxy value, purity ≥98.5%, low acid value, and good stability.

The application provides a method for synthesizing triaminotriphenylmethane, which does not need to use a solvent, uses N,N'-dibenzylaniline and trialkoxymethane as synthetic raw materials, and makes N,N'-dibenzylaniline and trialkoxymethane undergo a Friedel-Crafts alkylation reaction, so as to avoid the generation of 2,4',4"-triaminotriphenylmethane isomers in a traditional synthesis method by using the steric effect of two benzyl protective groups, thereby obtaining 4,4',4"-tri(N,N'-dibenzylaminophenyl)methane with high selectivity. 4,4',4"-tri(N,N'-dibenzylaminophenyl)methane is further subjected to a debenzylation reaction under neutral conditions to form triaminotriphenylmethane. According to the chemical structural formula of the target product, the benzyl group as the protective group of the amino group is reduced under a neutral environment, and the benzyl group is removed, and the formed byproduct is only toluene, which not only ensures the high yield and high selectivity of the target product, but also is very beneficial to obtaining high-purity 4,4',4"-triaminotriphenylmethane, and conforms to the principle of green chemistry.

The invention belongs to the technical field of synthesis of 2, 3-dipicolinic acid, and relates to a catalyst for synthesizing 2, 3-dipicolinic acid as well as a preparation method and application thereof, the catalyst is prepared from a carrier, and active components and auxiliaries loaded on the carrier; the carrier is boron nitride modified aluminum oxide, the active component is palladium-cobalt bimetal, and the auxiliary agent is magnesium; the catalyst comprises the following components in percentage by mass: 0.2 wt%-3wt% of palladium, 0.5 wt%-4wt% of cobalt, 0.05 wt%-0.3 wt% of magnesium, 5wt%-15wt% of boron nitride and the balance of an aluminum oxide carrier. The catalyst is prepared by adopting an ultrasonic-assisted sol-gel method, so that high dispersion and strong interaction of active components are realized. The catalyst shows high catalytic activity, high selectivity and excellent stability in a dichloropyridine carbonylation reaction, carbon monoxide is used as a carbonyl source, the atom economy is high, and the green chemical requirement is met.

The invention discloses a method for catalytically synthesizing a secondary amine acetate derivative by using lignite residues, which comprises the following steps: taking an amine (primary amine) compound and an aryl diazo ester compound as raw materials to react for preparation, and taking the lignite residues as a catalyst. The catalyst lignite residue adopted by the method is wide in source, low in cost and easy to obtain, the reaction condition is mild, the yield is good, gram-scale reaction can be achieved, and the method has industrialization prospects. The lignite residues are high in catalytic activity and can be recycled, recycling of waste resources is achieved, the problem that the lignite residues are difficult to treat is solved, and the method conforms to the sustainable development concepts of environmental protection and green chemistry.

The invention provides a preparation method of fluoride ether bacteria amide, which comprises the following steps: dissolving pentafluorobenzonitrile in a solvent, dropwise adding a sodium methoxide solution at-10-30 DEG C for 2-15 hours, continuing to carry out heat preservation reaction for 0.5-2 hours after dropwise adding, and carrying out post-treatment to obtain 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile; the preparation method comprises the following steps: jointly dissolving 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile, 3-chloro-5-(trifluoromethyl) pyridine-2-yl) methanol and a catalyst acid in a solvent, reacting at 50-110 DEG C for 5-32 hours, and performing post-treatment on the obtained reaction liquid to obtain fluoride ether bacteria amide, according to the method, sodium methoxide and pentafluorobenzonitrile which are low in price and easy to obtain are subjected to etherification reaction, thionyl chloride and bis (trichloromethyl) carbonate are not used, the green chemical principle is met, and the method has the advantages of being short in step, safe and easy to operate and the like, so that the method has high implementation value and practical production applicability.

The invention discloses a synthesis method of 5-(1H-pyrrole-1-yl)-2-mercaptobenzimidazole, which comprises the following steps: carrying out cyclization condensation reaction on o-phenylenediamine and thiourea in an acidic environment provided by hydrochloric acid to obtain 2-mercaptobenzimidazole; the preparation method comprises the following steps: carrying out nitration reaction on 2-mercaptobenzimidazole, sulfuric acid and nitric acid to obtain 2-mercapto-5-nitrobenzimidazole; the preparation method comprises the following steps: carrying out nitro reduction reaction on 2-sulfydryl-5-nitrobenzimidazole and hydrogen under the catalysis of nickel to obtain 5-amino-2-sulfydryl benzimidazole; the preparation method comprises the following steps: carrying out an N-alkylation reaction on 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran under the catalysis of copper chloride to generate 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole, and carrying out a reaction on the 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran to generate the 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole. The method disclosed by the invention has the outstanding advantages of mild and easily-controlled conditions, simple and convenient post-treatment, high yield, economy, environmental protection, suitability for large-scale production and the like, conforms to the green chemical development concept, and has important application value.

The invention discloses an enantiomer crystallization resolution method of delta-dodecalactone, which comprises the following steps: hydrolyzing delta-dodecalactone under an alkaline condition for ring opening, acidifying to obtain 5-hydroxylauric acid, adding a dehydroabietylamine solution, dissolving in an alcohol solvent or a solvent system consisting of the alcohol solvent and other solvents, fully reacting, cooling, slowly crystallizing, filtering, washing, and drying to obtain the delta-dodecalactone enantiomer. Filtering, adding ethyl acetate and hydrochloric acid into a filter cake for dissolving, carrying out liquid-liquid extraction and washing an organic phase, and carrying out rotary evaporation concentration on the organic phase to obtain optically enriched delta-dodecalactone; the method is simple to operate and does not depend on expensive special equipment, and the sample loading amount is greatly increased; due to the introduction of dehydroabietylamine, the 5-hydroxylauric acid and the dehydroabietylamine form diastereoisomer salt, and chiral separation is carried out in the crystallization process; the reaction safety is high, and the requirements of green chemistry are met.

The application discloses a kind of sulphur-containing polydopamine melanin nanoparticles and preparation method and application, preparation raw materials include polyhydroxy compound and sulphur-containing compound, the weight ratio of the polyhydroxy compound and the sulphur-containing compound is (1-100) :(1-100), the preparation raw materials also include water, organic solvent and acid-base regulator.The application occurs self-polymerization reaction under alkaline condition with dopamine and sulphur-containing compound, without additional crosslinking agent and oxidant, and the nanoparticles obtained have excellent photothermal performance.In photothermal therapy, biomedical imaging, water purification, functional coating and other aspects, it shows great application potential.And preparation reaction condition is mild, without additional catalyst and oxidant, process is safe, post-processing is simple, and no harmful waste water and waste residue to environment, meet the requirements of green chemistry.

Laboratory Apparatus For Controlled Green Chemical Synthesis Operations

This invention belongs to the field of organic synthetic chemistry technology, specifically relating to a selenium-based indoloquinazoline derivative, its preparation method, and its application, comprising: in an organic solvent, using aromatic amine compounds, malononitrile, and diselenoether as raw materials, in the presence of a palladium catalyst and an organic base, at 90°C... o The reaction was carried out under C conditions with stirring to obtain a selenyl indoline quinazoline derivative. This method features mild reaction conditions, simple operation, high yield, and good functional group compatibility, conforming to the principles of green chemistry. Furthermore, the selenyl indoline quinazoline derivative provided by this invention exhibits good inhibitory activity against Plasmodium, providing a drug lead compound for the development of novel antimalarial drugs and holding significant importance for the prevention and / or treatment of malaria.

The invention relates to the technical field of carbon dioxide adsorbents, in particular to a silicon-based / aluminum-based solid amine adsorbent prepared from montmorillonite and a preparation method and application of the silicon-based / aluminum-based solid amine adsorbent. According to the invention, the montmorillonite subjected to acid activation treatment is extracted to obtain the silicon-based nano material with silicon dioxide as a main component. In addition, through step-by-step neutralization treatment on the strongly acidic filtrate, metal ions in the filtrate are successfully extracted and converted into an aluminum-based nano material with aluminum oxide as a main component. The solid amine adsorbent is prepared by taking a silicon-based and aluminum-based composite nano material with high specific surface area and high surface activity as a carrier and combining amino functionalization treatment. According to the method, high-added-value overall utilization of the montmorillonite is achieved, the montmorillonite is converted into a high-capacity and high-selectivity novel trapping material from low-adsorbability minerals, the original acid filtrate with high corrosivity is converted into an environment-friendly sodium chloride neutral solution, and green chemistry and circular economy concepts are practiced.

The application provides a one-dimensional high-entropy alloy, a preparation method and application of the one-dimensional high-entropy alloy in CO2 ring addition reaction, and relates to the technical field of high-entropy alloys.The molar ratio of iron salt, cobalt salt, nickel salt, manganese salt, chromium salt and cerium salt in the one-dimensional high-entropy alloy is 1:1:1:1:1:1;the high-entropy alloy has a fiber structure, the fiber has a hierarchical pore structure which is interconnected, including macropores or mesopores formed by decomposition of the self-sacrificing template 1, and mesopores or micropores formed by decomposition of the self-sacrificing template 2.Through improvement of the process conditions, the one-dimensional high-entropy alloy material with a unique structure can be prepared under relatively mild conditions, so that the whole reaction process is safer and more economical, and meets the goal of green chemistry and sustainable development.Meanwhile, the one-dimensional high-entropy alloy material prepared provides a large specific surface area, fully exposes active sites, and can realize efficient and stable conversion of the carbon dioxide ring addition reaction.

The invention discloses a preparation method of an intermediate of macloxvir. The preparation method comprises the following steps: step 1, carrying out halogenation reaction; step 2, elimination reaction; step 3, addition reaction; step 4, ring closing reaction; the starting raw materials, the solvent and the catalyst selected in the invention are industrial-grade cheap and easily available products, have the advantage of low production raw material cost, and provide economic feasibility support for industrial large-scale production; reaction conditions of each step in the reaction process are mild, byproducts are few, the yield is high, and a target product can be prepared more efficiently; meanwhile, the synthesis route is high in atom utilization rate and excellent in atom economy, the used solvent and reagent are high in stability and easy to recycle and reuse, generation and emission of industrial three wastes are greatly reduced, the environment-friendly treatment cost is reduced, and the concept of green chemistry and sustainable development is met; the method gives consideration to economy, high efficiency and environmental friendliness, and solves the problems of low yield, violent reaction conditions and high cost of raw materials and auxiliary materials in the existing method.

The application belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 2-aryl-2-cyclohexanedione enol ester compounds. The method uses a transition metal complex as a catalyst, and uses a phenyl boronic acid compound and an iodine onium compound as raw materials, first synthesizes a 3-hydroxy-2-aryl-2-cyclohexenone compound, and then synthesizes the 2-aryl-2-cyclohexanedione enol ester compound through acylation. The reaction condition is mild, no additional additives (such as alkali-sodium acetate, expensive silver salt-silver acetate, etc.) need to be added, the C-C bond can be efficiently and quickly constructed, the 2-aryl-2-cyclohexanedione cyclization derivative is obtained, the reaction operation is simple, the reaction time is short, the method has high efficiency and high safety, the substrate range is wide, the functional group tolerance is good, the method conforms to the concept of green chemistry and high atomic economy, and is very suitable for large-scale industrial production.

The invention provides an aminomethylation reaction method based on a pyrazolo [1, 5-a] pyrimidine nitrogen-containing fused heterocycle substrate, a product and application, and belongs to the technical field of chemistry. Pyrazolo [1, 5-a] pyrimidine nitrogen-containing fused heterocycle, secondary amine and glyoxylic acid are used as raw materials, an aminomethylation reaction is achieved at the C3 site of pyrazolo [1, 5-a] pyrimidine through heating for the first time, a transition metal catalyst or a chemical oxidizing agent is not needed, the drug purification problem caused by metal residues and oxidation byproduct pollution are avoided, and the purity of the product is improved. The method is a novel efficient, simple, convenient and environment-friendly nitrogen-containing fused heterocyclic aromatic hydrocarbon functionalization strategy, the reaction can be directly carried out at the temperature of 100-120 DEG C, shielding gas does not need to be filled, and compared with some reactions needing high-temperature or high-pressure conditions, the mild reaction conditions are easier to control, side reactions are reduced, and the yield of the target product is increased. Meanwhile, the reaction conditions are also beneficial to reducing energy consumption, and conform to the concept of green chemistry.

This invention provides a method for preparing graphene quantum dots based on thermal coal and a plasma reaction system, belonging to the field of graphene quantum dot preparation technology. The method includes the following steps: using thermal coal as raw material, it undergoes electrochemical oxidation and KOH ball milling sequentially to obtain pretreated coal; the pretreated coal is introduced into an axial magnetic rotating microwave plasma reactor for segmented temperature-controlled dissociation and recombination reactions; during the reaction, a porous alumina template is used for confined growth, and after the reaction, liquid nitrogen quenching is employed to obtain graphene quantum dots. This invention uses thermal coal to replace high-purity graphite as the carbon source, reducing raw material costs by more than 99%; the pretreatment process, through the synergistic effect of electrochemical oxidation and KOH ball milling, eliminates the need for strong acids and alkalis throughout, completely avoiding the pollution problems of large amounts of acidic and heavy metal-containing wastewater and waste gas generated by the traditional Hummers method, thus aligning with the concepts of green chemistry and sustainable development.

The invention discloses modified lignin with high photothermal conversion performance and a preparation method and application thereof. The method comprises the following steps: mixing a molten salt hydrate solution with hydrochloric acid to prepare an acidic molten salt hydrate solution, adding lignin, and carrying out a heating reaction to obtain the modified lignin. After being treated by the method, under the same illumination condition, the surface temperature of the obtained material can reach 126 DEG C at most, and the photothermal conversion efficiency reaches 44.23%. The acidic molten salt hydrate adopted by the invention is composed of low-toxicity and biodegradable salt and water, a large amount of volatile organic solvent used in the traditional method is fundamentally abandoned, the green chemistry principle is met, the method is environment-friendly, the solvent is easy to recycle, and the environmental risk and the production cost are reduced.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method and application of a benzofuranone compound. The benzofuranone compound is prepared through a combined technical scheme of alpha-bromoketone / ethyl acetate + t-BuOH / NaOAc + efficient short-time mild cyclization, and the method is high in reaction efficiency, good in selectivity and mild in condition, conforms to green chemistry and has a good application prospect.

This invention discloses a method for extracting lignin with high phenolic hydroxyl content, belonging to the fields of biomass refining and green chemistry. The method involves pretreating plant fiber raw materials with bio-enzymes to obtain a solid residue; then, the solid residue is extracted and purified using a catalytic eutectic solvent to obtain the lignin with high phenolic hydroxyl content. A two-step strategy of "enzyme pretreatment exposure + catalytic DES directional bond breaking" is employed to extract lignin with high phenolic hydroxyl content from plant fibers. Enzyme pretreatment effectively breaks down the biomass degradation barrier, removing most of the carbohydrates and fully exposing the lignin. This not only results in a lignin yield of over 90% for subsequent DES extraction, but more importantly, it creates an optimal interaction interface for the DES catalyst to selectively break the β-O-4 ether bonds of lignin molecules, thereby generating a large number of phenolic hydroxyl groups in situ, significantly increasing the lignin content to far exceed that of lignin extracted by traditional methods and conventional DES, and producing a product with excellent reactivity.

The invention discloses a synthesis method of a tetranitrobiimidazole amine compound, which comprises the synthesis steps of 2, 2 '-diamino-4, 4', 5, 5 '-tetranitrobiimidazole (TNDABI): at room temperature, dissolving TNBI in ethanol, stirring, slowly dropwise adding ammonia water, stirring to react, concentrating a reaction system, filtering to obtain 4, 4', 5, 5 '-tetranitrobiimidazole diammonium salt, dissolving in THF, stirring, adding an MSH reagent in batches, stirring, and reacting at room temperature to obtain the 2, 2'-diamino-4, 4 ', 5, 5'-tetranitrobiimidazole amine compound. Carrying out rotary evaporation to remove THF, and pulping and purifying a mixed system of ethanol and water to obtain TNDAB; the synthesis method of 2-amino-4, 4 ', 5, 5'-tetranitrobiimidazole (TNABI) comprises the following steps: at room temperature, dissolving TNBI in acetonitrile, stirring, slowly dropwise adding DBU, continuously stirring for reaction, adding an MSH reagent in batches, stirring overnight, filtering, washing a filter cake with acetonitrile, spin-drying an organic phase, adding water and hydrochloric acid to adjust the pH value to 3-4, and filtering to obtain TNABI. The method has the advantages of high yield and simple and fast post-treatment process, conforms to the green chemical production concept, and can realize the synthesis of key energetic intermediates in the fields of composite explosives and solid propellants.

According to the manganese selenide-carbon nanotube composite porous carbon material and the preparation method thereof provided by the invention, carbon nanotubes with excellent conductivity, nano selenium powder, manganese salt and polyvinylpyrrolidone are used as reaction raw materials, selenylation and carbonization are completed in one step through temperature programming, the reaction process is shortened, and the yield is increased. According to the preparation method, the production cost is reduced, the economic and time cost of production is reduced, the problems that various chemical reagents need to be added and the preparation process is complex in the current preparation process of the negative electrode material are solved, and the adopted preparation method is free of pollutant emission, conforms to the green chemistry principle and is beneficial to environmental protection.

The invention relates to a metal hydroxide for a heat storage system and a green preparation method and application thereof. The green preparation method of the metal hydroxide, provided by the invention, comprises the following steps: dissolving metal acetate in water, and preparing a metal acetate aqueous solution with the metal ion concentration of 0.01-1mol / L; placing the metal acetate aqueous solution in an open container, and carrying out evaporation concentration treatment at 30-95 DEG C for 1-96 hours to generate a metal hydroxide precipitate; and carrying out solid-liquid separation on the metal hydroxide precipitate, washing and drying to obtain the metal hydroxide. The method does not need to add an alkaline agent or an organic auxiliary agent, avoids generation of by-products of salts and high-salt waste liquid, and accords with 12 principles of green chemistry; reaction conditions are mild, the process is simple, operation can be carried out at normal temperature and normal pressure, energy consumption is low, and safety is high; the raw material conversion rate is high, mother liquor can be recycled, and high-atom-economy and low-cost production is achieved.

The application discloses a three-component coupling method of aromatic trifluoroalkyl compounds, conjugated olefins and nucleophilic reagents, under the condition of room temperature and inert atmosphere, the aromatic trifluoroalkyl compounds generate aromatic difluoroalkyl-palladium complexes under the condition of a palladium catalyst, a phosphine ligand, an organic solvent, a base and light; the aromatic difluoroalkyl-palladium complexes are added to the conjugated olefins, and then added to amine or 1,3-dicarbonyl compounds to obtain difluoroalkyl functionalization products. The method has the advantages of easy availability of raw materials, simple operation, mild reaction conditions, wide substrate applicability and the like, meets the development requirements of green chemistry, and is expected to be widely applied in the modification of drug molecules or natural product molecules.

The invention discloses a photoisomerization method of carotenoid, which comprises the following steps: dispersing high cis carotenoid in an organic solvent, carrying out photoisomerization in an illumination kettle until the proportion of all-trans carotenoid is not obviously increased, cooling, crystallizing, and filtering to obtain carotenoid solid with high all-trans proportion, and the filtrate sleeve is used as a solvent for next batch of isomerization. The isomerization method has the characteristics of mild conditions, high efficiency, controllability, cleanness and the like, accords with green chemistry and sustainable development concepts, and is simple in isomerization extraction operation, high in extraction yield and suitable for large-scale implementation.