998 results about "Repair skin" patented technology

Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.

A skin resurfacing device for peeling the outermost layer of the skin for renewing the skin surface and repairing skin damage including a housing, a skin sensor, and a skin treater. The skin treater consists of an abrasive tip, a first end, a transparent portion, a first filter, and a second end, all of which are detachable and replaceable. The skin treater is connected to a vacuum source by a tubular hose. The vacuum provides both closeness of contact between the abrasive tip and the user's skin and the suctioning of skin debris peeled off. The skin treater, especially the abrasive tip are made with common material and mass production process so that they are disposable and economic.

The invention relates to the technical field of cosmetics, and discloses a nona-oligopeptide composition for skin repairing and application thereof. The nona-oligopeptide composition is prepared from, by weight, 1-30 parts of palmitoyl-tripeptide-1, 1-30 parts of tripeptide-1 copper, 1-50 parts of palmitoyl-tripeptide, 1-30 parts of carnosine, 1-30 parts of acetyl tetrapeptide-5, 1-30 parts of palmitoyl-tetrapeptide-7, 0.1-30 parts of acetyl hexapeptide-8, 0.1-30 parts of nonapeptide-1, and 1-30 parts of nisin. The nona-oligopeptide composition has the effect of a cell factor sample, affects the growth of skin flora, is applied to dermatology and skin beautifying, and has the effects of repairing skin lesion, adjusting metabolism and inhibiting skin condition conditioned pathogen growth.

Incision and closure surgical device designed to assist in operative surgery as a means of effecting and repairing skin wounds. A slide fastener is fitted to a self-adhesive sheet that is attached to the skin surface. The slider of the slide fastener contains a contact electrode for electrocoagulation fitted with a cutting edge. As the slide fastener is opened, the slider simultaneously effects the incision by means of the cutting edge of the electrode, severing both the flexible sheet and the skin beneath. For closing the incision, the stringer tapes of the slide fastener interlock by the action of the slider, thereby bringing both the edges of the flexible sheet and the wound beneath into apposition. As the slider is drawn forwards closing the stringer tapes, electrical energy is applied by the electrode at the union site of the wound edges, which have previously been brought into apposition by the mechanical action of the slide fastener, thus ensuring that the edges become adhered in full depth as a result of electrical coagulation.

The invention discloses a skin burn repair material and a preparing method thereof, and belongs to the field of biomedicine. A functional loading substance is added into a polymer to prepare the repair material through the coaxial electrostatic spinning process, and the upper surface layer micro-nano structure is adjusted so that the repair material can resist adhesion of outside microorganisms and bacteria. The prepared repair material containing the functional loading substance with antibacterial, antiphlogistic and repair promoting functions repairs the skin burn area in a targeted mode based on the characteristics of different stages of the burnt skin repair process. The adopted base material has high biocompatibility, secondary damage to the wound region of traditional medical gauze when fresh dressing is changed for a wound is avoided, and secondary infection caused by external factors can be effectively resisted. The skin burn repair material and the preparing method thereof can be effectively applied to biomedicine related fields and have the possibility of extensive clinic application.

The invention relates to hydrogel as well as a preparation method and a purpose of the hydrogel. The hydrogel is prepared through electron beam or Gamma-ray radiation on natural polymers or derivates of the natural polymers after the medicine active ingredient loading in oxygen-free environment. The hydrogel has good biocompatibility and use safety, the biological effects of the natural polymers or the derivates of the natural polymers on the wound healing and the skin repair protection can be permanently and fully exerted in local parts in the hydrogel mode, good medicine slow release functions of the hydrogel are also fully utilized, the required medicine active ingredients are specifically added, good efficiencies and wide purposes are given to the hydrogel, and the hydrogel can be used in the fields of skin, mucosa and cornea wound dressings, filling materials, tissue engineering materials, cell culture media and the like, and can also be used in the field of daily use articles such as skin care products and cosmetics.

The invention discloses a protein skin care product having the function of skin repair and care, which contains a protein composition with 0.3% to 5% of mass fraction, wherein the protein composition is composed of keratin and collagen with the mass ratio of the keratin to the collagen being 1: 0.2 to 2. The protein skin care product of the invention having the function of skin repair and care includes mask liquid, cream and cleansing emulsion.

The invention discloses OCT-based in-situ three-dimensional printing skin repairing equipment and an implementation method thereof. The implementation method comprises the following steps: scanning a skin injury region by adopting an OCT technology to acquire a high-resolution three-dimensional skin injury OCT image; carrying out three-dimensional bionic structural design and modeling on the skin injury part based on the OCT image so as to ensure the reconstruction requirements of skin repair to layered interfaces and vascular networks in tissues; and then, transmitting the modeled skin injury repair model data to a 3D biological printer to carry out model layering and printing, thereby implementing quick, accurate and in-situ repair on the injured part. The OCT-based in-situ three-dimensional printing skin repairing equipment has the advantages of no contact, no injury and real-time imaging, meets the requirement of skin in-situ printing on high-resolution imaging of internal micro-structures, and can acquire distribution and density information of blood vessels in the skin corium layer so as to be convenient for constructing a three-dimensional model closer to real skin structures and functions.

The invention provides an application of a human umbilical cord mesenchymal stem cell complex cell factor in preparing a biological agent for repairing skin injury. The skin injury includes laser burn, thermal burn, cold injury or common trauma skin physical and chemical injury. According to the application, an umbilical cord stem cell complex growth factor is firstly used for the treatment of human skin laser injury; the human umbilical cord mesenchymal stem cell complex cell factor can be preserved in maximal activity and plays a maximal role of injury repair and treatment under a certain preservation condition.

The invention relates to the technical field of masks, and particularly relates to a Dendrobium officinale moisturizing and repair sleeping mask and a preparation method thereof. The mask comprises a phase A component and a phase B component, wherein the phase A component comprises moisturizer, emulsifier, sodium hyaluronate A and water; the phase B component comprises Dendrobium officinale extracting solution, Crocus sativus extract, ganoderma lucidum extract, agilawood extract, sodium hyaluronate B and cosolvent. The mask is prepared from Crocus sativus, ganoderma lucidum, agilawood and Dendrobium officinale, wherein the Crocus sativus achieves the main effect of activating blood circulation to dissipate blood stasis; the ganoderma lucidum and the agilawood respectively achieve the auxiliary effects of invigorating qi and calming the nerves, and promoting circulation of qi to relieve pain; the Dendrobium officinale achieves the adjuvant effect of nourishing yin and promoting salivation; and the whole composition achieves the effects of promoting flow of qi and blood circulation, dispersing blood stasis and nourishing the kidney-yin. Besides, since the Dendrobium officinale extracting solution contains abundant colloid, the loss of moisture and collagen in the skin can be supplemented, elastic fibers can be repaired, and cell tissues can be reformed, so that the original elasticity and gloss of the skin are recovered, the remarkable freckle removal effect is achieved; and under the condition of ensuring that the skin is sufficiently moisturized, the mask has a greatly improved skin repair function.

The invention discloses a human-derived adipose tissue-derived stem cell factor, a preparation method and application thereof, and particularly discloses a method for culturing a human-derived adipose tissue-derived stem cell factor. The method comprises the following steps: culturing human adipose tissue-derived stem cells in a high-coenzyme serum-free culture medium until the cell confluence is 75-85 percent, and collecting supernatant. The invention further discloses a method for preparing human-derived adipose tissue-derived stem cell factor concentrated solution, the concentrated solution prepared by the method, further application of the concentrated solution, a cell factor concentrate prepared by the method, cosmetics and medicines prepared from the cell factor concentrate. The concentrated solution prepared by the method has high content of adipose tissue-derived stem cell factors and stable quality, and a product prepared by combining the concentrated solution with other materials in a specific ratio has a good effect of repairing skin injury; and the method is simple and feasible, is suitable for large-scale production, and has excellent market prospect.

The invention discloses a skin barrier repairing preparation. The preparation is prepared from the following components: deionized water, sucrose stearate, phytosteryl isostearate, vitamin E, glycerinum, butylene glycol, 1,2-pentylene glycol, octyldodecanol, polydimethylsiloxane, hydrogenated polyisobutene, oleic acid, linoleic acid, ceramide 2, ceramide 3, ceramide 6II, sodium hyaluronate, xanthan gum, disodium EDTA, acrylates C10-30 alkyl acrylate crosslinked polymer, allantoin and sorbitan caprylate. The invention further provides a method for preparing the skin barrier repairing preparation. According to the preparation method, the problem of dissolving compound ceramide can be solved, the impact of ceramide crystallization on stability under a low-temperature condition can be reduced, the stability of the preparation can be improved, and other skin repairing components can be added and compounded with the compound ceramide. The skin barrier repairing preparation has an excellent product formula stability and a multiple repairing effect on the skin barrier.

The invention discloses a method for preparing ultra-low molecular weight hyaluronic acid oligosaccharides and a salt thereof through combination of solid-liquid biphasic enzymolysis and ultrafiltration. The method comprises the following steps: degrading hyaluronic acid and a salt thereof by utilizing hyaluronidase produced by bacilli; preparing high-concentration hyaluronic acid enzymatic hydrolysate by adopting the method of combining a solid-liquid biphasic enzymolysis system and an ultrafiltration system, and then performing inactivating, activated carbon adsorption and impurity removal,filtering and spray-drying to obtain the ultra-low molecular weight hyaluronic acid oligosaccharides and the salt thereof with the molecular weight of less than or equal to 3 kDa. The product preparedby the method is high in stability, ultra-low in molecular weight, good in inflammation resistance and percutaneous absorptivity, high in purity, strong in oxidation resistance, does not have cytotoxicity, has the advantages of repairing skin cell damage and the like, and can be widely applied to the fields of cosmetics, food and medicines. According to the method, the process flow is easy to operate; conditions are mild; various alcohols are not used; the energy consumption is relatively low; the method does not have damage to a product structure, does not have environmental pollution, and is suitable for large-scale industrial production.

The invention relates to photo-crosslinking sericin protein hydrogel and a preparation method and application thereof. The preparation method comprises the steps that methyl propenyl modified sericin protein is prepared into a solution to be mixed with a photoinitiator (Irgacure 2959) solution, and the sericin protein hydrogel is obtained through ultraviolet irradiation. The obtained sericin protein hydrogel has the good biodegradability, autofluorescence characteristic and injectable property, and wounds caused by implanting or taking out biomaterials can be effectively reduced. Most importantly, the sericin protein hydrogel has good biocompatibility both in vivo and in vitro, and adhesion of carried cells can be effectively promoted. Serving as 2D and 3D cytoskeleton, the sericin protein hydrogel can effectively promote proliferation of the carried cells and promote the carried cells to form functional tissue under the condition of being free of serum support; serving as wound accessories, the sericin protein hydrogel can repair skin wounds and can serve as tissue engineering and regenerative medicine biological materials.

The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.

A skin augmentation composition comprises a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier. Methods for enhancing the repair of damaged skin and the prevention of developing wounds in a subject having damaged skin comprises administering to a portion of damaged skin, a composition comprising a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier.

The invention provides a novel skin anti-allergy and repair composition, and also provides skin repair cream containing the skin anti-allergy and repair composition, and a preparation method of the skin repair cream. An anti-allergy and anti-inflammatory traditional Chinese medicine composition extract aiming at sensitive or damaged skin multi-dermatitis is adopted, meanwhile, other component rawmaterials are supplemented, and after compounding, the skin repair cream has synergetic effects of clearing heat, detoxifying and cooling blood, and can be beneficial to diminishing inflammation, sterilizing, astringing, repairing, improving skin resistance, eliminating scytitis, astringing, moistening, lustring skins, repairing damaged parts, and recovering elasticity and luster of the skins. Theskin repair cream can be used for eliminating carbuncle swell, cleansing, lustring, nourishing and protecting the skins, and is suitable for skin types with skin allergy, pruritus, desquamation, inflammation and the like caused by misusing cosmetics.

The invention belongs to the field of skin repair and provides mesenchymal stem cell factor freeze-dried powder as well as a preparation method and application thereof. The mesenchymal stem cell factor freeze-dried powder prepared by the method provided by the invention is high in purity, injuries of foreign additives on the human body and skin can be avoided, and potential hazards of skin allergy are avoided. The prepared freeze-dried powder product is stable in property, so that the biological activity of the mesenchymal stem cell factor freeze-dried powder is achieved for a long time.

The invention discloses a speckle-removing composition, a preparation method thereof and applications thereof. The speckle-removing composition is prepared from raw materials, by weight, comprising 5-20 parts of saussurea involucrate, 5-20 parts of donkey-hide glue, 5-25 parts of liquorice, 5-25 parts of placenta, 5-20 parts of collagen, 5-20 parts of hyaluronic acid, 5-25 parts of vitamin E, 1-15 parts of vitamin B6, 5-20 parts of oat polypeptides, 5-20 parts of pearl powder, 1-20 parts of aloe, 5-25 parts of safflower, 5-25 parts of white peony roots, 1-20 parts of vitamin C, 5-20 parts of vitamin B3 and 1-15 parts of vitamin B5. The invention provides the speckle-removing composition. The speckle-removing composition has advantages of no irritation; no toxic or side effects; high safety; no hypersensitivity; capability of providing radical cure; good speckle removing effects; low recurrence rate; capability of replenishing nutrition for skin, whitening skin, preserving moisture and repairing skin pits; and capability of making skin smooth, fine, white, clear and wettish. The speckle removing cure rate is 96.7%.

The invention discloses a novel anti-allergy repairing composition for skin. The anti-allergy repairing composition comprises the following components by weight percent: 5%-12% of moisturizing agent, 0.1%-3.0% of thickener, 1%-4% of skin repairing agent, 0.1%-1.5% of preservative, and the balance of water. The invention also discloses a preparation method of the skin repairing agent. The anti-allergy repairing composition for skin can be prepared into cream or water aqua, can be directly smeared at the infected part and has no toxicity or harm to human skin. The skin repairing composite component has strong effects of clearing heat and detoxifying, being anti-allergy, repairing skin, diminishing inflammation and astringing; other auxiliary additive components are selected from the moisturizing agent, preservative and thickener and the like which can keep the skin tender and smooth and moisturize the skin and are mild and non-irritant to skin. The anti-allergy repairing composition is convenient to use, achieves the purposes of moisturizing, diminishing inflammation and relieving itching and repairing damaged skin, and is applicable to sensitive skin and skin allergy, pruritus, desquamation, red and swollen skin and couperose skin that are caused by misuse of cosmetics.

The invention discloses skin-protecting and acne-removing Chinese medicinal facial mask powder, which relates to an acne-removing and skin-protecting Chinese medicine. The skin-protecting and acne-removing Chinese medicinal facial mask powder comprises large-head atractylodes rhizome, common bletilla tuber, Japanese ampelopsis root, white poria, white paeony root and natural pearl powder. The skin-protecting and acne-removing Chinese medicinal facial mask powder is characterized in that: the facial mask powder comprises the following components in parts by weight after components are added: 2-6 parts of large-head atractylodes rhizome, 2-6 parts of common bletilla tuber, 5-15 parts of Japanese ampelopsis root, 5-15 parts of white poria, 5-15 parts of white paeony root, 5-15 parts of natural pearl powder, 2-6 parts of bitter almond kernel, 2-6 parts of giant typhonium rhizome, 10-30 parts of pearl barley, 10-30 parts of mung bean, 10-30 parts of soybean, 5-15 parts of edible talc powder, 5-15 parts of hungaian morningglory root, 5-15 parts of larva of silkworm with batrytis, 5-10 parts of ginkgo, 5-15 parts of tribulusterrestris and 5-15 parts of common perilla. The facial mask powder is prepared by the following steps of: smashing each component into coarse powder of 100 meshes respectively; proportioning coarse powder, and stirring; smashing into fine powder of 200-500 meshes; cooling to the normal temperature; and packing the fine powder. The skin-protecting and acne-removing Chinese medicinal facial mask powder has the effects of effectively repairing skin corium broken collagen fibers, promoting blood circulation by removing blood stasis, diminishing inflammation, resisting bacteria, and softening and relieving the formation of acne marks, acne scars and pigmentation.

The invention relates to a porous bacterial cellulose skin repair material with a density structure and a preparation method thereof. The porous bacterial cellulose skin repair material with the 'upper dense and lower loose' structure similar to human skin is prepared by controlling the culture condition of bacterial cellulose and adding sustained-release microspheres in the culture process. A loose layer is tightly combined with a dense layer, so that obvious physical layering is avoided, and the structural continuity is good; and gradient changes of the structures are produced in the loose layer and the dense layer, and multiple pores distributed uniformly are formed in the loose layer, so that the upper dense and lower loose gradient structure of the human skin is simulated to the utmost degree. Cells easily enter the material, the healing period of a wound is obviously shortened, and proliferation of healed scars is effectively reduced; and good air permeability and water holding property of the bacterial cellulose are kept, the wound surface can be kept in a wet environment, and healing of the wound surface is facilitated. The forming process is simple, the culture period is short, the preparation process is environment-friendly, simple, convenient and quick, and the preparation cost is low.

The invention discloses an anti-aging skin care composition containing multiple natural extracts and biological active polypeptide, an anti-aging skin care mask essence and a preparation method thereof. The anti-aging skin care mask essence has the advantages that the characteristic of compounding combination in the traditional Chinese herbal medicines is utilized, and a moisturizer is combined with the biological active polypeptide and the multiple natural extracts according to a proper ratio of usage amount to form the mask essence; the multiple functions of moisturizing, water supplementing, inflammation diminishing, anti-oxidizing, skin repair and the like are combined; while the skin nutrient metabolism is improved and the skin elasticity is maintained, the tissues of surface skin arerepaired, so as to realize multiple effects of moisturizing, wrinkle resisting and aging resisting.

The invention relates to a stem cell preparation for repairing skin ulcer. The stem cell preparation consists of mesenchymal stem cells and exogenous cell factors. The stem cell preparation is prepared from the mesenchymal stem cells in combination with the exogenous cell factors, so that the directional differentiation of the mesenchymal stem cells towards endothelial cells is promoted; and through the paracrine of the mesenchymal stem cells as well as the exogenous cell factors, the growth of the endothelial cells is stimulated, fibroblast and capillary growth as well as collagen synthesis and granulation in a wound surface are enhanced, and the proliferation of skin keratinocytes and endothelial cells is improved, so that the purpose of rapidly and effectively repairing skin with ulcer injury is achieved.