251 results about "Repair skin" patented technology

The invention relates to the technical field of skin care, in particular to a collagen composition with anti-wrinkle and repairing effects and a preparation method. Comprising 1.5-4.5 parts of mixed collagen, 2.5-5 parts of mixed polypeptide and 4-8 parts of mixed extract, wherein the mixed extract comprises 1-2 parts of centella asiatica extract, 1-2 parts of polygonum cuspidatum root extract, 1-2 parts of bilberry fruit extract and 1-2 parts of bidens pilosa extract; the collagen is directly supplied to the skin to supplement collagen, and is mainly used for repairing the skin structure, increasing the density, elasticity and compactness of the skin and remarkably improving fine wrinkles and looseness; the polypeptide inhibits the expression of MMP-1; the natural plant active ingredients promote the expression of TGF-beta, enhance the activity of fibroblasts, accelerate the synthesis of collagen, prevent excessive oxidation of skin, repair skin inflammation, activate cell energy and delay skin aging.

The invention belongs to the field of synthetic biology, and particularly relates to collagen fusion polypeptide as well as application and a preparation method thereof. The collagen fusion polypeptide provided by the invention comprises: (a) a first polypeptide of recombinant III-type collagen; and (b) a second polypeptide comprising a trimerized folding domain. The collagen fusion polypeptide provided by the invention has the advantages of low immunogenicity, good biocompatibility, high biological activity and the like, can significantly promote proliferation and migration of human skin fibroblasts, and has stronger ability of promoting regeneration of endogenous collagen. The collagen fusion polypeptide has a triple helix structure similar to natural collagen, and can be self-assembled to form collagenous fibers which are good in morphology and similar to natural collagen. The method can be widely applied to the fields of skin repair dressings, biological materials, artificial implants, medical instruments, cosmetics, health care products, food and the like.

The invention provides a novel human-derived II-type collagen COLII-14K-H and a coding gene thereof, the coding gene is shown as SEQ ID NO.1, and the amino acid sequence is shown as SEQ ID NO.2. The invention further provides a preparation method of the novel human-derived II-type collagen COLII-14K-H. The invention also provides a preparation method of the human-derived II-type collagen COLII-14K-H and application of the human-derived II-type collagen COLII-14K-H in preparation of cartilage repair drugs, skin repair drugs and skin care products. The inventor-derived II-type collagen can obviously improve the gene expression level of the collagen, so that the content of the collagen in human dermal fibroblasts is improved, and the skin aging is delayed; meanwhile, the protein fragment can show a remarkable skin repairing effect at low concentration, provides a new treatment choice for skin repairing, and can be widely applied to the fields of skin repairing and nursing.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses an antibacterial dressing for skin repair and a preparation method thereof, and relates to the field of medical dressings. The antibacterial dressing for skin repair is prepared from the following raw materials in parts by weight: 4-8 parts of carboxymethyl chitosan, 2-5 parts of collagen, 5-10 parts of glycerol, 10-20 parts of a framework material, 1-2 parts of an antibacterial agent, 1-3 parts of a humectant and 70 parts of purified water. The prepared antibacterial dressing for skin repair has good moisturizing performance and antibacterial performance.

The invention aims to provide a cold compress device for repairing skin injury and caring skin, and relates to the technical field of medical instruments, two side plates are symmetrically arranged on a base in a sliding mode, a soaking assembly is arranged on the base and located between the side plates, and a rotating plate of the soaking assembly is rotated to drive two soaking plates to clamp gauze to soak the gauze; the gauze can be quickly soaked; a rotating head is rotatably mounted on a side plate, gauze on a soaking plate is clamped through a clamping assembly, a width adjusting motor in a rotating seat drives a bidirectional lead screw to rotate, clamping plates are driven to slide in opposite directions, the width of the clamped gauze is reduced, and a torsion motor on the side plate drives the rotating seat to rotate, so that the gauze is tightened. The tightened gauze is loosened by reversing the twisting motor, then the clamping plates are driven by the reversing width adjusting motor to slide back to back, the clamped gauze is unfolded, the gauze can be more conveniently wet-applied to the skin, the gauze can be more rapidly twisted to be free of water dripping through the twisting motor, and the wet-applying efficiency is improved.

The present invention belongs to the technical field of skin care, and discloses a skin repair composition and a skin care product, wherein the skin repair composition comprises the following components by weight percentage: 30-50% wheat germ oil, 1-5% ceramide 3, 1-10% sodium hyaluronate, and 40-60% bifid yeast fermentation product lysate. The present invention utilizes bifid yeast fermentation product lysate to help restore the activity of fibroblasts and keratinocytes, repair cell damage and protect the components in the extracellular matrix ECM, and further strengthens the damage repair speed of ECM by compounding sodium hyaluronate and ceramide, helps cells and extracellular matrix maintain a healthy state and quickly repair damage, and helps strengthen intercellular lipids and cell adhesion at the same time, and finally helps form a good skin surface sebum film through the synergistic effect of wheat germ oil and sodium hyaluronate, and the four cooperate with each other to significantly improve the skin repair effect.

The scar removing cream is prepared from the following raw materials in percentage by weight: 30 to 80 percent of silica gel component, 5 to 30 percent of solvent, 0.1 to 10 percent of emulsifying agent, 1 to 5 percent of thickening agent, 0.01 to 10 percent of extract / synergistic component, 0.1 to 20 percent of medicament component, 1 to 50 percent of moisturizing component, 0.01 to 0.1 percent of growth factor, 0.1 to 2 percent of other component, 0.01 to 0.5 percent of preservative and 0.1 to 2 percent of pH (Potential of Hydrogen) regulator. The traditional Chinese medicine composition has the effects of improving skin repair, whitening and diminishing inflammation, accelerates skin elasticity recovery and reduces scars.

The invention discloses a composition containing a polypeptide exosome and application of the composition in preparation of a product with skin repair ability, and particularly relates to the technical field of biology, the composition comprises polypeptide-exosome composite nanoparticles, and a polypeptide containing a GRGDS motif and an umbilical cord Wharton's jelly exosome are covalently crosslinked; the lipid double-layer coating layer comprises phosphatidylcholine, cholesterol and PEG-2000, and the molar ratio of the phosphatidylcholine to the cholesterol to the PEG-2000 is 5: 3: 2; the synergist is prepared from 0.1 to 5 percent of epicatechin gallate and 2 to 8 percent of recombinant collagen III oligopeptide. The nano-liposome is prepared through microfluidic self-assembly and a film hydration-ultrasonic intercalation method, and can be loaded on a degradable microneedle patch, so that targeted slow release of a wound part is realized. Through the synergistic effect of targeted delivery, oxidation resistance and collagen regeneration, the skin repair efficiency is remarkably improved, and the healing time is shortened.

The invention relates to a whitening and repairing composition containing PDRN and polypeptide and application of the whitening and repairing composition. The composition comprises sodium hyaluronate, PDRN, polypeptide, vitamin C and cane sugar. Sodium hyaluronate, nucleic acid and polypeptide are adopted, so that the activity of collagen in the skin is enhanced, the moisture of cuticle and the integrity of a fiber structure are kept, the content of melanin in the epidermis is reduced, the skin barrier is repaired, the skin blood circulation is improved, anti-oxidation and anti-inflammatory treatment is performed, the skin color is brightened, and chromatosis is relieved, and sodium hyaluronate, nucleic acid and polypeptide are matched with one another; meanwhile, the release rate of nutritional ingredients is slowed down after the composition is injected into the skin, the action time is prolonged, and a better anti-degradation effect is achieved.

The invention discloses a stem cell composition for promoting skin cell repair and a preparation method and application thereof, and belongs to the technical field of skin repair. The stem cell composition for promoting skin cell repair is prepared by mixing the skin repair peptide separated from cultured giant salamanders with umbilical cord mesenchymal stem cell supernate for the first time. The skin repair peptide and the umbilical cord mesenchymal stem cell supernate in the composition have a synergistic effect, and the skin repair peptide and the umbilical cord mesenchymal stem cell supernate are combined to effectively improve fibroblast proliferation and promote secretion of type I and type III collagen, so that skin injury repair is facilitated, and the composition has a good commercial application prospect.

The invention provides a cell active peptide composition with anti-allergy and red fading effects and a preparation method and medical beauty application thereof, and belongs to the technical field of medicine and beauty. The composition is prepared from dipeptide-1, tripeptide-1, palmitoyl tripeptide-8, palmitoyl tetrapeptide-7, sh-pentapeptide-1, hydrolyzed silk, a mussel extract, dipeptide-2, acetyl tetrapeptide-3, ceramide, 4-tert-butyl cyclohexanol, bisabolol, sodium hyaluronate and the like. The composition can repair skin barrier injury; the skin nerve dysfunction is improved; the immune function is enhanced, and skin inflammation is eliminated; the elasticity of capillary walls is enhanced, and couperose skin is repaired. The composition disclosed by the invention is applied to skin medicine and skin beauty, can effectively reduce the skin redness average value, the red area and the redness a value, strengthens the brick wall structure, is mild in effect, and has the functions of resisting allergy, fading red, relieving, calming and regulating immunity.

The invention discloses a collagen peptide and a dressing preparation formed by combining the collagen peptide and hesperetin. And the collagen peptide is obtained by carrying out enzymolysis on amino acid sequences as shown in SEQ ID NO.5-SEQ ID NO.8. The collagen peptide is prepared from the collagen peptide. The polypeptide and the preparation thereof have the functions of resisting oxidation and repairing skin injury.

The invention discloses an Ectoin and hydrolyzed collagen silanol composition as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a hydrolyzed collagen silanol derivative: hydrolyzing a silane coupling agent in an acidic organic solvent aqueous solution to obtain silanol hydrolysate; the preparation method comprises the following steps: dissolving hydrolyzed collagen in deionized water, adjusting the pH value to 8-10, stirring, adding silanol hydrolysate for reaction, cooling to room temperature, and freeze-drying to obtain hydrolyzed collagen silanol derivative powder; the preparation method comprises the following steps: preparing an Ectoine and hydrolyzed collagen silanol composition: dissolving hydrolyzed collagen silanol derivative powder and Ectoine in pure water together, and carrying out ultrasonic treatment to obtain the Ectoine and hydrolyzed collagen silanol composition, the prepared composition can inhibit skin heat injury, inhibit skin inflammatory response, promote skin collagen regeneration and repair skin barrier, and can be applied as a raw material of skin care products or medical beauty products.

The invention discloses a mycosporine-like amino acid-protein cross-linked compound as well as a preparation method and application thereof, the structural formula of the mycosporine-like amino acid-protein cross-linked compound is as shown in the following formula (I): # imgabs0 # (I), in the formula (I), R is-CH2OH or-CH (OH) CH3, and the amido bond connection curve represents the peptide chain of the protein. The invention further discloses a hydrogel prepared from the mycosporine-like amino acid-protein cross-linked compound. The invention also discloses application of the mycosporine-like amino acid-protein cross-linked compound or the hydrogel in preparation of ultraviolet protection, anti-aging, wound management biological scaffolds, anti-inflammation, skin repair or hair care products and application in development of biological materials, medical dressings or cosmetics.

The invention discloses a high-expression recombinant collagen allosteric body as well as a construction method and application thereof, a recombinant gene is formed by recombining a type III collagen gene, and stable GXY triad mutation is performed on the basis of an original collagen sequence. The sequence of the recombinant protein is shown as SEQ ID NO.2, the recombinant collagen obtained by the method has similar physicochemical properties and biological functions with the original sequence, and can be applied to injection filling type anti-aging wrinkle removal, facial rejuvenation, skin beautifying, nursing and anti-aging and patch type skin repair dressings, and the active collagen has the fields of repair, moisturizing, whitening and the like.

The application discloses a skin repair dressing and a preparation method thereof, and belongs to the technical field of medical dressings. The skin repair dressing comprises the following raw materials in parts by weight: carboxymethyl chitosan 4-6 parts, sodium alginate 2-4 parts, polyvinyl alcohol 8-10 parts, recombinant human collagen 1-2 parts, sodium hyaluronate 0.5-1 part, a crosslinking agent 1.5-2 parts, nano filler 0.1-0.5 part, an antioxidant 0.5-1 part and deionized water 80-90 parts; the crosslinking agent is prepared by reacting glutathione with dithio-bismaleimidyl ethane to obtain an intermediate 1, and then reacting with 4-formylphenylboronic acid. The skin repair dressing prepared by the application has excellent tensile properties and antibacterial properties.

The invention discloses an anti-aging repairing composition as well as a preparation method and application thereof, and particularly belongs to the field of preparations for dressing and makeup. The composition is prepared from the following components: a dendrobium officinale extract, oligopeptide-215, a kangaroo claw extract, an euglena parvata extract and a cymbidium hookerianum extract. The composition provided by the invention has an obvious inhibition effect on inflammatory factors, effectively promotes migration of skin keratinocytes to achieve the effect of repairing the skin, and meanwhile, the composition can promote generation of collagen and elastin fibers to achieve the effects of resisting wrinkles and tightening the skin; the skin external preparation containing the composition provided by the invention has the effects of tightening, resisting wrinkles and repairing.

The invention relates to a composition containing nucleic acid and polypeptide and application thereof. The composition comprises nucleic acid, polypeptide and auxiliary materials. The nucleic acid and the functional polypeptide are compounded and combined, the problems that a single polypeptide is short in half-life period and short in-vivo retention time are solved, meanwhile, the composition can effectively promote tissue regeneration, stimulate regeneration of fiber cells and collagen, repair skin barriers and improve wrinkles, and can effectively improve blood vessel microcirculation and reduce hyperpigmentation while resisting wrinkles in a synergistic mode. The product disclosed by the invention is produced by a sterile process, is high in safety, and can be applied to the medical cosmetology fields such as plastic and aesthetic surgery, trauma healing and the like.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The invention provides a composition for repairing a skin barrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention discloses a composition for repairing a skin barrier. The composition comprises ceramide NP1, ceramide AP, ceramide EOP, asiaticoside and DNA sodium. The composition is used for repairing skin from related proteins such as endogenous and endogenous injury, inflammatory factor inhibition, light injury, skin cuticle barrier and the like, and can deeply resist inflammation, relieve and maintain stability in an endogenous and endogenous two-way manner, and repair the damaged skin barrier in a multi-level and multi-dimensional manner, so that the skin problems such as skin dryness, roughness, desquamation, redness and swelling, pruritus and the like are improved.

The invention discloses a preparation method of a three-dimensional umbilical cord mesenchymal stem cell exosome and application of the three-dimensional umbilical cord mesenchymal stem cell exosome in the fields of medicines and medical beauty. The preparation method comprises the step of amplifying umbilical cord mesenchymal stem cells (UC-MSCs) by adopting a three-dimensional culture system. Experiments show that IGF-1, EGF, VEGF, TGF-beta, PDGF, FGF and the like in the exosome subjected to three-dimensional culture are beneficial to skin repair and oxidation resistance, and the content of cell active factors for promoting collagen secretion is remarkably increased. The umbilical cord mesenchymal stem cell exosome significantly improves the fibroblast proliferation activity, and UV-induced skin fibroblast damage model construction and function verification experiments also prove that the exosome can promote the HA level recovery of damaged skin fibroblasts. The invention provides an efficient and safe biological material for tissue repair.

The invention discloses a healing-promoting patch, a preparation method and application, and belongs to the field of functional composite materials. The healing promoting application is formed by packaging an upper layer structure, a middle layer structure and a lower layer structure. The upper layer structure is a bioadhesive film; the middle-layer structure is a liquid metal material; and the lower layer structure is a fluorine surface flexible conductive film. The upper-layer structure has good biocompatibility and tissue adhesion, the middle-layer structure has good liquid flow property and excellent drivability, the lower-layer structure has good conductivity, and fluorine on the upper surface of the lower-layer structure has strong electron-withdrawing capability. The healing-promoting application has good biocompatibility, skin adhesion and skin compliance, can be widely applied to the field of medical materials, can change an electric signal of a wound environment through self-power generation, plays a positive role in tissue repair, is beneficial to wound collagen synthesis, inflammation inhibition and wound hair follicle regeneration activation, and has a good healing-promoting effect. The material can be used as a wound application for promoting skin repair and a medical material for repairing other tissues.

The invention relates to the technical field of dressings, and discloses a dressing with a skin repair function and a production process thereof, the dressing with the skin repair function comprises the following raw materials: antibacterial cellulose, anti-inflammatory repair type carrageenan, diallyldimethylammonium chloride, an initiator and deionized water; wherein the antibacterial cellulose is prepared from bacterial cellulose and oleanolic acid; the anti-inflammatory repair type carrageenan is prepared from alkenyl carrageenan and baicalin; the alkenyl carrageenan is prepared from carrageenan and glycidyl methacrylate; the dressing prepared by the invention has an excellent and long-acting antibacterial effect, can effectively inhibit the reproduction of bacteria in a moist environment, provides a good living environment for repairing skin cells, does not easily cause inflammation, avoids scars, accelerates the wound healing rate, and can effectively promote the regeneration and repairing of the skin cells.

The invention provides oral recombinant human elastin capable of repairing skin subacute aging injury and application of the oral recombinant human elastin, and belongs to the technical field of biotechnology and functional food. The oral recombinant human elastin capable of repairing skin subacute aging injury is prepared in a gene recombination expression mode. The recombinant human elastin has both a beta-spiral hydrophobic structure domain and a lysine-rich hydrophilic region, and shows excellent biological safety and biological activity; after the traditional Chinese medicine composition is prepared into an oral preparation, skin wrinkles can be remarkably reduced, the skin water content and dermis density can be improved, transdermal water loss can be reduced, the hydroxyproline level can be increased, collagen generation can be promoted, elasticity can be recovered, and skin oxidative stress reaction can be effectively inhibited. The method solves the problems that the natural elastin source is limited and the biological safety is insufficient, and has a wide industrialization prospect.

The invention relates to the technical field of biology, in particular to recombinant III-type humanized collagen as well as a preparation method and application thereof. The amino acid sequence of the recombinant III type humanized collagen is shown as SEQ ID NO. 1; the invention provides a new sequence of the recombinant III-type humanized collagen, the new recombinant III-type humanized collagen is obtained, and cell experiment tests prove that the new recombinant III-type humanized collagen obtained by the invention can obviously promote the proliferation and migration ability of human skin fibroblasts, and can be used for preparing the human skin fibroblasts. It means that the recombinant III-type humanized collagen provided by the invention has stronger skin repair ability, and has huge commercial application value.

This invention discloses a composition with whitening and freckle-removing effects, its preparation method, and its application, belonging to the field of composition technology. The composition provided by this invention reduces the body's oxidative stress level, providing a suitable internal microenvironment for the efficacy of various drugs and the repair of damage; it provides a sufficient, diverse, and easily absorbed material basis for skin damage repair; it significantly improves the whitening and freckle-removing effect by increasing the activity, purity, and content of the components that directly have whitening and freckle-removing effects; and it promotes the excretion of metabolic waste by improving gastrointestinal health. It is extremely safe, requires minimal equipment, and is environmentally friendly, making it suitable for daily skin repair and whitening / freckle-removing edible use.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to Chinese herbal medicine emulsifiable paste for dermatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: radix sophorae flavescentis, cortex phellodendri, cortex dictamni, fructus cnidii, fructus kochiae, radix scutellariae, radix paeoniae rubra, radix salviae miltiorrhizae, herba schizonepetae, radix saposhnikoviae Systematic design is carried out aiming at complex pathogenesis of seborrheic dermatitis, medicinal materials such as radix sophorae flavescentis and cortex phellodendri are used for synergistically clearing heat and drying dampness, malassezia is inhibited, and lipid control and bacteriostasis are carried out from the source; radix scutellariae, radix salviae miltiorrhizae and the like are combined to cool and activate blood and control inflammation for a long time; the herba schizonepetae, the radix saposhnikoviae and the like are added for targeted itching relieving and secondary injury reduction; in the dosage form, a low-oil-burden matrix composed of light grease such as jojoba oil and squalane is adopted, the texture is light and thin, hair follicles are not blocked, and phytosterol is introduced to synchronously repair the skin barrier; according to the system, the use comfort and compliance are remarkably improved while permeation of active ingredients is guaranteed.

The utility model discloses an autologous repair microneedle injector, which relates to the technical field of medical instruments and comprises a liquid storage tube, a pushing mechanism is arranged in the liquid storage tube, the bottom of the pushing mechanism is fixedly connected with a blocking block, the blocking block is inserted into the lower side wall of the liquid storage tube in a sliding manner, a microneedle liquid penetrating head is fixedly mounted on the bottom surface of the blocking block, and the microneedle liquid penetrating head is fixedly connected with the liquid storage tube. A limiting head is fixedly installed on the bottom face of the liquid storage pipe, the micro-needle liquid penetrating head is arranged in the limiting head, a through hole is formed in the surface of the lower side wall of the limiting head, the specification of the micro-needle liquid penetrating head is matched with that of the through hole, an extrusion mechanism is arranged in the liquid storage pipe, and a liquid adding assembly is arranged on the side face of the liquid storage pipe. Through cooperation of the extrusion mechanism and other mechanisms, rapid connection of microneedle puncturing and repairing stock solution coating is achieved, the repairing stock solution can enter a wound in time, the skin repairing effect after a microneedle operation is guaranteed, and the situation that the coating opportunity is delayed due to the fact that the self-flowing speed of the repairing stock solution is low is avoided.